Benzeneboronic acid is a versatile building block in organic synthesis. It can be synthesized through a variety of methods, including the reaction of phenylmagnesium bromide with trimethyl borate. Benzeneboronic acid is known for its ability to undergo Suzuki-Miyaura cross-coupling reactions, which are widely used in the synthesis of pharmaceuticals, natural products, and materials. Its importance stems from its role in the formation of carbon-carbon bonds, a fundamental process in organic chemistry. The study of benzeneboronic acid is driven by its applications in drug discovery, material science, and the development of new synthetic methodologies.'
| ID Source | ID |
|---|---|
| PubMed CID | 66827 |
| CHEMBL ID | 21485 |
| CHEBI ID | 44923 |
| SCHEMBL ID | 4453 |
| MeSH ID | M0056397 |
| Synonym |
|---|
| AC-1888 |
| phenyl-boronic acid |
| phenylboron dihydroxide |
| 98-80-6 |
| phenylboric acid |
| wln: qbqr |
| dihydroxyphenylborane |
| phenyldihydroxyborane |
| boronic acid, phenyl- |
| boric acid, phenyl- |
| nsc66487 |
| usaf bo-2 |
| acide phenylborique |
| phenylboronic acid |
| nsc-66487 |
| benzeneboronic acid , |
| kyselina fenylborita [czech] |
| ai3-18036 |
| einecs 202-701-9 |
| nsc 66487 |
| brn 0970972 |
| acide phenylborique [french] |
| t-500 |
| inchi=1/c6h7bo2/c8-7(9)6-4-2-1-3-5-6/h1-5,8-9 |
| phenyl boronic acid |
| phenylboronic acid, 95% |
| CHEBI:44923 , |
| dihydroxy(phenyl)borane |
| phenylboranediol |
| borophenylic acid |
| DB01795 |
| bdbm26996 |
| phb(oh)2 |
| phenylboronic acid, 22 |
| chembl21485 , |
| B0857 |
| AKOS000264727 |
| STK891157 |
| A845913 |
| NCGC00249450-01 |
| 4-16-00-01654 (beilstein handbook reference) |
| boronic acid, b-phenyl- |
| l12h7b02g5 , |
| unii-l12h7b02g5 |
| kyselina fenylborita |
| c6h7bo2 |
| phenylboronicacid |
| FT-0631515 |
| AS-2259 |
| AM20060348 |
| benzeneboronic acid [mi] |
| SCHEMBL4453 |
| penylboronic acid |
| benzene-boronic acid |
| phenyl boronoic acid |
| ph-b(oh)2 |
| dihydroxyphenyl borane |
| phenyboronic acid |
| c6h5b(oh)2 |
| benzenboronic acid |
| b-phenyl-boronic acid |
| benzene boronic acid |
| dihydroxy-phenylborane |
| DTXSID9059179 |
| W-100062 |
| HMS3604B07 |
| phenylboronic acid; |
| mfcd00002103 |
| F3146-0086 |
| mfcd02093711 |
| J-802271 |
| phenylboronic acid, purum, >=97.0% (hplc) |
| CS-W001090 |
| GEO-02109 |
| SY001599 |
| BCP22775 |
| Q408739 |
| phenyl-d5-boronic acid;phenylboronic acid-d5 |
| b-(phenyl-2,3,4,5,6-d5)boronic acid |
| BCP30011 |
| OL10071 |
| HMS3745G03 |
| phenyl boronicacid |
| SY257095 |
| 2,3,4,5,6-pentadeuteriumbenzeneboronic acid |
| EN300-35190 |
| Z111782400 |
| HY-W001090 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "Cationic dendrimers are widely used as nonviral gene vectors, however, current gene materials based on dendrimers are either little effective or too toxic on the transfected cells." | ( Clustering Small Dendrimers into Nanoaggregates for Efficient DNA and siRNA Delivery with Minimal Toxicity. Cheng, Y; Liu, C; Shao, N; Wang, Y, 2016) | 0.43 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " The purpose of this study was to improve the pharmacokinetic characteristics of DZNep in vivo through developing a unilamellar pegylated liposomal formulation encapsulating DZNep (L-DZNep)." | ( Loading 3-deazaneplanocin A into pegylated unilamellar liposomes by forming transient phenylboronic acid-drug complex and its pharmacokinetic features in Sprague-Dawley rats. Chan, E; Li, J; Sun, F; Yu, Q, 2012) | 0.38 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " This block copolymer conjugate may be useful to improve the bioavailability of topical formulations." | ( Development of mucoadhesive drug delivery system using phenylboronic acid functionalized poly(D,L-lactide)-b-dextran nanoparticles. Gu, FX; Jones, L; Liu, S, 2012) | 0.38 |
| "In principle, not only efficient but rapid transfection is required since it can maximize the bioavailability of vector-carried gene prior to the cellular excretion." | ( Acidity-responsive gene delivery for "superfast" nuclear translocation and transfection with high efficiency. Feng, J; Jia, HZ; Qin, SY; Wan, SS; Zeng, X; Zhang, XZ; Zhu, JY; Zhuo, RX, 2016) | 0.43 |
| " However, different preclinical and clinical studies have noted significant shortcomings, such as nonspecific tumor targeting and low bioavailability which limit their usage in therapeutics." | ( Targeted delivery of quercetin via pH-responsive zinc oxide nanoparticles for breast cancer therapy. Chatterjee, S; Das, J; Ghosh, N; Kundu, M; Manna, P; Sadhukhan, P; Sil, PC, 2019) | 0.51 |
| " It is usually treated with eye drops, which has low bioavailability owing to rapid clearance from the ocular surface and leads to poor patient compliance and side effects." | ( Phenylboronic acid-tethered chondroitin sulfate-based mucoadhesive nanostructured lipid carriers for the treatment of dry eye syndrome. Li, J; Liu, D; Pan, W; Song, Y; Tan, G; Yu, Y, 2019) | 0.51 |
| " Most chemotherapeutics, however, have poor water solubility due to their hydrophobicity, which makes them less suited to biomedical applications; CUR is no exception because of its low bioavailability and extremely high hydrophobicity." | ( Phenylboronic acid-based core-shell drug delivery platform clasping 1,3-dicarbonyl compounds by a coordinate interaction. Jung, S; Kim, WJ; Lee, J, 2021) | 0.62 |
| Excerpt | Relevance | Reference |
|---|---|---|
| " As a result, with a relatively low DOX dosage (2 mg kg(-1) per injection) the in vivo antitumor effect on H22-bearing BALB/c mice shows that the micelles have a high therapeutic efficacy against solid tumors while minimal side effects against normal tissues." | ( A Nanoplatform with Precise Control over Release of Cargo for Enhanced Cancer Therapy. Qu, Q; Wang, Y; Zhang, L; Zhang, X; Zhou, S, 2016) | 0.43 |
| " However, eye drop formulations require frequent dosing with high drug concentrations due to poor ocular surface retention, which leads to poor patient compliance and high risks of side effects." | ( Prolonged Ocular Retention of Mucoadhesive Nanoparticle Eye Drop Formulation Enables Treatment of Eye Diseases Using Significantly Reduced Dosage. Ahmad, A; Boyd, S; Chang, CN; Dozois, MD; Gu, FX; Hileeto, D; Jones, LW; Liang, H; Liu, S; Ng, DL; Reyad, MM, 2016) | 0.43 |
| "Topical eye drops still face challenges of low-drug treatment effects and frequent dosing in ophthalmic applications due to the low preocular retention rate and low transcorneal permeability." | ( Mucoadhesive phenylboronic acid conjugated chitosan oligosaccharide-vitamin E copolymer for topical ocular delivery of voriconazole: Synthesis, in vitro/vivo evaluation, and mechanism. Feng, J; Han, J; Li, K; Li, Y; Sai, S; Sheng, Y; Sun, X; Tian, B; Zhang, J, 2022) | 0.72 |
| " Formulation with high polymer dosage showed better tumor targeting and antitumor activity, and activity of inhibiting HepG2 with higher content of SA-containing glycosphingolipids was higher than that of anti-B16." | ( Phenylboronic acid-modified polymaleic anhydride-F127 micelles for pH-activated targeting delivery of doxorubicin. Chen, S; Feng, R; Li, H; Song, Z; Teng, F; Wang, M; Zhu, L, 2022) | 0.72 |
| Class | Description |
|---|---|
| boronic acids | Compounds having the structure RB(OH)2. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Carbonic anhydrase | Astrosclera willeyana | Ki | 9.6000 | 0.0320 | 1.5172 | 9.6000 | AID647373 |
| Carbonic anhydrase | Stylophora pistillata | Ki | 0.0007 | 0.0000 | 0.6867 | 10.0000 | AID552130 |
| Carbonic anhydrase | Stylophora pistillata | Ki | 0.0000 | 0.0000 | 0.5071 | 5.7100 | AID552131 |
| Carbonic anhydrase 12 | Homo sapiens (human) | Ki | 425.0000 | 0.0002 | 1.1043 | 9.9000 | AID1460773; AID310902 |
| Acyl-protein thioesterase 1 | Homo sapiens (human) | IC50 (µMol) | 19.9500 | 0.0025 | 1.1761 | 3.5500 | AID1799826 |
| Acyl-protein thioesterase 2 | Homo sapiens (human) | IC50 (µMol) | 19.9500 | 0.0196 | 1.2873 | 3.5500 | AID1799826 |
| Beta-lactamase | Escherichia coli K-12 | Ki | 10.5000 | 0.0270 | 3.6413 | 7.3000 | AID38398 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 42,544.9474 | 0.0000 | 1.3726 | 10.0000 | AID1161930; AID1262263; AID1278739; AID1306523; AID1312152; AID1460764; AID1798763; AID1803484; AID238317; AID238578; AID238687; AID310899; AID367653; AID392569; AID411397; AID424442; AID552127; AID598726; AID724722; AID730754; AID763569 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 20,104.9619 | 0.0000 | 0.7236 | 9.9200 | AID1058395; AID1070020; AID1161931; AID1161950; AID1235241; AID1237475; AID1262264; AID1278740; AID1306524; AID1312153; AID1336557; AID1430526; AID1460765; AID1461934; AID1798763; AID1803485; AID238327; AID238604; AID238715; AID310900; AID367654; AID392568; AID411398; AID424443; AID552128; AID598728; AID724721; AID730373; AID730753; AID758952; AID763568 |
| Carbonic anhydrase 3 | Homo sapiens (human) | Ki | 50.0000 | 0.0002 | 2.0102 | 10.0000 | AID1460766 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 10,323.9150 | 0.0002 | 1.9720 | 9.9200 | AID1460767; AID1798763; AID238605; AID367655; AID392570 |
| Carbonic anhydrase 6 | Homo sapiens (human) | Ki | 25.0004 | 0.0001 | 1.4710 | 9.9200 | AID1460770; AID552129 |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | Ki | 23,100.0000 | 0.0000 | 0.3845 | 8.6000 | AID1161931 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 1,516.6682 | 0.0000 | 1.2725 | 9.9000 | AID1460768; AID238579; AID238688 |
