| Substance | Description | Relationhip Strength | Studies | Trials | Classes | Roles |
|---|
| 4-hydroxybenzoic acid | [no description available] | medium | 1 | 0 | monohydroxybenzoic acid | algal metabolite;
plant metabolite |
| 7,8-dihydroxyflavone | [no description available] | medium | 2 | 0 | dihydroxyflavone | antidepressant;
antineoplastic agent;
antioxidant;
plant metabolite;
tropomyosin-related kinase B receptor agonist |
| emodin | [no description available] | medium | 1 | 0 | trihydroxyanthraquinone | antineoplastic agent;
laxative;
plant metabolite;
tyrosine kinase inhibitor |
| lavendustin a | [no description available] | medium | 1 | 0 | aromatic amine | |
| lavendustin b | [no description available] | medium | 1 | 0 | | |
| adenosine monophosphate | [no description available] | medium | 1 | 0 | adenosine 5'-phosphate;
purine ribonucleoside 5'-monophosphate | adenosine A1 receptor agonist;
cofactor;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
EC 3.1.3.11 (fructose-bisphosphatase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical |
| 1-hydroxyanthraquinone | [no description available] | medium | 1 | 0 | monohydroxyanthraquinone | |
| physcione | [no description available] | medium | 1 | 0 | dihydroxyanthraquinone | anti-inflammatory agent;
antibacterial agent;
antifungal agent;
antineoplastic agent;
apoptosis inducer;
hepatoprotective agent;
metabolite |
| flavone | [no description available] | medium | 1 | 0 | flavones | metabolite;
nematicide |
| adenosine 5'-tetraphosphate | [no description available] | medium | 1 | 0 | adenosine 5'-phosphate;
purine ribonucleoside 5'-tetraphosphate | |
| diadenosine tetraphosphate | [no description available] | medium | 1 | 0 | diadenosyl tetraphosphate | Escherichia coli metabolite;
mouse metabolite |
| staurosporine | [no description available] | medium | 1 | 0 | indolocarbazole alkaloid;
organic heterooctacyclic compound | apoptosis inducer;
bacterial metabolite;
EC 2.7.11.13 (protein kinase C) inhibitor;
geroprotector |
| pinocembrin | [no description available] | medium | 1 | 0 | (2S)-flavan-4-one;
dihydroxyflavanone | antineoplastic agent;
antioxidant;
metabolite;
neuroprotective agent;
vasodilator agent |
| 4'-amino-6-hydroxyflavone | [no description available] | medium | 1 | 0 | flavones | |
| (hydroxy-2-naphthalenylmethyl)phosphonic acid | [no description available] | medium | 1 | 0 | | |
| 5'-(sulfonylbenzoyl)adenosine | [no description available] | medium | 1 | 0 | | |
| 4'-hydroxyflavone | [no description available] | medium | 2 | 0 | | |
| 3',4',5'-trimethoxyflavone | [no description available] | medium | 1 | 0 | ether;
flavonoids | |
| naringenin | [no description available] | medium | 4 | 0 | (2S)-flavan-4-one;
naringenin | expectorant;
plant metabolite |
| taxifolin | [no description available] | medium | 1 | 0 | taxifolin | metabolite |
| ferulic acid | [no description available] | medium | 1 | 0 | ferulic acids | anti-inflammatory agent;
antioxidant;
apoptosis inhibitor;
cardioprotective agent;
MALDI matrix material;
plant metabolite |
| trans-4-coumaric acid | [no description available] | medium | 1 | 0 | 4-coumaric acid | food component;
mouse metabolite;
plant metabolite |
| ag-213 | [no description available] | medium | 1 | 0 | | |
| 3,3',4,5'-tetrahydroxystilbene | [no description available] | medium | 1 | 0 | catechols;
polyphenol;
resorcinols;
stilbenol | antineoplastic agent;
apoptosis inducer;
geroprotector;
hypoglycemic agent;
plant metabolite;
protein kinase inhibitor;
tyrosine kinase inhibitor |
| 7,8,3'-trihydroxyflavone | [no description available] | medium | 2 | 0 | | |
| (2S)-7-hydroxyflavanone | [no description available] | medium | 1 | 0 | 7-hydroxyflavanone | |
| caffeic acid | [no description available] | medium | 1 | 0 | caffeic acid | geroprotector;
mouse metabolite |
| quercetin | [no description available] | medium | 4 | 0 | 7-hydroxyflavonol;
pentahydroxyflavone | antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger |
| biochanin a | [no description available] | medium | 1 | 0 | 4'-methoxyisoflavones;
7-hydroxyisoflavones | antineoplastic agent;
EC 3.5.1.99 (fatty acid amide hydrolase) inhibitor;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor |
| acacetin | [no description available] | medium | 4 | 0 | dihydroxyflavone;
monomethoxyflavone | anticonvulsant;
plant metabolite |
| apigenin | [no description available] | medium | 5 | 0 | trihydroxyflavone | antineoplastic agent;
metabolite |
| luteolin | [no description available] | medium | 3 | 0 | 3'-hydroxyflavonoid;
tetrahydroxyflavone | angiogenesis inhibitor;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
c-Jun N-terminal kinase inhibitor;
EC 2.3.1.85 (fatty acid synthase) inhibitor;
immunomodulator;
nephroprotective agent;
plant metabolite;
radical scavenger;
vascular endothelial growth factor receptor antagonist |
| kaempferol | [no description available] | medium | 4 | 0 | 7-hydroxyflavonol;
flavonols;
tetrahydroxyflavone | antibacterial agent;
geroprotector;
human blood serum metabolite;
human urinary metabolite;
human xenobiotic metabolite;
plant metabolite |
| genistein | [no description available] | medium | 2 | 0 | 7-hydroxyisoflavones | antineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
human urinary metabolite;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor |
| genistin | [no description available] | medium | 1 | 0 | 7-hydroxyisoflavones 7-O-beta-D-glucoside | |
| chrysin | [no description available] | medium | 4 | 0 | 7-hydroxyflavonol;
dihydroxyflavone | anti-inflammatory agent;
antineoplastic agent;
antioxidant;
EC 2.7.11.18 (myosin-light-chain kinase) inhibitor;
hepatoprotective agent;
plant metabolite |
| fisetin | [no description available] | medium | 2 | 0 | 3'-hydroxyflavonoid;
7-hydroxyflavonol;
tetrahydroxyflavone | anti-inflammatory agent;
antioxidant;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
metabolite;
plant metabolite |
| galangin | [no description available] | medium | 2 | 0 | 7-hydroxyflavonol;
trihydroxyflavone | antimicrobial agent;
EC 3.1.1.3 (triacylglycerol lipase) inhibitor;
plant metabolite |
| genkwanin | [no description available] | medium | 3 | 0 | dihydroxyflavone;
monomethoxyflavone | metabolite |
| myricetin | [no description available] | medium | 2 | 0 | 7-hydroxyflavonol;
hexahydroxyflavone | antineoplastic agent;
antioxidant;
cyclooxygenase 1 inhibitor;
food component;
geroprotector;
hypoglycemic agent;
plant metabolite |
| daidzein | [no description available] | medium | 3 | 0 | 7-hydroxyisoflavones | antineoplastic agent;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
phytoestrogen;
plant metabolite |
| orobol | [no description available] | medium | 1 | 0 | 7-hydroxyisoflavones | anti-inflammatory agent;
fungal metabolite;
plant metabolite;
radical scavenger |
| prunetin | [no description available] | medium | 1 | 0 | 7-methoxyisoflavones;
hydroxyisoflavone | anti-inflammatory agent;
EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor;
EC 1.3.1.22 [3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+))] inhibitor;
metabolite |
| 7-hydroxyflavone | [no description available] | medium | 2 | 0 | hydroxyflavonoid | |
| syringetin | [no description available] | medium | 3 | 0 | 3',5'-dimethoxyflavone;
3'-methoxyflavones;
7-hydroxyflavonol;
dimethoxyflavone;
tetrahydroxyflavone | metabolite;
platelet aggregation inhibitor |
| 4',7-dihydroxyflavone | [no description available] | medium | 5 | 0 | dihydroxyflavone | metabolite |
| fustin | [no description available] | medium | 1 | 0 | | |
| erbstatin | [no description available] | medium | 1 | 0 | | |
| ag 538 | [no description available] | medium | 1 | 0 | | |
| ag 99 | [no description available] | medium | 1 | 0 | | |
| tyrphostin ag 555 | [no description available] | medium | 1 | 0 | | |
| tyrphostin ag-494 | [no description available] | medium | 1 | 0 | | |
| ag-490 | [no description available] | medium | 1 | 0 | catechols;
enamide;
monocarboxylic acid amide;
nitrile;
secondary carboxamide | anti-inflammatory agent;
antioxidant;
apoptosis inducer;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor;
geroprotector;
STAT3 inhibitor |
| alpha-cyano-4-hydroxycinnamic acid | [no description available] | medium | 1 | 0 | monohydroxycinnamic acid;
nitrile;
phenols | MALDI matrix material |
| ag 30 | [no description available] | medium | 1 | 0 | | |
| ag 112 | [no description available] | medium | 1 | 0 | | |
| ag 183 | [no description available] | medium | 1 | 0 | | |
| methyl 2,5-dihydroxycinnamate | [no description available] | medium | 1 | 0 | cinnamate ester;
hydroquinones;
methyl ester | EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor;
geroprotector;
human urinary metabolite;
plant metabolite |
| psi-tectorigenin | [no description available] | medium | 1 | 0 | | |
| st 638 | [no description available] | medium | 1 | 0 | | |
| herbimycin | [no description available] | medium | 1 | 0 | | |
| st 271 | [no description available] | medium | 1 | 0 | | |
| 1,2-dihydroxy-4-(nitroethenyl)benzene | [no description available] | medium | 1 | 0 | | |
| diguanosine tetraphosphate | [no description available] | medium | 1 | 0 | guanosine 5'-phosphate;
purine ribonucleoside 5'-tetraphosphate | Escherichia coli metabolite;
mouse metabolite |
| pedalitin | [no description available] | medium | 1 | 0 | monomethoxyflavone;
tetrahydroxyflavone | EC 1.17.3.2 (xanthine oxidase) inhibitor;
metabolite |
| xanthomicrol | [no description available] | medium | 1 | 0 | dihydroxyflavone;
trimethoxyflavone | antineoplastic agent;
plant metabolite |
| sideritoflavone | [no description available] | medium | 1 | 0 | ether;
flavonoids | |
| cirsiliol | [no description available] | medium | 1 | 0 | dimethoxyflavone;
trihydroxyflavone | plant metabolite |
| nevadensin | [no description available] | medium | 1 | 0 | dihydroxyflavone;
trimethoxyflavone | plant metabolite |
| cirsilineol | [no description available] | medium | 1 | 0 | dihydroxyflavone;
trimethoxyflavone | antineoplastic agent;
plant metabolite |
| 4',5-dihydroxy-3',6,7,8-tetramethoxyflavone | [no description available] | medium | 1 | 0 | | |
| cirsimaritin | [no description available] | medium | 1 | 0 | dihydroxyflavone;
dimethoxyflavone | |
| demethoxysudachitin | [no description available] | medium | 1 | 0 | ether;
flavonoids | |
| dexmedetomidine | [no description available] | medium | 1 | 0 | trihydroxyflavone;
trimethoxyflavone | antineoplastic agent;
metabolite |
| axillarin | [no description available] | medium | 1 | 0 | dimethoxyflavone;
tetrahydroxyflavone | plant metabolite |
| 6-hydroxyluteolin | [no description available] | medium | 1 | 0 | pentahydroxyflavone | |
| 3',4'-didemethylnobiletin | [no description available] | medium | 1 | 0 | | |
| sudachitin | [no description available] | medium | 1 | 0 | ether;
flavonoids | |
| 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone | [no description available] | medium | 1 | 0 | ether;
flavonoids | |
| fenofibrate | [no description available] | medium | 2 | 0 | aromatic ether;
chlorobenzophenone;
isopropyl ester;
monochlorobenzenes | antilipemic drug;
environmental contaminant;
geroprotector;
xenobiotic |
| pirinixic acid | [no description available] | medium | 2 | 0 | aryl sulfide;
organochlorine compound;
pyrimidines | |
| hesperetin | [no description available] | medium | 2 | 0 | 3'-hydroxyflavanones;
4'-methoxyflavanones;
monomethoxyflavanone;
trihydroxyflavanone | antineoplastic agent;
antioxidant;
plant metabolite |
| rosiglitazone | [no description available] | medium | 2 | 0 | aminopyridine;
thiazolidinediones | EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor;
ferroptosis inhibitor;
insulin-sensitizing drug |
| 3',4'-dihydroxyflavone | [no description available] | medium | 3 | 0 | | |
| isoliquiritigenin | [no description available] | medium | 1 | 0 | chalcones | antineoplastic agent;
biological pigment;
EC 1.14.18.1 (tyrosinase) inhibitor;
GABA modulator;
geroprotector;
metabolite;
NMDA receptor antagonist |
| formononetin | [no description available] | medium | 2 | 0 | 4'-methoxyisoflavones;
7-hydroxyisoflavones | phytoestrogen;
plant metabolite |
| chrysoeriol | [no description available] | medium | 2 | 0 | monomethoxyflavone;
trihydroxyflavone | antineoplastic agent;
antioxidant;
metabolite |
| diosmetin | [no description available] | medium | 3 | 0 | 3'-hydroxyflavonoid;
monomethoxyflavone;
trihydroxyflavone | angiogenesis inhibitor;
anti-inflammatory agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
bone density conservation agent;
cardioprotective agent;
plant metabolite;
tropomyosin-related kinase B receptor agonist;
vasodilator agent |
| psi-baptigenin | [no description available] | medium | 2 | 0 | 7-hydroxyisoflavones;
benzodioxoles | antiprotozoal drug;
plant metabolite |
| 3',4',7-trihydroxyisoflavone | [no description available] | medium | 1 | 0 | 7-hydroxyisoflavones | antineoplastic agent;
EC 1.3.1.22 [3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+))] inhibitor;
metabolite |
| 6,7,4'-trihydroxyisoflavone | [no description available] | medium | 2 | 0 | 7-hydroxyisoflavones | anti-inflammatory agent;
antimutagen;
EC 1.14.18.1 (tyrosinase) inhibitor;
metabolite;
PPARalpha agonist;
PPARgamma agonist |
| cladrin | [no description available] | medium | 1 | 0 | | |
| gw 1929 | [no description available] | medium | 1 | 0 | benzophenones | |
| bezafibrate | [no description available] | medium | 1 | 0 | aromatic ether;
monocarboxylic acid amide;
monocarboxylic acid;
monochlorobenzenes | antilipemic drug;
environmental contaminant;
geroprotector;
xenobiotic |
| eriodictyol | [no description available] | medium | 1 | 0 | 3'-hydroxyflavanones;
tetrahydroxyflavanone | |
| 3-methylquercetin | [no description available] | medium | 1 | 0 | 7-hydroxyflavonol;
monomethoxyflavone;
tetrahydroxyflavone | anticoagulant;
EC 1.14.18.1 (tyrosinase) inhibitor;
metabolite |
| rhamnetin | [no description available] | medium | 1 | 0 | monomethoxyflavone;
tetrahydroxyflavone | anti-inflammatory agent;
antioxidant;
metabolite |
| baicalin | [no description available] | low | 0 | 0 | dihydroxyflavone;
glucosiduronic acid;
glycosyloxyflavone;
monosaccharide derivative | antiatherosclerotic agent;
antibacterial agent;
anticoronaviral agent;
antineoplastic agent;
antioxidant;
cardioprotective agent;
EC 2.7.7.48 (RNA-directed RNA polymerase) inhibitor;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
ferroptosis inhibitor;
neuroprotective agent;
non-steroidal anti-inflammatory drug;
plant metabolite;
prodrug |
| eupatorin | [no description available] | low | 0 | 0 | dihydroxyflavone;
polyphenol;
trimethoxyflavone | anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
Brassica napus metabolite;
calcium channel blocker;
P450 inhibitor;
vasodilator agent |
| swertisin | [no description available] | low | 0 | 0 | dihydroxyflavone;
flavone C-glycoside;
monomethoxyflavone;
monosaccharide derivative;
polyphenol | adenosine A1 receptor antagonist;
anti-inflammatory agent;
antioxidant;
hypoglycemic agent;
plant metabolite |
| skullcapflavone ii | [no description available] | low | 0 | 0 | dihydroxyflavone;
tetramethoxyflavone | anti-asthmatic drug;
plant metabolite |
| spinosin | [no description available] | low | 0 | 0 | dihydroxyflavone;
flavone C-glycoside;
monomethoxyflavone | anxiolytic drug;
plant metabolite |
| 4',6-dihydroxy-5,7-dimethoxyflavone | [no description available] | low | 0 | 0 | dihydroxyflavone;
dimethoxyflavone | |
| saponarin | [no description available] | low | 0 | 0 | C-glycosyl compound;
dihydroxyflavone;
glycosyloxyflavone;
monosaccharide derivative | metabolite |
| 6-prenylchrysin | [no description available] | low | 0 | 0 | 7-hydroxyflavonol;
dihydroxyflavone | |
| sideroxylin | [no description available] | low | 0 | 0 | dihydroxyflavone;
monomethoxyflavone | plant metabolite |
| ladanein | [no description available] | low | 0 | 0 | dihydroxyflavone;
dimethoxyflavone | antiviral agent;
plant metabolite;
radical scavenger |
| eupatilin | [no description available] | low | 0 | 0 | dihydroxyflavone;
trimethoxyflavone | anti-inflammatory agent;
anti-ulcer drug;
antineoplastic agent;
EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor;
metabolite |
| ayanin | [no description available] | low | 0 | 0 | dihydroxyflavone;
trimethoxyflavone | plant metabolite |
| apigetrin | [no description available] | low | 0 | 0 | beta-D-glucoside;
dihydroxyflavone;
glycosyloxyflavone;
monosaccharide derivative | antibacterial agent;
metabolite;
non-steroidal anti-inflammatory drug |
| apiin | [no description available] | low | 0 | 0 | beta-D-glucoside;
dihydroxyflavone;
glycosyloxyflavone | EC 3.2.1.18 (exo-alpha-sialidase) inhibitor;
plant metabolite |
| chrysosplenetin b | [no description available] | low | 0 | 0 | dihydroxyflavone;
tetramethoxyflavone | antiviral agent;
plant metabolite |
| pachypodol | [no description available] | low | 0 | 0 | dihydroxyflavone;
trimethoxyflavone | antiemetic;
plant metabolite |
| robinin | [no description available] | low | 0 | 0 | dihydroxyflavone;
glycosyloxyflavone | plant metabolite |
| santin | [no description available] | low | 0 | 0 | dihydroxyflavone;
trimethoxyflavone | plant metabolite |
| wogonin | [no description available] | low | 0 | 0 | dihydroxyflavone;
monomethoxyflavone | angiogenesis inhibitor;
antineoplastic agent;
cyclooxygenase 2 inhibitor;
plant metabolite |
| rhoifolin | [no description available] | low | 0 | 0 | dihydroxyflavone;
glycosyloxyflavone;
neohesperidoside | metabolite |
| alvocidib | [no description available] | low | 0 | 0 | dihydroxyflavone;
hydroxypiperidine;
monochlorobenzenes;
tertiary amino compound | antineoplastic agent;
antirheumatic drug;
apoptosis inducer;
EC 2.7.11.22 (cyclin-dependent kinase) inhibitor |
| casticin | [no description available] | low | 0 | 0 | dihydroxyflavone;
tetramethoxyflavone | apoptosis inducer;
plant metabolite |
| 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one | [no description available] | low | 0 | 0 | dihydroxyflavone;
monomethoxyflavone | antineoplastic agent;
EC 1.14.13.39 (nitric oxide synthase) inhibitor |
| 5,7-dihydroxy-4',6-dimethoxyflavone | [no description available] | low | 0 | 0 | dihydroxyflavone;
dimethoxyflavone | plant metabolite |
| ermanin | [no description available] | low | 0 | 0 | dihydroxyflavone;
dimethoxyflavone | anti-inflammatory agent;
antimycobacterial drug;
antineoplastic agent;
apoptosis inducer;
plant metabolite |
| 3',4',5'-O-trimethyltricetin | [no description available] | low | 0 | 0 | 3',5'-dimethoxyflavone;
dihydroxyflavone;
trimethoxyflavone | |
| 5,4'-dihydroxy-7,3'-dimethoxyflavone | [no description available] | low | 0 | 0 | dihydroxyflavone;
dimethoxyflavone | anti-allergic agent;
anti-inflammatory agent;
antibacterial agent;
antioxidant;
melanin synthesis inhibitor;
plant metabolite |
| lespenefril | [no description available] | low | 0 | 0 | alpha-L-rhamnoside;
dihydroxyflavone;
glycosyloxyflavone;
monosaccharide derivative;
polyphenol | anti-inflammatory agent;
antidepressant;
antineoplastic agent;
apoptosis inducer;
bone density conservation agent;
hypoglycemic agent;
immunomodulator;
plant metabolite |