Page last updated: 2024-12-11

engeletin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

engeletin: dihydroflavonol glycoside from the leaves of Stelechocarpus cauliflorus; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
Stelechocarpusgenus[no description available]AnnonaceaeThe custard-apple plant family of the order Magnoliales, subclass Magnoliidae, class Magnoliopsida. Some members provide large pulpy fruits and commercial timber. Leaves and wood are often fragrant. Leaves are simple, with smooth margins, and alternately arranged in two rows along the stems.[MeSH]

Cross-References

ID SourceID
PubMed CID6453452
SCHEMBL ID5575048
MeSH IDM0513741

Synonyms (27)

Synonym
ACON1_000852
MEGXP0_000364
NCGC00169295-01
engeletin
(2r,3r)-5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-2,3-dihydrochromen-4-one
4h-1-benzopyran-4-one, 3-((6-deoxy-alpha-l-mannopyranosyl)oxy)-2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-, (2r-trans)-
3-((6-deoxy-alpha-l-mannopyranosyl)oxy)-2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-4h-1-benzopyran-4-one (2r-trans)-
572-31-6
engelitin
S9170
SCHEMBL5575048
AC-34264
AS-75029
(2r,3r)-5,7-dihydroxy-2-(4-hydroxyphenyl)-3-{[(2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}-3,4-dihydro-2h-1-benzopyran-4-one
aromadendrin 3-rhamnoside
mfcd20274680
HY-N0436
CS-0008955
AKOS037514632
Q5377536
(2r,3r)-5,7-dihydroxy-2-(4-hydroxyphenyl)-3-(((2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyltetrahydro-2h-pyran-2-yl)oxy)chroman-4-one
(2r,3r)-5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(2s,3r,4r,5s,6s)-3,4,5-trihydroxy-6-methyl-oxan-2-yl]oxy-chroman-4-one
(2r,3r)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-3,4-dihydro-2h-chromen-3-yl alpha-l-mannopyranoside
DTXSID70972649
CCG-269060
dihydrokaempferol 3-rhamnoside
(2r,3r)-3-[(6-deoxy-alpha-l-mannopyranosyl)oxy]-2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-4h-1-benzopyran-4-one

Research Excerpts

Overview

Engeletin is a pure flavanonol class phytocompound present in the skin of white grapes and white wine. It is a natural derivative of Smilax glabra rhizomilax that exhibits anti-inflammatory activity.

ExcerptReferenceRelevance
"Engeletin is a pure flavanonol class phytocompound present in the skin of white grapes and white wine."( Medicinal Importance, Pharmacological Activities, and Analytical Aspects of Engeletin in Medicine: Therapeutic Benefit Through Scientific Data Analysis.
Patel, DK, 2023
)
1.86
"Engeletin is a potent natural compound with antioxidant and anti-inflammatory properties. "( Engeletin mediates antiarrhythmic effects in mice with isoproterenol-induced cardiac remodeling.
Fang, Z; Jiang, X; Liu, Z; Tao, B, 2023
)
3.8
"Engeletin is a flavononol glycoside that possesses anti-inflammatory effect."( Engeletin Attenuates Aβ1-42-Induced Oxidative Stress and Neuroinflammation by Keap1/Nrf2 Pathway.
Huang, Z; Ji, H; Shi, J; Zhi, Z; Zhu, X, 2020
)
2.72
"Engeletin is a natural derivative of Smilax glabra rhizomilax that exhibits anti-inflammatory activity and suppresses lipid peroxidation. "( Engeletin protects against cerebral ischemia/reperfusion injury by modulating the VEGF/vasohibin and Ang-1/Tie-2 pathways.
Li, S; Liu, H; Ren, R; Wang, X; Xu, Y; Zhang, S; Zhu, H, 2021
)
3.51
"Engeletin is a potentially effective agent for the treatment of lung injury."( Protective and Therapeutic Effects of Engeletin on LPS-Induced Acute Lung Injury.
Chen, L; Jiang, X; Sun, Y; Wang, X; Wei, J; Zhang, Z, 2018
)
1.47

Effects

Engeletin has attracted scientific attention mainly due to its antiinflammatory and anti-tumor potential. Enge letin has been discovered to exert anti-inflammatory effects in various diseases.

ExcerptReferenceRelevance
"Engeletin has numerous pharmacological activities in medicine."( Medicinal Importance, Pharmacological Activities, and Analytical Aspects of Engeletin in Medicine: Therapeutic Benefit Through Scientific Data Analysis.
Patel, DK, 2023
)
1.86
"Engeletin has attracted scientific attention mainly due to its antiinflammatory and anti-tumor potential."( Medicinal Importance, Pharmacological Activities, and Analytical Aspects of Engeletin in Medicine: Therapeutic Benefit Through Scientific Data Analysis.
Patel, DK, 2023
)
1.86
"Engeletin has been discovered to exert anti-inflammatory effects in various diseases."( Engeletin ameliorates sevoflurane-induced cognitive impairment by activating PPAR-gamma in neonatal mice.
Jiang, S; Wang, X; Xiong, Y, 2023
)
3.07

Actions

ExcerptReferenceRelevance
"Engeletin could inhibit the occurrence of cervical cancer and delay the development of liver damage and lung cancer in mice."( Medicinal Importance, Pharmacological Activities, and Analytical Aspects of Engeletin in Medicine: Therapeutic Benefit Through Scientific Data Analysis.
Patel, DK, 2023
)
1.86

Treatment

Engeletin treatment significantly attenuated uterus damage and decreased myeloperoxidase activity. The treatment of enge letin suppressed the activation of microglia and apoptosis induced by SEV in the hippocampus of neonatal mice.

ExcerptReferenceRelevance
"Engeletin treatment significantly attenuated uterus damage and decreased myeloperoxidase activity."( Engeletin Alleviates Lipopolysaccharide-Induced Endometritis in Mice by Inhibiting TLR4-mediated NF-κB Activation.
Deng, G; Jiang, K; Li, C; Qiu, C; Wu, H; Zhao, G, 2016
)
2.6
"The treatment of engeletin dramatically suppressed the activation of microglia and apoptosis induced by SEV in the hippocampus of neonatal mice."( Engeletin ameliorates sevoflurane-induced cognitive impairment by activating PPAR-gamma in neonatal mice.
Jiang, S; Wang, X; Xiong, Y, 2023
)
2.68
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (28)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (7.14)29.6817
2010's12 (42.86)24.3611
2020's14 (50.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 23.94

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index23.94 (24.57)
Research Supply Index3.37 (2.92)
Research Growth Index5.67 (4.65)
Search Engine Demand Index23.28 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (23.94)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other28 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]