An EC 6.3.* (C-N bond-forming ligase) inhibitor that interferes with the action of glutamate--ammonia ligase (EC 6.3.1.2).
ChEBI ID: 24319
| Member | Definition | Class |
|---|---|---|
| glutamate | An alpha-amino-acid anion that is the conjugate base of L-glutamic acid, having anionic carboxy groups and a cationic amino group | L-glutamate(1-) |
| methionine sulfoximine | A methionine sulfoximine in which the amino group has S-stereochemistry. | L-methionine sulfoximine zwitterion; L-methionine sulfoximine |
| tabtoxinine beta-lactam | tabtoxinine beta-lactam |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 5 (14.29) | 18.7374 |
| 1990's | 2 (5.71) | 18.2507 |
| 2000's | 7 (20.00) | 29.6817 |
| 2010's | 15 (42.86) | 24.3611 |
| 2020's | 6 (17.14) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 35 (100.00%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 0.0067 | 1 | 1 |
| endonuclease IV | Escherichia coli | Potency | 19.9526 | 1 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 6.7294 | 1 | 2 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 1.3371 | 1 | 1 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 16.9441 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 0.5623 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Chain A, Glutamate carboxypeptidase III | Homo sapiens (human) | Ki | 270.0000 | 1 | 3 |
| Chain A, Glutamate receptor 4 | Rattus norvegicus (Norway rat) | Ki | 0.1710 | 1 | 1 |
| Chain A, Glutamate receptor ionotropic, kainate 2 | Homo sapiens (human) | Ki | 0.2900 | 1 | 2 |
| Chain A, Glutamate receptor, ionotropic kainate 1 | Homo sapiens (human) | Ki | 0.2900 | 1 | 18 |
| Chain A, Glutamate receptor, ionotropic kainate 3 | Rattus norvegicus (Norway rat) | Ki | 7.4300 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Chain A, Ionotropic glutamate receptor bacterial homologue | Nostoc punctiforme PCC 73102 | Kd | 25.0000 | 1 | 1 |