Page last updated: 2024-12-07

4,4'-dihydroxystilbene

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Cross-References

ID SourceID
PubMed CID5282363
CHEMBL ID196731
CHEBI ID36012
CHEBI ID34368
MeSH IDM0055399

Synonyms (48)

Synonym
BIDD:ER0188
CHEBI:36012 ,
4,4'-(ethene-1,2-diyl)diphenol
4,4'-ethene-1,2-diyldiphenol
4,4'-(1,2-ethenediyl)bisphenol
4,4'-[(1e)-ethene-1,2-diyl]diphenol
trans-stilbene-4,4'-diol
4,4'-(e)-ethene-1,2-diyldiphenol
CHEBI:34368
stilbene-4,4'-diol
659-22-3
nsc-4184
p,p'-dihydroxystilbene
4,4'-stilbenediol
nsc4184
phenol,4'-(1,2-ethenediyl)bis-
4,4'-dioxystilbene
4,4'-dihydroxystilbene ,
4,4'-dihydroxy-trans-stilbene
EC-000.1580
4,4'-dihydroxy stibene
LMPK13090018
AKOS000278359
CHEMBL196731 ,
trans-4,4'-dihydroxystilbene
15058-36-3
phenol, 4,4'-(1,2-ethenediyl)bis-, (e)-
unii-921uxx4izl
921uxx4izl ,
4,4'-stilbenediol, (e)-
(e)-4,4'-dihydroxystilbene
phenol, 4,4'-(1e)-1,2-ethenediylbis-
trans-4,4'-stilbenediol
4-[(e)-2-(4-hydroxyphenyl)ethenyl]phenol
phenol, 4,4'-[(e)-1,2-ethenediyl]bis-
einecs 211-530-9
nsc 4184
6drs5v9w5c ,
unii-6drs5v9w5c
bdbm50410524
DTXSID7022465
4,4 inverted exclamation mark -dihydroxystilbene
Q27891518
(e)-4,4'-stilbenediol
(e)-4,4'-(ethene-1,2-diyl)diphenol
4,4/'-(z)-ethene-1,2-diyldiphenol
1,1-dichloroheptan-2-one
4-[(1e)-2-(4-hydroxyphenyl)ethenyl]phenol

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" Stilbene derivatives with electron-withdrawing functional groups were 2-3 times more toxic than the H2O2 control, indicating that they may form toxic metabolites in the presence of H2O2."( The functional group on (E)-4,4'-disubstituted stilbenes influences toxicity and antioxidative activity in differentiated PC-12 cells.
Fradinger, EA; Galbreath, M; Garcia, GX; Isovitsch, R; Larsen, SW; Pye, C, 2013
)
0.39

Pharmacokinetics

ExcerptReferenceRelevance
" The pharmacokinetic profiles of DHS were subsequently assessed in Sprague-Dawley rats."( Determination of naturally occurring resveratrol analog trans-4,4'-dihydroxystilbene in rat plasma by liquid chromatography-tandem mass spectrometry: application to a pharmacokinetic study.
Chen, W; Elhennawy, MG; Lin, HS; Xiang, X; Yeo, SC, 2015
)
0.42

Bioavailability

ExcerptReferenceRelevance
" When it was given as an oral suspension (10 mg/kg), DHS was absorbed slowly (t max 180 or 300 min) with very limited plasma exposure and absolute oral bioavailability (F = 2."( Determination of naturally occurring resveratrol analog trans-4,4'-dihydroxystilbene in rat plasma by liquid chromatography-tandem mass spectrometry: application to a pharmacokinetic study.
Chen, W; Elhennawy, MG; Lin, HS; Xiang, X; Yeo, SC, 2015
)
0.42
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
stilbene-4,4'-diol
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (3)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Androgen receptorRattus norvegicus (Norway rat)IC50 (µMol)83.17640.00101.979414.1600AID255211
Transient receptor potential cation channel subfamily A member 1Rattus norvegicus (Norway rat)IC50 (µMol)25.20000.45003.42437.5000AID1272522
Transient receptor potential cation channel subfamily V member 1Homo sapiens (human)IC50 (µMol)10.00000.00020.606010.0000AID1272526
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Transient receptor potential cation channel subfamily A member 1Rattus norvegicus (Norway rat)EC50 (µMol)11.00000.06002.22238.4000AID1272523
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (37)

Processvia Protein(s)Taxonomy
thermoceptionTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
negative regulation of transcription by RNA polymerase IITransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
fever generationTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
microglial cell activationTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
diet induced thermogenesisTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
peptide secretionTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
negative regulation of systemic arterial blood pressureTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
lipid metabolic processTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
cell surface receptor signaling pathwayTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
positive regulation of cytosolic calcium ion concentrationTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
chemosensory behaviorTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
negative regulation of heart rateTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
negative regulation of mitochondrial membrane potentialTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
glutamate secretionTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
calcium-mediated signalingTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
cellular response to heatTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
positive regulation of apoptotic processTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
response to peptide hormoneTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
positive regulation of nitric oxide biosynthetic processTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
behavioral response to painTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
sensory perception of mechanical stimulusTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
detection of temperature stimulus involved in thermoceptionTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
detection of temperature stimulus involved in sensory perception of painTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
detection of chemical stimulus involved in sensory perception of painTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
protein homotetramerizationTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
excitatory postsynaptic potentialTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
smooth muscle contraction involved in micturitionTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
calcium ion transmembrane transportTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
cellular response to alkaloidTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
cellular response to ATPTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
cellular response to tumor necrosis factorTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
cellular response to acidic pHTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
cellular response to temperature stimulusTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
negative regulation of establishment of blood-brain barrierTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
calcium ion import across plasma membraneTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
response to capsazepineTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
cellular response to nerve growth factor stimulusTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (15)

Processvia Protein(s)Taxonomy
transmembrane signaling receptor activityTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
extracellular ligand-gated monoatomic ion channel activityTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
excitatory extracellular ligand-gated monoatomic ion channel activityTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
voltage-gated calcium channel activityTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
calcium channel activityTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
protein bindingTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
calmodulin bindingTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
ATP bindingTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
intracellularly gated calcium channel activityTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
chloride channel regulator activityTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
phosphatidylinositol bindingTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
identical protein bindingTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
metal ion bindingTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
phosphoprotein bindingTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
temperature-gated ion channel activityTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (6)

Processvia Protein(s)Taxonomy
plasma membraneTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
external side of plasma membraneTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
membraneTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
dendritic spine membraneTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
neuronal cell bodyTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
postsynaptic membraneTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
plasma membraneTransient receptor potential cation channel subfamily V member 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (40)