| Carbonic anhydrase | Methanosarcina thermophila | Ki | 155.5000 | 0.0600 | 0.9714 | 8.5000 | AID1803493; AID238607 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Ki | 8.3000 | 0.0002 | 1.3737 | 9.9000 | AID1460771; AID265737 |
| Succinyl-diaminopimelate desuccinylase | Haemophilus influenzae Rd KW20 | IC50 (µMol) | 107.0000 | 3.3000 | 3.3000 | 3.3000 | AID467024 |
| Succinyl-diaminopimelate desuccinylase | Haemophilus influenzae Rd KW20 | Ki | 56.9000 | 1.8200 | 1.8200 | 1.8200 | AID467025 |
| Angiotensin-converting enzyme | Rattus norvegicus (Norway rat) | Ki | 10.5000 | 0.0001 | 1.9642 | 7.3000 | AID38398 |
| Carbonic anhydrase | Saccharomyces cerevisiae S288C | Ki | 38,200.0000 | 0.0820 | 0.5609 | 8.7000 | AID411400 |
| Fatty-acid amide hydrolase 1 | Rattus norvegicus (Norway rat) | IC50 (µMol) | 2.6000 | 0.0005 | 1.3313 | 8.0000 | AID346655 |
| Beta-carbonic anhydrase 1 | Mycobacterium tuberculosis H37Rv | Ki | 58.0000 | 0.0048 | 3.3841 | 9.8400 | AID1312159 |
| Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | Homo sapiens (human) | IC50 (µMol) | 10.0000 | 0.0011 | 1.0958 | 10.0000 | AID1483460 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 85.0000 | 0.0001 | 0.7874 | 9.9000 | AID1460772; AID310901 |
| Carbonic anhydrase | Methanothermobacter thermautotrophicus str. Delta H | Ki | 200.0000 | 5.3500 | 5.3500 | 5.3500 | AID238958 |
| Carbonic anhydrase | Candida albicans SC5314 | Ki | 30,850.0000 | 0.0105 | 1.4444 | 8.3470 | AID411399; AID424445 |
| Carbonic anhydrase | Nakaseomyces glabratus CBS 138 | Ki | 100.0000 | 0.0070 | 1.2174 | 9.1700 | AID433253 |
| Carbonic anhydrase 13 | Homo sapiens (human) | Ki | 50.0000 | 0.0003 | 1.2309 | 9.8000 | AID1460774 |
| Carbonic anhydrase 15 | Mus musculus (house mouse) | Ki | 13,647.7467 | 0.0009 | 1.8846 | 10.0000 | AID1460776; AID1798763; AID392571 |
| Carbonic anhydrase 13 | Mus musculus (house mouse) | Ki | 2,850.0000 | 0.0002 | 1.3974 | 9.9000 | AID238853 |
| Carbonic anhydrase | Pseudomonas aeruginosa PAO1 | Ki | 8.0000 | 0.0759 | 6.2690 | 9.0000 | AID1237477 |
| Carbonic anhydrase 14 | Homo sapiens (human) | Ki | 71.0000 | 0.0002 | 1.5099 | 9.9000 | AID1460775; AID310903 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | Ki | 1,516.6682 | 0.0000 | 1.3412 | 9.9700 | AID1460769; AID238579; AID238688 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Carbonic anhydrase 1 | Homo sapiens (human) | Kinact | 58,600.0000 | 0.0100 | 0.9387 | 8.6000 | AID387187 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Kinact | 23,100.0000 | 0.0030 | 0.7946 | 10.0000 | AID387188 |
| Carbonic anhydrase 6 | Homo sapiens (human) | Kinact | 820.0000 | 0.0009 | 0.7261 | 5.3000 | AID305488 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Kinact | 1,040.0000 | 0.0200 | 0.8580 | 9.4000 | AID301198 |
| Carbonic anhydrase | Candida albicans SC5314 | Kinact | 30,850.0000 | 0.1320 | 0.1320 | 0.1320 | AID387434 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | Kinact | 970.0000 | 0.0090 | 0.9231 | 9.0400 | AID301197 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1799826 | Enzymatic Protein Activity Assay from Article 10.1002/cbic.201200571: \\Boron-based inhibitors of acyl protein thioesterases 1 and 2.\\ | 2013 | Chembiochem : a European journal of chemical biology, Jan-02, Volume: 14, Issue:1 | Boron-based inhibitors of acyl protein thioesterases 1 and 2. |
| AID1803254 | CA Inhibition Assay from Article 10.3109/14756366.2011.649268: \\Inhibition of the alpha- and beta-carbonic anhydrases from the gastric pathogen Helycobacter pylori with anions.\\ | 2013 | Journal of enzyme inhibition and medicinal chemistry, Apr, Volume: 28, Issue:2 | Inhibition of the alpha- and beta-carbonic anhydrases from the gastric pathogen Helycobacter pylori with anions. |
| AID1798763 | CA Inhibition Assay from Article 10.1016/j.bmcl.2008.12.082: \\Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions.\\ | 2009 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 19, Issue:4 | Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions. |
| AID1803484 | ChEMBL_158304 (CHEMBL763189) from Article 10.1016/j.bmc.2016.05.029: \\Anion inhibition profiles of a-, u00DF- and u00BF-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.\\ | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae. |
| AID1803493 | ChEMBL_158313 (CHEMBL763370) from Article 10.1016/j.bmc.2016.05.029: \\Anion inhibition profiles of a-, u00DF- and u00BF-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.\\ | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae. |
| AID1803491 | ChEMBL_158311 (CHEMBL763368) from Article 10.1016/j.bmc.2016.05.029: \\Anion inhibition profiles of a-, u00DF- and u00BF-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.\\ | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae. |
| AID1802941 | Urease Inhibition Assay from Article 10.3109/14756360903468155: \\Inhibition studies of soybean (Glycine max) urease with heavy metals, sodium salts of mineral acids, boric acid, and boronic acids.\\ | 2010 | Journal of enzyme inhibition and medicinal chemistry, Oct, Volume: 25, Issue:5 | Inhibition studies of soybean (Glycine max) urease with heavy metals, sodium salts of mineral acids, boric acid, and boronic acids. |
| AID1803486 | ChEMBL_158306 (CHEMBL763191) from Article 10.1016/j.bmc.2016.05.029: \\Anion inhibition profiles of a-, u00DF- and u00BF-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.\\ | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae. |
| AID1803487 | ChEMBL_158307 (CHEMBL763192) from Article 10.1016/j.bmc.2016.05.029: \\Anion inhibition profiles of a-, u00DF- and u00BF-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.\\ | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae. |
| AID1803485 | ChEMBL_158305 (CHEMBL763190) from Article 10.1016/j.bmc.2016.05.029: \\Anion inhibition profiles of a-, u00DF- and u00BF-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.\\ | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae. |
| AID1550427 | Inhibition of extended-spectrum beta lactamase in Klebsiella pneumoniae ATCC 700603 assessed as potentiation of ceftazidime-induced antibacterial activity by measuring diameter of zone inhibition at 0.3 mg incubated for 18 hrs in presence of 10 ug ceftazi | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Antimicrobial and KPC/AmpC inhibitory activity of functionalized benzosiloxaboroles. |
| AID1550429 | Inhibition of beta lactamase KPC-2 in Klebsiella pneumoniae ATCC BAA 1705 assessed as potentiation of ceftazidime-induced antibacterial activity by measuring ceftazidime MIC at 16 mg/L incubated for 18 hrs by broth dilution method | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Antimicrobial and KPC/AmpC inhibitory activity of functionalized benzosiloxaboroles. |
| AID238687 | Inhibitory activity against human carbonic anhydrase I expressed in Escherichia coli | 2004 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 14, Issue:21 | Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. |
| AID467025 | Inhibition of Haemophilus influenzae recombinant DapE by competitive binding assay | 2009 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22 | Inhibitors of bacterial N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) and demonstration of in vitro antimicrobial activity. |
| AID346657 | Inhibition of human recombinant MGL at 100 uM | 2008 | Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22 | Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. |
| AID723362 | Neuroprotective activity in human APP695-transfected SH-SY5Y cells assessed as GSH-glutathione disulfide level after 16 hrs (Rvb = 4.71 +/- 0.48 nmol/mg) | 2013 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 23, Issue:2 | Discovery of alkenylboronic acids as neuroprotective agents affecting multiple biological targets involved in Alzheimer's disease. |
| AID424443 | Inhibition of human recombinant cytosolic carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay | 2009 | Bioorganic & medicinal chemistry letters, May-15, Volume: 19, Issue:10 | Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. |
| AID1161952 | Inhibition of Porphyromonas gingivalis beta-carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration method | 2014 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 24, Issue:18 | Anion inhibition study of the β-class carbonic anhydrase (PgiCAb) from the oral pathogen Porphyromonas gingivalis. |
| AID493709 | Inhibition of synthetic melanin polymerization after 30 to 60 mins by UV-vis spectroscopic analysis | 2010 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15 | Aryl boronic acid inhibition of synthetic melanin polymerization. |
| AID730754 | Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay | 2013 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 23, Issue:6 | Anion inhibition studies of the α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae. |
| AID1058389 | Inhibition of Clostridium perfringens carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay | 2013 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24 | Anion inhibition studies of a β-carbonic anhydrase from Clostridium perfringens. |
| AID1550426 | Inhibition of beta lactamase CMY-2 in Escherichia coli 77 assessed as potentiation of ceftazidime-induced antibacterial activity by measuring diameter of zone inhibition at 0.3 mg incubated for 18 hrs in presence of 30 ug ceftazidime by CLSI disc diffusio | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Antimicrobial and KPC/AmpC inhibitory activity of functionalized benzosiloxaboroles. |
