leucinostatin a

Description

leucinostatin A: isolated from Penicillium lilacinum; A 20668 A,B,& C are polypeptide antibiotics that inhibit phosphorylation of ADP, Mg ATPase; RN given refers to leucinostatin A [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	133612155
MeSH ID	M0051975

Synonyms (2)

Synonym
76600-38-9
leucinostatin a

Research Excerpts

Overview

Leucinostatin A (Leu-A) is a nonapeptide exerting a remarkable activity especially against Candida albicans and Cryptococcus neoformans. Its employment is limited due its toxicity.

Excerpt	Reference
"Leucinostatin A (Leu-A) is a nonapeptide exerting a remarkable activity especially against Candida albicans and Cryptococcus neoformans; nevertheless, its employment is limited due its toxicity. "	( Leucinostatin-A loaded nanospheres: characterization and in vivo toxicity and efficacy evaluation. Blasi, P; Giovagnoli, S; Perioli, L; Ricci, M; Rossi, C; Vescovi, C, 2004)

Toxicity

Excerpt	Reference
" Acute toxicity showed that the LD50 was increased more than 18-fold and the study on systemic candidiasis models revealed high effectiveness of the NS in reducing either the growth of fungal colonies in infected mice liver or in the mortality index."	( Leucinostatin-A loaded nanospheres: characterization and in vivo toxicity and efficacy evaluation. Blasi, P; Giovagnoli, S; Perioli, L; Ricci, M; Rossi, C; Vescovi, C, 2004)

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (35)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	12 (34.29)	18.7374
1990's	6 (17.14)	18.2507
2000's	4 (11.43)	29.6817
2010's	8 (22.86)	24.3611
2020's	5 (14.29)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	5 (14.29%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	30 (85.71%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
lactic acid Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed). 2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.	2.02	1	2-hydroxy monocarboxylic acid	algal metabolite; Daphnia magna metabolite
suramin Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.. suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.	2.05	1	naphthalenesulfonic acid; phenylureas; secondary carboxamide	angiogenesis inhibitor; antinematodal drug; antineoplastic agent; apoptosis inhibitor; EC 2.7.11.13 (protein kinase C) inhibitor; GABA antagonist; GABA-gated chloride channel antagonist; purinergic receptor P2 antagonist; ryanodine receptor agonist; trypanocidal drug
uridine [no description available]	1.95	1	uridines	drug metabolite; fundamental metabolite; human metabolite
3-hydroxybutanal [no description available]	2.15	1
dicyclohexylcarbodiimide 1,3-dicyclohexylcarbodiimide : A carbodiimide compound having a cyclohexyl substituent on both nitrogen atoms.	1.96	1	carbodiimide	ATP synthase inhibitor; cross-linking reagent; peptide coupling reagent
glucose, (beta-d)-isomer beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.	1.99	1	D-glucopyranose	epitope; mouse metabolite
quercetin [no description available]	1.96	1	7-hydroxyflavonol; pentahydroxyflavone	antibacterial agent; antineoplastic agent; antioxidant; Aurora kinase inhibitor; chelator; EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor; geroprotector; phytoestrogen; plant metabolite; protein kinase inhibitor; radical scavenger
tentoxin tentoxin: cyclic peptide from fungus Alternaria tenuis Auct.; structure	3.05	1	lactam
leucinostatin b leucinostatin B: from Paecilomyces lilacinus A-267; structure given in second source	3.22	6
ossamycin ossamycin : A macrolide antibiotic that was originally isolated from the culture broths of Streptomyces hygroscopicus var. ossamyceticus.	3.05	1	cyclic hemiketal; macrolide antibiotic; organic heterotetracyclic compound; secondary alcohol; spiroketal; tertiary alcohol	antineoplastic agent; bacterial metabolite
alamethicin Alamethicin: A cyclic nonadecapeptide antibiotic that can act as an ionophore and is produced by strains of Trichoderma viride. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)	8.56	2
triethyltin sulfate Triethyltin sulfate: not the sulfate salt of triethyltin	1.96	1
atpenin a4 atpenin A4: from Penicillium sp. FO-125; MW C15-H22-N-O5-Cl	2.05	1
cpzen-45 CPZEN-45: caprazamycin derivative; structure in first source	3.31	1
tsushimycin tsushimycin: from Streptomyces Z-237	8.56	2
oligomycins Oligomycins: A closely related group of toxic substances elaborated by various strains of Streptomyces. They are 26-membered macrolides with lactone moieties and double bonds and inhibit various ATPases, causing uncoupling of phosphorylation from mitochondrial respiration. Used as tools in cytochemistry. Some specific oligomycins are RUTAMYCIN, peliomycin, and botrycidin (formerly venturicidin X).	3.46	2
trypan blue Trypan Blue: A diazo-naphthalene sulfonate that is widely used as a stain.. trypan blue : An organosulfonate salt that is the tetrasodium salt of 3,3'-[(3,3'-dimethylbiphenyl-4,4'-diyl)didiazene-2,1-diyl]bis(5-amino-4-hydroxynaphthalene-2,7-disulfonic acid).	1.95	1

Condition	Relationship Strength	Studies
Cancer of Prostate [description not available]	2.52	2
Prostatic Neoplasms Tumors or cancer of the PROSTATE.	2.52	2
African Sleeping Sickness [description not available]	2.05	1
Trypanosomiasis, African A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces African sleeping sickness. Nagana is a rapidly fatal trypanosomiasis of horses and other animals.	2.05	1
Candida Infection [description not available]	2.02	1
Candidiasis Infection with a fungus of the genus CANDIDA. It is usually a superficial infection of the moist areas of the body and is generally caused by CANDIDA ALBICANS. (Dorland, 27th ed)	2.02	1
Eye Disorders [description not available]	1.96	1
Eye Diseases Diseases affecting the eye.	1.96	1
Leukemia L 1210 [description not available]	1.95	1

chemdatabank.com