Page last updated: 2024-12-09

hirsutanone

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Description

hirsutanone: from methanolic extract of the aerial parts of Viscum cruciatum (Viscaceae) [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
ViscumgenusA plant genus in the family VISCACEAE, order Santalales, subclass Rosidae, class Magnoliopsida. Species of this genus contain cytotoxic LECTINS. The common name of MISTLETOE is used for many species of this and the LORANTHACEAE families.[MeSH]SantalaceaeA plant family of the order Santalales, subclass Rosidae, class Magnoliopsida. They are parasites that form connections (haustoria) to their hosts to obtain water and nutrients. The one-seeded fruit may be surrounded by a brightly colored nut-like structure.[MeSH]
Viscum cruciatumspecies[no description available]SantalaceaeA plant family of the order Santalales, subclass Rosidae, class Magnoliopsida. They are parasites that form connections (haustoria) to their hosts to obtain water and nutrients. The one-seeded fruit may be surrounded by a brightly colored nut-like structure.[MeSH]

Cross-References

ID SourceID
PubMed CID637394
CHEMBL ID464274
CHEBI ID183478
SCHEMBL ID1225021
MeSH IDM0408603

Synonyms (24)

Synonym
1,7-di-(3',4'-dihydroxyphenyl)-4-hepten-3-one
(4e)-1,7-bis(3,4-dihydroxyphenyl)hept-4-en-3-one
4-hepten-3-one, 1,7-bis(3,4-dihydroxyphenyl)-, (4e)-
inchi=1/c19h20o5/c20-15(8-5-14-7-10-17(22)19(24)12-14)4-2-1-3-13-6-9-16(21)18(23)11-13/h2,4,6-7,9-12,21-24h,1,3,5,8h2/b4-2
hirsutanone
1,7-bis-(3,4-dihydroxy-phenyl)-hept-4-en-3-one
CHEMBL464274
hirsutenone
dehydrohirsutanonol
(e)-1,7-bis(3,4-dihydroxyphenyl)hept-4-en-3-one
41137-87-5
CHEBI:183478
SCHEMBL1225021
1,7-bis-(3,4-dihydroxyphenyl)-4-hepten-3-one
vq04k2mmm5 ,
unii-vq04k2mmm5
(4e)-1,7-bis(3,4-dihydroxyphenyl)-4-hepten-3-one
bdbm50478445
hirsutenone, >=95% (lc/ms-elsd)
DTXSID00873736
FS-9874
CS-0024513
HY-N4042
AKOS040761834

Research Excerpts

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
diarylheptanoidA family of plant metabolites with a common 1,7-diphenylheptane structural skeleton, carrying various substituents. They are mainly distributed in the roots, rhizomes and bark of Alpinia, Zingiber, Curcuma and Alnus species.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (10)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Spike glycoproteinBetacoronavirus England 1IC50 (µMol)4.10000.03002.72839.5100AID1804127
Replicase polyprotein 1abBetacoronavirus England 1IC50 (µMol)4.10000.00403.43889.5100AID1804127
Transmembrane protease serine 2Homo sapiens (human)IC50 (µMol)4.10000.01802.61989.5100AID1804127
Procathepsin LHomo sapiens (human)IC50 (µMol)4.10000.00021.66619.5100AID1804127
Replicase polyprotein 1aSevere acute respiratory syndrome-related coronavirusIC50 (µMol)4.10000.03002.29719.5100AID1804127
Replicase polyprotein 1abHuman coronavirus 229EIC50 (µMol)4.10000.03002.14419.5100AID1804127
Replicase polyprotein 1abSevere acute respiratory syndrome-related coronavirusIC50 (µMol)4.10000.00402.92669.9600AID1804127
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2IC50 (µMol)4.10000.00022.45859.9600AID1804127; AID1845464
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusIC50 (µMol)4.10000.03002.77319.5100AID1804127
Angiotensin-converting enzyme 2 Homo sapiens (human)IC50 (µMol)4.10000.00042.207910.0000AID1804127
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (48)

