Page last updated: 2024-12-09

5,7,3',4'-tetramethylluteolin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

5,7,3',4'-tetramethylluteolin: a flavonoid from the East Asian medicinal plant Orthosiphon spicatus; prevents oxidative inactivation of 15-lipoxygenase; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
OrthosiphongenusA plant genus of the family LAMIACEAE that contains pimarane-type diterpenes. Several species of Orthosiphon are also called Java tea.[MeSH]LamiaceaeThe mint plant family. They are characteristically aromatic, and many of them are cultivated for their oils. Most have square stems, opposite leaves, and two-lipped, open-mouthed, tubular corollas (united petals), with five-lobed, bell-like calyxes (united sepals).[MeSH]

Cross-References

ID SourceID
PubMed CID631170
CHEMBL ID327340
SCHEMBL ID1421511
MeSH IDM0269695

Synonyms (32)

Synonym
CHEMBL327340
tetramethylluteolin
tetramethoxyluteolin
2-(3,4-dimethoxyphenyl)-5,7-dimethoxy-4h-1-benzopyran-4-one
4h-1-benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-5,7-dimethoxy-
luteolin tetramethyl ether
855-97-0
3',4',5,7-tetramethoxyflavone
3',4',5,7-tetramethyl-luteolin
5,7,3',4'-tetramethylluteolin
luteolin 5,7,3',4'-tetramethyl ether
LMPK12111074
2-(3,4-dimethoxyphenyl)-5,7-dimethoxychromen-4-one
2-(3,4-dimethoxyphenyl)-5,7-dimethoxy-chromen-4-one
A841374
FT-0614125
2-(3,4-dimethoxyphenyl)-5,7-dimethoxy-4h-chromen-4-one
AKOS015851531
DTXSID80234705
SCHEMBL1421511
AC-34780
flavone, 3',4',5,7-tetramethoxy
2-(3,4-dimethoxyphenyl)-5,7-dimethoxy-4h-chromen-4-one #
mfcd00017558
AS-69763
5,7,3',4'-tetramethoxyflavone
HY-N7030
CS-W011898
3 inverted exclamation mark ,4 inverted exclamation mark ,5,7-tetramethoxyflavone
SY252783
E88611
?3',4',5,7-tetramethoxyflavone
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (14)

Assay IDTitleYearJournalArticle
AID596671Induction of adipogenesis in mouse 3T3L1 cells assessed as increase in triglyceride level at 3 uM on day 8 relative to control2011Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells.
AID622584Inhibition of NF-kappaB activation expressed in HCT116 cells assessed as inhibition of TNF-alpha-induced transcriptional activation at 10 uM after 12 hrs by luciferase reporter gene assay relative to control2011Bioorganic & medicinal chemistry letters, Oct-15, Volume: 21, Issue:20
Relationship between the structures of flavonoids and their NF-κB-dependent transcriptional activities.
AID201080Minimum inhibitory concentration, that inhibits growth of Staphylococcus aureus in the presence of subinhibitory (30 ug/mL) Berberine; Inactive2001Journal of medicinal chemistry, Jan-18, Volume: 44, Issue:2
Flavonolignan and flavone inhibitors of a Staphylococcus aureus multidrug resistance pump: structure-activity relationships.
AID1474745Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated NO production at 20 uM by ELISA relative to control2017Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11
Identification and structure activity relationship of novel flavone derivatives that inhibit the production of nitric oxide and PGE
AID596673Induction of adipogenesis in mouse 3T3L1 cells assessed as increase in triglyceride level at 30 uM on day 8 relative to control2011Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells.
AID596672Induction of adipogenesis in mouse 3T3L1 cells assessed as increase in triglyceride level at 10 uM on day 8 relative to control2011Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells.
AID1474749Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated NO production by ELISA2017Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11
Identification and structure activity relationship of novel flavone derivatives that inhibit the production of nitric oxide and PGE
AID1677633Activation of CRE-mediated transcription in rat PC12D cells transfected with pCRE-firefly luciferase and pRL-null-renilla luciferase assessed as increase in CRE-driven firefly luciferase activity at 30 uM by dual luciferase reporter gene assay2020Bioorganic & medicinal chemistry letters, 12-01, Volume: 30, Issue:23
Effect of methoxyflavones contained in Kaempferia parviflora on CRE-mediated transcription in PC12D cells.
AID1677634Effect on transcription in rat PC12D cells transfected with pCRE-firefly luciferase and pRL-null-renilla luciferase assessed as renilla luciferase activity at 30 uM by dual luciferase reporter gene assay2020Bioorganic & medicinal chemistry letters, 12-01, Volume: 30, Issue:23
Effect of methoxyflavones contained in Kaempferia parviflora on CRE-mediated transcription in PC12D cells.
AID1677632Cytotoxicity against rat PC12D cells assessed as reduction in cell viability at 30 uM by MTT assay2020Bioorganic & medicinal chemistry letters, 12-01, Volume: 30, Issue:23
Effect of methoxyflavones contained in Kaempferia parviflora on CRE-mediated transcription in PC12D cells.
AID1474750Cytotoxicity against mouse RAW264.7 cells by MTT assay2017Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11
Identification and structure activity relationship of novel flavone derivatives that inhibit the production of nitric oxide and PGE
AID596670Induction of adipogenesis in mouse 3T3L1 cells assessed as increase in triglyceride level at 1 uM on day 8 relative to control2011Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells.
AID1474747Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated PGE2 production by ELISA2017Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11
Identification and structure activity relationship of novel flavone derivatives that inhibit the production of nitric oxide and PGE
AID1474748Cytotoxicity against LPS-stimulated mouse RAW264.7 cells assessed as cell viability at 20 uM by MTT assay (Rvb = 100.01 +/- 0.05 %)2017Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11
Identification and structure activity relationship of novel flavone derivatives that inhibit the production of nitric oxide and PGE
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (12.50)18.2507
2000's1 (12.50)29.6817
2010's5 (62.50)24.3611
2020's1 (12.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.13

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.13 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index5.33 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.13)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]