An EC 3.1.4.* (phosphoric diester hydrolase) inhibitor that interferes with the action of phosphatidylinositol-specific phospholipase C (EC 3.1.4.11).
ChEBI ID: 64763
| Member | Definition | Class |
|---|---|---|
| u 73122 | An aza-steroid that is 3-O-methyl-17beta-estradiol in which the 17beta-hydroxy group is replaced by a 6-(maleimid-1-yl)hexylamino group. An inibitor of phospholipase C. | U-73122 |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (0.08) | 18.7374 |
| 1990's | 297 (24.09) | 18.2507 |
| 2000's | 658 (53.37) | 29.6817 |
| 2010's | 258 (20.92) | 24.3611 |
| 2020's | 19 (1.54) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 2 (0.16%) | 5.53% |
| Reviews | 3 (0.24%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 1,247 (99.60%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Telomerase reverse transcriptase | Homo sapiens (human) | IC50 | 0.2000 | 1 | 1 |