engeletin
Description
engeletin: dihydroflavonol glycoside from the leaves of Stelechocarpus cauliflorus; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Related Flora
Flora | Rank | Flora Definition | Family | Family Definition |
---|---|---|---|---|
Stelechocarpus | genus | [no description available] | Annonaceae | The custard-apple plant family of the order Magnoliales, subclass Magnoliidae, class Magnoliopsida. Some members provide large pulpy fruits and commercial timber. Leaves and wood are often fragrant. Leaves are simple, with smooth margins, and alternately arranged in two rows along the stems.[MeSH] |
Cross-References
ID Source | ID |
---|---|
PubMed CID | 6453452 |
SCHEMBL ID | 5575048 |
MeSH ID | M0513741 |
Synonyms (27)
Synonym |
---|
ACON1_000852 |
MEGXP0_000364 |
NCGC00169295-01 |
engeletin |
(2r,3r)-5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-2,3-dihydrochromen-4-one |
4h-1-benzopyran-4-one, 3-((6-deoxy-alpha-l-mannopyranosyl)oxy)-2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-, (2r-trans)- |
3-((6-deoxy-alpha-l-mannopyranosyl)oxy)-2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-4h-1-benzopyran-4-one (2r-trans)- |
572-31-6 |
engelitin |
S9170 |
SCHEMBL5575048 |
AC-34264 |
AS-75029 |
(2r,3r)-5,7-dihydroxy-2-(4-hydroxyphenyl)-3-{[(2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}-3,4-dihydro-2h-1-benzopyran-4-one |
aromadendrin 3-rhamnoside |
mfcd20274680 |
HY-N0436 |
CS-0008955 |
AKOS037514632 |
Q5377536 |
(2r,3r)-5,7-dihydroxy-2-(4-hydroxyphenyl)-3-(((2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyltetrahydro-2h-pyran-2-yl)oxy)chroman-4-one |
(2r,3r)-5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(2s,3r,4r,5s,6s)-3,4,5-trihydroxy-6-methyl-oxan-2-yl]oxy-chroman-4-one |
(2r,3r)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-3,4-dihydro-2h-chromen-3-yl alpha-l-mannopyranoside |
DTXSID70972649 |
CCG-269060 |
dihydrokaempferol 3-rhamnoside |
(2r,3r)-3-[(6-deoxy-alpha-l-mannopyranosyl)oxy]-2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-4h-1-benzopyran-4-one |
Research Excerpts
Overview
Engeletin is a pure flavanonol class phytocompound present in the skin of white grapes and white wine. It is a natural derivative of Smilax glabra rhizomilax that exhibits anti-inflammatory activity.
Effects
Engeletin has attracted scientific attention mainly due to its antiinflammatory and anti-tumor potential. Enge letin has been discovered to exert anti-inflammatory effects in various diseases.
Excerpt | Reference | Relevance |
---|---|---|
"Engeletin has numerous pharmacological activities in medicine." | ( Medicinal Importance, Pharmacological Activities, and Analytical Aspects of Engeletin in Medicine: Therapeutic Benefit Through Scientific Data Analysis. Patel, DK, 2023) | 1.86 |
"Engeletin has attracted scientific attention mainly due to its antiinflammatory and anti-tumor potential." | ( Medicinal Importance, Pharmacological Activities, and Analytical Aspects of Engeletin in Medicine: Therapeutic Benefit Through Scientific Data Analysis. Patel, DK, 2023) | 1.86 |
"Engeletin has been discovered to exert anti-inflammatory effects in various diseases." | ( Engeletin ameliorates sevoflurane-induced cognitive impairment by activating PPAR-gamma in neonatal mice. Jiang, S; Wang, X; Xiong, Y, 2023) | 3.07 |
Actions
Excerpt | Reference | Relevance |
---|---|---|
"Engeletin could inhibit the occurrence of cervical cancer and delay the development of liver damage and lung cancer in mice." | ( Medicinal Importance, Pharmacological Activities, and Analytical Aspects of Engeletin in Medicine: Therapeutic Benefit Through Scientific Data Analysis. Patel, DK, 2023) | 1.86 |
Treatment
Engeletin treatment significantly attenuated uterus damage and decreased myeloperoxidase activity. The treatment of enge letin suppressed the activation of microglia and apoptosis induced by SEV in the hippocampus of neonatal mice.
Excerpt | Reference | Relevance |
---|---|---|
"Engeletin treatment significantly attenuated uterus damage and decreased myeloperoxidase activity." | ( Engeletin Alleviates Lipopolysaccharide-Induced Endometritis in Mice by Inhibiting TLR4-mediated NF-κB Activation. Deng, G; Jiang, K; Li, C; Qiu, C; Wu, H; Zhao, G, 2016) | 2.6 |
"The treatment of engeletin dramatically suppressed the activation of microglia and apoptosis induced by SEV in the hippocampus of neonatal mice." | ( Engeletin ameliorates sevoflurane-induced cognitive impairment by activating PPAR-gamma in neonatal mice. Jiang, S; Wang, X; Xiong, Y, 2023) | 2.68 |
Research
Studies (28)
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 2 (7.14) | 29.6817 |
2010's | 12 (42.86) | 24.3611 |
2020's | 14 (50.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 23.94
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (23.94) All Compounds (24.57) |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 28 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |