Page last updated: 2024-12-10

plumericin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

plumericin: from bark of Plumeria rubra; structure given in first source; RN given refers to (3aS-(3E,3aalpha,4abeta,7abeta,9aR*,9bbeta))-isomer; RN for cpd without isomeric designation not avail 5/91 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Flora	Rank	Flora Definition	Family	Family Definition
Plumeria	genus	A plant genus of the family APOCYNACEAE that contains plumericin, uleine and demethoxyaspidospermine.[MeSH]	Apocynaceae	The dogbane family of the order Gentianales. Members of the family have milky, often poisonous juice, smooth-margined leaves, and flowers in clusters.[MeSH]

Cross-References

ID Source	ID
PubMed CID	5281545
CHEMBL ID	517300
CHEBI ID	8274
SCHEMBL ID	4894690
MeSH ID	M0187355

Synonyms (24)

Synonym
plumericin
2h,4,5-trioxadicyclopent[a,hi]indene-7-carboxylic acid, 3-ethylidene-3,3a,7a,9b-tetrahydro-2-oxo-, methyl ester, [3as-(3e,3a.alpha.,4a.beta.,7a.beta.,9ar*,9b.beta.)]-
77-16-7
2h,4,5-trioxa-1h-dicyclopent[a,hi]indene-7-carboxylic acid, 3-ethylidene-3,3a.beta.,7a.alpha.,9b.alpha.-tetrahydro-2-oxo-, methyl ester
nsc-112152
methyl (e)-ethylidene(oxo)[?]carboxylate
C09796
chebi:8274 ,
plurnericin
CHEMBL517300
nsc 112152
2h,4ah-1,4,5-trioxadicyclopent(a,hi)indene-7-carboxylic acid, 3-ethylidene-3,3a,7a,9b-tetrahydro-2-oxo-, methyl ester, (3e,3as,4ar,7as,9as,9bs)-
l0126u506z ,
2h,4ah-1,4,5-trioxadicyclopent(a,hi)indene-7-carboxylic acid, 3-ethylidene-3,3a,7a,9b-tetrahydro-2-oxo-, methyl ester, (3as-(3e,3aalpha,4abeta,7abeta,9ar*,9bbeta))-
unii-l0126u506z
nci-112152
(1r,5s,8s,9s,10s)-plumericin
plumericin [mi]
(+)-plumericin
SCHEMBL4894690
bdbm50480284
Q27108026
DTXSID301018956
methyl (1s,4s,8r,10s,11e,14s)-11-ethylidene-12-oxo-7,9,13-trioxatetracyclo[6.5.1.01,10.04,14]tetradeca-2,5-diene-5-carboxylate

Research Excerpts

Overview

Plumericin is a potent inhibitor of NF-κB pathways with a new chemical scaffold.

Excerpt	Reference	Relevance
"Plumericin is a potent inhibitor of NF-κB pathways with a new chemical scaffold. "	( Identification of plumericin as a potent new inhibitor of the NF-κB pathway with anti-inflammatory activity in vitro and in vivo. Atanasov, AG; Awad, EM; Bochkov, V; Breuss, JM; Cabaravdic, M; Dirsch, VM; Fakhrudin, N; Grzywacz, AM; Heiss, EH; Liu, R; Malainer, C; Mihaly-Bison, J; Noha, SM; Rollinger, JM; Schachner, D; Schuster, D; Stuppner, H; Waltenberger, B, 2014)	2.18

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

Class	Description
terpene lactone
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (24)

Assay ID	Title	Year	Journal	Article
AID421907	Cytotoxicity against human H460 cells	2009	Journal of natural products, Mar-27, Volume: 72, Issue:3	A multipronged approach to the study of peruvian ethnomedicinal plants: a legacy of the ICBG-Peru Project.
AID421910	Cytotoxicity against human MCF7 cells	2009	Journal of natural products, Mar-27, Volume: 72, Issue:3	A multipronged approach to the study of peruvian ethnomedicinal plants: a legacy of the ICBG-Peru Project.
AID1514104	Antileishmanial activity against Leishmania donovani amastigotes infected in mouse J774G8 cells after 48 to 72 hrs by Giemsa staining-based bright-field microscopic analysis	2018	European journal of medicinal chemistry, Dec-05, Volume: 160	Leishmania treatment and prevention: Natural and synthesized drugs.
AID334065	Cytotoxicity against mouse M109 cells	1997	Journal of natural products, Dec, Volume: 60, Issue:12	Bioactive iridoids and a new lignan from Allamanda cathartica and Himatanthus fallax from the Suriname rainforest.
AID1514103	Antileishmanial activity against Leishmania donovani promastigotes after 48 hrs by MTT assay	2018	European journal of medicinal chemistry, Dec-05, Volume: 160	Leishmania treatment and prevention: Natural and synthesized drugs.
AID336526	Cytotoxicity against human lung cancer cells
AID336528	Cytotoxicity against human KB cells
AID421906	Cytotoxicity against mouse 3T3 cells	2009	Journal of natural products, Mar-27, Volume: 72, Issue:3	A multipronged approach to the study of peruvian ethnomedicinal plants: a legacy of the ICBG-Peru Project.
AID336523	Cytotoxicity against human HT1080 cells
AID338971	Cytotoxicity against human 9KB cells
AID421909	Cytotoxicity against human DU145 cells	2009	Journal of natural products, Mar-27, Volume: 72, Issue:3	A multipronged approach to the study of peruvian ethnomedicinal plants: a legacy of the ICBG-Peru Project.
AID421908	Cytotoxicity against human ME180 cells	2009	Journal of natural products, Mar-27, Volume: 72, Issue:3	A multipronged approach to the study of peruvian ethnomedicinal plants: a legacy of the ICBG-Peru Project.
AID336527	Cytotoxicity against human colon cancer cells
AID421918	Antituberculosis activity against Mycobacterium tuberculosis H37Rv	2009	Journal of natural products, Mar-27, Volume: 72, Issue:3	A multipronged approach to the study of peruvian ethnomedicinal plants: a legacy of the ICBG-Peru Project.
AID338725	Toxicity in brine shrimp
AID338973	Antitumor activity against Agrobacterium tumefaciens-induced crown gall tumor in potato tubers by potato disk assay
AID421905	Antimicrobial activity against Saccharomyces cerevisiae RS321	2009	Journal of natural products, Mar-27, Volume: 72, Issue:3	A multipronged approach to the study of peruvian ethnomedicinal plants: a legacy of the ICBG-Peru Project.
AID421916	Antileishmanial activity against Leishmania amazonensis axenic amastigotes	2009	Journal of natural products, Mar-27, Volume: 72, Issue:3	A multipronged approach to the study of peruvian ethnomedicinal plants: a legacy of the ICBG-Peru Project.
AID421912	Cytotoxicity against human HT-29 cells	2009	Journal of natural products, Mar-27, Volume: 72, Issue:3	A multipronged approach to the study of peruvian ethnomedicinal plants: a legacy of the ICBG-Peru Project.
AID334066	Antimicrobial activity against yeast Sc7	1997	Journal of natural products, Dec, Volume: 60, Issue:12	Bioactive iridoids and a new lignan from Allamanda cathartica and Himatanthus fallax from the Suriname rainforest.
AID336524	Cytotoxicity against human melanoma cells
AID336525	Cytotoxicity against human breast cancer cells
AID397122	Inhibition of HIV1 RT
AID336529	Cytotoxicity against mouse P388 cells
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (16)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (6.25)	18.7374
1990's	2 (12.50)	18.2507
2000's	6 (37.50)	29.6817
2010's	6 (37.50)	24.3611
2020's	1 (6.25)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 23.59

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	23.59 (24.57)
Research Supply Index	3.00 (2.92)
Research Growth Index	4.95 (4.65)
Search Engine Demand Index	23.28 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (23.59)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	3 (15.79%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	16 (84.21%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
miltefosine miltefosine: hexadecyl phosphocholine derivative of cisplatin; did not substantially activate HIV long terminal repeat; less toxic than cisplatin. miltefosine : A phospholipid that is the hexadecyl monoester of phosphocholine.	3.27	1	phosphocholines; phospholipid	anti-inflammatory agent; anticoronaviral agent; antifungal agent; antineoplastic agent; antiprotozoal drug; apoptosis inducer; immunomodulator; protein kinase inhibitor
spironolactone Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827). spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.	2.42	2	3-oxo-Delta(4) steroid; oxaspiro compound; steroid lactone; thioester	aldosterone antagonist; antihypertensive agent; diuretic; environmental contaminant; xenobiotic
thianthrene thianthrene: in its electron deficient state, effects formation of high-energy phosphate bonds in process of oxidative phosphorylation; structure. thianthrene : The organosulfur heterocyclic compound that is the parent compound of the thianthrenes, a tricyclic structure comprising two benzene rings fused to the b and e sides of 1,4-dithin.	3.27	1	mancude organic heterotricyclic parent; organosulfur heterocyclic compound; thianthrenes
10-deacetylbaccatine iii 10-deacetylbaccatine III: structure given in first source	3.27	1	secondary alpha-hydroxy ketone; tetracyclic diterpenoid
o 129 O 129: vibriostatic. 2,4-diamino-6,7-diisopropylpteridine : A member of the class of pteridines that is pteridine in which the hydrogens at positions 2 and 4 are replaced by amino groups, whilst those at positions 6 and 7 are replaced by isopropyl groups.. vibriostatic agent : Any compound that inhibits the growth of bacteria of the genus Vibrio.	3.27	1	primary amino compound; pteridines	antifolate; vibriostatic agent
iridoids Iridoids: A type of MONOTERPENES, derived from geraniol. They have the general form of cyclopentanopyran, but in some cases, one of the rings is broken as in the case of secoiridoid. They are different from the similarly named iridals (TRITERPENES).	10.06	13
perhydrotriphenylene [no description available]	3.14	1
quercetin [no description available]	3.27	1	7-hydroxyflavonol; pentahydroxyflavone	antibacterial agent; antineoplastic agent; antioxidant; Aurora kinase inhibitor; chelator; EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor; geroprotector; phytoestrogen; plant metabolite; protein kinase inhibitor; radical scavenger
luteolin [no description available]	3.27	1	3'-hydroxyflavonoid; tetrahydroxyflavone	angiogenesis inhibitor; anti-inflammatory agent; antineoplastic agent; apoptosis inducer; c-Jun N-terminal kinase inhibitor; EC 2.3.1.85 (fatty acid synthase) inhibitor; immunomodulator; nephroprotective agent; plant metabolite; radical scavenger; vascular endothelial growth factor receptor antagonist
isoplumericin isoplumericin: isolated from Plumeria rubra	5.26	9	terpene lactone
licochalcone a licochalcone A: has both anti-inflammatory and antineoplastic activities; structure given in first source; isolated from root of Glycyrrhiza inflata; RN given refers to (E)-isomer	3.27	1	chalcones
eupomatenoid 5 eupomatenoid 5: RN given for (E)-isomer; structure in first source	3.27	1
cyclin d1 Cyclin D1: Protein encoded by the bcl-1 gene which plays a critical role in regulating the cell cycle. Overexpression of cyclin D1 is the result of bcl-1 rearrangement, a t(11;14) translocation, and is implicated in various neoplasms.	2.13	1

Condition	Relationship Strength	Studies
Innate Inflammatory Response [description not available]	2.55	2
Bowel Diseases, Inflammatory [description not available]	2.25	1
Colitis Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.	2.25	1
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	7.55	2
Inflammatory Bowel Diseases Chronic, non-specific inflammation of the GASTROINTESTINAL TRACT. Etiology may be genetic or environmental. This term includes CROHN DISEASE and ULCERATIVE COLITIS.	2.25	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.1	1
Tuberculosis, Drug-Resistant [description not available]	2.08	1
Tuberculosis, Multidrug-Resistant Tuberculosis resistant to chemotherapy with two or more ANTITUBERCULAR AGENTS, including at least ISONIAZID and RIFAMPICIN. The problem of resistance is particularly troublesome in tuberculous OPPORTUNISTIC INFECTIONS associated with HIV INFECTIONS. It requires the use of second line drugs which are more toxic than the first line regimens. TB with isolates that have developed further resistance to at least three of the six classes of second line drugs is defined as EXTENSIVELY DRUG-RESISTANT TUBERCULOSIS.	2.08	1
Leukemia P388 An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.	1.97	1

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