Page last updated: 2024-11-12
ginsenoside rb3
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Related Flora
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Panax | genus | An araliaceous genus of plants that contains a number of pharmacologically active agents used as stimulants, sedatives, and tonics, especially in traditional medicine. Sometimes confused with Siberian ginseng (ELEUTHEROCOCCUS).[MeSH] | Araliaceae | The ginseng plant family of the order Apiales, subclass Rosidae, class Magnoliopsida. Leaves are generally alternate, large, and compound. Flowers are five-parted and arranged in compound flat-topped umbels. The fruit is a berry or (rarely) a drupe (a one-seeded fruit). It is well known for plant preparations used as adaptogens (immune support and anti-fatigue).[MeSH] |
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 12912363 |
| CHEMBL ID | 507688 |
| CHEBI ID | 77153 |
| MeSH ID | M0129857 |
Synonyms (21)
| Synonym |
|---|
| ginsenoside rb3 , |
| alpha-d-glucopyranoside, (3-beta,12-beta)-3-((2-o-beta-d-glucopyranosyl-beta-d-glucopyranosyl)oxy)-12-hydroxydammar-24-en-20-yl 6-o-beta-d-xylopyranosyl- |
| CHEMBL507688 , |
| chebi:77153 , |
| bdbm50317540 |
| unii-w6v49a8fjq |
| w6v49a8fjq , |
| S9208 |
| gypenoside iv |
| CS-3831 |
| (3beta,12beta)-20-{[6-o-(beta-d-xylopyranosyl)-beta-d-glucopyranosyl]oxy}-12-hydroxydammar-24-en-3-yl 2-o-beta-d-glucopyranosyl-beta-d-glucopyranoside |
| 3beta-[beta-d-glucopyranosyl-(1->2)-beta-d glucopyranosyloxy]-20-[beta-d-xylopyranosyl-(1->2)-beta-d glucopyranosyloxy]dammar-24-en-12beta-ol |
| HY-N0041 |
| ginsenoside rb3, analytical standard |
| mfcd10566396 |
| NCGC00485982-01 |
| .beta.-d-glucopyranoside, (3.beta.,12.beta.)-3-((2-o-.beta.-d-glucopyranosyl-.beta.-d-glucopyranosyl)oxy)-12-hydroxydammar-24-en-20-yl 6-o-.beta.-d-xylopyranosyl- |
| AKOS037514669 |
| Q27146709 |
| CCG-270634 |
| DTXSID601317092 |
Research Excerpts
Overview
Ginsenoside Rb3 (G-Rb3) is a natural product derived from ginseng that has cardio-protective effect.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Ginsenoside Rb3 (G-Rb3) is a natural product derived from ginseng that has cardio-protective effect." | ( Ginsenoside Rb3 regulates energy metabolism and apoptosis in cardiomyocytes via activating PPARα pathway. Chen, X; Gao, P; Guo, D; Li, C; Li, W; Ma, L; Shao, M; Wang, Q; Wang, X; Wang, Y; Wu, Y, 2019) | 2.68 |
Effects
Ginsenoside Rb3 has been proved to have antidepressant-like effects. It possesses 1 xylose and 3 glucose moieties with 20(S)-protopanaxadiol (PPD) as the aglycone.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Ginsenoside Rb3 has a significant protective effect on hypoxic-ischemic injury of neurons, and this involves the stabilization of the cell membrane, the inhibition of the expression and activity of NOS, especially iNOS activity." | ( [Protective effects of ginsenoside RB3 on hypoxic/ischemic brain injury and involved mechanisms]. Jiang, S; Jiang, ZL; Shen, HM; Zhang, ZJ, 2006) | 2.09 |
| "Ginsenoside Rb3 (G‑Rb3) has been demonstrated to alleviate myocardial ischemia reperfusion injury (MIRI); however, it is difficult to separate G‑Rb2 from its isomer G‑Rb3. " | ( Combination of the ginsenosides Rb3 and Rb2 exerts protective effects against myocardial ischemia reperfusion injury in rats. Fu, W; Jiang, Y; Liu, X; Sui, D; Yu, X, 2020) | 2 |
| "Ginsenoside Rb3 has been proved to have antidepressant-like effects, which possesses 1 xylose and 3 glucose moieties with 20(S)-protopanaxadiol (PPD) as the aglycone. " | ( Antidepressant-like effects of ginsenosides: A comparison of ginsenoside Rb3 and its four deglycosylated derivatives, Rg3, Rh2, compound K, and 20(S)-protopanaxadiol in mice models of despair. Li, Z; Lou, C; Yang, H; Zhang, H; Zhong, Z; Zhou, Z, 2016) | 2.12 |
