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dithiolopyrrolone antibiotic

A class of antibiotics that possess the unique pyrrolinonodithiole (4H-[1,2]dithiolo[4,3-b]pyrrol-5-one) skeleton linked upto three variable acyl groups.

ChEBI ID: 156449

Members (3)

MemberDefinitionRole
acetopyrrothineA dithiolopyrrolone antibiotic that is 4,5-dihydro[1,2]dithiolo[4,3-b]pyrrole in which the hydrogens at positions 4,5 and 6 have been replaced by methyl, oxo and acetamido groups, respectively. It is a potent inhibitor of RNA polymerases, inhibits the angiogenesis of human umbilical vein endothelial cells, and also inhibits JAMM metalloproteases.thiolutin
aureothricinA dithiolopyrrolone antibiotic that is 4,5-dihydro[1,2]dithiolo[4,3-b]pyrrole in which the hydrogens at positions 4,5 and 6 have been replaced by methyl, oxo and propanoylamino groups, respectively. It is a moderate antimicrobial by-product of the thiolutin fermentation in various Streptomyces species.aureothricin
holomycinA dithiolopyrrolone antibiotic that is 4,5-dihydro[1,2]dithiolo[4,3-b]pyrrole in which the hydrogens at positions 5 and 6 have been replaced by oxo and acetamido groups, respectively. It is an inhibitor of DNA-dependent RNA polymerase, and exhibits antibacterial and antitumour properties.holomycin

Research

Studies (83)

TimeframeStudies, Drugs in This Class (%)All Drugs %
pre-199016 (19.28)18.7374
1990's7 (8.43)18.2507
2000's17 (20.48)29.6817
2010's27 (32.53)24.3611
2020's16 (19.28)2.80

Study Types

Publication TypeStudies, Drugs in This Class (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews4 (4.44%)6.00%
Case Studies0 (0.00%)4.05%
Observational2 (2.22%)0.25%
Other84 (93.33%)84.16%