Assay IDTitleYearJournalArticle
AID1272522Antagonist activity at rat TRPA1 expressed in HEK293 cells assessed as inhibition of allyl isothiocyanate-induced increase of intracellular calcium level2016Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3
TRPA1 channels as targets for resveratrol and related stilbenoids.
AID1272525Agonist activity at human TRPV1 expressed in HEK293 cells assessed as induction of intracellular calcium level relative to allyl isothiocyanate2016Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3
TRPA1 channels as targets for resveratrol and related stilbenoids.
AID416360Inhibition of Fe(2+)/ascorbate-induced lipid peroxidation in human erythrocyte ghosts assessed as inhibition of malondialdehyde formation per mg of protein at 1 uM after 30 mins2009Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6
4,4'-Dihydroxy-trans-stilbene, a resveratrol analogue, exhibited enhanced antioxidant activity and cytotoxicity.
AID1314128Toxicity in rat thymocytes assessed as increase in cell death at 1000 uM measured after 4 hrs by flow cytometric analysis relative to control2016Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16
A facile and rapid access to resveratrol derivatives and their radioprotective activity.
AID1314122Radioprotective activity in rat thymocytes assessed as radio-modification factor pretreated at 10 uM followed by 2 Gy X-ray irradiation measured after 4 hrs by flow cytometric analysis relative to control2016Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16
A facile and rapid access to resveratrol derivatives and their radioprotective activity.
AID436345Selectivity for human ERbeta receptor over human ERalpha receptor2009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Bibenzyl- and stilbene-core compounds with non-polar linker atom substituents as selective ligands for estrogen receptor beta.
AID416362Inhibition of Fe(2+)/ascorbate-induced lipid peroxidation in human erythrocyte ghosts assessed as inhibition of malondialdehyde formation per mg of protein at 3 uM after 30 mins2009Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6
4,4'-Dihydroxy-trans-stilbene, a resveratrol analogue, exhibited enhanced antioxidant activity and cytotoxicity.
AID436347Agonist activity at ERbeta expressed in human HEC1 cells assessed as relative transcriptional potency after 24 hrs by luciferase-beta galactosidase reporter gene assay relative to estradiol2009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Bibenzyl- and stilbene-core compounds with non-polar linker atom substituents as selective ligands for estrogen receptor beta.
AID1368419Inhibition of ovine COX1 assessed as reduction in PGF2alpha level at 100 uM using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition by ELISA relative to control2018Bioorganic & medicinal chemistry, 01-01, Volume: 26, Issue:1
Synthesis, in vitro and in silico evaluation of novel trans-stilbene analogues as potential COX-2 inhibitors.
AID1314125Toxicity in rat thymocytes assessed as increase in cell death at 1 uM measured after 4 hrs by flow cytometric analysis relative to control2016Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16
A facile and rapid access to resveratrol derivatives and their radioprotective activity.
AID1314123Radioprotective activity in rat thymocytes assessed as radio-modification factor pretreated at 100 uM followed by 2 Gy X-ray irradiation measured after 4 hrs by flow cytometric analysis relative to control2016Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16
A facile and rapid access to resveratrol derivatives and their radioprotective activity.
AID436349Agonist activity at ERalpha expressed in human HEC1 cells assessed as transcriptional potency after 24 hrs by luciferase-beta galactosidase reporter gene assay2009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Bibenzyl- and stilbene-core compounds with non-polar linker atom substituents as selective ligands for estrogen receptor beta.
AID1314126Toxicity in rat thymocytes assessed as increase in cell death at 10 uM measured after 4 hrs by flow cytometric analysis relative to control2016Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16
A facile and rapid access to resveratrol derivatives and their radioprotective activity.
AID1314121Radioprotective activity in rat thymocytes assessed as radio-modification factor pretreated at 1 uM followed by 2 Gy X-ray irradiation measured after 4 hrs by flow cytometric analysis relative to control2016Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16
A facile and rapid access to resveratrol derivatives and their radioprotective activity.
AID1261080Selectivity ratio of IC50 for HEK293 cells to IC50 for human HT-29 cells2015European journal of medicinal chemistry, Oct-20, Volume: 103Inhibitory effect of cytotoxic stilbenes related to resveratrol on the expression of the VEGF, hTERT and c-Myc genes.
AID481674Induction of human ApoA-1 gene expression in human Caco-2 cells co-transfected with luc-beta-galactosidase after 48 hrs assessed as luciferase activity by luminometer relative to control2010European journal of medicinal chemistry, May, Volume: 45, Issue:5
Stilbene analogs as inducers of apolipoprotein-I transcription.
AID528480Antioxidant activity assessed as DPPH radical scavenging activity by spectrophotometric analysis2010Journal of medicinal chemistry, Nov-25, Volume: 53, Issue:22
Phenolic bis-styrylbenzenes as β-amyloid binding ligands and free radical scavengers.
AID255211Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881)2005Journal of medicinal chemistry, Sep-08, Volume: 48, Issue:18
Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals.
AID1261078Cytotoxicity against human MCF7 cells assessed inhibition of cell proliferation after 2 days by MTT assay2015European journal of medicinal chemistry, Oct-20, Volume: 103Inhibitory effect of cytotoxic stilbenes related to resveratrol on the expression of the VEGF, hTERT and c-Myc genes.
AID436343Displacement of [3H]estradiol from human full length ERalpha assessed as relative binding affinity by competitive radiometric binding assay relative to estradiol2009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Bibenzyl- and stilbene-core compounds with non-polar linker atom substituents as selective ligands for estrogen receptor beta.