| AID723365 | Cytotoxicity against human APP695-transfected SH-SY5Y cells at 10 uM after 24 hrs by MTT assay | 2013 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 23, Issue:2 | Discovery of alkenylboronic acids as neuroprotective agents affecting multiple biological targets involved in Alzheimer's disease. |
| AID1237475 | Inhibition of human carbonic anhydrase-2 by CO2 hydration reaction based colorimetric stopped-flow method | 2015 | Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15 | Structure and inhibition studies of a type II beta-carbonic anhydrase psCA3 from Pseudomonas aeruginosa. |
| AID301197 | Inhibition of human mitochondrial CA5B by CO2 hydration assay | 2007 | Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21 | Carbonic anhydrase inhibitors: the inhibition profiles of the human mitochondrial isoforms VA and VB with anions are very different. |
| AID1550442 | Inhibition of beta lactamase KPC-3 in Escherichia coli 82 TR assessed as potentiation of meropenem-induced antibacterial activity by measuring meropenem MIC at 16 mg/L incubated for 18 hrs by broth dilution method (Rvb = 2 mg/L) | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Antimicrobial and KPC/AmpC inhibitory activity of functionalized benzosiloxaboroles. |
| AID1312154 | Inhibition of Candida albicans beta-carbonic anhydrase preincubated for 15 mins by stopped-flow CO2 hydration assay | 2016 | Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18 | Bortezomib inhibits bacterial and fungal β-carbonic anhydrases. |
| AID758948 | Inhibition of Porphyromonas gingivalis recombinant CA by CO2 hydration assay | 2013 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 23, Issue:14 | A highly catalytically active γ-carbonic anhydrase from the pathogenic anaerobe Porphyromonas gingivalis and its inhibition profile with anions and small molecules. |
| AID367654 | Inhibition of human carbonic anhydrase 2 measured by CO2 hydration reaction assay | 2009 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 19, Issue:3 | Carbonic anhydrase inhibitors: inhibition studies of a coral secretory isoform with inorganic anions. |
| AID1127994 | Toxicity in fluoroquinolone-resistant Staphylococcus aureus 1199B expressing NorA at 100 ug/ml after 24 hrs by microdilution method | 2014 | Journal of medicinal chemistry, Mar-27, Volume: 57, Issue:6 | First identification of boronic species as novel potential inhibitors of the Staphylococcus aureus NorA efflux pump. |
| AID1460775 | Inhibition of human CA14 by stopped-flow CO2 hydrase assay | 2017 | Bioorganic & medicinal chemistry, 10-01, Volume: 25, Issue:19 | Bortezomib inhibits mammalian carbonic anhydrases. |
| AID392570 | Inhibition of human recombinant carbonic anhydrase 4 by CO2 hydration reaction | 2009 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 19, Issue:4 | Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions. |
| AID367653 | Inhibition of human carbonic anhydrase 1 measured by CO2 hydration reaction assay | 2009 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 19, Issue:3 | Carbonic anhydrase inhibitors: inhibition studies of a coral secretory isoform with inorganic anions. |
| AID1070022 | Inhibition of Legionella pneumophila carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydrase assay | 2014 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 24, Issue:4 | Anion inhibition studies of two new β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila. |
| AID1336558 | Inhibition of Methanosarcina thermophila recombinant carbonic anhydrase gamma assessed as inhibition of CO2 hydration preincubated for 15 mins by Lineweaver-burk plot method | |||
| AID763568 | Inhibition of human carbonic anhydrase-2 at 20 degC preincubated for 15 mins by stopped-flow CO2 hydrase assay | 2013 | Bioorganic & medicinal chemistry, Aug-01, Volume: 21, Issue:15 | Anion inhibition studies of the α-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease. |
| AID387189 | Inhibition of Methanobacterium thermoautotrophicum Cab at 20 degC by CO2 hydration method | 2008 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 18, Issue:18 | Carbonic anhydrase inhibitors: inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with simple anions. |
| AID238958 | Inhibitory constant against methanoarchaeon Methanobacterium thermoautotrophicum (Cab) | 2004 | Bioorganic & medicinal chemistry letters, Sep-06, Volume: 14, Issue:17 | Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions. |
| AID1235245 | Inhibition of Pseudoalteromonas haloplanktis gamma-CA after 15 mins by stopped-flow/Co2 hydration assay | 2015 | Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15 | Cloning, characterization and anion inhibition studies of a new γ-carbonic anhydrase from the Antarctic bacterium Pseudoalteromonas haloplanktis. |
| AID724722 | Inhibition of human recombinant wild type CA1 by stopped-flow CO2 hydration method | 2013 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1 | Restoring catalytic activity to the human carbonic anhydrase (CA) related proteins VIII, X and XI affords isoforms with high catalytic efficiency and susceptibility to anion inhibition. |
| AID346655 | Inhibition of Wistar rat brain FAAH assessed as [3H]arachidonoylethanolamide hydrolysis | 2008 | Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22 | Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. |
| AID1278739 | Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydration assay | 2016 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5 | Anion inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae. |
| AID1269931 | Inhibition of Colwellia psychrerythraea gamma carbonic anhydrase expressed in Escherichia coli incubated for 15 mins prior to testing by stopped flow CO2 hydration method | 2016 | Bioorganic & medicinal chemistry, Feb-15, Volume: 24, Issue:4 | Cloning, characterization and anion inhibition studies of a γ-carbonic anhydrase from the Antarctic bacterium Colwellia psychrerythraea. |
| AID1550357 | Inhibition of beta lactamase KPC-2 in Klebsiella pneumoniae ATCC BAA 1705 assessed as potentiation of meropenem-induced antibacterial activity by measuring meropenem MIC at 16 mg/L incubated for 18 hrs by broth dilution method (Rvb = 64 mg/L) | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Antimicrobial and KPC/AmpC inhibitory activity of functionalized benzosiloxaboroles. |
| AID310902 | Inhibition of human recombinant catalytic domain CA12 | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6 | Carbonic anhydrase inhibitors. Inhibition of transmembrane isozymes XII (cancer-associated) and XIV with anions. |
| AID730372 | Inhibition of Flaveria bidentis beta-carbonic anhydrase-1 preincubated for 15 mins by stopped flow CO2 hydration assay | 2013 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 23, Issue:6 | Kinetic and anion inhibition studies of a β-carbonic anhydrase (FbiCA 1) from the C4 plant Flaveria bidentis. |
| AID310900 | Inhibition of human recombinant CA2 | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6 | Carbonic anhydrase inhibitors. Inhibition of transmembrane isozymes XII (cancer-associated) and XIV with anions. |
| AID1312156 | Inhibition of Cryptococcus neoformans beta-carbonic anhydrase preincubated for 15 mins by stopped-flow CO2 hydration assay | 2016 | Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18 | Bortezomib inhibits bacterial and fungal β-carbonic anhydrases. |
| AID677271 | Inhibition of Helicobacter pylori alpha-carbonic anhydrase-catalyzed CO2 hydration reaction preincubated for 15 mins by stopped flow CO2 hydrase assay | 2012 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17 | Anion inhibition studies of an α-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1. |
| AID1262267 | Inhibition of Chionodraco hamatus alphaCA incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay | 2015 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 25, Issue:23 | Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus. |
| AID227383 | Fluorescence intensity change with respect to glucose binding (100 mM) was determined by Fluorescence experiment; PBA is not fluorescent. | 2002 | Bioorganic & medicinal chemistry letters, Dec-02, Volume: 12, Issue:23 | A glucose-selective fluorescence sensor based on boronic acid-diol recognition. |
| AID1550443 | Inhibition of beta lactamase KPC-3 in Klebsiella pneumoniae 83 assessed as potentiation of meropenem-induced antibacterial activity by measuring meropenem MIC at 16 mg/L incubated for 18 hrs by broth dilution method (Rvb = 32 mg/L) | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Antimicrobial and KPC/AmpC inhibitory activity of functionalized benzosiloxaboroles. |
| AID238604 | Inhibition constant against human carbonic anhydrase isozyme hCA II | 2004 | Bioorganic & medicinal chemistry letters, Dec-06, Volume: 14, Issue:23 | Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions. |
| AID1550428 | Inhibition of extended-spectrum beta lactamase in Klebsiella pneumoniae ATCC 700603 assessed as potentiation of cefotaxime-induced antibacterial activity by measuring diameter of zone inhibition at 0.3 mg incubated for 18 hrs in presence of 10 ug cefotaxi | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Antimicrobial and KPC/AmpC inhibitory activity of functionalized benzosiloxaboroles. |
| AID227931 | Binding constant for complexation with Fructose by Fluorescence experiment | 2002 | Bioorganic & medicinal chemistry letters, Dec-02, Volume: 12, Issue:23 | A glucose-selective fluorescence sensor based on boronic acid-diol recognition. |
