An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the action of ceramidase (EC 3.5.1.23).
ChEBI ID: 71551
| Member | Definition | Class |
|---|---|---|
| n-oleoylethanolamine | An N-(long-chain-acyl)ethanolamine that is the ethanolamide of oleic acid. The monounsaturated analogue of the endocannabinoid anandamide. | oleoyl ethanolamide |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 3 (0.69) | 18.7374 |
| 1990's | 15 (3.46) | 18.2507 |
| 2000's | 108 (24.88) | 29.6817 |
| 2010's | 242 (55.76) | 24.3611 |
| 2020's | 66 (15.21) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 17 (3.90%) | 5.53% |
| Reviews | 31 (7.11%) | 6.00% |
| Case Studies | 1 (0.23%) | 4.05% |
| Observational | 1 (0.23%) | 0.25% |
| Other | 386 (88.53%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| alpha-galactosidase | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| arylsulfatase A | Homo sapiens (human) | Potency | 1.0691 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 11.5774 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 19.9526 | 2 | 2 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 50.1187 | 1 | 1 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 19.9526 | 1 | 1 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 17.7828 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 37.6460 | 2 | 2 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 31.6228 | 2 | 2 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 17.6588 | 1 | 2 |
| endonuclease IV | Escherichia coli | Potency | 17.7828 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 10.5909 | 1 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 23.4536 | 1 | 2 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 8.4368 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 24.0353 | 2 | 2 |
| GLS protein | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 31.6228 | 1 | 3 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 11.9048 | 2 | 2 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 10.0000 | 1 | 1 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 63.0957 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 32.1841 | 1 | 3 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 0.1122 | 2 | 2 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 7.0795 | 1 | 2 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 89.1251 | 1 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 19.5646 | 2 | 3 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 29.4170 | 3 | 4 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 22.4113 | 2 | 4 |
| tumor susceptibility gene 101 protein | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Acid ceramidase | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| Acid ceramidase | Homo sapiens (human) | Ki | 500.0000 | 1 | 1 |
| Cannabinoid receptor 1 | Homo sapiens (human) | Ki | 3.3250 | 3 | 4 |
| Cannabinoid receptor 1 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 2 |
| Cannabinoid receptor 2 | Homo sapiens (human) | Ki | 7.7750 | 3 | 4 |
| Corticotropin-releasing factor receptor 2 | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| Fatty acid-binding protein, liver | Mus musculus (house mouse) | Ki | 0.0430 | 1 | 1 |
| Fatty-acid amide hydrolase 1 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Transient receptor potential cation channel subfamily V member 2 | Rattus norvegicus (Norway rat) | IC50 | 3.6000 | 2 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Cannabinoid receptor 1 | Mus musculus (house mouse) | EC50 | 0.1850 | 1 | 1 |
| Cannabinoid receptor 2 | Mus musculus (house mouse) | EC50 | 0.1850 | 1 | 1 |
| Cytochrome P450 2C8 | Homo sapiens (human) | EC50 | 0.1850 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | EC50 | 0.1850 | 1 | 1 |
| Glucose-dependent insulinotropic receptor | Homo sapiens (human) | EC50 | 2.3043 | 7 | 7 |
| Glucose-dependent insulinotropic receptor | Mus musculus (house mouse) | EC50 | 2.9000 | 1 | 1 |
| Peroxisome proliferator-activated receptor alpha | Homo sapiens (human) | EC50 | 0.1438 | 5 | 5 |
| Peroxisome proliferator-activated receptor delta | Homo sapiens (human) | EC50 | 1.1000 | 1 | 1 |
| Renin | Homo sapiens (human) | EC50 | 0.1850 | 1 | 1 |
| Transient receptor potential cation channel subfamily V member 1 | Homo sapiens (human) | EC50 | 2.0575 | 4 | 4 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | Mycobacterium tuberculosis H37Rv | AC50 | 100.0000 | 1 | 1 |
| heat shock protein 90, putative | Plasmodium falciparum 3D7 | AC50 | 9.2500 | 1 | 1 |
| heat shock protein HSP 90-alpha isoform 2 | Homo sapiens (human) | AC50 | 7.6660 | 1 | 1 |