arildone profile

Arildone is a synthetic compound with a unique chemical structure. It exhibits a range of biological activities, including anti-inflammatory, antiviral, and immunomodulatory properties. Arildone has been studied for its potential therapeutic effects in conditions like rheumatoid arthritis, HIV infection, and cancer. Its mechanism of action involves interfering with the activity of certain enzymes and signaling pathways. While initial research showed promising results, further investigation is needed to determine its clinical efficacy and safety. Arildone has been synthesized using various organic chemistry techniques. The compound has attracted scientific interest due to its potential for treating various diseases and its unique structural features.'

ID Source	ID
PubMed CID	41782
CHEMBL ID	26319
CHEBI ID	177546
SCHEMBL ID	146967
MeSH ID	M0074723

Synonym
CHEBI:177546
4-[6-(2-chloro-4-methoxyphenoxy)hexyl]heptane-3,5-dione
4-[6-(2-chloro-4-methoxy-phenoxy)hexyl]heptane-3,5-dione
arildone
3, 4-[6-(2-chloro-4-methoxyphenoxy)hexyl]-
nsc222800
4-[6-(2-chloro-4-methoxyphenoxy)hexyl]-3,5-heptanedione
win 38020
56219-57-9
nsc-222800
win-38020
D02984
arildone (usan)
4-(6-(2-chloro-4-methoxy)phenoxy)hexyl-3,5-heptanedione
3,5-heptanedione, 4-(6-(2-chloro-4-methoxyphenoxy)hexyl)-
arildonum [inn-latin]
4-(6-(2-chloro-4-methoxyphenoxy)hexyl)-3,5-heptanedione
arildona [inn-spanish]
einecs 260-066-3
arildone [usan:inn]
CHEMBL26319
arildona
nsc 222800
arildonum
69mbn7jf59 ,
unii-69mbn7jf59
arildone [inn]
arildone [mart.]
arildone [usan]
SCHEMBL146967
DIXRMZGIJNJUGL-UHFFFAOYSA-N
DTXSID30204771
Q27264361

Excerpt	Reference	Relevance
"Arildone is an aryl diketone which is inhibitory in vitro against herpes simplex virus type 2 at a concentration of 2 micrograms/ml or less. "	( A placebo-controlled trial of topical 8% arildone cream early in recurrent genital herpes. Bosso, JA; Corey, L; Douglas, JM; Frank, JA; Johnston, JM; Judson, FN; Levin, MJ; McMillan, JA; Spruance, SL; Weiner, LB, 1986)	1.98

Excerpt	Reference	Relevance
"Arildone did not inhibit interferon (IFN) production or IFN activity."	( Activity of arildone with or without interferon against acute hemorrhagic conjunctivitis viruses in cell culture. Carr, DJ; Langford, MP; Yin-Murphy, M, 1985)	1.37

Class	Description
methoxybenzenes	Any aromatic ether that consists of a benzene skeleton substituted with one or more methoxy groups.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (26)

Assay ID	Title	Year	Journal	Article
AID1135473	Antiviral activity against Herpes simplex virus 2 Curtis assessed as inhibition of virus-induced cytopathic effect at 37 degC after 72 hrs by two-fold dilution method	1977	Journal of medicinal chemistry, Jun, Volume: 20, Issue:6	Antiviral activity of some beta-diketones. 1. Aryl alkyl diketones. In vitro activity against both RNA and DNA viruses.
AID1135469	Antiviral activity against Herpes simplex virus 1 assessed as inhibition of virus-induced cytopathic effect at 37 degC after 72 hrs by two-fold dilution method	1977	Journal of medicinal chemistry, Jun, Volume: 20, Issue:6	Antiviral activity of some beta-diketones. 1. Aryl alkyl diketones. In vitro activity against both RNA and DNA viruses.
AID79172	Effect on the development of Herpetic vesicles in Guinea pigs infected intradermally with Herpes virus Hominis, Type 1,AA strain on day 3 at 8 % concentration	1984	Journal of medicinal chemistry, May, Volume: 27, Issue:5	Synthesis of some phosphonates with antiherpetic activity.
AID79168	Effect on the development of Herpetic vesicles in Guinea pigs infected intradermally with Herpes virus Hominis, Type 1,AA strain on day 1 at 8 % concentration	1984	Journal of medicinal chemistry, May, Volume: 27, Issue:5	Synthesis of some phosphonates with antiherpetic activity.
AID1135463	Antiviral activity against Herpes simplex virus 2 assessed as inhibition of virus-induced cytopathic effect after 72 hrs by two-fold dilution method	1977	Journal of medicinal chemistry, Jun, Volume: 20, Issue:6	Antiviral activity of some beta-diketones. 1. Aryl alkyl diketones. In vitro activity against both RNA and DNA viruses.
AID1135467	Antiviral activity against Parainfluenza virus assessed as inhibition of virus-induced cytopathic effect at 37 degC after 72 hrs by two-fold dilution method	1977	Journal of medicinal chemistry, Jun, Volume: 20, Issue:6	Antiviral activity of some beta-diketones. 1. Aryl alkyl diketones. In vitro activity against both RNA and DNA viruses.
AID1135474	Antiviral activity against Human rhinovirus 2 assessed as inhibition of virus-induced cytopathic effect at 37 degC after 72 hrs by two-fold dilution method	1977	Journal of medicinal chemistry, Jun, Volume: 20, Issue:6	Antiviral activity of some beta-diketones. 1. Aryl alkyl diketones. In vitro activity against both RNA and DNA viruses.
AID76489	Effect on the growth of Herpes simplex Type 1 on the skin of Guinea pigs infected intradermally on day 2 at 8 % concentration	1984	Journal of medicinal chemistry, May, Volume: 27, Issue:5	Synthesis of some phosphonates with antiherpetic activity.
AID235581	In vitro therapeutic index as ratio of cytotoxicity to inhibition of viral replication	1988	Journal of medicinal chemistry, Jul, Volume: 31, Issue:7	7-Aminoquinolines. A novel class of agents active against herpesviruses.
AID1135466	Antiviral activity against Human rhinovirus 17 assessed as inhibition of virus-induced cytopathic effect at 37 degC after 72 hrs by two-fold dilution method	1977	Journal of medicinal chemistry, Jun, Volume: 20, Issue:6	Antiviral activity of some beta-diketones. 1. Aryl alkyl diketones. In vitro activity against both RNA and DNA viruses.
AID1135471	Antiviral activity against Equine rhinovirus infected in rhesus monkey trachea assessed as reduction in viral yield at 100 ug/ml after 3 days followed by compound-washout measured after 24 hrs by human CATR cell-based titration method relative to control	1977	Journal of medicinal chemistry, Jun, Volume: 20, Issue:6	Antiviral activity of some beta-diketones. 1. Aryl alkyl diketones. In vitro activity against both RNA and DNA viruses.
AID1135472	Antiviral activity against Herpes simplex virus 1 Sheely assessed as inhibition of virus-induced cytopathic effect at 37 degC after 72 hrs by two-fold dilution method	1977	Journal of medicinal chemistry, Jun, Volume: 20, Issue:6	Antiviral activity of some beta-diketones. 1. Aryl alkyl diketones. In vitro activity against both RNA and DNA viruses.
AID76493	Effect on the growth of Herpes simplex Type 1 on the skin of Guinea pigs infected intradermally on day 4 at 8 % concentration	1984	Journal of medicinal chemistry, May, Volume: 27, Issue:5	Synthesis of some phosphonates with antiherpetic activity.
AID85548	In vitro cytotoxicity against herpes simplex virus type-1 (HSV-1) HF strain in infected KB cells	1988	Journal of medicinal chemistry, Jul, Volume: 31, Issue:7	7-Aminoquinolines. A novel class of agents active against herpesviruses.