AID1054305Antioxidant activity in rat differentiated PC12 cells assessed as inhibition of H2O2-induced cell death after 15 hrs by MTS assay2013Bioorganic & medicinal chemistry letters, Dec-01, Volume: 23, Issue:23
The functional group on (E)-4,4'-disubstituted stilbenes influences toxicity and antioxidative activity in differentiated PC-12 cells.
AID481675Induction of human ApoA-1 gene expression in human Caco-2 cells co-transfected with luc-beta-galactosidase after 48 hrs assessed as luciferase activity by luminometer relative to resveratrol2010European journal of medicinal chemistry, May, Volume: 45, Issue:5
Stilbene analogs as inducers of apolipoprotein-I transcription.
AID528474Binding affinity to beta-amyloid plaque in APP/PS1 transgenic mouse brain assessed as signal-to-noise ratio after 30 mins by DAPI staining2010Journal of medicinal chemistry, Nov-25, Volume: 53, Issue:22
Phenolic bis-styrylbenzenes as β-amyloid binding ligands and free radical scavengers.
AID436344Displacement of [3H]estradiol from human full length ERbeta relative binding affinity by competitive radiometric binding assay relative to estradiol2009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Bibenzyl- and stilbene-core compounds with non-polar linker atom substituents as selective ligands for estrogen receptor beta.
AID1272526Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of allyl isothiocyanate-induced increase of intracellular calcium level2016Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3
TRPA1 channels as targets for resveratrol and related stilbenoids.
AID436346Agonist activity at ERalpha expressed in human HEC1 cells assessed as relative transcriptional potency after 24 hrs by luciferase-beta galactosidase reporter gene assay relative to estradiol2009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Bibenzyl- and stilbene-core compounds with non-polar linker atom substituents as selective ligands for estrogen receptor beta.
AID1261079Cytotoxicity against HEK293 cells assessed inhibition of cell proliferation after 2 days by MTT assay2015European journal of medicinal chemistry, Oct-20, Volume: 103Inhibitory effect of cytotoxic stilbenes related to resveratrol on the expression of the VEGF, hTERT and c-Myc genes.
AID416361Inhibition of Fe(2+)/ascorbate-induced lipid peroxidation in human erythrocyte ghosts assessed as inhibition of malondialdehyde formation per mg of protein at 2 uM after 30 mins2009Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6
4,4'-Dihydroxy-trans-stilbene, a resveratrol analogue, exhibited enhanced antioxidant activity and cytotoxicity.
AID1368420Inhibition of human COX2 assessed as reduction in PGF2alpha level at 100 uM using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition by ELISA relative to control2018Bioorganic & medicinal chemistry, 01-01, Volume: 26, Issue:1
Synthesis, in vitro and in silico evaluation of novel trans-stilbene analogues as potential COX-2 inhibitors.
AID436348Selectivity ratio of relative transcription potency for ERbeta to relative transcription potency for ERalpha expressed in human HEC1 cells2009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Bibenzyl- and stilbene-core compounds with non-polar linker atom substituents as selective ligands for estrogen receptor beta.
AID1314127Toxicity in rat thymocytes assessed as increase in cell death at 100 uM measured after 4 hrs by flow cytometric analysis relative to control2016Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16
A facile and rapid access to resveratrol derivatives and their radioprotective activity.
AID1314124Radioprotective activity in rat thymocytes assessed as radio-modification factor pretreated at 1000 uM followed by 2 Gy X-ray irradiation measured after 4 hrs by flow cytometric analysis relative to control2016Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16
A facile and rapid access to resveratrol derivatives and their radioprotective activity.
AID1272523Agonist activity at rat TRPA1 expressed in HEK293 cells assessed as induction of intracellular calcium level2016Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3
TRPA1 channels as targets for resveratrol and related stilbenoids.
AID1261077Cytotoxicity against human HT-29 cells assessed inhibition of cell proliferation after 2 days by MTT assay2015European journal of medicinal chemistry, Oct-20, Volume: 103Inhibitory effect of cytotoxic stilbenes related to resveratrol on the expression of the VEGF, hTERT and c-Myc genes.
AID528473Binding affinity to amyloid beta (1 to 40) in APP/PS1 transgenic mouse brain by fluorescence titration analysis2010Journal of medicinal chemistry, Nov-25, Volume: 53, Issue:22
Phenolic bis-styrylbenzenes as β-amyloid binding ligands and free radical scavengers.
AID1272524Agonist activity at rat TRPA1 expressed in HEK293 cells assessed as induction of intracellular calcium level relative to allyl isothiocyanate2016Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3
TRPA1 channels as targets for resveratrol and related stilbenoids.
AID436351Selectivity ratio of EC50 for ERbeta to EC50 for ERalpha expressed in human HEC1 cells2009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Bibenzyl- and stilbene-core compounds with non-polar linker atom substituents as selective ligands for estrogen receptor beta.
AID416363Cytotoxicity against human HL60 cells after 48 hrs by MTT assay2009Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6
4,4'-Dihydroxy-trans-stilbene, a resveratrol analogue, exhibited enhanced antioxidant activity and cytotoxicity.
AID436350Agonist activity at ERbeta expressed in human HEC1 cells assessed as transcriptional potency after 24 hrs by luciferase-beta galactosidase reporter gene assay2009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Bibenzyl- and stilbene-core compounds with non-polar linker atom substituents as selective ligands for estrogen receptor beta.
AID1261081Selectivity ratio of IC50 for HEK293 cells to IC50 for human MCF7 cells2015European journal of medicinal chemistry, Oct-20, Volume: 103Inhibitory effect of cytotoxic stilbenes related to resveratrol on the expression of the VEGF, hTERT and c-Myc genes.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (24)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (4.17)18.7374
1990's0 (0.00)18.2507
2000's5 (20.83)29.6817
2010's16 (66.67)24.3611
2020's2 (8.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other24 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]