Processvia Protein(s)Taxonomy
viral translationTransmembrane protease serine 2Homo sapiens (human)
proteolysisTransmembrane protease serine 2Homo sapiens (human)
protein autoprocessingTransmembrane protease serine 2Homo sapiens (human)
positive regulation of viral entry into host cellTransmembrane protease serine 2Homo sapiens (human)
adaptive immune responseProcathepsin LHomo sapiens (human)
proteolysisProcathepsin LHomo sapiens (human)
protein autoprocessingProcathepsin LHomo sapiens (human)
fusion of virus membrane with host plasma membraneProcathepsin LHomo sapiens (human)
receptor-mediated endocytosis of virus by host cellProcathepsin LHomo sapiens (human)
antigen processing and presentationProcathepsin LHomo sapiens (human)
antigen processing and presentation of exogenous peptide antigen via MHC class IIProcathepsin LHomo sapiens (human)
collagen catabolic processProcathepsin LHomo sapiens (human)
zymogen activationProcathepsin LHomo sapiens (human)
enkephalin processingProcathepsin LHomo sapiens (human)
fusion of virus membrane with host endosome membraneProcathepsin LHomo sapiens (human)
CD4-positive, alpha-beta T cell lineage commitmentProcathepsin LHomo sapiens (human)
symbiont entry into host cellProcathepsin LHomo sapiens (human)
antigen processing and presentation of peptide antigenProcathepsin LHomo sapiens (human)
proteolysis involved in protein catabolic processProcathepsin LHomo sapiens (human)
elastin catabolic processProcathepsin LHomo sapiens (human)
macrophage apoptotic processProcathepsin LHomo sapiens (human)
cellular response to thyroid hormone stimulusProcathepsin LHomo sapiens (human)
positive regulation of apoptotic signaling pathwayProcathepsin LHomo sapiens (human)
positive regulation of peptidase activityProcathepsin LHomo sapiens (human)
immune responseProcathepsin LHomo sapiens (human)
symbiont-mediated perturbation of host ubiquitin-like protein modificationReplicase polyprotein 1aSevere acute respiratory syndrome-related coronavirus
symbiont-mediated perturbation of host ubiquitin-like protein modificationReplicase polyprotein 1abSevere acute respiratory syndrome-related coronavirus
negative regulation of signaling receptor activityAngiotensin-converting enzyme 2 Homo sapiens (human)
symbiont entry into host cellAngiotensin-converting enzyme 2 Homo sapiens (human)
regulation of cytokine productionAngiotensin-converting enzyme 2 Homo sapiens (human)
angiotensin maturationAngiotensin-converting enzyme 2 Homo sapiens (human)
angiotensin-mediated drinking behaviorAngiotensin-converting enzyme 2 Homo sapiens (human)
regulation of systemic arterial blood pressure by renin-angiotensinAngiotensin-converting enzyme 2 Homo sapiens (human)
tryptophan transportAngiotensin-converting enzyme 2 Homo sapiens (human)
viral life cycleAngiotensin-converting enzyme 2 Homo sapiens (human)
receptor-mediated endocytosis of virus by host cellAngiotensin-converting enzyme 2 Homo sapiens (human)
regulation of vasoconstrictionAngiotensin-converting enzyme 2 Homo sapiens (human)
regulation of transmembrane transporter activityAngiotensin-converting enzyme 2 Homo sapiens (human)
regulation of cell population proliferationAngiotensin-converting enzyme 2 Homo sapiens (human)
symbiont entry into host cellAngiotensin-converting enzyme 2 Homo sapiens (human)
receptor-mediated virion attachment to host cellAngiotensin-converting enzyme 2 Homo sapiens (human)
negative regulation of smooth muscle cell proliferationAngiotensin-converting enzyme 2 Homo sapiens (human)
regulation of inflammatory responseAngiotensin-converting enzyme 2 Homo sapiens (human)
positive regulation of amino acid transportAngiotensin-converting enzyme 2 Homo sapiens (human)
maternal process involved in female pregnancyAngiotensin-converting enzyme 2 Homo sapiens (human)
positive regulation of cardiac muscle contractionAngiotensin-converting enzyme 2 Homo sapiens (human)
membrane fusionAngiotensin-converting enzyme 2 Homo sapiens (human)
negative regulation of ERK1 and ERK2 cascadeAngiotensin-converting enzyme 2 Homo sapiens (human)
blood vessel diameter maintenanceAngiotensin-converting enzyme 2 Homo sapiens (human)
entry receptor-mediated virion attachment to host cellAngiotensin-converting enzyme 2 Homo sapiens (human)
positive regulation of gap junction assemblyAngiotensin-converting enzyme 2 Homo sapiens (human)
regulation of cardiac conductionAngiotensin-converting enzyme 2 Homo sapiens (human)
positive regulation of L-proline import across plasma membraneAngiotensin-converting enzyme 2 Homo sapiens (human)
positive regulation of reactive oxygen species metabolic processAngiotensin-converting enzyme 2 Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (30)

Processvia Protein(s)Taxonomy
serine-type endopeptidase activityTransmembrane protease serine 2Homo sapiens (human)
protein bindingTransmembrane protease serine 2Homo sapiens (human)
serine-type peptidase activityTransmembrane protease serine 2Homo sapiens (human)
fibronectin bindingProcathepsin LHomo sapiens (human)
cysteine-type endopeptidase activityProcathepsin LHomo sapiens (human)
protein bindingProcathepsin LHomo sapiens (human)
collagen bindingProcathepsin LHomo sapiens (human)
cysteine-type peptidase activityProcathepsin LHomo sapiens (human)
histone bindingProcathepsin LHomo sapiens (human)
proteoglycan bindingProcathepsin LHomo sapiens (human)
serpin family protein bindingProcathepsin LHomo sapiens (human)
cysteine-type endopeptidase activator activity involved in apoptotic processProcathepsin LHomo sapiens (human)
RNA-dependent RNA polymerase activityReplicase polyprotein 1aSevere acute respiratory syndrome-related coronavirus
cysteine-type endopeptidase activityReplicase polyprotein 1aSevere acute respiratory syndrome-related coronavirus
K63-linked deubiquitinase activityReplicase polyprotein 1aSevere acute respiratory syndrome-related coronavirus
K48-linked deubiquitinase activityReplicase polyprotein 1aSevere acute respiratory syndrome-related coronavirus
3'-5'-RNA exonuclease activityReplicase polyprotein 1abSevere acute respiratory syndrome-related coronavirus
RNA-dependent RNA polymerase activityReplicase polyprotein 1abSevere acute respiratory syndrome-related coronavirus
cysteine-type endopeptidase activityReplicase polyprotein 1abSevere acute respiratory syndrome-related coronavirus
mRNA 5'-cap (guanine-N7-)-methyltransferase activityReplicase polyprotein 1abSevere acute respiratory syndrome-related coronavirus
mRNA (nucleoside-2'-O-)-methyltransferase activityReplicase polyprotein 1abSevere acute respiratory syndrome-related coronavirus
5'-3' RNA helicase activityReplicase polyprotein 1abSevere acute respiratory syndrome-related coronavirus
K63-linked deubiquitinase activityReplicase polyprotein 1abSevere acute respiratory syndrome-related coronavirus
K48-linked deubiquitinase activityReplicase polyprotein 1abSevere acute respiratory syndrome-related coronavirus
3'-5'-RNA exonuclease activityReplicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2
RNA-dependent RNA polymerase activityReplicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2
cysteine-type endopeptidase activityReplicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2
mRNA 5'-cap (guanine-N7-)-methyltransferase activityReplicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2
mRNA (nucleoside-2'-O-)-methyltransferase activityReplicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2
mRNA guanylyltransferase activityReplicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2
RNA endonuclease activity, producing 3'-phosphomonoestersReplicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2
ISG15-specific peptidase activityReplicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2
5'-3' RNA helicase activityReplicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2
protein guanylyltransferase activityReplicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2
virus receptor activityAngiotensin-converting enzyme 2 Homo sapiens (human)
endopeptidase activityAngiotensin-converting enzyme 2 Homo sapiens (human)
carboxypeptidase activityAngiotensin-converting enzyme 2 Homo sapiens (human)
metallocarboxypeptidase activityAngiotensin-converting enzyme 2 Homo sapiens (human)
protein bindingAngiotensin-converting enzyme 2 Homo sapiens (human)
metallopeptidase activityAngiotensin-converting enzyme 2 Homo sapiens (human)
peptidyl-dipeptidase activityAngiotensin-converting enzyme 2 Homo sapiens (human)
zinc ion bindingAngiotensin-converting enzyme 2 Homo sapiens (human)
identical protein bindingAngiotensin-converting enzyme 2 Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (25)