| AID1550358 | Inhibition of beta lactamase KPC-2 in Klebsiella pneumoniae 75 assessed as potentiation of meropenem-induced antibacterial activity by measuring meropenem MIC at 16 mg/L incubated for 18 hrs by broth dilution method (Rvb = 32 mg/L) | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Antimicrobial and KPC/AmpC inhibitory activity of functionalized benzosiloxaboroles. |
| AID238579 | Inhibition constant against human carbonic anhydrase isozyme hCA V | 2004 | Bioorganic & medicinal chemistry letters, Dec-06, Volume: 14, Issue:23 | Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions. |
| AID411399 | Inhibition of Candida albicans carbonic anhydrase overexpressed in Escherichia coli BL21 (DE3) by CO2 hydration stopped-flow assay | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with anions. |
| AID552127 | Inhibition of human recombinant CA1 by stopped-flow CO2 hydration assay | 2011 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 21, Issue:2 | Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata. |
| AID1550438 | Inhibition of beta lactamase CMY-2 in Escherichia coli 77 assessed as potentiation of ceftazidime-induced antibacterial activity by measuring ceftazidime MIC at 16 mg/L incubated for 18 hrs by broth dilution method (Rvb = 32 mg/L) | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Antimicrobial and KPC/AmpC inhibitory activity of functionalized benzosiloxaboroles. |
| AID310901 | Inhibition of human recombinant catalytic domain CA9 | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6 | Carbonic anhydrase inhibitors. Inhibition of transmembrane isozymes XII (cancer-associated) and XIV with anions. |
| AID1262263 | Inhibition of human CA1 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay | 2015 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 25, Issue:23 | Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus. |
| AID1336557 | Inhibition of human recombinant carbonic anhydrase 2 assessed as inhibition of CO2 hydration preincubated for 15 mins by Lineweaver-burk plot method | |||
| AID1312162 | Inhibition of Flaveria bidentis beta-carbonic anhydrase preincubated for 15 mins by stopped-flow CO2 hydration assay | 2016 | Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18 | Bortezomib inhibits bacterial and fungal β-carbonic anhydrases. |
| AID1460766 | Inhibition of human CA3 by stopped-flow CO2 hydrase assay | 2017 | Bioorganic & medicinal chemistry, 10-01, Volume: 25, Issue:19 | Bortezomib inhibits mammalian carbonic anhydrases. |
| AID301198 | Inhibition of human mitochondrial CA5A by CO2 hydration assay | 2007 | Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21 | Carbonic anhydrase inhibitors: the inhibition profiles of the human mitochondrial isoforms VA and VB with anions are very different. |
| AID1460776 | Inhibition of mouse CA15 by stopped-flow CO2 hydrase assay | 2017 | Bioorganic & medicinal chemistry, 10-01, Volume: 25, Issue:19 | Bortezomib inhibits mammalian carbonic anhydrases. |
| AID758950 | Inhibition of Methanosarcina thermophila recombinant gamma-CA by CO2 hydration assay | 2013 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 23, Issue:14 | A highly catalytically active γ-carbonic anhydrase from the pathogenic anaerobe Porphyromonas gingivalis and its inhibition profile with anions and small molecules. |
| AID265737 | Inhibition of human recombinant CA7 | 2006 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 16, Issue:12 | Carbonic anhydrase inhibitors: inhibition of the cytosolic human isozyme VII with anions. |
| AID677270 | Inhibition of Sulfurihydrogenibium yellowstonense YO3AOP1 alpha-carbonic anhydrase-catalyzed CO2 hydration reaction preincubated for 15 mins by stopped flow CO2 hydrase assay | 2012 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17 | Anion inhibition studies of an α-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1. |
| AID1336560 | Inhibition of Nostoc commune recombinant carbonic anhydrase gamma assessed as inhibition of CO2 hydration preincubated for 15 mins by Lineweaver-burk plot method | |||
| AID1235242 | Inhibition of archaeon Methanosarcina thermophila gamma-CA after 15 mins by stopped-flow/Co2 hydration assay | 2015 | Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15 | Cloning, characterization and anion inhibition studies of a new γ-carbonic anhydrase from the Antarctic bacterium Pseudoalteromonas haloplanktis. |
| AID367656 | Inhibition of Stylophora pistillata carbonic anhydrase measured by CO2 hydration reaction assay | 2009 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 19, Issue:3 | Carbonic anhydrase inhibitors: inhibition studies of a coral secretory isoform with inorganic anions. |
| AID749399 | Inhibition of ORAl1/2/3 in HEK293 cells assessed as inhibition of Ca2+ influx up to 500 uM after 10 mins by FLIPR assay in presence of thapsigargin | 2013 | Bioorganic & medicinal chemistry, Jun-01, Volume: 21, Issue:11 | Design, synthesis and pharmacological characterization of analogs of 2-aminoethyl diphenylborinate (2-APB), a known store-operated calcium channel blocker, for inhibition of TRPV6-mediated calcium transport. |
| AID1312159 | Inhibition of Mycobacterium tuberculosis beta-carbonic anhydrase Rv1284 preincubated for 15 mins by stopped-flow CO2 hydration assay | 2016 | Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18 | Bortezomib inhibits bacterial and fungal β-carbonic anhydrases. |
| AID1127993 | Toxicity in Staphylococcus aureus ATCC 25923 at 100 ug/ml after 24 hrs by microdilution method | 2014 | Journal of medicinal chemistry, Mar-27, Volume: 57, Issue:6 | First identification of boronic species as novel potential inhibitors of the Staphylococcus aureus NorA efflux pump. |
| AID1161951 | Inhibition of Porphyromonas gingivalis gamma-carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration method | 2014 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 24, Issue:18 | Anion inhibition study of the β-class carbonic anhydrase (PgiCAb) from the oral pathogen Porphyromonas gingivalis. |
| AID467024 | Inhibition of Haemophilus influenzae recombinant DapE | 2009 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22 | Inhibitors of bacterial N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) and demonstration of in vitro antimicrobial activity. |
| AID1312153 | Inhibition of human carbonic anhydrase-2 preincubated for 15 mins by stopped-flow CO2 hydration assay | 2016 | Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18 | Bortezomib inhibits bacterial and fungal β-carbonic anhydrases. |
| AID227937 | Binding constant with catechol dye alizarin red S in 0.1 M PBS buffer at the pH=7.5 | 2004 | Bioorganic & medicinal chemistry letters, Jan-05, Volume: 14, Issue:1 | 3-Methoxycarbonyl-5-nitrophenyl boronic acid: high affinity diol recognition at neutral pH. |
| AID1312155 | Inhibition of Candida glabrata beta-carbonic anhydrase preincubated for 15 mins by stopped-flow CO2 hydration assay | 2016 | Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18 | Bortezomib inhibits bacterial and fungal β-carbonic anhydrases. |
| AID723356 | Neuroprotective activity in human APP695-transfected SH-SY5Y cells assessed as inhibition of ROS production at 5 uM after 60 mins by DCFA-DA assay | 2013 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 23, Issue:2 | Discovery of alkenylboronic acids as neuroprotective agents affecting multiple biological targets involved in Alzheimer's disease. |
| AID552129 | Inhibition of human recombinant CA6 by stopped-flow CO2 hydration assay | 2011 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 21, Issue:2 | Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata. |
| AID1483460 | Inhibition of full length human C-terminal 6-His-tagged ATXbeta using FS-3 as substrate preincubated for 20 mins followed by substrate addition by fluorescence assay | 2017 | Journal of medicinal chemistry, 06-22, Volume: 60, Issue:12 | Repurposing Suzuki Coupling Reagents as a Directed Fragment Library Targeting Serine Hydrolases and Related Enzymes. |
| AID1312160 | Inhibition of Mycobacterium tuberculosis beta-carbonic anhydrase Rv3588 preincubated for 15 mins by stopped-flow CO2 hydration assay | 2016 | Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18 | Bortezomib inhibits bacterial and fungal β-carbonic anhydrases. |
| AID1461938 | Inhibition of recombinant His6-tagged Francisella tularensis beta-CA (227 residues) expressed in Escherichia coli BL21(DE3) incubated for 15 mins by stopped-flow CO2 hydration assay | |||
| AID723363 | Neuroprotective activity in human APP695-transfected SH-SY5Y cells assessed as increase of glutathione level after 16 hrs (Rvb = 17.79 +/- 1.59 nmol/mg) | 2013 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 23, Issue:2 | Discovery of alkenylboronic acids as neuroprotective agents affecting multiple biological targets involved in Alzheimer's disease. |
| AID305488 | Inhibition of full length human recombinant full length CA6 expressed in Escherichia coli BL21 by CO2 hydration method | 2007 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 17, Issue:4 | Carbonic anhydrase inhibitors. Inhibition studies of the human secretory isoform VI with anions. |
| AID1550425 | Inhibition of beta lactamase AmpC in Pseudomonas aeruginosa MUW 700 assessed as potentiation of ceftazidime-induced antibacterial activity by measuring diameter of zone inhibition at 0.3 mg incubated for 18 hrs in presence of 30 ug ceftazidime by CLSI dis | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Antimicrobial and KPC/AmpC inhibitory activity of functionalized benzosiloxaboroles. |
