| Assay ID | Title | Year | Journal | Article |
|---|
| AID1223522 | Cmax in Wistar rat brain at 750 mg/kg, po by LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 40, Issue:12
| Pharmacokinetics, bioavailability, tissue distribution, excretion, and metabolite identification of methoxyflavones in Kaempferia parviflora extract in rats. |
| AID596470 | Effect on C/EBPbeta mRNA expression in mouse 3T3L1 cells at 10 uM on day 8 by RT-PCR relative to beta-actin mRNA expression | 2011 | Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
| Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells. |
| AID596452 | Induction of insulin-stimulated 2-deoxy-D- 2,6-[3H]-glucose uptake in differentiated mouse 3T3L1 cells at 30 uM compound treated for 20 mins with insulin by liquid scintillation counting (Rvb = 100.0 %) | 2011 | Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
| Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells. |
| AID220005 | Relative inhibition of cAMP and cGMP hydrolysis by cytosolic phosphodiesterase | 1982 | Journal of medicinal chemistry, Oct, Volume: 25, Issue:10
| Pentasubstituted quercetin analogues as selective inhibitors of particulate 3':5'-cyclic-AMP phosphodiesterase from rat brain. |
| AID666771 | Inhibition of thrombin in New Zealand rabbit plasma assessed as fibrinogen level at 100 uM by coagulometry | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Metabolism-based synthesis, biologic evaluation and SARs analysis of O-methylated analogs of quercetin as thrombin inhibitors. |
| AID596454 | Effect on adiponectin mRNA expression in mouse 3T3L1 cells at 3 uM on day 8 by RT-PCR relative to beta-actin mRNA expression | 2011 | Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
| Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells. |
| AID596677 | Induction of adiponectin protein secretion in mouse 3T3L1 cells at 30 uM on day 8 by ELISA relative to control | 2011 | Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
| Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells. |
| AID596455 | Effect on adiponectin mRNA expression in mouse 3T3L1 cells at 30 uM on day 8 by RT-PCR relative to beta-actin mRNA expression | 2011 | Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
| Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells. |
| AID596449 | Induction of insulin-stimulated 2-deoxy-D- 2,6-[3H]-glucose uptake in mouse 3T3L1 cells chronically treated at 30 uM by liquid scintillation counting (Rvb = 100.0 %) | 2011 | Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
| Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells. |
| AID1223521 | Cmax in Wistar rat lung at 750 mg/kg, po by LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 40, Issue:12
| Pharmacokinetics, bioavailability, tissue distribution, excretion, and metabolite identification of methoxyflavones in Kaempferia parviflora extract in rats. |
| AID596457 | Effect on PPARgamma2 mRNA expression in mouse 3T3L1 cells at 3 uM on day 8 by RT-PCR relative to beta-actin mRNA expression | 2011 | Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
| Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells. |
| AID596671 | Induction of adipogenesis in mouse 3T3L1 cells assessed as increase in triglyceride level at 3 uM on day 8 relative to control | 2011 | Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
| Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells. |
| AID1223558 | Elimination rate constant in Wistar rat at 250 mg/kg, po by HPLC analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 40, Issue:12
| Pharmacokinetics, bioavailability, tissue distribution, excretion, and metabolite identification of methoxyflavones in Kaempferia parviflora extract in rats. |
| AID1705065 | Inhibition of biotinylated 5-(4-((Z)-3-Carboxy-3-hydroxyacryloyl)-4-(4-chlorobenzyl)piperidine-1-carbonyl)-2-((13,35-dioxo-39-((3aR,4R,6aS)-2-oxohexahydro-1H-thieno[3,4-d]imidazole-4-yl)-3,6,9,16,19,22,25,28,31-nonaoxa-12,34-diazanonatriacontyl)oxy)benzoi | 2020 | European journal of medicinal chemistry, Dec-15, Volume: 208 | Unraveling the anti-influenza effect of flavonoids: Experimental validation of luteolin and its congeners as potent influenza endonuclease inhibitors. |
| AID596464 | Effect on aP2 mRNA expression in mouse 3T3L1 cells at 10 uM on day 8 by RT-PCR relative to beta-actin mRNA expression | 2011 | Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
| Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells. |
| AID596469 | Effect on C/EBPbeta mRNA expression in mouse 3T3L1 cells at 3 uM on day 8 by RT-PCR relative to beta-actin mRNA expression | 2011 | Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
| Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells. |
| AID1223564 | Volume of distribution in Wistar rat at 250 mg/kg, po by HPLC analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 40, Issue:12
| Pharmacokinetics, bioavailability, tissue distribution, excretion, and metabolite identification of methoxyflavones in Kaempferia parviflora extract in rats. |
| AID768691 | Inhibition of human BCRP expressed in MDCK2 cells assessed as accumulation of Hoechst 33342 preincubated for 30 mins before Hoechst 33342 addition measured after 120 mins by fluorescence assay | 2013 | European journal of medicinal chemistry, Sep, Volume: 67 | Synthesis and biological evaluation of flavones and benzoflavones as inhibitors of BCRP/ABCG2. |
| AID1223549 | Drug metabolism in Wistar rat assessed as excretion of 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,7-dimethoxy-4H-chromen-4-one in urine/feces at 750 mg/kg, po by LC-MS and LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 40, Issue:12
| Pharmacokinetics, bioavailability, tissue distribution, excretion, and metabolite identification of methoxyflavones in Kaempferia parviflora extract in rats. |
| AID220001 | Inhibition of rat brain cytosolic cAMP phosphodiesterase | 1982 | Journal of medicinal chemistry, Oct, Volume: 25, Issue:10
| Pentasubstituted quercetin analogues as selective inhibitors of particulate 3':5'-cyclic-AMP phosphodiesterase from rat brain. |
| AID220162 | Inhibition of rat brain particulate cGMP phosphodiesterase | 1982 | Journal of medicinal chemistry, Oct, Volume: 25, Issue:10
| Pentasubstituted quercetin analogues as selective inhibitors of particulate 3':5'-cyclic-AMP phosphodiesterase from rat brain. |
| AID1223556 | Half life in Wistar rat at 250 mg/kg, po by HPLC analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 40, Issue:12
| Pharmacokinetics, bioavailability, tissue distribution, excretion, and metabolite identification of methoxyflavones in Kaempferia parviflora extract in rats. |
| AID1223534 | Drug metabolism in Wistar rat assessed as excretion of 3,5-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-methoxy-4H-chromen-4-one in feces at 750 mg/kg, po by LC-MS and LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 40, Issue:12
| Pharmacokinetics, bioavailability, tissue distribution, excretion, and metabolite identification of methoxyflavones in Kaempferia parviflora extract in rats. |
| AID1223565 | Absorption rate constant in Wistar rat at 250 mg/kg, po by HPLC analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 40, Issue:12
| Pharmacokinetics, bioavailability, tissue distribution, excretion, and metabolite identification of methoxyflavones in Kaempferia parviflora extract in rats. |
| AID596669 | Induction of adipogenesis in mouse 3T3L1 cells assessed as increase in triglyceride level at 0.3 uM on day 8 relative to control | 2011 | Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
| Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells. |
| AID596247 | Effect on C/EBPdelta mRNA expression in mouse 3T3L1 adipocytes at 30 uM on day 8 by RT-PCR relative to beta-actin mRNA expression | 2011 | Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
| Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells. |
| AID596673 | Induction of adipogenesis in mouse 3T3L1 cells assessed as increase in triglyceride level at 30 uM on day 8 relative to control | 2011 | Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
| Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells. |
| AID596466 | Effect on C/EBPalpha mRNA expression in mouse 3T3L1 cells at 3 uM on day 8 by RT-PCR relative to beta-actin mRNA expression | 2011 | Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
| Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells. |
| AID596468 | Effect on C/EBPalpha mRNA expression in mouse 3T3L1 cells at 30 uM on day 8 by RT-PCR relative to beta-actin mRNA expression | 2011 | Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
| Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells. |
| AID596246 | Effect on C/EBPdelta mRNA expression in mouse 3T3L1 cells at 10 uM on day 8 by RT-PCR relative to beta-actin mRNA expression | 2011 | Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
| Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells. |
| AID596672 | Induction of adipogenesis in mouse 3T3L1 cells assessed as increase in triglyceride level at 10 uM on day 8 relative to control | 2011 | Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
| Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells. |
| AID1223561 | Clearance in Wistar rat at 250 mg/kg, iv by HPLC analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 40, Issue:12
| Pharmacokinetics, bioavailability, tissue distribution, excretion, and metabolite identification of methoxyflavones in Kaempferia parviflora extract in rats. |
| AID1677633 | Activation of CRE-mediated transcription in rat PC12D cells transfected with pCRE-firefly luciferase and pRL-null-renilla luciferase assessed as increase in CRE-driven firefly luciferase activity at 30 uM by dual luciferase reporter gene assay | 2020 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 30, Issue:23
| Effect of methoxyflavones contained in Kaempferia parviflora on CRE-mediated transcription in PC12D cells. |
| AID768685 | Inhibition of MRP1 (unknown origin) expressed in human 2008 cells assessed as calcein-AM accumulation at 10 uM preincubated for 30 mins before calcein-AM addition measured up to 90 mins by fluorescence assay relative to control | 2013 | European journal of medicinal chemistry, Sep, Volume: 67 | Synthesis and biological evaluation of flavones and benzoflavones as inhibitors of BCRP/ABCG2. |
| AID1223557 | Half life in Wistar rat at 250 mg/kg, iv by HPLC analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 40, Issue:12
| Pharmacokinetics, bioavailability, tissue distribution, excretion, and metabolite identification of methoxyflavones in Kaempferia parviflora extract in rats. |
| AID1223560 | Clearance in Wistar rat at 250 mg/kg, po by HPLC analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 40, Issue:12
| Pharmacokinetics, bioavailability, tissue distribution, excretion, and metabolite identification of methoxyflavones in Kaempferia parviflora extract in rats. |
| AID596679 | Induction of insulin-stimulated 2-deoxy-D- 2,6-[3H]-glucose uptake in mouse 3T3L1 cells chronically treated at 3 uM by liquid scintillation counting (Rvb = 100.0 %) | 2011 | Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
| Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells. |
| AID596676 | Induction of adiponectin protein secretion in mouse 3T3L1 cells at 10 uM on day 8 by ELISA relative to control | 2011 | Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
| Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells. |
| AID1223567 | AUC (0.083 to 4 hrs) in Wistar rat liver at 750 mg/kg, po by LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 40, Issue:12
| Pharmacokinetics, bioavailability, tissue distribution, excretion, and metabolite identification of methoxyflavones in Kaempferia parviflora extract in rats. |
| AID596462 | Effect on GlUT4 mRNA expression in mouse 3T3L1 cells at 30 uM on day 8 by RT-PCR relative to beta-actin mRNA expression | 2011 | Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
| Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells. |
| AID1223527 | Tmax in Wistar rat brain at 750 mg/kg, po by LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 40, Issue:12
| Pharmacokinetics, bioavailability, tissue distribution, excretion, and metabolite identification of methoxyflavones in Kaempferia parviflora extract in rats. |
| AID1223519 | Cmax in Wistar rat liver at 750 mg/kg, po by LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 40, Issue:12
| Pharmacokinetics, bioavailability, tissue distribution, excretion, and metabolite identification of methoxyflavones in Kaempferia parviflora extract in rats. |
| AID1223563 | Cmax in Wistar rat at 250 mg/kg, po by HPLC analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 40, Issue:12
| Pharmacokinetics, bioavailability, tissue distribution, excretion, and metabolite identification of methoxyflavones in Kaempferia parviflora extract in rats. |
| AID768683 | Inhibition of MRP1 (unknown origin) expressed in human 2008 cells assessed as calcein-AM accumulation preincubated for 30 mins before calcein-AM addition measured up to 90 mins by fluorescence assay | 2013 | European journal of medicinal chemistry, Sep, Volume: 67 | Synthesis and biological evaluation of flavones and benzoflavones as inhibitors of BCRP/ABCG2. |
| AID1223547 | Drug excretion in Wistar rat feces at 750 mg/kg, po after 18 to 24 hrs by HPLC-UV analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 40, Issue:12
| Pharmacokinetics, bioavailability, tissue distribution, excretion, and metabolite identification of methoxyflavones in Kaempferia parviflora extract in rats. |
| AID1677634 | Effect on transcription in rat PC12D cells transfected with pCRE-firefly luciferase and pRL-null-renilla luciferase assessed as renilla luciferase activity at 30 uM by dual luciferase reporter gene assay | 2020 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 30, Issue:23
| Effect of methoxyflavones contained in Kaempferia parviflora on CRE-mediated transcription in PC12D cells. |
| AID596467 | Effect on C/EBPalpha mRNA expression in mouse 3T3L1 cells at 10 uM on day 8 by RT-PCR relative to beta-actin mRNA expression | 2011 | Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
| Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells. |
| AID666857 | Reversal of BCRP-mediated drug resistant in human HEK293/R2 cells assessed as potentiation of topotecan-induced cytotoxicity at 1 uM after 5 days by MTS assay | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis of methylated quercetin derivatives and their reversal activities on P-gp- and BCRP-mediated multidrug resistance tumour cells. |
| AID1223524 | Tmax in Wistar rat liver at 750 mg/kg, po by LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 40, Issue:12
| Pharmacokinetics, bioavailability, tissue distribution, excretion, and metabolite identification of methoxyflavones in Kaempferia parviflora extract in rats. |
| AID666855 | Cytotoxicity against mouse L929 cells after 5 days by MTS assay | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis of methylated quercetin derivatives and their reversal activities on P-gp- and BCRP-mediated multidrug resistance tumour cells. |
| AID596670 | Induction of adipogenesis in mouse 3T3L1 cells assessed as increase in triglyceride level at 1 uM on day 8 relative to control | 2011 | Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
| Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells. |
| AID1223555 | AUC in Wistar rat at 250 mg/kg, iv by HPLC analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 40, Issue:12
| Pharmacokinetics, bioavailability, tissue distribution, excretion, and metabolite identification of methoxyflavones in Kaempferia parviflora extract in rats. |
| AID1223559 | Elimination rate constant in Wistar rat at 250 mg/kg, iv by HPLC analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 40, Issue:12
| Pharmacokinetics, bioavailability, tissue distribution, excretion, and metabolite identification of methoxyflavones in Kaempferia parviflora extract in rats. |
| AID1871969 | Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins under dark condition | 2022 | European journal of medicinal chemistry, Feb-05, Volume: 229 | Quercetin derivatives: Drug design, development, and biological activities, a review. |
| AID219998 | Inhibition of rat brain cytosolic cAMP phosphodiesterase | 1982 | Journal of medicinal chemistry, Oct, Volume: 25, Issue:10
| Pentasubstituted quercetin analogues as selective inhibitors of particulate 3':5'-cyclic-AMP phosphodiesterase from rat brain. |
| AID220159 | Inhibition of rat brain cytosolic cGMP phosphodiesterase | 1982 | Journal of medicinal chemistry, Oct, Volume: 25, Issue:10
| Pentasubstituted quercetin analogues as selective inhibitors of particulate 3':5'-cyclic-AMP phosphodiesterase from rat brain. |
| AID666768 | Inhibition of thrombin in New Zealand rabbit plasma assessed as thrombin time at 100 uM after 3 mins by coagulometry | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Metabolism-based synthesis, biologic evaluation and SARs analysis of O-methylated analogs of quercetin as thrombin inhibitors. |
| AID596451 | Induction of insulin-stimulated 2-deoxy-D- 2,6-[3H]-glucose uptake in differentiated mouse 3T3L1 cells at 10 uM compound treated for 20 mins with insulin by liquid scintillation counting (Rvb = 100.0 %) | 2011 | Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
| Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells. |
| AID596667 | Induction of adipogenesis in mouse 3T3L1 cells assessed as increase in triglyceride level on day 8 | 2011 | Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
| Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells. |
| AID1223530 | Drug excretion in Wistar rat urine at 750 mg/kg, po after 12 hrs by HPLC-UV analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 40, Issue:12
| Pharmacokinetics, bioavailability, tissue distribution, excretion, and metabolite identification of methoxyflavones in Kaempferia parviflora extract in rats. |
| AID1223554 | AUC in Wistar rat at 250 mg/kg, po by HPLC analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 40, Issue:12
| Pharmacokinetics, bioavailability, tissue distribution, excretion, and metabolite identification of methoxyflavones in Kaempferia parviflora extract in rats. |
| AID596450 | Induction of insulin-stimulated 2-deoxy-D- 2,6-[3H]-glucose uptake in differentiated mouse 3T3L1 cells at 3 uM compound treated for 20 mins with insulin by liquid scintillation counting (Rvb = 100.0 %) | 2011 | Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
| Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells. |
| AID596674 | Induction of adiponectin protein secretion in mouse 3T3L1 cells at 1 uM on day 8 by ELISA relative to control | 2011 | Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
| Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells. |
| AID1223566 | Oral bioavailability in Wistar rat at 250 mg/kg by HPLC analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 40, Issue:12
| Pharmacokinetics, bioavailability, tissue distribution, excretion, and metabolite identification of methoxyflavones in Kaempferia parviflora extract in rats. |
| AID1223536 | Drug excretion in Wistar rat feces at 750 mg/kg, po after up to 72 hrs by HPLC-UV analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 40, Issue:12
| Pharmacokinetics, bioavailability, tissue distribution, excretion, and metabolite identification of methoxyflavones in Kaempferia parviflora extract in rats. |
| AID666770 | Inhibition of thrombin in New Zealand rabbit plasma assessed as activated partial thromboplastin time at 100 uM after 3 mins by coagulometry | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Metabolism-based synthesis, biologic evaluation and SARs analysis of O-methylated analogs of quercetin as thrombin inhibitors. |
| AID1223535 | Drug excretion in Wistar rat urine at 750 mg/kg, po after up to 72 hrs by HPLC-UV analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 40, Issue:12
| Pharmacokinetics, bioavailability, tissue distribution, excretion, and metabolite identification of methoxyflavones in Kaempferia parviflora extract in rats. |
| AID1223570 | AUC (0.083 to 4 hrs) in Wistar rat brain at 750 mg/kg, po by LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 40, Issue:12
| Pharmacokinetics, bioavailability, tissue distribution, excretion, and metabolite identification of methoxyflavones in Kaempferia parviflora extract in rats. |
| AID1677632 | Cytotoxicity against rat PC12D cells assessed as reduction in cell viability at 30 uM by MTT assay | 2020 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 30, Issue:23
| Effect of methoxyflavones contained in Kaempferia parviflora on CRE-mediated transcription in PC12D cells. |
| AID1223545 | Drug excretion in Wistar rat urine at 750 mg/kg, po after 24 to 72 hrs by HPLC-UV analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 40, Issue:12
| Pharmacokinetics, bioavailability, tissue distribution, excretion, and metabolite identification of methoxyflavones in Kaempferia parviflora extract in rats. |
| AID666853 | Cytotoxicity against human LCC-6 cells after 5 days by MTS assay | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis of methylated quercetin derivatives and their reversal activities on P-gp- and BCRP-mediated multidrug resistance tumour cells. |
| AID1223569 | AUC (0.083 to 4 hrs) in Wistar rat lung at 750 mg/kg, po by LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 40, Issue:12
| Pharmacokinetics, bioavailability, tissue distribution, excretion, and metabolite identification of methoxyflavones in Kaempferia parviflora extract in rats. |
| AID768689 | Inhibition of human BCRP expressed in MDCK2 cells assessed as accumulation of pheophorbide-A preincubated for 30 mins before pheophorbide-A addition measured after 120 mins by flow cytometry | 2013 | European journal of medicinal chemistry, Sep, Volume: 67 | Synthesis and biological evaluation of flavones and benzoflavones as inhibitors of BCRP/ABCG2. |
| AID596245 | Effect on C/EBPdelta mRNA expression in mouse 3T3L1 cells at 3 uM on day 8 by RT-PCR relative to beta-actin mRNA expression | 2011 | Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
| Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells. |
| AID666769 | Inhibition of thrombin in New Zealand rabbit plasma assessed as prothrombin time at 100 uM by coagulometry | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Metabolism-based synthesis, biologic evaluation and SARs analysis of O-methylated analogs of quercetin as thrombin inhibitors. |
| AID1223526 | Tmax in Wistar rat lung at 750 mg/kg, po by LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 40, Issue:12
| Pharmacokinetics, bioavailability, tissue distribution, excretion, and metabolite identification of methoxyflavones in Kaempferia parviflora extract in rats. |