Actions
| Excerpt | Reference | Relevance |
|---|---|---|
| "Ginsenoside Rb3 can enhance the hippocampal neuronal viability, decrease the LDH leakage, elevate the viability of cNOS, and in the same time weaken iNOS's viability." | ( [Effects and mechanisms of ginsenoside Rb3 on glutamate excitotoxic injury in cultured neurons of rat hippocampus]. Gu, XS; Jiang, ZL; Shen, HM, 2006) | 2.07 |
Treatment
| Excerpt | Reference | Relevance |
|---|---|---|
| "Treatment with ginsenoside Rb3 also decreased plasma endothelin and angiotensin II levels." | ( Ginsenoside Rb3 ameliorates myocardial ischemia-reperfusion injury in rats. Han, B; Qu, S; Shi, Y; Sui, D; Yu, X, 2011) | 2.15 |
Toxicity
| Excerpt | Reference | Relevance |
|---|---|---|
| " Inhibition of autophagy induced inactivation of apoptosis, which suggested that autophagy played an adverse effect on cisplatin-evoked renal damage." | ( Ginsenoside Rb3 provides protective effects against cisplatin-induced nephrotoxicity via regulation of AMPK-/mTOR-mediated autophagy and inhibition of apoptosis in vitro and in vivo. Chen, C; Hou, JG; Li, W; Liu, WC; Ma, ZN; Ren, S; Wang, YP; Wang, Z; Xing, JJ, 2019) | 1.96 |
Pharmacokinetics
| Excerpt | Reference | Relevance |
|---|---|---|
| " The value of Rb(1) is higher than that of Rb(2) or Rb(3), indicating that ginsenosides with hexose and hydroxyl groups (Rb(1)) could present better pharmacokinetic behaviors than those with pentose groups in the same glycosylation site by oral administration." | ( Determination of ginsenosides Rb1, Rb2, and Rb3 in rat plasma by a rapid and sensitive liquid chromatography tandem mass spectrometry method: Application in a pharmacokinetic study. Liu, M; Liu, Z; Su, C; Su, W; Tang, L; Yang, C; Zhao, J, 2012) | 0.38 |
| " The aim of this study is to develop a rapid resolution liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (RRLC-Q-TOF-MS) method for pharmacokinetic study of ginsenoside Rb3 and simultaneous determination of metabolites in rats." | ( Pharmacokinetic and metabolic studies of ginsenoside Rb3 in rats using RRLC-Q-TOF-MS. Chen, C; Liu, S; Ma, Y; Wu, W; Zhao, L, 2018) | 0.94 |
Bioavailability
Dosage Studied
| Excerpt | Relevance | Reference |
|---|---|---|
| " Interestingly, C-K showed antidepressant-like activities similar to that of Rb3, and Rg3 displayed antidepressant-like effects at lower dosage and faster time, indicating it has better effects than Rb3, whereas Rh2 and PPD failed to show any effect." | ( Antidepressant-like effects of ginsenosides: A comparison of ginsenoside Rb3 and its four deglycosylated derivatives, Rg3, Rh2, compound K, and 20(S)-protopanaxadiol in mice models of despair. Li, Z; Lou, C; Yang, H; Zhang, H; Zhong, Z; Zhou, Z, 2016) | 0.68 |
| " However, how to improve its oral bioavailability and reduce its dosage remains to be studied." | ( Synergistic Effects of Ginsenoside Rb3 and Ferruginol in Ischemia-Induced Myocardial Infarction. Chen, X; Jiang, Q; Li, C; Li, J; Liu, T; Wang, H; Wang, Q; Wang, W; Wang, Y; Xue, S, 2022) | 1.03 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Roles (6)
| Role | Description |
|---|---|
| plant metabolite | Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. |
| antioxidant | A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides. |
| antidepressant | Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. |
| cardioprotective agent | Any protective agent that is able to prevent damage to the heart. |
| NMDA receptor antagonist | Any substance that inhibits the action of N-methyl-D-aspartate (NMDA) receptors. They tend to induce a state known as dissociative anesthesia, marked by catalepsy, amnesia, and analgesia, while side effects can include hallucinations, nightmares, and confusion. Due to their psychotomimetic effects, many NMDA receptor antagonists are used as recreational drugs. |
| neuroprotective agent | Any compound that can be used for the treatment of neurodegenerative disorders. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
Drug Classes (5)
| Class | Description |
|---|---|
| 12beta-hydroxy steroid | |
| beta-D-glucoside | Any D-glucoside in which the anomeric centre has beta-configuration. |
| disaccharide derivative | A carbohydrate derivative that is formally obtained from a disaccharide. |
| ginsenoside | Triterpenoid saponins with a dammarane-like skeleton originally isolated from ginseng (Panax) species. Use of the term has been extended to include semi-synthetic derivatives. |
| tetracyclic triterpenoid | Any triterpenoid consisting of a tetracyclic skeleton. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
Protein Targets (3)
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| DNA topoisomerase 1 | Homo sapiens (human) | IC50 (µMol) | 250.0000 | 0.0210 | 1.8626 | 10.0000 | AID480992 |
| DNA topoisomerase 2-alpha | Homo sapiens (human) | IC50 (µMol) | 250.0000 | 0.4800 | 4.3564 | 9.9400 | AID480993 |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | IC50 (µMol) | 250.0000 | 0.0003 | 0.7123 | 7.0700 | AID480992 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
Biological Processes (24)
Molecular Functions (20)
Ceullar Components (16)
Bioassays (20)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1 | Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID337109 | Hepatoprotective activity against D-galactosamine/LPS-induced liver injury in ddY mouse assessed as inhibition of serum aspartate transaminase level at 50 mg/kg, ip administered 1 hr before D-galactosamine/LPS challenge by Reitman-Frankel method | 2003 | Journal of natural products, Jul, Volume: 66, Issue:7 | Structures of new dammarane-type Triterpene Saponins from the flower buds of Panax notoginseng and hepatoprotective effects of principal Ginseng Saponins. |
| AID337110 | Hepatoprotective activity against D-galactosamine/LPS-induced liver injury in ddY mouse assessed as inhibition of serum aspartate transaminase level at 100 mg/kg, ip administered 1 hr before D-galactosamine/LPS challenge by Reitman-Frankel method | 2003 | Journal of natural products, Jul, Volume: 66, Issue:7 | Structures of new dammarane-type Triterpene Saponins from the flower buds of Panax notoginseng and hepatoprotective effects of principal Ginseng Saponins. |
| AID480995 | Cytotoxicity against human A549 cells at 25 uM after 48 hrs by WST8 assay | 2010 | Bioorganic & medicinal chemistry letters, May-01, Volume: 20, Issue:9 | Cytotoxicity and inhibition of DNA topoisomerase I of polyhydroxylated triterpenoids and triterpenoid glycosides. |
| AID480992 | Inhibition of human DNA topoisomerase 1-mediated relaxation of supercoiled DNA by gel electrophoresis | 2010 | Bioorganic & medicinal chemistry letters, May-01, Volume: 20, Issue:9 | Cytotoxicity and inhibition of DNA topoisomerase I of polyhydroxylated triterpenoids and triterpenoid glycosides. |
| AID397817 | Effect on neurite outgrowth activity in human SK-N-SH cells assessed as increase in number of vericosites at 100 uM after 5 days | 2002 | Journal of natural products, Sep, Volume: 65, Issue:9 | Dammarane-type Saponins from Panax japonicus and their neurite outgrowth activity in SK-N-SH cells. |