AID1135477	Antiviral activity against Equine rhinovirus infected in rhesus monkey trachea assessed as reduction in viral yield at 400 ug/ml after 3 days followed by compound-washout measured after 24 hrs by human CATR cell-based titration method relative to control	1977	Journal of medicinal chemistry, Jun, Volume: 20, Issue:6	Antiviral activity of some beta-diketones. 1. Aryl alkyl diketones. In vitro activity against both RNA and DNA viruses.
AID1135468	Antiviral activity against Respiratory syncytial virus assessed as inhibition of virus-induced cytopathic effect at 37 degC after 72 hrs by two-fold dilution method	1977	Journal of medicinal chemistry, Jun, Volume: 20, Issue:6	Antiviral activity of some beta-diketones. 1. Aryl alkyl diketones. In vitro activity against both RNA and DNA viruses.
AID1135465	Antiviral activity against Human rhinovirus 14 assessed as inhibition of virus-induced cytopathic effect at 37 degC after 72 hrs by two-fold dilution method	1977	Journal of medicinal chemistry, Jun, Volume: 20, Issue:6	Antiviral activity of some beta-diketones. 1. Aryl alkyl diketones. In vitro activity against both RNA and DNA viruses.
AID1135475	Antiviral activity against Influenza A2 virus Jap 170 infected in ferret trachea assessed as reduction in viral yield at 200 ug/ml after 3 days followed by compound-washout measured after 24 hrs by chick embryo-based hemagglutination titration method rela	1977	Journal of medicinal chemistry, Jun, Volume: 20, Issue:6	Antiviral activity of some beta-diketones. 1. Aryl alkyl diketones. In vitro activity against both RNA and DNA viruses.
AID79170	Effect on the development of Herpetic vesicles in Guinea pigs infected intradermally with Herpes virus Hominis, Type 1,AA strain on day 2 at 8 % concentration	1984	Journal of medicinal chemistry, May, Volume: 27, Issue:5	Synthesis of some phosphonates with antiherpetic activity.
AID76487	Effect on the growth of Herpes simplex Type 1 on the skin of Guinea pigs infected intradermally on day 1 at 8 % concentration	1984	Journal of medicinal chemistry, May, Volume: 27, Issue:5	Synthesis of some phosphonates with antiherpetic activity.
AID85552	Inhibitory activity against herpes simplex virus type-1 (HSV-1) replication in KB cells	1988	Journal of medicinal chemistry, Jul, Volume: 31, Issue:7	7-Aminoquinolines. A novel class of agents active against herpesviruses.
AID76491	Effect on the growth of Herpes simplex Type 1 on the skin of Guinea pigs infected intradermally on day 3 at 8 % concentration	1984	Journal of medicinal chemistry, May, Volume: 27, Issue:5	Synthesis of some phosphonates with antiherpetic activity.
AID1135461	Antiviral activity against Equine rhinovirus assessed as inhibition of virus-induced cytopathic effect after 48 hrs by two-fold dilution method	1977	Journal of medicinal chemistry, Jun, Volume: 20, Issue:6	Antiviral activity of some beta-diketones. 1. Aryl alkyl diketones. In vitro activity against both RNA and DNA viruses.
AID1135476	Antiviral activity against Influenza A2 virus Jap 170 infected in ferret trachea assessed as reduction in viral yield at 400 ug/ml after 3 days followed by compound-washout measured after 24 hrs by chick embryo-based hemagglutination titration method rela	1977	Journal of medicinal chemistry, Jun, Volume: 20, Issue:6	Antiviral activity of some beta-diketones. 1. Aryl alkyl diketones. In vitro activity against both RNA and DNA viruses.
AID79174	Effect on the development of Herpetic vesicles in Guinea pigs infected intradermally with Herpes virus Hominis, Type 1,AA strain on day 4 at 8 % concentration	1984	Journal of medicinal chemistry, May, Volume: 27, Issue:5	Synthesis of some phosphonates with antiherpetic activity.