| AID598732 | Inhibition of Salmonella Typhimurium carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay at pH 8.3 | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium. |
| AID38398 | Inhibitory activity against Escherichia coli AmpC beta-lactamase. | 1998 | Journal of medicinal chemistry, Nov-05, Volume: 41, Issue:23 | Structure-based enhancement of boronic acid-based inhibitors of AmpC beta-lactamase. |
| AID1460765 | Inhibition of human CA2 by stopped-flow CO2 hydrase assay | 2017 | Bioorganic & medicinal chemistry, 10-01, Volume: 25, Issue:19 | Bortezomib inhibits mammalian carbonic anhydrases. |
| AID238715 | Inhibitory activity against human carbonic anhydrase II expressed in Escherichia coli | 2004 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 14, Issue:21 | Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. |
| AID552128 | Inhibition of human recombinant CA2 by stopped-flow CO2 hydration assay | 2011 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 21, Issue:2 | Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata. |
| AID552131 | Inhibition of Stylophora pistillata carbonic anhydrase 2 by stopped-flow CO2 hydration assay | 2011 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 21, Issue:2 | Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata. |
| AID387434 | Inhibition of Candida albicans Nce103 at 20 degC by CO2 hydration method | 2008 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 18, Issue:18 | Carbonic anhydrase inhibitors: inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with simple anions. |
| AID424445 | Inhibition of Candida albicans recombinant Carbonic anhydrase pre-incubated for 15 mins by CO2 hydration stopped-flow assay | 2009 | Bioorganic & medicinal chemistry letters, May-15, Volume: 19, Issue:10 | Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. |
| AID238317 | Inhibitory constant against carbonic anhydrase I | 2004 | Bioorganic & medicinal chemistry letters, Sep-06, Volume: 14, Issue:17 | Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions. |
| AID730368 | Inhibition of Helicobacter pylori beta-carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay | 2013 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 23, Issue:6 | Kinetic and anion inhibition studies of a β-carbonic anhydrase (FbiCA 1) from the C4 plant Flaveria bidentis. |
| AID424444 | Inhibition of Cryptococcus neoformans recombinant Carbonic anhydrase 2 pre-incubated for 15 mins by CO2 hydration stopped-flow assay | 2009 | Bioorganic & medicinal chemistry letters, May-15, Volume: 19, Issue:10 | Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. |
| AID1460768 | Inhibition of human CA5A by stopped-flow CO2 hydrase assay | 2017 | Bioorganic & medicinal chemistry, 10-01, Volume: 25, Issue:19 | Bortezomib inhibits mammalian carbonic anhydrases. |
| AID730752 | Inhibition of Helicobacter pylori alpha carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay | 2013 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 23, Issue:6 | Anion inhibition studies of the α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae. |
| AID1550440 | Inhibition of beta lactamase KPC-2 in Escherichia coli 76 assessed as potentiation of meropenem-induced antibacterial activity by measuring meropenem MIC at 16 mg/L incubated for 18 hrs by broth dilution method (Rvb = >64 mg/L) | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Antimicrobial and KPC/AmpC inhibitory activity of functionalized benzosiloxaboroles. |
| AID493710 | Inhibition of synthetic melanin polymerization at 2 mM after 30 to 60 mins by UV-vis spectroscopic analysis relative to control | 2010 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15 | Aryl boronic acid inhibition of synthetic melanin polymerization. |
| AID1161950 | Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration method | 2014 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 24, Issue:18 | Anion inhibition study of the β-class carbonic anhydrase (PgiCAb) from the oral pathogen Porphyromonas gingivalis. |
| AID437830 | Inhibition of penicillin-resistant Streptococcus pneumoniae 5204 PBP2X assessed as residual activity at 500 uM preincubated for 4 hrs before addition of substrate mixture of (R)-[2-(benzoylamino)propionylsulfanyl]acetic acid and 5,5'-dithiobis(2-nitrobenz | 2009 | Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19 | Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors. |
| AID1550433 | Inhibition of beta lactamase KPC-3 in Escherichia coli 82 TR assessed as potentiation of ceftazidime-induced antibacterial activity by measuring ceftazidime MIC at 16 mg/L incubated for 18 hrs by broth dilution method (Rvb = 32 mg/L) | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Antimicrobial and KPC/AmpC inhibitory activity of functionalized benzosiloxaboroles. |
| AID411400 | Inhibition of Saccharomyces cerevisiae carbonic anhydrase overexpressed in Escherichia coli BL21 (DE3) by CO2 hydration stopped-flow assay | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with anions. |
| AID552785 | Inhibition of Streptococcus pneumoniae beta-carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay | 2011 | Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1 | Inhibition of the β-carbonic anhydrase from Streptococcus pneumoniae by inorganic anions and small molecules: Toward innovative drug design of antiinfectives? |
| AID1550435 | Inhibition of beta lactamase VIM in Pseudomonas aeruginosa 698 assessed as potentiation of ceftazidime-induced antibacterial activity by measuring ceftazidime MIC at 16 mg/L incubated for 18 hrs by broth dilution method (Rvb = 64 mg/L) | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Antimicrobial and KPC/AmpC inhibitory activity of functionalized benzosiloxaboroles. |
| AID730753 | Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay | 2013 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 23, Issue:6 | Anion inhibition studies of the α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae. |
| AID1306526 | Inhibition of Vibrio cholerae alpha carbonic anhydrase preincubated for 15 mins by stopped-flow CO2 hydrase assay | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae. |
| AID1262264 | Inhibition of human CA2 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay | 2015 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 25, Issue:23 | Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus. |
| AID437827 | Inhibition of penicillin-sensitive Streptococcus pneumoniae R6 PBP2X assessed as residual activity at 500 uM preincubated for 60 mins before addition of substrate mixture of (R)-[2-(benzoylamino)propionylsulfanyl]acetic acid and 5,5'-dithiobis(2-nitrobenz | 2009 | Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19 | Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors. |
| AID552130 | Inhibition of Stylophora pistillata carbonic anhydrase by stopped-flow CO2 hydration assay | 2011 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 21, Issue:2 | Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata. |
| AID238607 | Inhibitory constant against Zn-Cam (Methanosarcina thermophila) | 2004 | Bioorganic & medicinal chemistry letters, Sep-06, Volume: 14, Issue:17 | Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions. |
| AID1550430 | Inhibition of beta lactamase KPC-2 in Klebsiella pneumoniae 75 assessed as potentiation of ceftazidime-induced antibacterial activity by measuring ceftazidime MIC at 16 mg/L incubated for 18 hrs by broth dilution method (Rvb = 64 mg/L) | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Antimicrobial and KPC/AmpC inhibitory activity of functionalized benzosiloxaboroles. |
| AID723364 | Neuroprotective activity in human APP695-transfected SH-SY5Y cells assessed as decrease of malondialdehyde level after 16 hrs (Rvb = 52 +/- 1.84 nmol/mg) | 2013 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 23, Issue:2 | Discovery of alkenylboronic acids as neuroprotective agents affecting multiple biological targets involved in Alzheimer's disease. |
| AID1235244 | Inhibition of Nostoc commune CA after 15 mins by stopped-flow/Co2 hydration assay | 2015 | Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15 | Cloning, characterization and anion inhibition studies of a new γ-carbonic anhydrase from the Antarctic bacterium Pseudoalteromonas haloplanktis. |
| AID1161932 | Inhibition of recombinant Plasmodium falciparum eta-carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration method | 2014 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 24, Issue:18 | Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum--the η-carbonic anhydrases. |
| AID1430527 | Inhibition of Burkholderia pseudomallei recombinant carbonic anhydrase gamma incubated for 15 mins prior to testing by stopped flow CO2 hydration method | |||
| AID1430528 | Inhibition of Burkholderia pseudomallei recombinant His-tagged carbonic anhydrase beta (256 residues) expressed in Escherichia coli BL21 (DE3) incubated for 15 mins prior to testing by stopped flow CO2 hydration method | |||
| AID367655 | Inhibition of human secreted carbonic anhydrase 4 measured by CO2 hydration reaction assay | 2009 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 19, Issue:3 | Carbonic anhydrase inhibitors: inhibition studies of a coral secretory isoform with inorganic anions. |
| AID1336559 | Inhibition of Porphyromonas gingivalis recombinant carbonic anhydrase gamma assessed as inhibition of CO2 hydration preincubated for 15 mins by Lineweaver-burk plot method | |||
| AID387188 | Inhibition of human carbonic anhydrase 2 at 20 degC by CO2 hydration method | 2008 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 18, Issue:18 | Carbonic anhydrase inhibitors: inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with simple anions. |
| AID1461935 | Inhibition of Burkholderia pseudomallei beta-CA incubated for 15 mins by stopped-flow CO2 hydration assay | |||
| AID1312218 | Inhibition of Plasmodium falciparum full length recombinant His-fused Eta-carbonic anhydrase domain preincubated for 15 mins by stopped-flow CO2 hydrase assay | 2016 | Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18 | Anion inhibition profiles of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum. |
| AID763566 | Inhibition of Brucella suis beta carbonic anhydrase-2 at 20 degC by stopped-flow CO2 hydrase assay | 2013 | Bioorganic & medicinal chemistry, Aug-01, Volume: 21, Issue:15 | Anion inhibition studies of the α-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease. |
| AID1306525 | Inhibition of Helicobacter pylori alpha carbonic anhydrase preincubated for 15 mins by stopped-flow CO2 hydrase assay | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae. |
| AID598728 | Inhibition of recombinant human carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay at pH 8.3 | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium. |
| AID1550432 | Inhibition of beta lactamase KPC-3 in Klebsiella pneumoniae 81 assessed as potentiation of ceftazidime-induced antibacterial activity by measuring ceftazidime MIC at 16 mg/L incubated for 18 hrs by broth dilution method (Rvb = >64 mg/L) | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Antimicrobial and KPC/AmpC inhibitory activity of functionalized benzosiloxaboroles. |
| AID1550434 | Inhibition of beta lactamase KPC-3 in Klebsiella pneumoniae 83 assessed as potentiation of ceftazidime-induced antibacterial activity by measuring ceftazidime MIC at 16 mg/L incubated for 18 hrs by broth dilution method (Rvb = >64 mg/L) | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Antimicrobial and KPC/AmpC inhibitory activity of functionalized benzosiloxaboroles. |
| AID1550356 | Inhibition of beta lactamase CMY-2 in Klebsiella pneumoniae 78 assessed as potentiation of ceftazidime-induced antibacterial activity by measuring ceftazidime MIC at 16 mg/L incubated for 18 hrs by broth dilution method (Rvb = >64 mg/L) | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Antimicrobial and KPC/AmpC inhibitory activity of functionalized benzosiloxaboroles. |
| AID749398 | Inhibition of ORAl1/2/3 in HEK293 cells assessed as inhibition of Cd2+ influx up to 500 uM after 10 mins by FLIPR assay in presence of thapsigargin | 2013 | Bioorganic & medicinal chemistry, Jun-01, Volume: 21, Issue:11 | Design, synthesis and pharmacological characterization of analogs of 2-aminoethyl diphenylborinate (2-APB), a known store-operated calcium channel blocker, for inhibition of TRPV6-mediated calcium transport. |
| AID1161931 | Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration method | 2014 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 24, Issue:18 | Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum--the η-carbonic anhydrases. |
| AID598731 | Inhibition of Salmonella Typhimurium carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay at pH 8.3 | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium. |
| AID1336561 | Inhibition of Pseudoalteromonas haloplanktis recombinant carbonic anhydrase gamma assessed as inhibition of CO2 hydration preincubated for 15 mins by Lineweaver-burk plot method | |||
| AID1235243 | Inhibition of Porphyromonas gingivalis CA after 15 mins by stopped-flow/Co2 hydration assay | 2015 | Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15 | Cloning, characterization and anion inhibition studies of a new γ-carbonic anhydrase from the Antarctic bacterium Pseudoalteromonas haloplanktis. |
| AID238327 | Inhibitory constant against carbonic anhydrase II | 2004 | Bioorganic & medicinal chemistry letters, Sep-06, Volume: 14, Issue:17 | Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions. |
| AID1550444 | Inhibition of beta lactamase VIM in Pseudomonas aeruginosa 698 assessed as potentiation of meropenem-induced antibacterial activity by measuring meropenem MIC at 16 mg/L incubated for 18 hrs by broth dilution method (Rvb = 16 mg/L) | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Antimicrobial and KPC/AmpC inhibitory activity of functionalized benzosiloxaboroles. |
| AID1306524 | Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydrase assay | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae. |
| AID730751 | Inhibition of Vibrio cholerae alpha carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay | 2013 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 23, Issue:6 | Anion inhibition studies of the α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae. |
| AID724718 | Inhibition of human recombinant CA11 mutant after 15 mins by stopped-flow CO2 hydration method | 2013 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1 | Restoring catalytic activity to the human carbonic anhydrase (CA) related proteins VIII, X and XI affords isoforms with high catalytic efficiency and susceptibility to anion inhibition. |
| AID723357 | Neuroprotective activity in human APP695-transfected SH-SY5Y cells assessed as inhibition of H2O2-induced ROS production at 5 uM after 60 mins by DCFA-DA assay | 2013 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 23, Issue:2 | Discovery of alkenylboronic acids as neuroprotective agents affecting multiple biological targets involved in Alzheimer's disease. |
| AID437821 | Solubility in sodium phosphate buffer saline of pH 7.2 at 1 mM | 2009 | Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19 | Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors. |
| AID1278742 | Inhibition of recombinant Vibrio cholerae beta-carbonic anhydrase expressed in competent Escherichia coli BL21(DE3) cells preincubated for 15 mins by stopped-flow CO2 hydration assay | 2016 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5 | Anion inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae. |
| AID310899 | Inhibition of human recombinant carbonic anhydrase 1 | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6 | Carbonic anhydrase inhibitors. Inhibition of transmembrane isozymes XII (cancer-associated) and XIV with anions. |
| AID1460774 | Inhibition of human CA13 by stopped-flow CO2 hydrase assay | 2017 | Bioorganic & medicinal chemistry, 10-01, Volume: 25, Issue:19 | Bortezomib inhibits mammalian carbonic anhydrases. |
| AID1550441 | Inhibition of beta lactamase KPC-3 in Klebsiella pneumoniae 81 assessed as potentiation of meropenem-induced antibacterial activity by measuring meropenem MIC at 16 mg/L incubated for 18 hrs by broth dilution method (Rvb = 16 mg/L) | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Antimicrobial and KPC/AmpC inhibitory activity of functionalized benzosiloxaboroles. |
| AID749400 | Inhibition of human TRPV6 transfected in HEK293 cells assessed as inhibition of Cd2+ influx up to 500 uM after 5 mins by FLIPR assay | 2013 | Bioorganic & medicinal chemistry, Jun-01, Volume: 21, Issue:11 | Design, synthesis and pharmacological characterization of analogs of 2-aminoethyl diphenylborinate (2-APB), a known store-operated calcium channel blocker, for inhibition of TRPV6-mediated calcium transport. |
| AID238688 | Inhibitory activity against human carbonic anhydrase V expressed in Escherichia coli | 2004 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 14, Issue:21 | Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. |
| AID1430526 | Inhibition of recombinant human carbonic anhydrase 2 assessed as inhibition of CO2 hydration incubated for 15 mins prior to testing by stopped flow CO2 hydration method | |||
| AID730373 | Inhibition of human cytosolic carbonic anhydrase-2 preincubated for 15 mins by stopped flow CO2 hydration assay | 2013 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 23, Issue:6 | Kinetic and anion inhibition studies of a β-carbonic anhydrase (FbiCA 1) from the C4 plant Flaveria bidentis. |
| AID433253 | Inhibition of Candida glabrata carbonic anhydrase by stopped flow CO2 hydration assay | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16 | Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the pathogenic yeast Candida glabrata with anions. |
| AID1070020 | Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydrase assay | 2014 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 24, Issue:4 | Anion inhibition studies of two new β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila. |
| AID1306532 | Inhibition of Vibrio cholerae recombinant carbonic anhydrase gamma expressed in Escherichia coli DE3 cells preincubated for 15 mins by stopped-flow CO2 hydrase assay | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae. |
| AID238578 | Inhibition constant against human carbonic anhydrase isozyme hCA I | 2004 | Bioorganic & medicinal chemistry letters, Dec-06, Volume: 14, Issue:23 | Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions. |
| AID1278740 | Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydration assay | 2016 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5 | Anion inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae. |