| AID1172640 | Inhibition of cell proliferation of rat C6 cells assessed as cell viability at 100 uM after 72 hrs by sulforhodamine B assay | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22 | Bioactive triterpenoid saponins and phenolic compounds against glioma cells. |
| AID334335 | Induction of morphological transformation of rat ASK cells into astrocytes at 100 ug/ml after 1 hr by light microscopy | |||
| AID481001 | Cytotoxicity against human PANC1 cells at 25 uM after 48 hrs by WST8 assay | 2010 | Bioorganic & medicinal chemistry letters, May-01, Volume: 20, Issue:9 | Cytotoxicity and inhibition of DNA topoisomerase I of polyhydroxylated triterpenoids and triterpenoid glycosides. |
| AID480993 | Inhibition of human DNA topoisomerase 2-mediated relaxation of supercoiled DNA by gel electrophoresis | 2010 | Bioorganic & medicinal chemistry letters, May-01, Volume: 20, Issue:9 | Cytotoxicity and inhibition of DNA topoisomerase I of polyhydroxylated triterpenoids and triterpenoid glycosides. |
| AID337106 | Hepatoprotective activity against D-galactosamine/LPS-induced liver injury in ddY mouse assessed as inhibition of serum alanine transaminase level at 50 mg/kg, ip administered 1 hr before D-galactosamine/LPS challenge by Reitman-Frankel method | 2003 | Journal of natural products, Jul, Volume: 66, Issue:7 | Structures of new dammarane-type Triterpene Saponins from the flower buds of Panax notoginseng and hepatoprotective effects of principal Ginseng Saponins. |
| AID397814 | Induction of neurite outgrowth in human SK-N-SH cells at 100 uM after 5 days relative to control | 2002 | Journal of natural products, Sep, Volume: 65, Issue:9 | Dammarane-type Saponins from Panax japonicus and their neurite outgrowth activity in SK-N-SH cells. |
| AID1172639 | Inhibition of cell proliferation of human U251 cells assessed as cell viability at 100 uM after 72 hrs by sulforhodamine B assay | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22 | Bioactive triterpenoid saponins and phenolic compounds against glioma cells. |
| AID480999 | Cytotoxicity against human HL60 cells at 25 uM after 48 hrs by WST8 assay | 2010 | Bioorganic & medicinal chemistry letters, May-01, Volume: 20, Issue:9 | Cytotoxicity and inhibition of DNA topoisomerase I of polyhydroxylated triterpenoids and triterpenoid glycosides. |
| AID480997 | Cytotoxicity against human PC3 cells at 25 uM after 48 hrs by WST8 assay | 2010 | Bioorganic & medicinal chemistry letters, May-01, Volume: 20, Issue:9 | Cytotoxicity and inhibition of DNA topoisomerase I of polyhydroxylated triterpenoids and triterpenoid glycosides. |
| AID337107 | Hepatoprotective activity against D-galactosamine/LPS-induced liver injury in ddY mouse assessed as inhibition of serum alanine transaminase level at 100 mg/kg, ip administered 1 hr before D-galactosamine/LPS challenge by Reitman-Frankel method | 2003 | Journal of natural products, Jul, Volume: 66, Issue:7 | Structures of new dammarane-type Triterpene Saponins from the flower buds of Panax notoginseng and hepatoprotective effects of principal Ginseng Saponins. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (60)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (1.67) | 18.7374 |
| 1990's | 1 (1.67) | 18.2507 |
| 2000's | 11 (18.33) | 29.6817 |
| 2010's | 29 (48.33) | 24.3611 |
| 2020's | 18 (30.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 21.04
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (21.04) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 61 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||