Processvia Protein(s)Taxonomy
extracellular regionTransmembrane protease serine 2Homo sapiens (human)
nucleoplasmTransmembrane protease serine 2Homo sapiens (human)
plasma membraneTransmembrane protease serine 2Homo sapiens (human)
extracellular exosomeTransmembrane protease serine 2Homo sapiens (human)
extracellular regionProcathepsin LHomo sapiens (human)
extracellular spaceProcathepsin LHomo sapiens (human)
nucleusProcathepsin LHomo sapiens (human)
lysosomeProcathepsin LHomo sapiens (human)
multivesicular bodyProcathepsin LHomo sapiens (human)
Golgi apparatusProcathepsin LHomo sapiens (human)
plasma membraneProcathepsin LHomo sapiens (human)
apical plasma membraneProcathepsin LHomo sapiens (human)
endolysosome lumenProcathepsin LHomo sapiens (human)
chromaffin granuleProcathepsin LHomo sapiens (human)
lysosomal lumenProcathepsin LHomo sapiens (human)
intracellular membrane-bounded organelleProcathepsin LHomo sapiens (human)
collagen-containing extracellular matrixProcathepsin LHomo sapiens (human)
extracellular exosomeProcathepsin LHomo sapiens (human)
endocytic vesicle lumenProcathepsin LHomo sapiens (human)
extracellular spaceProcathepsin LHomo sapiens (human)
lysosomeProcathepsin LHomo sapiens (human)
double membrane vesicle viral factory outer membraneReplicase polyprotein 1aSevere acute respiratory syndrome-related coronavirus
double membrane vesicle viral factory outer membraneReplicase polyprotein 1abSevere acute respiratory syndrome-related coronavirus
double membrane vesicle viral factory outer membraneReplicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2
virion membraneSpike glycoproteinSevere acute respiratory syndrome-related coronavirus
plasma membraneAngiotensin-converting enzyme 2 Homo sapiens (human)
extracellular regionAngiotensin-converting enzyme 2 Homo sapiens (human)
extracellular spaceAngiotensin-converting enzyme 2 Homo sapiens (human)
endoplasmic reticulum lumenAngiotensin-converting enzyme 2 Homo sapiens (human)
plasma membraneAngiotensin-converting enzyme 2 Homo sapiens (human)
ciliumAngiotensin-converting enzyme 2 Homo sapiens (human)
cell surfaceAngiotensin-converting enzyme 2 Homo sapiens (human)
membraneAngiotensin-converting enzyme 2 Homo sapiens (human)
apical plasma membraneAngiotensin-converting enzyme 2 Homo sapiens (human)
endocytic vesicle membraneAngiotensin-converting enzyme 2 Homo sapiens (human)
brush border membraneAngiotensin-converting enzyme 2 Homo sapiens (human)
membrane raftAngiotensin-converting enzyme 2 Homo sapiens (human)
extracellular exosomeAngiotensin-converting enzyme 2 Homo sapiens (human)
extracellular spaceAngiotensin-converting enzyme 2 Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (29)

Assay IDTitleYearJournalArticle
AID597201Antifibrotic activity against rat HSC-T6 cells assessed as inhibition of proliferation after 48 hrs by BrdU incorporation assay2011Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10
Antifibrotic constituents of Alnus firma on hepatic stellate cells.
AID597206Cytotoxicity against rat HSC-T6 cells assessed as decrease in LDH release2011Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10
Antifibrotic constituents of Alnus firma on hepatic stellate cells.
AID597207Decrease in collagen content in rat HSC-T6 cells at 10 to 100 uM after 48 hrs by sirius red-based colorimetric assay2011Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10
Antifibrotic constituents of Alnus firma on hepatic stellate cells.
AID1717783Noncompetitive inhibition of SARS-CoV C-terminal 6His-tagged papain-like protease expressed in Escherichia coli BL21 (DE3) CodonPlus-RIL cells using Arg-Leu-Arg-Gly-Gly-AMC as substrate by fluorescence method2020Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22
Chinese Therapeutic Strategy for Fighting COVID-19 and Potential Small-Molecule Inhibitors against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
AID466919Antitrypanosomal activity against multidrug-resistant Trypanosoma brucei brucei B48 after 48 hrs by alamar blue assay2010European journal of medicinal chemistry, Mar, Volume: 45, Issue:3
Curcuminoid analogs with potent activity against Trypanosoma and Leishmania species.
AID597202Induction of cell death in rat HSC-T6 cells assessed as decrease in cell viability after 48 hrs by MTT assay2011Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10
Antifibrotic constituents of Alnus firma on hepatic stellate cells.
AID1692492Inhibition of C-terminal 6His-tagged SARS-CoV 3C-like protease expressed in Escherichia coli BL21 (DE3) CodonPlus-RIL using 12-mer fluorogenic peptide Dabcyl-KNSTLQSGLRKE-Edans as substrate incubated for 60 mins by fluorescence method2020Journal of medicinal chemistry, 11-12, Volume: 63, Issue:21
COVID-19: Drug Targets and Potential Treatments.
AID1692493Inhibition of C-terminal 6His-tagged SARS-CoV papain-like protease expressed in Escherichia coli BL21 (DE3) CodonPlus-RIL using Arg-Leu-Arg-Gly-Gly-AMC as substrate by fluorescence method2020Journal of medicinal chemistry, 11-12, Volume: 63, Issue:21
COVID-19: Drug Targets and Potential Treatments.
AID466918Antitrypanosomal activity against diminazene-resistant Trypanosoma brucei brucei deltaTbat1-KO after 48 hrs by alamar blue assay2010European journal of medicinal chemistry, Mar, Volume: 45, Issue:3
Curcuminoid analogs with potent activity against Trypanosoma and Leishmania species.
AID1732775Inhibition of SARS CoV papain-like protease using Arg-Leu-Arg-Gly-Gly-AMC as substrate by fluorescence method2021European journal of medicinal chemistry, Apr-05, Volume: 215Protease targeted COVID-19 drug discovery: What we have learned from the past SARS-CoV inhibitors?
AID1732776Inhibition of SARS CoV 3C-like protease using 12-mer fluorogenic peptide Dabcyl-KNSTLQSGLRKE-Edans as substrate incubated for 60 mins by fluorometric assay2021European journal of medicinal chemistry, Apr-05, Volume: 215Protease targeted COVID-19 drug discovery: What we have learned from the past SARS-CoV inhibitors?
AID597205Induction of apoptosis in rat HSC-T6 cells assessed as increase in caspase-3/7 activity at 10 to 100 ug/ml after 24 to 48 hrs2011Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10
Antifibrotic constituents of Alnus firma on hepatic stellate cells.
AID1845464Inhibition of C-terminal his6-tagged recombinant SARS-CoV-2 3CL protease expressed in Escherichia coli BL21 (DE3) using Dabcyl-KNSTLQSGLRKE-Edans as substrate incubated for 60 mins by fluorescence plate reader2021Journal of natural products, 01-22, Volume: 84, Issue:1
Natural Products with Potential to Treat RNA Virus Pathogens Including SARS-CoV-2.
AID738069Inhibition of differentiation of mouse 3T3L1 cells assessed as reduction of lipid accumulation after 8 days by using Oil Red O staining by spectrophotometry relative to control2013Bioorganic & medicinal chemistry letters, Apr-01, Volume: 23, Issue:7
Anti-adipogenic diarylheptanoids from Alnus hirsuta f. sibirica on 3T3-L1 cells.
AID461110Cytotoxicity against CEF cells by MTT assay2010Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3
Anti-influenza diarylheptanoids from the bark of Alnus japonica.