| AID424442 | Inhibition of human recombinant cytosolic carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay | 2009 | Bioorganic & medicinal chemistry letters, May-15, Volume: 19, Issue:10 | Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. |
| AID227936 | Binding constant for complexation with glucose by Fluorescence experiment | 2002 | Bioorganic & medicinal chemistry letters, Dec-02, Volume: 12, Issue:23 | A glucose-selective fluorescence sensor based on boronic acid-diol recognition. |
| AID598726 | Inhibition of recombinant human carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay at pH 8.3 | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium. |
| AID723366 | Inhibition of AChE (unknown origin) measured for 3 mins by Ellman colorimetric method | 2013 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 23, Issue:2 | Discovery of alkenylboronic acids as neuroprotective agents affecting multiple biological targets involved in Alzheimer's disease. |
| AID763565 | Inhibition of recombinant Trypanosoma cruzi CL Brener alpha carbonic anhydrase expressed in baculovirus infected SF9 cells at 20 degC preincubated for 15 mins by stopped-flow CO2 hydrase assay | 2013 | Bioorganic & medicinal chemistry, Aug-01, Volume: 21, Issue:15 | Anion inhibition studies of the α-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease. |
| AID392571 | Inhibition of mouse recombinant carbonic anhydrase 15 expressed in COS7 cells by CO2 hydration reaction | 2009 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 19, Issue:4 | Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions. |
| AID724719 | Inhibition of human recombinant CA10 mutant after 15 mins by stopped-flow CO2 hydration method | 2013 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1 | Restoring catalytic activity to the human carbonic anhydrase (CA) related proteins VIII, X and XI affords isoforms with high catalytic efficiency and susceptibility to anion inhibition. |
| AID724721 | Inhibition of human recombinant wild type CA2 by stopped-flow CO2 hydration method | 2013 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1 | Restoring catalytic activity to the human carbonic anhydrase (CA) related proteins VIII, X and XI affords isoforms with high catalytic efficiency and susceptibility to anion inhibition. |
| AID1550359 | Inhibition of beta lactamase CTX-M-2 in Escherichia coli 557 assessed as potentiation of ceftazidime-induced antibacterial activity by measuring ceftazidime MIC at 16 mg/L incubated for 18 hrs by broth dilution method (Rvb = 16 mg/L) | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Antimicrobial and KPC/AmpC inhibitory activity of functionalized benzosiloxaboroles. |
| AID763569 | Inhibition of human carbonic anhydrase-1 at 20 degC preincubated for 15 mins by stopped-flow CO2 hydrase assay | 2013 | Bioorganic & medicinal chemistry, Aug-01, Volume: 21, Issue:15 | Anion inhibition studies of the α-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease. |
| AID437823 | Inhibition of Actinomadura sp. R39 penicillin-binding protein at 0.5 mM preincubated for 60 mins before addition of substrate mixture of (R)-[2-(benzoylamino)propionylsulfanyl]acetic acid and 5,5'-dithiobis(2-nitrobenzoic acid) | 2009 | Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19 | Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors. |
| AID1058395 | Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay | 2013 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24 | Anion inhibition studies of a β-carbonic anhydrase from Clostridium perfringens. |
| AID723360 | Neuroprotective activity in human APP695-transfected SH-SY5Y cells assessed as inhibition of H2O2-induced decrease in glutathione level after 16 hrs (Rvb = 22.95 +/- 0.59 nmol/mg) | 2013 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 23, Issue:2 | Discovery of alkenylboronic acids as neuroprotective agents affecting multiple biological targets involved in Alzheimer's disease. |
| AID1312161 | Inhibition of Drosophila melanogaster beta-carbonic anhydrase preincubated for 15 mins by stopped-flow CO2 hydration assay | 2016 | Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18 | Bortezomib inhibits bacterial and fungal β-carbonic anhydrases. |
| AID238653 | Inhibitory constant against carbonic anhydrase IV; nt= not tested | 2004 | Bioorganic & medicinal chemistry letters, Sep-06, Volume: 14, Issue:17 | Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions. |
| AID265738 | Selectivity for human CA7 over murine CA13 | 2006 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 16, Issue:12 | Carbonic anhydrase inhibitors: inhibition of the cytosolic human isozyme VII with anions. |
| AID1278741 | Inhibition of Vibrio cholerae alpha-carbonic anhydrase preincubated for 15 mins by stopped-flow CO2 hydration assay | 2016 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5 | Anion inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae. |
| AID1237477 | Inhibition of Pseudomonas aeruginosa PAO1 type-2 beta-carbonic anhydrase psCA3 expressed in Escherichia coli Tuner BL21 (DE3) cells pre-incubated for 15 mins at pH 8.3 and 293K by CO2 hydration reaction based colorimetric stopped-flow method | 2015 | Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15 | Structure and inhibition studies of a type II beta-carbonic anhydrase psCA3 from Pseudomonas aeruginosa. |
| AID1306530 | Inhibition of Vibrio cholerae carbonic anhydrase beta preincubated for 15 mins by stopped-flow CO2 hydrase assay | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae. |
| AID265740 | Selectivity for human CA7 over human CA1 | 2006 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 16, Issue:12 | Carbonic anhydrase inhibitors: inhibition of the cytosolic human isozyme VII with anions. |
| AID1461934 | Inhibition of human CA2 incubated for 15 mins by stopped-flow CO2 hydration assay | |||
| AID227934 | Binding constant for complexation with Galactose by Fluorescence experiment | 2002 | Bioorganic & medicinal chemistry letters, Dec-02, Volume: 12, Issue:23 | A glucose-selective fluorescence sensor based on boronic acid-diol recognition. |
| AID310903 | Inhibition of human recombinant full length CA14 | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6 | Carbonic anhydrase inhibitors. Inhibition of transmembrane isozymes XII (cancer-associated) and XIV with anions. |
| AID1312152 | Inhibition of human carbonic anhydrase-1 preincubated for 15 mins by stopped-flow CO2 hydration assay | 2016 | Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18 | Bortezomib inhibits bacterial and fungal β-carbonic anhydrases. |
| AID1336562 | Inhibition of Burkholderia pseudomallei recombinant His-tagged carbonic anhydrase gamma expressed in Escherichia coli BL21 (DE3) assessed as inhibition of CO2 hydration preincubated for 15 mins by Lineweaver-burk plot method | |||
| AID1550431 | Inhibition of beta lactamase KPC-2 in Escherichia coli 76 assessed as potentiation of ceftazidime-induced antibacterial activity by measuring ceftazidime MIC at 16 mg/L incubated for 18 hrs by broth dilution method (Rvb = >64 mg/L) | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Antimicrobial and KPC/AmpC inhibitory activity of functionalized benzosiloxaboroles. |
| AID647373 | Inhibition of Astrosclera willeyana recombinant GST-tagged astrosclerin 3 expressed in Escherichia coli BL21-DE3-RIPL cells preincubated for 15 mins measured for 10 to 100 secs by stopped flow CO2 hydration assay | 2012 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 22, Issue:3 | Anion inhibition studies of an α-carbonic anhydrase from the living fossil Astrosclera willeyana. |
| AID1460772 | Inhibition of human CA9 by stopped-flow CO2 hydrase assay | 2017 | Bioorganic & medicinal chemistry, 10-01, Volume: 25, Issue:19 | Bortezomib inhibits mammalian carbonic anhydrases. |
| AID1460773 | Inhibition of human CA12 by stopped-flow CO2 hydrase assay | 2017 | Bioorganic & medicinal chemistry, 10-01, Volume: 25, Issue:19 | Bortezomib inhibits mammalian carbonic anhydrases. |
| AID1127995 | Toxicity in Staphylococcus aureus ATCC 25923 after 24 hrs by microdilution method | 2014 | Journal of medicinal chemistry, Mar-27, Volume: 57, Issue:6 | First identification of boronic species as novel potential inhibitors of the Staphylococcus aureus NorA efflux pump. |
| AID1460771 | Inhibition of human CA7 by stopped-flow CO2 hydrase assay | 2017 | Bioorganic & medicinal chemistry, 10-01, Volume: 25, Issue:19 | Bortezomib inhibits mammalian carbonic anhydrases. |
| AID411398 | Inhibition of human carbonic anhydrase 2 by CO2 hydration stopped-flow assay | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with anions. |
| AID234771 | Selectivity for Glucose to Fructose was determined by Fluorescence experiment | 2002 | Bioorganic & medicinal chemistry letters, Dec-02, Volume: 12, Issue:23 | A glucose-selective fluorescence sensor based on boronic acid-diol recognition. |
| AID1306523 | Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydrase assay | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae. |
| AID749401 | Inhibition of human TRPV6 transfected in HEK293 cells assessed as inhibition of Ca2+ influx up to 500 uM after 5 mins by FLIPR assay | 2013 | Bioorganic & medicinal chemistry, Jun-01, Volume: 21, Issue:11 | Design, synthesis and pharmacological characterization of analogs of 2-aminoethyl diphenylborinate (2-APB), a known store-operated calcium channel blocker, for inhibition of TRPV6-mediated calcium transport. |