| AID1223531 | Drug excretion in Wistar rat feces at 750 mg/kg, po after 12 hrs by HPLC-UV analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 40, Issue:12
| Pharmacokinetics, bioavailability, tissue distribution, excretion, and metabolite identification of methoxyflavones in Kaempferia parviflora extract in rats. |
| AID596448 | Induction of insulin-stimulated 2-deoxy-D- 2,6-[3H]-glucose uptake in mouse 3T3L1 cells chronically treated at 10 uM by liquid scintillation counting (Rvb = 100.0 %) | 2011 | Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
| Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells. |
| AID596460 | Effect on GlUT4 mRNA expression in mouse 3T3L1 cells at 3 uM on day 8 by RT-PCR relative to beta-actin mRNA expression | 2011 | Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
| Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells. |
| AID1223562 | Tmax in Wistar rat at 250 mg/kg, po by HPLC analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 40, Issue:12
| Pharmacokinetics, bioavailability, tissue distribution, excretion, and metabolite identification of methoxyflavones in Kaempferia parviflora extract in rats. |
| AID1223568 | AUC (0.083 to 4 hrs) in Wistar rat kidney at 750 mg/kg, po by LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 40, Issue:12
| Pharmacokinetics, bioavailability, tissue distribution, excretion, and metabolite identification of methoxyflavones in Kaempferia parviflora extract in rats. |
| AID1223528 | Tmax in Wistar rat testes at 750 mg/kg, po by LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 40, Issue:12
| Pharmacokinetics, bioavailability, tissue distribution, excretion, and metabolite identification of methoxyflavones in Kaempferia parviflora extract in rats. |
| AID1223542 | Drug metabolism in Wistar rat assessed as excretion of 2-(3-hydroxy-4-methoxyphenyl)-3,5,7-trimethoxy-4H-chromen-4-one in urine at 750 mg/kg, po by LC-MS and LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 40, Issue:12
| Pharmacokinetics, bioavailability, tissue distribution, excretion, and metabolite identification of methoxyflavones in Kaempferia parviflora extract in rats. |
| AID596471 | Effect on C/EBPbeta mRNA expression in mouse 3T3L1 cells at 30 uM on day 8 by RT-PCR relative to beta-actin mRNA expression | 2011 | Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
| Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells. |
| AID596463 | Effect on aP2 mRNA expression in mouse 3T3L1 cells at 3 uM on day 8 by RT-PCR relative to beta-actin mRNA expression | 2011 | Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
| Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells. |
| AID666858 | Reversal of BCRP-mediated drug resistant in human MCF7-MX100 cells assessed as potentiation of topotecan-induced cytotoxicity at 1 uM after 5 days by MTS assay | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis of methylated quercetin derivatives and their reversal activities on P-gp- and BCRP-mediated multidrug resistance tumour cells. |
| AID596461 | Effect on GlUT4 mRNA expression in mouse 3T3L1 cells at 10 uM on day 8 by RT-PCR relative to beta-actin mRNA expression | 2011 | Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
| Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells. |
| AID1871970 | Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay relative to control | 2022 | European journal of medicinal chemistry, Feb-05, Volume: 229 | Quercetin derivatives: Drug design, development, and biological activities, a review. |
| AID596678 | Induction of insulin-stimulated 2-deoxy-D- 2,6-[3H]-glucose uptake in mouse 3T3L1 cells chronically treated at 1 uM by liquid scintillation counting (Rvb = 100.0 %) | 2011 | Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
| Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells. |
| AID596675 | Induction of adiponectin protein secretion in mouse 3T3L1 cells at 3 uM on day 8 by ELISA relative to control | 2011 | Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
| Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells. |
| AID220006 | Relative inhibition of cAMP and cGMP hydrolysis by particulate phosphodiesterase | 1982 | Journal of medicinal chemistry, Oct, Volume: 25, Issue:10
| Pentasubstituted quercetin analogues as selective inhibitors of particulate 3':5'-cyclic-AMP phosphodiesterase from rat brain. |
