Compounds > plumericin
Page last updated: 2024-12-10

plumericin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

plumericin: from bark of Plumeria rubra; structure given in first source; RN given refers to (3aS-(3E,3aalpha,4abeta,7abeta,9aR*,9bbeta))-isomer; RN for cpd without isomeric designation not avail 5/91 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
PlumeriagenusA plant genus of the family APOCYNACEAE that contains plumericin, uleine and demethoxyaspidospermine.[MeSH]ApocynaceaeThe dogbane family of the order Gentianales. Members of the family have milky, often poisonous juice, smooth-margined leaves, and flowers in clusters.[MeSH]

Cross-References

ID SourceID
PubMed CID5281545
CHEMBL ID517300
CHEBI ID8274
SCHEMBL ID4894690
MeSH IDM0187355

Synonyms (24)

Synonym
plumericin
2h,4,5-trioxadicyclopent[a,hi]indene-7-carboxylic acid, 3-ethylidene-3,3a,7a,9b-tetrahydro-2-oxo-, methyl ester, [3as-(3e,3a.alpha.,4a.beta.,7a.beta.,9ar*,9b.beta.)]-
77-16-7
2h,4,5-trioxa-1h-dicyclopent[a,hi]indene-7-carboxylic acid, 3-ethylidene-3,3a.beta.,7a.alpha.,9b.alpha.-tetrahydro-2-oxo-, methyl ester
nsc-112152
methyl (e)-ethylidene(oxo)[?]carboxylate
C09796
chebi:8274 ,
plurnericin
CHEMBL517300
nsc 112152
2h,4ah-1,4,5-trioxadicyclopent(a,hi)indene-7-carboxylic acid, 3-ethylidene-3,3a,7a,9b-tetrahydro-2-oxo-, methyl ester, (3e,3as,4ar,7as,9as,9bs)-
l0126u506z ,
2h,4ah-1,4,5-trioxadicyclopent(a,hi)indene-7-carboxylic acid, 3-ethylidene-3,3a,7a,9b-tetrahydro-2-oxo-, methyl ester, (3as-(3e,3aalpha,4abeta,7abeta,9ar*,9bbeta))-
unii-l0126u506z
nci-112152
(1r,5s,8s,9s,10s)-plumericin
plumericin [mi]
(+)-plumericin
SCHEMBL4894690
bdbm50480284
Q27108026
DTXSID301018956
methyl (1s,4s,8r,10s,11e,14s)-11-ethylidene-12-oxo-7,9,13-trioxatetracyclo[6.5.1.01,10.04,14]tetradeca-2,5-diene-5-carboxylate

Research Excerpts

Overview

Plumericin is a potent inhibitor of NF-κB pathways with a new chemical scaffold.

ExcerptReferenceRelevance
"Plumericin is a potent inhibitor of NF-κB pathways with a new chemical scaffold. "( Identification of plumericin as a potent new inhibitor of the NF-κB pathway with anti-inflammatory activity in vitro and in vivo.
Atanasov, AG; Awad, EM; Bochkov, V; Breuss, JM; Cabaravdic, M; Dirsch, VM; Fakhrudin, N; Grzywacz, AM; Heiss, EH; Liu, R; Malainer, C; Mihaly-Bison, J; Noha, SM; Rollinger, JM; Schachner, D; Schuster, D; Stuppner, H; Waltenberger, B, 2014)		2.18
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
terpene lactone
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (24)

Assay IDTitleYearJournalArticle
AID421907Cytotoxicity against human H460 cells2009Journal of natural products, Mar-27, Volume: 72, Issue:3
A multipronged approach to the study of peruvian ethnomedicinal plants: a legacy of the ICBG-Peru Project.
AID421910Cytotoxicity against human MCF7 cells2009Journal of natural products, Mar-27, Volume: 72, Issue:3
A multipronged approach to the study of peruvian ethnomedicinal plants: a legacy of the ICBG-Peru Project.
AID1514104Antileishmanial activity against Leishmania donovani amastigotes infected in mouse J774G8 cells after 48 to 72 hrs by Giemsa staining-based bright-field microscopic analysis2018European journal of medicinal chemistry, Dec-05, Volume: 160Leishmania treatment and prevention: Natural and synthesized drugs.
AID334065Cytotoxicity against mouse M109 cells1997Journal of natural products, Dec, Volume: 60, Issue:12
Bioactive iridoids and a new lignan from Allamanda cathartica and Himatanthus fallax from the Suriname rainforest.
AID1514103Antileishmanial activity against Leishmania donovani promastigotes after 48 hrs by MTT assay2018European journal of medicinal chemistry, Dec-05, Volume: 160Leishmania treatment and prevention: Natural and synthesized drugs.
AID336526Cytotoxicity against human lung cancer cells
AID336528Cytotoxicity against human KB cells
AID421906Cytotoxicity against mouse 3T3 cells2009Journal of natural products, Mar-27, Volume: 72, Issue:3
A multipronged approach to the study of peruvian ethnomedicinal plants: a legacy of the ICBG-Peru Project.
AID336523Cytotoxicity against human HT1080 cells
AID338971Cytotoxicity against human 9KB cells
AID421909Cytotoxicity against human DU145 cells2009Journal of natural products, Mar-27, Volume: 72, Issue:3
A multipronged approach to the study of peruvian ethnomedicinal plants: a legacy of the ICBG-Peru Project.
AID421908Cytotoxicity against human ME180 cells2009Journal of natural products, Mar-27, Volume: 72, Issue:3
A multipronged approach to the study of peruvian ethnomedicinal plants: a legacy of the ICBG-Peru Project.
AID336527Cytotoxicity against human colon cancer cells
AID421918Antituberculosis activity against Mycobacterium tuberculosis H37Rv2009Journal of natural products, Mar-27, Volume: 72, Issue:3
A multipronged approach to the study of peruvian ethnomedicinal plants: a legacy of the ICBG-Peru Project.
AID338725Toxicity in brine shrimp
AID338973Antitumor activity against Agrobacterium tumefaciens-induced crown gall tumor in potato tubers by potato disk assay
AID421905Antimicrobial activity against Saccharomyces cerevisiae RS3212009Journal of natural products, Mar-27, Volume: 72, Issue:3
A multipronged approach to the study of peruvian ethnomedicinal plants: a legacy of the ICBG-Peru Project.
AID421916Antileishmanial activity against Leishmania amazonensis axenic amastigotes2009Journal of natural products, Mar-27, Volume: 72, Issue:3
A multipronged approach to the study of peruvian ethnomedicinal plants: a legacy of the ICBG-Peru Project.
AID421912Cytotoxicity against human HT-29 cells2009Journal of natural products, Mar-27, Volume: 72, Issue:3
A multipronged approach to the study of peruvian ethnomedicinal plants: a legacy of the ICBG-Peru Project.
AID334066Antimicrobial activity against yeast Sc71997Journal of natural products, Dec, Volume: 60, Issue:12
Bioactive iridoids and a new lignan from Allamanda cathartica and Himatanthus fallax from the Suriname rainforest.
AID336524Cytotoxicity against human melanoma cells
AID336525Cytotoxicity against human breast cancer cells
AID397122Inhibition of HIV1 RT
AID336529Cytotoxicity against mouse P388 cells
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (16)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (6.25)18.7374
1990's2 (12.50)18.2507
2000's6 (37.50)29.6817
2010's6 (37.50)24.3611
2020's1 (6.25)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 23.59

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index23.59 (24.57)
Research Supply Index3.00 (2.92)
Research Growth Index4.95 (4.65)
Search Engine Demand Index23.28 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (23.59)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews3 (15.79%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other16 (84.21%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
miltefosine
miltefosine: hexadecyl phosphocholine derivative of cisplatin; did not substantially activate HIV long terminal repeat; less toxic than cisplatin. miltefosine : A phospholipid that is the hexadecyl monoester of phosphocholine.		3.2710phosphocholines;
phospholipid		anti-inflammatory agent;
anticoronaviral agent;
antifungal agent;
antineoplastic agent;
antiprotozoal drug;
apoptosis inducer;
immunomodulator;
protein kinase inhibitor
spironolactone
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827). spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.		2.42203-oxo-Delta(4) steroid;
oxaspiro compound;
steroid lactone;
thioester		aldosterone antagonist;
antihypertensive agent;
diuretic;
environmental contaminant;
xenobiotic
thianthrene
thianthrene: in its electron deficient state, effects formation of high-energy phosphate bonds in process of oxidative phosphorylation; structure. thianthrene : The organosulfur heterocyclic compound that is the parent compound of the thianthrenes, a tricyclic structure comprising two benzene rings fused to the b and e sides of 1,4-dithin.		3.2710mancude organic heterotricyclic parent;
organosulfur heterocyclic compound;
thianthrenes
10-deacetylbaccatine iii
10-deacetylbaccatine III: structure given in first source		3.2710secondary alpha-hydroxy ketone;
tetracyclic diterpenoid
o 129
O 129: vibriostatic. 2,4-diamino-6,7-diisopropylpteridine : A member of the class of pteridines that is pteridine in which the hydrogens at positions 2 and 4 are replaced by amino groups, whilst those at positions 6 and 7 are replaced by isopropyl groups.. vibriostatic agent : Any compound that inhibits the growth of bacteria of the genus Vibrio.		3.2710primary amino compound;
pteridines		antifolate;
vibriostatic agent
iridoids
Iridoids: A type of MONOTERPENES, derived from geraniol. They have the general form of cyclopentanopyran, but in some cases, one of the rings is broken as in the case of secoiridoid. They are different from the similarly named iridals (TRITERPENES).		10.06130
perhydrotriphenylene
[no description available]		3.1410
quercetin
[no description available]		3.27107-hydroxyflavonol;
pentahydroxyflavone		antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
luteolin
[no description available]		3.27103'-hydroxyflavonoid;
tetrahydroxyflavone		angiogenesis inhibitor;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
c-Jun N-terminal kinase inhibitor;
EC 2.3.1.85 (fatty acid synthase) inhibitor;
immunomodulator;
nephroprotective agent;
plant metabolite;
radical scavenger;
vascular endothelial growth factor receptor antagonist
isoplumericin
isoplumericin: isolated from Plumeria rubra		5.2690terpene lactone
licochalcone a
licochalcone A: has both anti-inflammatory and antineoplastic activities; structure given in first source; isolated from root of Glycyrrhiza inflata; RN given refers to (E)-isomer		3.2710chalcones
eupomatenoid 5
eupomatenoid 5: RN given for (E)-isomer; structure in first source		3.2710
cyclin d1
Cyclin D1: Protein encoded by the bcl-1 gene which plays a critical role in regulating the cell cycle. Overexpression of cyclin D1 is the result of bcl-1 rearrangement, a t(11;14) translocation, and is implicated in various neoplasms.		2.1310
ConditionIndicatedRelationship StrengthStudiesTrials
Innate Inflammatory Response
[description not available]		02.5520
Bowel Diseases, Inflammatory
[description not available]		02.2510
Colitis
Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.		02.2510
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		07.5520
Inflammatory Bowel Diseases
Chronic, non-specific inflammation of the GASTROINTESTINAL TRACT. Etiology may be genetic or environmental. This term includes CROHN DISEASE and ULCERATIVE COLITIS.		02.2510
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.110
Tuberculosis, Drug-Resistant
[description not available]		02.0810
Tuberculosis, Multidrug-Resistant
Tuberculosis resistant to chemotherapy with two or more ANTITUBERCULAR AGENTS, including at least ISONIAZID and RIFAMPICIN. The problem of resistance is particularly troublesome in tuberculous OPPORTUNISTIC INFECTIONS associated with HIV INFECTIONS. It requires the use of second line drugs which are more toxic than the first line regimens. TB with isolates that have developed further resistance to at least three of the six classes of second line drugs is defined as EXTENSIVELY DRUG-RESISTANT TUBERCULOSIS.		02.0810
Leukemia P388
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.		01.9710