Page last updated: 2024-12-10
norswertianolin
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Description
norswertianolin: RN given refers to beta-D-isomer; from Swertia randaiensis; shows depressant acitivity on cental nervous system [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
norswertianolin : A beta-D-glucoside that is bellidin in which a beta-D-glucopyranosyl residue is attached at position O-8. A natural product found particularly in Gentiana campestris and Gentiana germanica. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
Related Flora
Flora | Rank | Flora Definition | Family | Family Definition |
---|---|---|---|---|
Gentiana | genus | A plant genus of the family Gentianaceae whose members contain SECOIRIDOIDS and have been used in TRADITIONAL MEDICINE for suppressing INFLAMMATION.[MeSH] | Gentianaceae | A plant family of the order Gentianales, subclass Asteridae, class Magnoliopsida.[MeSH] |
Swertia | genus | A plant genus of the family GENTIANACEAE. It is a source of swertiapuniside and IRIDOID GLYCOSIDES.[MeSH] | Gentianaceae | A plant family of the order Gentianales, subclass Asteridae, class Magnoliopsida.[MeSH] |
Gentiana campestris | species | [no description available] | Gentianaceae | A plant family of the order Gentianales, subclass Asteridae, class Magnoliopsida.[MeSH] |
Cross-References
ID Source | ID |
---|---|
PubMed CID | 5281659 |
CHEMBL ID | 512072 |
CHEBI ID | 7638 |
SCHEMBL ID | 23782036 |
MeSH ID | M0157728 |
Synonyms (27)
Synonym |
---|
norswertianolin |
54954-12-0 |
8-(beta-d-glucopyranosyloxy)-1,3,5-trihydroxy-9h-xanthen-9-one |
ccris 5473 |
9h-xanthen-9-one, 8-(beta-d-glucopyranosyloxy)-1,3,5-trihydroxy- |
3,5,8-trihydroxyxanthone-1-o-glucoside |
chebi:7638 , |
CHEMBL512072 |
1,3,5-trihydroxy-8-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyxanthen-9-one |
4,6,8-trihydroxy-9-oxo-9h-xanthen-1-yl beta-d-glucopyranoside |
bellidin-8-o-beta-d-glucopyranoside |
DTXSID70203480 |
Q27089366 |
1,3,5-trihydroxy-8-(((2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-yl)oxy)-9h-xanthen-9-one |
MS-27410 |
E88785 |
CS-0034378 |
SCHEMBL23782036 |
HY-N6617 |
AKOS040758190 |
1,3,5-trihydroxyxanthone 8-o-beta-d-glucopyranoside |
3-o-demethylbellidifolin 8-o-beta-d-glucopyranoside |
1,3,5-trihydroxy-8-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-9h-xanthen-9-one |
8FEU38L6GD |
1,3,5,8-tetrahydroxyxanthen-9-one 8-glucoside |
demethylbellidifolin-8-o-glucoside |
8-o-glucosyldesmethylbellidifolin |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Roles (2)
Role | Description |
---|---|
metabolite | Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites. |
EC 3.1.1.7 (acetylcholinesterase) inhibitor | An EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of enzyme acetylcholinesterase (EC 3.1.1.7), which helps breaking down of acetylcholine into choline and acetic acid. |
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Drug Classes (2)
Class | Description |
---|---|
xanthones | Any member of the class of xanthenes based on a xanthone skeleton. |
beta-D-glucoside | Any D-glucoside in which the anomeric centre has beta-configuration. |
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Bioassays (3)
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID383158 | Inhibition of acetylcholinesterase at 10 uM by Ellman's method | 2008 | Journal of natural products, May, Volume: 71, Issue:5 | Xanthones from Gentianella amarella ssp. acuta with acetylcholinesterase and monoamine oxidase inhibitory activities. |
AID383159 | Inhibition of monoamine oxidase A at 10 uM | 2008 | Journal of natural products, May, Volume: 71, Issue:5 | Xanthones from Gentianella amarella ssp. acuta with acetylcholinesterase and monoamine oxidase inhibitory activities. |
AID383160 | Inhibition of monoamine oxidase B at 10 uM | 2008 | Journal of natural products, May, Volume: 71, Issue:5 | Xanthones from Gentianella amarella ssp. acuta with acetylcholinesterase and monoamine oxidase inhibitory activities. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (5)
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 1 (20.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 3 (60.00) | 29.6817 |
2010's | 1 (20.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 5 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |