Page last updated: 2024-12-08

n-benzoyl-n'-beta-d-glucopyranosyl urea

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID446600
CHEMBL ID489799
SCHEMBL ID4311564
MeSH IDM0425370

Synonyms (15)

Synonym
bzd ,
n-[(phenylcarbonyl)carbamoyl]-beta-d-glucopyranosylamine
1K06
1K08
DB04295 ,
n-(benzoylcarbamoyl)-beta-d-glucopyranosylamine
n-benzoyl-n'-beta-d-glucopyranosyl urea
n-[[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]carbamoyl]benzamide
n-benzoyl-n''-beta-d-glucopyranosyl urea
n-((2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-ylcarbamoyl)benzamide
1-benzoyl-3-((2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)-tetrahydro-2h-pyran-2-yl)urea
bdbm50263771
CHEMBL489799 ,
2QNB
SCHEMBL4311564
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (4)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, Glycogen PhosphorylaseOryctolagus cuniculus (rabbit)Ki4.60004.6000126.4000370.0000AID977610
Chain A, Glycogen PhosphorylaseOryctolagus cuniculus (rabbit)Ki4.60004.6000126.4000370.0000AID977610
Chain A, Glycogen Phosphorylase, Muscle FormOryctolagus cuniculus (rabbit)Ki4.60004.6000126.4000370.0000AID977610
Glycogen phosphorylase, muscle formOryctolagus cuniculus (rabbit)Ki4.60000.02504.89039.0000AID1186740; AID1321921; AID387864; AID427132; AID644850; AID767515
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (9)

Assay IDTitleYearJournalArticle
AID1811Experimentally measured binding affinity data derived from PDB2002European journal of biochemistry, Mar, Volume: 269, Issue:6
Binding of N-acetyl-N '-beta-D-glucopyranosyl urea and N-benzoyl-N '-beta-D-glucopyranosyl urea to glycogen phosphorylase b: kinetic and crystallographic studies.
AID977610Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB2002European journal of biochemistry, Mar, Volume: 269, Issue:6
Binding of N-acetyl-N '-beta-D-glucopyranosyl urea and N-benzoyl-N '-beta-D-glucopyranosyl urea to glycogen phosphorylase b: kinetic and crystallographic studies.
AID767515Inhibition of rabbit skeletal muscle glycogen phosphorylase b by Lineweaver-Burk plot method2013Bioorganic & medicinal chemistry, Sep-15, Volume: 21, Issue:18
Synthesis, enzyme kinetics and computational evaluation of N-(β-D-glucopyranosyl) oxadiazolecarboxamides as glycogen phosphorylase inhibitors.
AID1186740Inhibition of rabbit skeletal muscle glycogen phosphorylase b assessed as inorganic phosphate release2014Bioorganic & medicinal chemistry, Sep-01, Volume: 22, Issue:17
Structure based inhibitor design targeting glycogen phosphorylase B. Virtual screening, synthesis, biochemical and biological assessment of novel N-acyl-β-d-glucopyranosylamines.
AID387864Inhibition of rabbit muscle glycogen phosphorylase b2008Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20
Novel design principle validated: glucopyranosylidene-spiro-oxathiazole as new nanomolar inhibitor of glycogen phosphorylase, potential antidiabetic agent.
AID644850Inhibition of rabbit muscle glycogen phosphorylase b assessed as inorganic phosphate release at pH 6.82012Bioorganic & medicinal chemistry, Mar-01, Volume: 20, Issue:5
N-(4-Substituted-benzoyl)-N'-(β-d-glucopyranosyl)ureas as inhibitors of glycogen phosphorylase: Synthesis and evaluation by kinetic, crystallographic, and molecular modelling methods.
AID1321921Inhibition of rabbit muscle glycogen phosphorylase b2016Bioorganic & medicinal chemistry, 11-01, Volume: 24, Issue:21
Synthesis of (benzimidazol-2-yl)aniline derivatives as glycogen phosphorylase inhibitors.
AID427132Inhibition of rabbit muscle glycogen phosphorylase b2009Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13
Synthesis and structure-activity relationships of C-glycosylated oxadiazoles as inhibitors of glycogen phosphorylase.
AID977610Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB2012Bioorganic & medicinal chemistry, Mar-01, Volume: 20, Issue:5
N-(4-Substituted-benzoyl)-N'-(β-d-glucopyranosyl)ureas as inhibitors of glycogen phosphorylase: Synthesis and evaluation by kinetic, crystallographic, and molecular modelling methods.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (42.86)29.6817
2010's4 (57.14)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.51

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.51 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.59 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.51)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]