quercetin has been researched along with Stroke* in 1 studies
1 other study(ies) available for quercetin and Stroke
| Article | Year |
|---|---|
Α-aryl-N-alkyl nitrones, as potential agents for stroke treatment: synthesis, theoretical calculations, antioxidant, anti-inflammatory, neuroprotective, and brain-blood barrier permeability properties.
We report the synthesis, theoretical calculations, the antioxidant, anti-inflammatory, and neuroprotective properties, and the ability to cross the blood-brain barrier (BBB) of (Z)-α-aryl and heteroaryl-N-alkyl nitrones as potential agents for stroke treatment. The majority of nitrones compete with DMSO for hydroxyl radicals, and most of them are potent lipoxygenase inhibitors. Cell viability-related (MTT assay) studies clearly showed that nitrones 1-3 and 10 give rise to significant neuroprotection. When compounds 1-11 were tested for necrotic cell death (LDH release test) nitrones 1-3, 6, 7, and 9 proved to be neuroprotective agents. In vitro evaluation of the BBB penetration of selected nitrones 1, 2, 10, and 11 using the PAMPA-BBB assay showed that all of them cross the BBB. Permeable quinoline nitrones 2 and 3 show potent combined antioxidant and neuroprotective properties and, therefore, can be considered as new lead compounds for further development in specific tests for potential stroke treatment. Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Blood-Brain Barrier; Cell Hypoxia; Cell Survival; Cells, Cultured; Cerebral Cortex; Edema; Female; Free Radical Scavengers; Hydroxyl Radical; Lipid Peroxidation; Lipoxygenase Inhibitors; Male; Necrosis; Neurons; Neuroprotective Agents; Nitric Oxide Donors; Nitrogen Oxides; Oximes; Permeability; Quinolines; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Stereoisomerism; Stroke; Structure-Activity Relationship; Superoxides | 2012 |