| Assay ID | Title | Year | Journal | Article |
|---|
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | | | |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | | | |
| AID1474750 | Cytotoxicity against mouse RAW264.7 cells by MTT assay | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11
| Identification and structure activity relationship of novel flavone derivatives that inhibit the production of nitric oxide and PGE |
| AID1860354 | Inhibition of CYP450 in human liver microsomes assessed as inhibition of EpETrE formation at 10 uM in presence of arachidonic acid and NADPH by multi-enzyme assay based LC-MS/MS analysis relative to control | | | |
| AID774398 | Inhibition of human TNKS1 (1030 to 1317) using NAD+ as substrate by fluorescence assay | 2013 | Journal of medicinal chemistry, Oct-24, Volume: 56, Issue:20
| Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. |
| AID1166586 | Agonist activity at mouse MC3 receptor at 100 uM to 5 mM | 2014 | Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
| Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor. |
| AID1166598 | Agonist activity at human A3 receptor at 100 uM to 5 mM | 2014 | Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
| Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor. |
| AID1166595 | Agonist activity at human D5 receptor at 100 uM to 5 mM | 2014 | Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
| Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor. |
| AID1166581 | Agonist activity at human MC2 receptor at 100 uM to 5 mM | 2014 | Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
| Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor. |
| AID404067 | In vivo antitumor activity against mouse S180 cells | | | |
| AID1166594 | Agonist activity at human D1 receptor at 100 uM to 5 mM | 2014 | Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
| Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor. |
| AID1166589 | Agonist activity at human NMU1 receptor at 100 uM to 5 mM | 2014 | Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
| Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor. |
| AID765682 | Cytotoxicity against human neutrophils assessed as cell viability at 100 uM after 1 hr by trypan blue exclusion assay | 2013 | European journal of medicinal chemistry, Sep, Volume: 67 | Modulation of human neutrophils' oxidative burst by flavonoids. |
| AID1474748 | Cytotoxicity against LPS-stimulated mouse RAW264.7 cells assessed as cell viability at 20 uM by MTT assay (Rvb = 100.01 +/- 0.05 %) | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11
| Identification and structure activity relationship of novel flavone derivatives that inhibit the production of nitric oxide and PGE |
| AID1166600 | Agonist activity at human C5a receptor at 100 uM to 5 mM | 2014 | Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
| Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor. |
| AID1063902 | Inhibition of 5-LOX-mediated LTB4 production in human neutrophils using arachidonic acid as substrate at 40 uM preincubated for 10 mins followed by substrate addition measured after 8 mins by enzyme immunoassay relative to control | 2014 | European journal of medicinal chemistry, Jan-24, Volume: 72 | Inhibition of LOX by flavonoids: a structure-activity relationship study. |
| AID1166599 | Agonist activity at human PTH receptor at 100 uM to 5 mM | 2014 | Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
| Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor. |
| AID1166579 | Agonist activity at human NMU2R transfected in HEK293 cells after 7 hrs by luciferase reporter gene assay | 2014 | Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
| Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor. |
| AID765678 | Inhibition of oxidative burst in PMA-stimulated human neutrophils assessed as inhibition of superoxide anion radical-induced lucigenin oxidation up to 100 uM incubated for 5 mins prior to PMA challenge by chemiluminescence assay | 2013 | European journal of medicinal chemistry, Sep, Volume: 67 | Modulation of human neutrophils' oxidative burst by flavonoids. |
| AID1166590 | Agonist activity at human 5HT2C receptor at 100 uM to 5 mM | 2014 | Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
| Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor. |
| AID1166596 | Agonist activity at human A1 receptor at 100 uM to 5 mM | 2014 | Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
| Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor. |
| AID1166588 | Agonist activity at mouse MC5 receptor at 100 uM to 5 mM | 2014 | Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
| Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor. |
| AID1166582 | Agonist activity at human MC3 receptor at 100 uM to 5 mM | 2014 | Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
| Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor. |
| AID1166591 | Agonist activity at human orexin 2 receptor at 100 uM to 5 mM | 2014 | Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
| Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor. |
| AID338750 | Inhibition of bovine thymus p56LCK-catalyzed phosphorylation of angiotensin 1 by SDS-PAGE | | | |
| AID1166601 | Agonist activity at human NPY5 receptor at 100 uM to 5 mM | 2014 | Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
| Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor. |
| AID1474747 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated PGE2 production by ELISA | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11
| Identification and structure activity relationship of novel flavone derivatives that inhibit the production of nitric oxide and PGE |
| AID1166580 | Agonist activity at human MC1 receptor at 100 uM to 5 mM | 2014 | Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
| Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor. |