| AID238606 | Inhibition constant against human carbonic anhydrase isozyme hCA IX | 2004 | Bioorganic & medicinal chemistry letters, Dec-06, Volume: 14, Issue:23 | Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions. |
| AID724720 | Inhibition of human recombinant CA8 mutant after 15 mins by stopped-flow CO2 hydration method | 2013 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1 | Restoring catalytic activity to the human carbonic anhydrase (CA) related proteins VIII, X and XI affords isoforms with high catalytic efficiency and susceptibility to anion inhibition. |
| AID265739 | Selectivity for human CA7 over human CA2 | 2006 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 16, Issue:12 | Carbonic anhydrase inhibitors: inhibition of the cytosolic human isozyme VII with anions. |
| AID392569 | Inhibition of human recombinant carbonic anhydrase 1 by CO2 hydration reaction | 2009 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 19, Issue:4 | Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions. |
| AID392568 | Inhibition of human recombinant carbonic anhydrase 2 by CO2 hydration reaction | 2009 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 19, Issue:4 | Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions. |
| AID1070021 | Inhibition of Legionella pneumophila carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydrase assay | 2014 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 24, Issue:4 | Anion inhibition studies of two new β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila. |
| AID1550439 | Inhibition of beta lactamase SHV-12 in Klebsiella pneumoniae ATCC 700603 assessed as potentiation of ceftazidime-induced antibacterial activity by measuring ceftazidime MIC at 16 mg/L incubated for 18 hrs by broth dilution method (Rvb = 64 mg/L) | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Antimicrobial and KPC/AmpC inhibitory activity of functionalized benzosiloxaboroles. |
| AID1161930 | Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration method | 2014 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 24, Issue:18 | Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum--the η-carbonic anhydrases. |
| AID387190 | Inhibition of Cryptococcus neoformans Can2 at 20 degC by CO2 hydration method | 2008 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 18, Issue:18 | Carbonic anhydrase inhibitors: inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with simple anions. |
| AID758952 | Inhibition of human recombinant CA2 by CO2 hydration assay | 2013 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 23, Issue:14 | A highly catalytically active γ-carbonic anhydrase from the pathogenic anaerobe Porphyromonas gingivalis and its inhibition profile with anions and small molecules. |
| AID1460764 | Inhibition of human CA1 by stopped-flow CO2 hydrase assay | 2017 | Bioorganic & medicinal chemistry, 10-01, Volume: 25, Issue:19 | Bortezomib inhibits mammalian carbonic anhydrases. |
| AID1550445 | Inhibition of beta lactamase OXA-24 in Acinetobacter baumannii 181 assessed as potentiation of meropenem-induced antibacterial activity by measuring meropenem MIC at 16 mg/L incubated for 18 hrs by broth dilution method (Rvb = 16 mg/L) | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Antimicrobial and KPC/AmpC inhibitory activity of functionalized benzosiloxaboroles. |
| AID1312157 | Inhibition of Malassezia globosa beta-carbonic anhydrase preincubated for 15 mins by stopped-flow CO2 hydration assay | 2016 | Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18 | Bortezomib inhibits bacterial and fungal β-carbonic anhydrases. |
| AID1460770 | Inhibition of human CA6 by stopped-flow CO2 hydrase assay | 2017 | Bioorganic & medicinal chemistry, 10-01, Volume: 25, Issue:19 | Bortezomib inhibits mammalian carbonic anhydrases. |
| AID664799 | Dissociation constant, pKa of the compound in aqueous solution by spectrophotometry | 2012 | ACS medicinal chemistry letters, Jan-12, Volume: 3, Issue:1 | Ring Structure and Aromatic Substituent Effects on the pK a of the Benzoxaborole Pharmacophore. |
| AID238853 | Inhibitory activity against mouse carbonic anhydrase XIII expressed in Escherichia coli TOP 10 | 2004 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 14, Issue:21 | Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. |
| AID411397 | Inhibition of human carbonic anhydrase 1 by CO2 hydration stopped-flow assay | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with anions. |
| AID1550424 | Inhibition of beta lactamase KPC in Klebsiella pneumoniae ATCC BAA 1705 assessed as potentiation of meropenem-induced antibacterial activity by measuring diameter of zone inhibition at 0.3 mg incubated for 18 hrs in presence of 10 ug meropenem by CLSI dis | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Antimicrobial and KPC/AmpC inhibitory activity of functionalized benzosiloxaboroles. |
| AID723361 | Neuroprotective activity in human APP695-transfected SH-SY5Y cells assessed as decrease of H2O2-induced malondialdehyde level after 16 hrs (Rvb = 67.83 +/- 5.86 nmol/mg) | 2013 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 23, Issue:2 | Discovery of alkenylboronic acids as neuroprotective agents affecting multiple biological targets involved in Alzheimer's disease. |
| AID1460767 | Inhibition of human CA4 by stopped-flow CO2 hydrase assay | 2017 | Bioorganic & medicinal chemistry, 10-01, Volume: 25, Issue:19 | Bortezomib inhibits mammalian carbonic anhydrases. |
| AID723359 | Neuroprotective activity in human APP695-transfected SH-SY5Y cells assessed as H2O2-induced GSH-glutathione disulfide level after 16 hrs (Rvb = 6.85 +/- 0.92 nmol/mg) | 2013 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 23, Issue:2 | Discovery of alkenylboronic acids as neuroprotective agents affecting multiple biological targets involved in Alzheimer's disease. |
| AID1550436 | Inhibition of beta lactamase OXA-24 in Acinetobacter baumannii 181 assessed as potentiation of ceftazidime-induced antibacterial activity by measuring ceftazidime MIC at 16 mg/L incubated for 18 hrs by broth dilution method (Rvb = >64 mg/L) | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Antimicrobial and KPC/AmpC inhibitory activity of functionalized benzosiloxaboroles. |
| AID238605 | Inhibition constant against human carbonic anhydrase isozyme hCA IV | 2004 | Bioorganic & medicinal chemistry letters, Dec-06, Volume: 14, Issue:23 | Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions. |
| AID1550437 | Inhibition of beta lactamase AmpC in Pseudomonas aeruginosa 700 assessed as potentiation of ceftazidime-induced antibacterial activity by measuring ceftazidime MIC at 16 mg/L incubated for 18 hrs by broth dilution method (Rvb = >64 mg/L) | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Antimicrobial and KPC/AmpC inhibitory activity of functionalized benzosiloxaboroles. |
| AID387187 | Inhibition of human carbonic anhydrase 1 at 20 degC by CO2 hydration method | 2008 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 18, Issue:18 | Carbonic anhydrase inhibitors: inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with simple anions. |
| AID1460769 | Inhibition of human CA5B by stopped-flow CO2 hydrase assay | 2017 | Bioorganic & medicinal chemistry, 10-01, Volume: 25, Issue:19 | Bortezomib inhibits mammalian carbonic anhydrases. |
| AID1235241 | Inhibition of human CA2 after 15 mins by stopped-flow/Co2 hydration assay | 2015 | Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15 | Cloning, characterization and anion inhibition studies of a new γ-carbonic anhydrase from the Antarctic bacterium Pseudoalteromonas haloplanktis. |
| AID1550360 | Inhibition of beta lactamase OXA-15 in Pseudomonas aeruginosa 852 assessed as potentiation of ceftazidime-induced antibacterial activity by measuring ceftazidime MIC at 16 mg/L incubated for 18 hrs by broth dilution method (Rvb = >64 mg/L) | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Antimicrobial and KPC/AmpC inhibitory activity of functionalized benzosiloxaboroles. |
| AID763567 | Inhibition of Brucella suis beta carbonic anhydrase-1 at 20 degC by stopped-flow CO2 hydrase assay | 2013 | Bioorganic & medicinal chemistry, Aug-01, Volume: 21, Issue:15 | Anion inhibition studies of the α-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease. |
| AID1127992 | Inhibition of NorA in fluoroquinolone-resistant Staphylococcus aureus 1199B assessed as potentiation of 4 ug/ml of ciprofloxacin MIC at 100 ug/ml after 24 hrs by microdilution method | 2014 | Journal of medicinal chemistry, Mar-27, Volume: 57, Issue:6 | First identification of boronic species as novel potential inhibitors of the Staphylococcus aureus NorA efflux pump. |
| AID1312158 | Inhibition of Mycobacterium tuberculosis beta-carbonic anhydrase Rv3273 preincubated for 15 mins by stopped-flow CO2 hydration assay | 2016 | Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18 | Bortezomib inhibits bacterial and fungal β-carbonic anhydrases. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 22 (3.29) | 18.7374 |
| 1990's | 22 (3.29) | 18.2507 |
| 2000's | 110 (16.47) | 29.6817 |
| 2010's | 373 (55.84) | 24.3611 |
| 2020's | 141 (21.11) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.
| This Compound (48.36) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 16 (2.33%) | 6.00% |
| Case Studies | 1 (0.15%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 671 (97.53%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||