bharangin: inhibits the activity of penicillinase enzyme in E coli [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
ID Source | ID |
---|---|
PubMed CID | 194464 |
CHEMBL ID | 1807756 |
MeSH ID | M0166566 |
Synonym |
---|
bharangin |
72711-84-3 |
CHEMBL1807756 |
benzo(5,6)cyclohepta(1,2-b)pyran-2,9-dione, 3,4,11,11a-tetrahydro-10-hydroxy-4,4,11a-trimethyl-8-(1-methylethyl)-, (s)- |
DTXSID00993529 |
10-hydroxy-4,4,11a-trimethyl-8-(propan-2-yl)-3,4,11,11a-tetrahydrobenzo[5,6]cyclohepta[1,2-b]pyran-2,9-dione |
(3s)-15-hydroxy-3,7,7-trimethyl-13-propan-2-yl-4-oxatricyclo[9.4.0.03,8]pentadeca-1(15),8,10,12-tetraene-5,14-dione |
AKOS040747960 |
Bharangin is a diterpenoid quinonemethide. It has demonstrated therapeutic potential against leukemia, lymphoma, and multiple myeloma cells.
Excerpt | Reference | Relevance |
---|---|---|
"Bharangin is a diterpenoid quinonemethide that has demonstrated therapeutic potential against leukemia, lymphoma, and multiple myeloma cells." | ( Anti-cancer activities of Bharangin against breast cancer: Evidence for the role of NF-κB and lncRNAs. Awasthee, N; Gupta, SC; Nair, MS; Rai, V; Sajin Francis, K; Verma, SS, 2018) | 1.5 |
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID608688 | Cytotoxicity against human A549 cells after 48 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 21, Issue:15 | Cytotoxic diterpenoid quinonemethides from the roots of Pygmacopremna herbacea. |
AID608689 | Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 21, Issue:15 | Cytotoxic diterpenoid quinonemethides from the roots of Pygmacopremna herbacea. |
AID608691 | Cytotoxicity against human HeLa cells after 48 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 21, Issue:15 | Cytotoxic diterpenoid quinonemethides from the roots of Pygmacopremna herbacea. |
AID608687 | Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 21, Issue:15 | Cytotoxic diterpenoid quinonemethides from the roots of Pygmacopremna herbacea. |
AID608690 | Cytotoxicity against human PC3 cells after 48 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 21, Issue:15 | Cytotoxic diterpenoid quinonemethides from the roots of Pygmacopremna herbacea. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 1 (16.67) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 2 (33.33) | 29.6817 |
2010's | 3 (50.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.52) All Compounds (24.57) |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 6 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |