| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
4'-bromoflavone
4'-bromoflavone: structure in first source | 2.08 | 1 | 0 | | |
beta-naphthoflavone
beta-Naphthoflavone: A polyaromatic hydrocarbon inducer of P4501A1 and P4501A2 cytochromes. (Proc Soc Exp Biol Med 1994 Dec:207(3):302-308). beta-naphthoflavone : An extended flavonoid resulting from the formal fusion of a benzene ring with the f side of flavone. | 2.42 | 2 | 0 | extended flavonoid;
naphtho-gamma-pyrone;
organic heterotricyclic compound | aryl hydrocarbon receptor agonist |
cimetidine
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.. cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach. | 1.98 | 1 | 0 | aliphatic sulfide;
guanidines;
imidazoles;
nitrile | adjuvant;
analgesic;
anti-ulcer drug;
H2-receptor antagonist;
P450 inhibitor |
flavone
flavone: RN given refers to unlabeled cpd; structure given in first source. flavone : The simplest member of the class of flavones that consists of 4H-chromen-4-one bearing a phenyl substituent at position 2. | 2.42 | 2 | 0 | flavones | metabolite;
nematicide |
3-hydroxyflavone
3-hydroxyflavone: structure given in first source. flavonol : A monohydroxyflavone that is the 3-hydroxy derivative of flavone. | 7.74 | 3 | 0 | flavonols;
monohydroxyflavone | |
alpha-naphthoflavone
alpha-naphthoflavone: inhibits P4501A1 and P4501A2; stimulates some activities of P4503A4. alpha-naphthoflavone : An extended flavonoid resulting from the formal fusion of a benzene ring with the h side of flavone. A synthetic compound, it is an inhibitor of aromatase (EC 1.14.14.14). | 2.08 | 1 | 0 | extended flavonoid;
naphtho-gamma-pyrone;
organic heterotricyclic compound | aryl hydrocarbon receptor agonist;
aryl hydrocarbon receptor antagonist;
EC 1.14.14.14 (aromatase) inhibitor |
5-hydroxyflavone
[no description available] | 1.98 | 1 | 0 | flavones | |
6-hydroxyflavone
6-hydroxyflavone: antioxidant; structure in first source | 1.98 | 1 | 0 | hydroxyflavonoid | |
4'-methoxyflavone
4'-methoxyflavone: from seeds of Psoralea corylifolia (Fabaceae); structure in first source | 2.42 | 2 | 0 | ether;
flavonoids | |
5-Methoxyflavone
5-methoxyflavone: DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity; structure in first source | 1.98 | 1 | 0 | ether;
flavonoids | |
3,5,7,3',4'-pentamethoxyflavone
3,5,7,3',4'-pentamethoxyflavone: causes relaxation of cavernosum; structure in first source | 2.08 | 1 | 0 | | |
2'-methoxyflavone
[no description available] | 2.42 | 2 | 0 | ether;
flavonoids | |
6-methoxyflavone
6-methoxyflavone: suppresses NFAT-mediated T cell activation; structure in first source | 2.42 | 2 | 0 | ether;
flavonoids | |
4'-chloroflavone
4'-chloroflavone: structure given in first source | 2.08 | 1 | 0 | | |
2'-hydroxyflavone
2'-hydroxyflavone: isolated from Daphnopsis sellowiana; structure given in first source | 1.98 | 1 | 0 | flavones | |
4'-hydroxyflavone
4'-hydroxyflavone: structure in first source | 2.42 | 2 | 0 | | |
6-chloroflavone
6-chloroflavone: structure in first source | 2.08 | 1 | 0 | | |
3',4'-dimethoxy-alpha-naphthoflavone
3',4'-dimethoxy-alpha-naphthoflavone: activated Ah receptor; structure in first source | 2.08 | 1 | 0 | | |
7-methoxyflavone
7-methoxyflavone: an aromatase inhibitor | 2.42 | 2 | 0 | ether;
flavonoids | |
3'-methoxyflavone
3'-methoxyflavone : The parent member of the class of 3'-methoxyflavones that is flavone which carries a methoxy group at the 3'-position. | 1.98 | 1 | 0 | 3'-methoxyflavones | plant metabolite |
6-methylflavone
6-methylflavone: structure in first source | 2.08 | 1 | 0 | | |
quercetin
[no description available] | 7.17 | 1 | 0 | 7-hydroxyflavonol;
pentahydroxyflavone | antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger |
dinoprostone
prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins. | 1.98 | 1 | 0 | prostaglandins E | human metabolite;
mouse metabolite;
oxytocic |
baicalein
[no description available] | 7.17 | 1 | 0 | trihydroxyflavone | angiogenesis inhibitor;
anti-inflammatory agent;
antibacterial agent;
anticoronaviral agent;
antifungal agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
EC 1.13.11.31 (arachidonate 12-lipoxygenase) inhibitor;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
EC 4.1.1.17 (ornithine decarboxylase) inhibitor;
ferroptosis inhibitor;
geroprotector;
hormone antagonist;
plant metabolite;
prostaglandin antagonist;
radical scavenger |
7-hydroxyflavone
7-hydroxyflavone : A hydroxyflavonoid in which the flavone nucleus is substituted at position 7 by a hydroxy group. | 1.98 | 1 | 0 | hydroxyflavonoid | |
cyclosporine
ramihyphin A: one of the metabolites produced by Fusarium sp. S-435; RN given refers to cpd with unknown MF | 2.08 | 1 | 0 | homodetic cyclic peptide | anti-asthmatic drug;
anticoronaviral agent;
antifungal agent;
antirheumatic drug;
carcinogenic agent;
dermatologic drug;
EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor;
geroprotector;
immunosuppressive agent;
metabolite |
5-hydroxy-3,3',4',7-tetramethoxyflavone
5-hydroxy-3,7,3',4'-tetramethoxyflavone: from the rhizome of Kaempferia parviflora; inhibits monocyte adhesion and cellular reactive oxygen species production in human umbilical vein endothelial cells. 5-hydroxy-3,3',4',7-tetramethoxyflavone : A monohydroxyflavone that is 5-hydroxyflavone which is substituted by methoxy groups at positions 3,3',4' and 7. | 2.08 | 1 | 0 | 3'-methoxyflavones;
monohydroxyflavone;
tetramethoxyflavone | plant metabolite |
ko 143
[no description available] | 2.08 | 1 | 0 | beta-carbolines;
tert-butyl ester | |