| AID666859 | Reversal of MRP1-mediated drug resistant in human 2008/MRP1 cells assessed as potentiation of doxorubicin-induced cytotoxicity at 1 uM after 5 days by MTS assay | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis of methylated quercetin derivatives and their reversal activities on P-gp- and BCRP-mediated multidrug resistance tumour cells. |
| AID1223523 | Cmax in Wistar rat testes at 750 mg/kg, po by LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 40, Issue:12
| Pharmacokinetics, bioavailability, tissue distribution, excretion, and metabolite identification of methoxyflavones in Kaempferia parviflora extract in rats. |
| AID768684 | Inhibition of p-glycoprotein (unknown origin) expressed in human A2780Adr cells assessed as calcein-AM accumulation preincubated for 30 mins before calcein-AM addition measured up to 90 mins by fluorescence assay | 2013 | European journal of medicinal chemistry, Sep, Volume: 67 | Synthesis and biological evaluation of flavones and benzoflavones as inhibitors of BCRP/ABCG2. |
| AID666856 | Reversal of p-glycoprotein-mediated drug resistant in human LCC-6/MDR cells assessed as potentiation of paclitaxel-induced cytotoxicity at 1 uM after 5 days by MTS assay | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis of methylated quercetin derivatives and their reversal activities on P-gp- and BCRP-mediated multidrug resistance tumour cells. |
| AID768686 | Inhibition of p-glycoprotein (unknown origin) expressed in human A2780Adr cells assessed as calcein-AM accumulation at 10 uM preincubated for 30 mins before calcein-AM addition measured up to 90 mins by fluorescence assay relative to control | 2013 | European journal of medicinal chemistry, Sep, Volume: 67 | Synthesis and biological evaluation of flavones and benzoflavones as inhibitors of BCRP/ABCG2. |
| AID404008 | Cytotoxicity against human KB cells | | | |
| AID1223538 | AUC (0.083 to 4 hrs) in Wistar rat testes at 750 mg/kg, po by LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 40, Issue:12
| Pharmacokinetics, bioavailability, tissue distribution, excretion, and metabolite identification of methoxyflavones in Kaempferia parviflora extract in rats. |
| AID596459 | Effect on PPARgamma2 mRNA expression in mouse 3T3L1 cells at 30 uM on day 8 by RT-PCR relative to beta-actin mRNA expression | 2011 | Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
| Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells. |
| AID596456 | Effect on adiponectin mRNA expression in mouse 3T3L1 cells at 10 uM on day 8 by RT-PCR relative to beta-actin mRNA expression | 2011 | Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
| Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells. |
| AID596458 | Effect on PPARgamma2 mRNA expression in mouse 3T3L1 cells at 10 uM on day 8 by RT-PCR relative to beta-actin mRNA expression | 2011 | Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
| Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells. |
| AID666854 | Cytotoxicity against multidrug resistant human LCC-6 cells after 5 days by MTS assay | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis of methylated quercetin derivatives and their reversal activities on P-gp- and BCRP-mediated multidrug resistance tumour cells. |
| AID1871971 | Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay | 2022 | European journal of medicinal chemistry, Feb-05, Volume: 229 | Quercetin derivatives: Drug design, development, and biological activities, a review. |
| AID1223520 | Cmax in Wistar rat kidney at 750 mg/kg, po by LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 40, Issue:12
| Pharmacokinetics, bioavailability, tissue distribution, excretion, and metabolite identification of methoxyflavones in Kaempferia parviflora extract in rats. |
| AID596465 | Effect on aP2 mRNA expression in mouse 3T3L1 cells at 30 uM on day 8 by RT-PCR relative to beta-actin mRNA expression | 2011 | Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
| Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells. |
| AID1223525 | Tmax in Wistar rat kidney at 750 mg/kg, po by LC-MS/MS analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 40, Issue:12
| Pharmacokinetics, bioavailability, tissue distribution, excretion, and metabolite identification of methoxyflavones in Kaempferia parviflora extract in rats. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | | | |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | | | |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6
| A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| AID1159550 | Human Phosphogluconate dehydrogenase (6PGD) Inhibitor Screening | 2015 | Nature cell biology, Nov, Volume: 17, Issue:11
| 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |