positive regulation of viral entry into host cell

Definition

Target type: biologicalprocess

Any process that activates or increases the frequency, rate or extent of the introduction of viral entry into the host cell. [GOC:jl]

Positive regulation of viral entry into host cell is a complex and highly regulated process that involves multiple steps. It begins with the initial interaction between the virus and the host cell, often mediated by specific receptors on the cell surface. Once bound, the virus may undergo conformational changes or engage in further interactions with cellular factors, triggering the internalization of the viral particle into the cell. This internalization can occur through different mechanisms, including endocytosis, direct fusion with the plasma membrane, or micropinocytosis.

After internalization, the viral genome must be released from its protective coat to access the host cell machinery. This process, called uncoating, can involve enzymatic degradation of the viral capsid, pH changes within endosomes, or the action of cellular chaperones.

Finally, the viral genome must reach its destination within the host cell, where it can replicate and produce new viral particles. This may involve transport through the cytoplasm, interaction with cellular transport pathways, or delivery to specific cellular compartments.

Overall, positive regulation of viral entry involves a series of tightly coordinated steps that ensure efficient viral infection. This process is influenced by a variety of cellular factors, including receptors, signaling molecules, and cellular trafficking machinery. Understanding these intricate mechanisms is essential for developing antiviral therapies that target viral entry and prevent infection.'
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Proteins (10)

Compounds (97)