An EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor that interferes with the action of serine palmitoyltransferase (EC 2.3.1.50).
ChEBI ID: 59647
| Member | Definition | Class |
|---|---|---|
| L-cycloserine | A 4-amino-1,2-oxazolidin-3-one that has S configuration. An antibiotic isolated from Erwinia uredovora. | L-cycloserine |
| thermozymocidin | An amino acid-based antibiotic derived from certain thermophilic fungi; acts as a potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis. Myriocin also possesses immunosuppressant activity. | myriocin |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 4 (1.42) | 18.7374 |
| 1990's | 17 (6.05) | 18.2507 |
| 2000's | 84 (29.89) | 29.6817 |
| 2010's | 140 (49.82) | 24.3611 |
| 2020's | 36 (12.81) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 1 (0.35%) | 5.53% |
| Reviews | 15 (5.19%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 273 (94.46%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 14.1254 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 0.0028 | 2 | 2 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 15.8114 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| dopamine D1 receptor | Homo sapiens (human) | Potency | 4.6109 | 1 | 1 |
| endonuclease IV | Escherichia coli | Potency | 0.8913 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 5.3538 | 1 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 10.6074 | 1 | 2 |
| GALC protein | Homo sapiens (human) | Potency | 0.3162 | 1 | 1 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 11.8856 | 2 | 2 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 0.0023 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 9.1962 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 0.0568 | 2 | 3 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 0.8913 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Proton-coupled amino acid transporter 1 | Homo sapiens (human) | Ki | 7,400.0000 | 1 | 1 |
| Serine palmitoyltransferase 2 | Homo sapiens (human) | IC50 | 0.0001 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Serine palmitoyltransferase 1 | Homo sapiens (human) | EC50 | 0.0495 | 1 | 1 |