AID461108Antiviral activity against Influenza A virus (A/Korea/KBNP-0028/2000(H9N2)) infected in chicken egg after 5 days by hemagglutinination assay2010Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3
Anti-influenza diarylheptanoids from the bark of Alnus japonica.
AID1717782Inhibition of SARS-CoV C-terminal 6His-tagged papain-like protease expressed in Escherichia coli BL21 (DE3) CodonPlus-RIL cells using Arg-Leu-Arg-Gly-Gly-AMC as substrate by fluorescence method2020Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22
Chinese Therapeutic Strategy for Fighting COVID-19 and Potential Small-Molecule Inhibitors against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
AID597204Antiproliferative activity against rat HSC-T6 cells at 10 to 100 ug/ml after 24 to 48 hrs by BrdU incorporation assay2011Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10
Antifibrotic constituents of Alnus firma on hepatic stellate cells.
AID597203Induction of cell death in rat HSC-T6 cells assessed as decrease in cell viability at 100 uM by MTT assay2011Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10
Antifibrotic constituents of Alnus firma on hepatic stellate cells.
AID466922Cytotoxicity against HEK293 cells after 16 hrs by alamar blue assay2010European journal of medicinal chemistry, Mar, Volume: 45, Issue:3
Curcuminoid analogs with potent activity against Trypanosoma and Leishmania species.
AID461109Selectivity index, ratio of CC50 for CEF cells to EC50 for Influenza A virus (A/Korea/KBNP-0028/2000(H9N2))2010Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3
Anti-influenza diarylheptanoids from the bark of Alnus japonica.
AID403147Inhibition of human recombinant PKCalpha1998Journal of natural products, Nov, Volume: 61, Issue:11
Isolation and structure elucidation of new PKCalpha inhibitors from Pinus flexilis.
AID466917Antitrypanosomal activity against Trypanosoma brucei brucei 427 after 48 hrs by alamar blue assay2010European journal of medicinal chemistry, Mar, Volume: 45, Issue:3
Curcuminoid analogs with potent activity against Trypanosoma and Leishmania species.
AID738071Inhibition of differentiation of mouse 3T3L1 cells assessed as lipid accumulation at 50 uM after 8 days by using Oil Red O staining by spectrophotometry relative to control2013Bioorganic & medicinal chemistry letters, Apr-01, Volume: 23, Issue:7
Anti-adipogenic diarylheptanoids from Alnus hirsuta f. sibirica on 3T3-L1 cells.
AID738070Inhibition of differentiation of mouse 3T3L1 cells assessed as lipid accumulation at 100 uM after 8 days by using Oil Red O staining by spectrophotometry relative to control2013Bioorganic & medicinal chemistry letters, Apr-01, Volume: 23, Issue:7
Anti-adipogenic diarylheptanoids from Alnus hirsuta f. sibirica on 3T3-L1 cells.
AID466920Antileishmanial activity against Leishmania major Friedlin promastigotes after 48 hrs by alamar blue assay2010European journal of medicinal chemistry, Mar, Volume: 45, Issue:3
Curcuminoid analogs with potent activity against Trypanosoma and Leishmania species.
AID738072Inhibition of differentiation of mouse 3T3L1 cells assessed as lipid accumulation at 10 uM after 8 days by using Oil Red O staining by spectrophotometry relative to control2013Bioorganic & medicinal chemistry letters, Apr-01, Volume: 23, Issue:7
Anti-adipogenic diarylheptanoids from Alnus hirsuta f. sibirica on 3T3-L1 cells.
AID466921Antileishmanial activity against Leishmania mexicana MNYC/BZ/62/M379 amastigotes after 48 hrs by alamar blue assay2010European journal of medicinal chemistry, Mar, Volume: 45, Issue:3
Curcuminoid analogs with potent activity against Trypanosoma and Leishmania species.
AID1804127No assay is provided from Article 10.1002/med.21724: \\The recent outbreaks of human coronaviruses: A medicinal chemistry perspective.\\2021Medicinal research reviews, 01, Volume: 41, Issue:1
The recent outbreaks of human coronaviruses: A medicinal chemistry perspective.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (30)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (3.33)18.2507
2000's4 (13.33)29.6817
2010's19 (63.33)24.3611
2020's6 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.01

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.01 (24.57)
Research Supply Index3.43 (2.92)
Research Growth Index5.45 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.01)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews5 (16.67%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other25 (83.33%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]