AID1135470	Antiviral activity against Equine rhinovirus infected in rhesus monkey trachea assessed as reduction in viral yield at 200 ug/ml after 3 days followed by compound-washout measured after 24 hrs by human CATR cell-based titration method relative to control	1977	Journal of medicinal chemistry, Jun, Volume: 20, Issue:6	Antiviral activity of some beta-diketones. 1. Aryl alkyl diketones. In vitro activity against both RNA and DNA viruses.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	22 (88.00)	18.7374
1990's	2 (8.00)	18.2507
2000's	1 (4.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	3 (11.11%)	5.53%
Reviews	2 (7.41%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	22 (81.48%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
acetic acid Acetic Acid: Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed). acetic acid : A simple monocarboxylic acid containing two carbons.	1.96	1	0	monocarboxylic acid	antimicrobial food preservative; Daphnia magna metabolite; food acidity regulator; protic solvent
phosphonoacetic acid Phosphonoacetic Acid: A simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent.. phosphonoacetic acid : A member of the class of phosphonic acids that is phosphonic acid in which the hydrogen attached to the phosphorous is replaced by a carboxymethyl group.	4.85	2	1	monocarboxylic acid; phosphonic acids	antiviral agent; EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor
dimethyl sulfoxide Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.. dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.	3.35	1	1	sulfoxide; volatile organic compound	alkylating agent; antidote; Escherichia coli metabolite; geroprotector; MRI contrast agent; non-narcotic analgesic; polar aprotic solvent; radical scavenger
formaldehyde paraform: polymerized formaldehyde; RN given refers to parent cpd; used in root canal therapy	1.97	1	0	aldehyde; one-carbon compound	allergen; carcinogenic agent; disinfectant; EC 3.5.1.4 (amidase) inhibitor; environmental contaminant; Escherichia coli metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
amantadine amant: an antiviral compound consisting of an adamantane derivative chemically linked to a water-solube polyanioic matrix; structure in first source	4.44	1	1	adamantanes; primary aliphatic amine	analgesic; antiparkinson drug; antiviral drug; dopaminergic agent; NMDA receptor antagonist; non-narcotic analgesic
chloroquine Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.	1.97	1	0	aminoquinoline; organochlorine compound; secondary amino compound; tertiary amino compound	anticoronaviral agent; antimalarial; antirheumatic drug; autophagy inhibitor; dermatologic drug
foscarnet Foscarnet: An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.. phosphonoformic acid : Phosphoric acid in which one of the hydroxy groups is replaced by a carboxylic acid group. It is used as the trisodium salt as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to blindness) and as an alternative to ganciclovir for AIDS patients who require concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity.	1.97	1	0	carboxylic acid; one-carbon compound; phosphonic acids	antiviral drug; geroprotector; HIV-1 reverse transcriptase inhibitor; sodium-dependent Pi-transporter inhibitor
guanidine Guanidine: A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.. guanidine : An aminocarboxamidine, the parent compound of the guanidines.	2	1	0	carboxamidine; guanidines; one-carbon compound
ethidium Ethidium: A trypanocidal agent and possible antiviral agent that is widely used in experimental cell biology and biochemistry. Ethidium has several experimentally useful properties including binding to nucleic acids, noncompetitive inhibition of nicotinic acetylcholine receptors, and fluorescence among others. It is most commonly used as the bromide.. ethidium : The fluorescent compound widely used in experimental cell biology and biochemistry to reveal double-stranded DNA and RNA.	1.96	1	0	phenanthridines	fluorochrome; intercalator