| AID765677 | Inhibition of oxidative burst in PMA-stimulated human neutrophils assessed as inhibition of H2O2-induced oxidation of amplex red incubated for 5 mins prior to PMA challenge by fluorescence assay | 2013 | European journal of medicinal chemistry, Sep, Volume: 67 | Modulation of human neutrophils' oxidative burst by flavonoids. |
| AID1166593 | Agonist activity at human M1 receptor at 100 uM to 5 mM | 2014 | Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
| Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor. |
| AID213412 | Ability to inhibit protein-tyrosine kinase activity of p56lck (isolated from bovine thymus) in vitro. | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
| Synthesis and protein-tyrosine kinase inhibitory activities of flavonoid analogues. |
| AID765681 | Inhibition of oxidative burst in PMA-stimulated human neutrophils assessed as inhibition of ROS-induced luminol oxidation incubated for 5 mins prior to PMA challenge by chemiluminescence assay | 2013 | European journal of medicinal chemistry, Sep, Volume: 67 | Modulation of human neutrophils' oxidative burst by flavonoids. |
| AID1166597 | Agonist activity at human A2a receptor at 100 uM to 5 mM | 2014 | Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
| Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor. |
| AID1668637 | Inhibition of human liver FBP1 at 200 uM incubated for 5 mins by fluorescence method relative to control | 2020 | Journal of natural products, 05-22, Volume: 83, Issue:5
| Structural Specificity of Flavonoids in the Inhibition of Human Fructose 1,6-Bisphosphatase. |
| AID404069 | In vivo antitumor activity against mouse L1210 cells | | | |
| AID1860353 | Inhibition of CYP450 in human liver microsomes assessed as inhibition of 20-HETE formation at 10 uM in presence of arachidonic acid and NADPH by multi-enzyme assay based LC-MS/MS analysis relative to control | | | |
| AID1474749 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated NO production by ELISA | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11
| Identification and structure activity relationship of novel flavone derivatives that inhibit the production of nitric oxide and PGE |
| AID1166585 | Agonist activity at mouse MC2 receptor at 100 uM to 5 mM | 2014 | Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
| Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor. |
| AID1860355 | Selectivity index, log ratio of Inhibition of CYP450 in human liver microsomes assessed as inhibition of EpETrE formation in presence of arachidonic acid to Inhibition of CYP450 in human liver microsomes assessed as inhibition of 20-HETE formation in pres | | | |
| AID404070 | In vivo antitumor activity against mouse CA-755 cells | | | |
| AID201080 | Minimum inhibitory concentration, that inhibits growth of Staphylococcus aureus in the presence of subinhibitory (30 ug/mL) Berberine; Inactive | 2001 | Journal of medicinal chemistry, Jan-18, Volume: 44, Issue:2
| Flavonolignan and flavone inhibitors of a Staphylococcus aureus multidrug resistance pump: structure-activity relationships. |
| AID1474745 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated NO production at 20 uM by ELISA relative to control | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11
| Identification and structure activity relationship of novel flavone derivatives that inhibit the production of nitric oxide and PGE |
| AID1166584 | Agonist activity at mouse MC1 receptor at 100 uM to 5 mM | 2014 | Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
| Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor. |
| AID188853 | Percent protection from gastric damage in rats relative to vehicle control following intraperitoneal administration of 20 mg/Kg | 1995 | Journal of medicinal chemistry, Dec-08, Volume: 38, Issue:25
| Synthesis and biological evaluation of substituted flavones as gastroprotective agents. |
| AID1166583 | Agonist activity at human MC4 receptor at 100 uM to 5 mM | 2014 | Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
| Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor. |
| AID1166587 | Agonist activity at mouse MC4 receptor at 100 uM to 5 mM | 2014 | Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
| Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor. |
| AID1166602 | Agonist activity at human Glu receptor at 100 uM to 5 mM | 2014 | Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
| Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor. |
| AID598366 | Antifungal activity against Candida parapsilosis ATCC 22019 after 48 hrs by broth microdilution technique | 2011 | Bioorganic & medicinal chemistry, May-15, Volume: 19, Issue:10
| Synthesis and antifungal activities of natural and synthetic biflavonoids. |
| AID1166592 | Agonist activity at human MCH1 receptor at 100 uM to 5 mM | 2014 | Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
| Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor. |
| AID358174 | Inhibition of p56 lck | 1992 | Journal of natural products, Nov, Volume: 55, Issue:11
| Protein-tyrosine kinase inhibition: mechanism-based discovery of antitumor agents. |
| AID605243 | Agonist activity at TrkB in E17 rat primary cortical neurons assessed as AKT phosphorylation at Ser 473 at 500 nM after 15 mins by ELISA | 2010 | Journal of medicinal chemistry, Dec-09, Volume: 53, Issue:23
| A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect. |
| AID1801003 | Fluorimetric Assay from Article 10.1016/j.bioorg.2014.11.008: \\Monoamine oxidase inhibitory activity of 2-aryl-4H-chromen-4-ones.\\ | 2015 | Bioorganic chemistry, Feb, Volume: 58 | Monoamine oxidase inhibitory activity of 2-aryl-4H-chromen-4-ones. |
| AID977611 | Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB | 2013 | Journal of medicinal chemistry, Oct-24, Volume: 56, Issue:20
| Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |