quercetin has been researched along with Muscular-Atrophy* in 1 studies
1 other study(ies) available for quercetin and Muscular-Atrophy
| Article | Year |
|---|---|
Quercetin prevents unloading-derived disused muscle atrophy by attenuating the induction of ubiquitin ligases in tail-suspension mice.
The effects of quercetin (1) were investigated on disused muscle atrophy using mice that underwent tail suspension. Periodic injection of 1 into the gastrocnemius muscle suppressed muscle weight loss and ubiquitin ligase expression. Compound 1 reduced the enhancement of lipid peroxidation in the muscle. Injection of N-acetyl-l-cysteine, but not flavone (2), also prevented muscle weight loss and enhancement of lipid peroxidation. These findings demonstrate that 1 can prevent disused muscle atrophy by attenuating the expression of ubiquitin ligases and that such prevention originates from its antioxidant activity. Topics: Acetylcysteine; Animals; Antioxidants; Flavones; Hindlimb Suspension; Lipid Peroxidation; Male; Mice; Mice, Inbred C57BL; Molecular Structure; Muscle, Skeletal; Muscular Atrophy; Polymerase Chain Reaction; Propane; Quercetin; Thiobarbituric Acid Reactive Substances; Ubiquitin-Protein Ligases | 2010 |