Any of the 26-membered ring macrolides produced by Streptomyces species that can be toxic to other organisms through their ability to inhibit mitochondrial membrane-bound ATP synthases.
ChEBI ID: 25675
| Member | Definition | Role |
|---|---|---|
| oligomycin a | An oligomycin with formula C45H74011. An inhibitor of mitochondrial F1FO ATP synthase that induces apoptosis in a variety of cell types and exhibits antifungal, antitumour, and nematicidal activities, but its clinical application has been limited by poor solubility in water and other biocompatible solvents. | oligomycin A |
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 3 (3.90) | 18.7374 |
| 1990's | 4 (5.19) | 18.2507 |
| 2000's | 15 (19.48) | 29.6817 |
| 2010's | 42 (54.55) | 24.3611 |
| 2020's | 13 (16.88) | 2.80 |
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 79 (100.00%) | 84.16% |