Page last updated: 2024-12-10

norswertianolin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

norswertianolin: RN given refers to beta-D-isomer; from Swertia randaiensis; shows depressant acitivity on cental nervous system [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

norswertianolin : A beta-D-glucoside that is bellidin in which a beta-D-glucopyranosyl residue is attached at position O-8. A natural product found particularly in Gentiana campestris and Gentiana germanica. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

FloraRankFlora DefinitionFamilyFamily Definition
GentianagenusA plant genus of the family Gentianaceae whose members contain SECOIRIDOIDS and have been used in TRADITIONAL MEDICINE for suppressing INFLAMMATION.[MeSH]GentianaceaeA plant family of the order Gentianales, subclass Asteridae, class Magnoliopsida.[MeSH]
SwertiagenusA plant genus of the family GENTIANACEAE. It is a source of swertiapuniside and IRIDOID GLYCOSIDES.[MeSH]GentianaceaeA plant family of the order Gentianales, subclass Asteridae, class Magnoliopsida.[MeSH]
Gentiana campestrisspecies[no description available]GentianaceaeA plant family of the order Gentianales, subclass Asteridae, class Magnoliopsida.[MeSH]

Cross-References

ID SourceID
PubMed CID5281659
CHEMBL ID512072
CHEBI ID7638
SCHEMBL ID23782036
MeSH IDM0157728

Synonyms (27)

Synonym
norswertianolin
54954-12-0
8-(beta-d-glucopyranosyloxy)-1,3,5-trihydroxy-9h-xanthen-9-one
ccris 5473
9h-xanthen-9-one, 8-(beta-d-glucopyranosyloxy)-1,3,5-trihydroxy-
3,5,8-trihydroxyxanthone-1-o-glucoside
chebi:7638 ,
CHEMBL512072
1,3,5-trihydroxy-8-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyxanthen-9-one
4,6,8-trihydroxy-9-oxo-9h-xanthen-1-yl beta-d-glucopyranoside
bellidin-8-o-beta-d-glucopyranoside
DTXSID70203480
Q27089366
1,3,5-trihydroxy-8-(((2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-yl)oxy)-9h-xanthen-9-one
MS-27410
E88785
CS-0034378
SCHEMBL23782036
HY-N6617
AKOS040758190
1,3,5-trihydroxyxanthone 8-o-beta-d-glucopyranoside
3-o-demethylbellidifolin 8-o-beta-d-glucopyranoside
1,3,5-trihydroxy-8-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-9h-xanthen-9-one
8FEU38L6GD
1,3,5,8-tetrahydroxyxanthen-9-one 8-glucoside
demethylbellidifolin-8-o-glucoside
8-o-glucosyldesmethylbellidifolin
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
EC 3.1.1.7 (acetylcholinesterase) inhibitorAn EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of enzyme acetylcholinesterase (EC 3.1.1.7), which helps breaking down of acetylcholine into choline and acetic acid.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
xanthonesAny member of the class of xanthenes based on a xanthone skeleton.
beta-D-glucosideAny D-glucoside in which the anomeric centre has beta-configuration.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID383158Inhibition of acetylcholinesterase at 10 uM by Ellman's method2008Journal of natural products, May, Volume: 71, Issue:5
Xanthones from Gentianella amarella ssp. acuta with acetylcholinesterase and monoamine oxidase inhibitory activities.
AID383159Inhibition of monoamine oxidase A at 10 uM2008Journal of natural products, May, Volume: 71, Issue:5
Xanthones from Gentianella amarella ssp. acuta with acetylcholinesterase and monoamine oxidase inhibitory activities.
AID383160Inhibition of monoamine oxidase B at 10 uM2008Journal of natural products, May, Volume: 71, Issue:5
Xanthones from Gentianella amarella ssp. acuta with acetylcholinesterase and monoamine oxidase inhibitory activities.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (20.00)18.7374
1990's0 (0.00)18.2507
2000's3 (60.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]