Page last updated: 2024-10-24

Dxr protein complex

Definition

Target type: cellularcomponent

A protein complex that is involved in the MEP pathway of IPP biosynthesis. It catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP). [GOC:bhm, PMID:15339150]

The Dxr protein complex, also known as 1-deoxy-D-xylulose 5-phosphate reductoisomerase, is a key enzyme in the biosynthesis of isoprenoids, essential molecules involved in a wide range of cellular functions. This complex is found in the cytoplasm of both prokaryotic and eukaryotic cells, specifically localized within the cytosol, the fluid portion of the cytoplasm. Within the cytosol, Dxr protein complexes assemble as homodimers, meaning they consist of two identical protein subunits. Each subunit contains a catalytic domain that binds the substrate, 1-deoxy-D-xylulose 5-phosphate (DXP), and catalyzes its conversion to 2-C-methyl-D-erythritol 4-phosphate (MEP). The Dxr protein complex is essential for the production of MEP, a key precursor for the biosynthesis of isoprenoids. Isoprenoids are a diverse group of molecules with crucial roles in various cellular processes, including cell signaling, membrane structure, and photosynthesis. The localization of the Dxr protein complex in the cytoplasm, specifically in the cytosol, reflects its central role in isoprenoid biosynthesis, a process that takes place within the cytoplasm of cells.'
"

Proteins (1)

ProteinDefinitionTaxonomy
1-deoxy-D-xylulose 5-phosphate reductoisomeraseA 1-deoxy-D-xylulose 5-phosphate reductoisomerase that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P45568]Escherichia coli K-12

Compounds (10)

CompoundDefinitionClassesRoles
fosmidomycinfosmidomycin : Propylphosphonic acid in which one of the hydrogens at position 3 is substituted by a formyl(hydroxy)amino group. An antibiotic obtained from Streptomyces lavendulae, it specifically inhibits DXP reductoisomerase (EC 1.1.1.267), a key enzyme in the non-mevalonate pathway of isoprenoid biosynthesis.

fosmidomycin: from Streptomyces lavendulae; RN given refers to parent cpd; structure in second source
hydroxamic acid;
phosphonic acids
antimicrobial agent;
bacterial metabolite;
EC 1.1.1.267 (1-deoxy-D-xylulose-5-phosphate reductoisomerase) inhibitor
3-aminopropylphosphonic acid(3-aminopropyl)phosphonic acid : A phosphonic acid in which the hydrogen attached to the phosphorus of phosphonic acid is substituted by a 3-aminopropyl group. It is a partial agonist of GABAB receptors.

3-aminopropylphosphonic acid: RN given refers to parent cpd; structure
phosphonic acids;
primary amino compound;
zwitterion
GABAB receptor agonist
n-hydroxy-4-phosphonobutanamideN-hydroxy-4-phosphonobutanamide: structure given in first source
3-(n-acetyl-n-hydroxy)aminopropylphosphonic acid3-(N-acetyl-N-hydroxy)aminopropylphosphonic acid: from Streptomyces rubellomurinus sp. nov.; interferes with bacterial cell wall synthesis; structure in first sourcephosphonoacetic acid
fosmidomycin monosodium salt
quercetin7-hydroxyflavonol;
pentahydroxyflavone
antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
luteolin3'-hydroxyflavonoid;
tetrahydroxyflavone
angiogenesis inhibitor;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
c-Jun N-terminal kinase inhibitor;
EC 2.3.1.85 (fatty acid synthase) inhibitor;
immunomodulator;
nephroprotective agent;
plant metabolite;
radical scavenger;
vascular endothelial growth factor receptor antagonist
baicaleintrihydroxyflavoneangiogenesis inhibitor;
anti-inflammatory agent;
antibacterial agent;
anticoronaviral agent;
antifungal agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
EC 1.13.11.31 (arachidonate 12-lipoxygenase) inhibitor;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
EC 4.1.1.17 (ornithine decarboxylase) inhibitor;
ferroptosis inhibitor;
geroprotector;
hormone antagonist;
plant metabolite;
prostaglandin antagonist;
radical scavenger
fisetin3'-hydroxyflavonoid;
7-hydroxyflavonol;
tetrahydroxyflavone
anti-inflammatory agent;
antioxidant;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
metabolite;
plant metabolite
myricetin7-hydroxyflavonol;
hexahydroxyflavone
antineoplastic agent;
antioxidant;
cyclooxygenase 1 inhibitor;
food component;
geroprotector;
hypoglycemic agent;
plant metabolite