thymidine [no description available]	1.95	1	0	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; metabolite; mouse metabolite
idoxuridine [no description available]	1.95	1	0	organoiodine compound; pyrimidine 2'-deoxyribonucleoside	antiviral drug; DNA synthesis inhibitor
kanamycin a Kanamycin: Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components.. kanamycin : Kanamycin is a naturally occurring antibiotic complex from Streptomyces kanamyceticus that consists of several components: kanamycin A, the major component (also usually designated as kanamycin), and kanamycins B, C, D and X the minor components.	1.97	1	0	kanamycins	bacterial metabolite
bromodeoxyuridine Bromodeoxyuridine: A nucleoside that substitutes for thymidine in DNA and thus acts as an antimetabolite. It causes breaks in chromosomes and has been proposed as an antiviral and antineoplastic agent. It has been given orphan drug status for use in the treatment of primary brain tumors.	4.44	1	1	pyrimidine 2'-deoxyribonucleoside	antimetabolite; antineoplastic agent
cycloheximide Cycloheximide: Antibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus. It acts by inhibiting elongation during protein synthesis.. cycloheximide : A dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium Streptomyces griseus.	1.97	1	0	antibiotic fungicide; cyclic ketone; dicarboximide; piperidine antibiotic; piperidones; secondary alcohol	anticoronaviral agent; bacterial metabolite; ferroptosis inhibitor; neuroprotective agent; protein synthesis inhibitor
cytarabine [no description available]	1.95	1	0	beta-D-arabinoside; monosaccharide derivative; pyrimidine nucleoside	antimetabolite; antineoplastic agent; antiviral agent; immunosuppressive agent
isoxazoles Isoxazoles: Azoles with an OXYGEN and a NITROGEN next to each other at the 1,2 positions, in contrast to OXAZOLES that have nitrogens at the 1,3 positions.. isoxazole : A monocyclic heteroarene with a structure consisting of a 5-membered ring containing three carbon atoms and an oxygen and nitrogen atom adjacent to each other. It is the parent of the class of isoxazoles.. isoxazoles : Oxazoles in which the N and O atoms are adjacent.	2.41	2	0	isoxazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
myristic acid Myristic Acid: A saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils. It is used to synthesize flavor and as an ingredient in soaps and cosmetics. (From Dorland, 28th ed). tetradecanoic acid : A straight-chain, fourteen-carbon, long-chain saturated fatty acid mostly found in milk fat.. tetradecanoate : A long-chain fatty acid anion that is the conjugate base of myristic acid; major species at pH 7.3.	1.97	1	0	long-chain fatty acid; straight-chain saturated fatty acid	algal metabolite; Daphnia magna metabolite; EC 3.1.1.1 (carboxylesterase) inhibitor; human metabolite
neutral red Neutral Red: A vital dye used as an indicator and biological stain. Various adverse effects have been observed in biological systems.. neutral red : A hydrochloride obtained by combining the free base of neutral red with one equivalent of hydrochloric acid. Neutral red acts as a pH indicator, changing from red to yellow between pH 6.8 and 8.0.	1.96	1	0	hydrochloride	acid-base indicator; dye; two-colour indicator
3-hydroxyflavone 3-hydroxyflavone: structure given in first source. flavonol : A monohydroxyflavone that is the 3-hydroxy derivative of flavone.	1.96	1	0	flavonols; monohydroxyflavone
vidarabine adenine arabinoside : A purine nucleoside in which adenine is attached to arabinofuranose via a beta-N(9)-glycosidic bond.	5.14	3	1	beta-D-arabinoside; purine nucleoside	antineoplastic agent; bacterial metabolite; nucleoside antibiotic
phenyl acetate phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid.	1.96	1	0	benzenes; phenyl acetates
laurocapram laurocapram: enhances percutaneous absorption of different chemicals; structure given in first source	1.98	1	0
disoxaril disoxaril: antipicornavirus agent	2.41	2	0	aromatic ether
thymine arabinoside thymine arabinoside: selectively inhibits replication of herpes simplex virus	1.97	1	0	N-glycosyl compound
4',6-dichloroflavan 4',6-dichloroflavan: antirhinovirus cpd; structure given in first source	1.96	1	0
ethyl-2-methylthio-4-methyl-5-pyrimidine carboxylate [no description available]	2.41	2	0
brivudine brivudine: anti-herpes agent	4.44	1	1
phenylthiourea Phenylthiourea: Phenylthiourea is a THIOUREA derivative containing a phenyl ring. Depending on their genetic makeup, humans can find it either bitter-tasting or tasteless.. N-phenylthiourea : A member of the class of thioureas that is thiourea in which one of the hydrogens is replaced by a phenyl group. Depending on their genetic makeup, humans find it either very bitter-tasting or tasteless. This unusual property resulted in N-phenylthiourea being used in paternity testing prior to the advent of DNA testing.	2.41	2	0	thioureas	EC 1.14.18.1 (tyrosinase) inhibitor
n-phenyl-n'-3-hydroxyphenylthiourea [no description available]	2.41	2	0
rhodanine 2-mercaptothiazolinone: metabolite in urine from persons exposed to CS2; structure	3.06	1	0	thiazolidinone
sodium dodecyl sulfate Sodium Dodecyl Sulfate: An anionic surfactant, usually a mixture of sodium alkyl sulfates, mainly the lauryl; lowers surface tension of aqueous solutions; used as fat emulsifier, wetting agent, detergent in cosmetics, pharmaceuticals and toothpastes; also as research tool in protein biochemistry.. sodium dodecyl sulfate : An organic sodium salt that is the sodium salt of dodecyl hydrogen sulfate.	1.96	1	0	organic sodium salt	detergent; protein denaturant
quercetin [no description available]	6.96	1	0	7-hydroxyflavonol; pentahydroxyflavone	antibacterial agent; antineoplastic agent; antioxidant; Aurora kinase inhibitor; chelator; EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor; geroprotector; phytoestrogen; plant metabolite; protein kinase inhibitor; radical scavenger
3-methylquercetin isorhamnetin : A monomethoxyflavone that is quercetin in which the hydroxy group at position 3' is replaced by a methoxy group.	6.96	1	0	7-hydroxyflavonol; monomethoxyflavone; tetrahydroxyflavone	anticoagulant; EC 1.14.18.1 (tyrosinase) inhibitor; metabolite
viroxime [no description available]	3.78	3	0
hbbpc [no description available]	2.41	2	0
acyclovir Acyclovir: A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.. acyclovir : An oxopurine that is guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections.	5.14	3	1	2-aminopurines; oxopurine	antimetabolite; antiviral drug
guanine [no description available]	4.44	1	1	2-aminopurines; oxopurine; purine nucleobase	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite

Condition	Relationship Strength	Studies	Trials
Herpes Simplex Virus Infection [description not available]	1.96	1	0
Dermatoses [description not available]	1.96	1	0
Herpes Simplex A group of acute infections caused by herpes simplex virus type 1 or type 2 that is characterized by the development of one or more small fluid-filled vesicles with a raised erythematous base on the skin or mucous membrane. It occurs as a primary infection or recurs due to a reactivation of a latent infection. (Dorland, 27th ed.)	1.96	1	0
Skin Diseases Diseases involving the DERMIS or EPIDERMIS.	1.96	1	0
Cytomegalic Inclusion Disease [description not available]	1.96	1	0
Cytomegalovirus Infections Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults.	6.96	1	0
Cytomegalovirus A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.	2.37	2	0
Hepatitis B Virus Infection [description not available]	4.26	1	1
B Virus Infection [description not available]	4.67	2	1
Benign Neoplasms [description not available]	4.26	1	1
Viral Diseases [description not available]	4.26	1	1
Hepatitis B INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.	4.26	1	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	4.26	1	1
Virus Diseases A general term for diseases caused by viruses.	4.26	1	1
Encephalitis, Polio [description not available]	3.28	2	0
Poliomyelitis An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)	3.28	2	0
Conjunctivitis, Acute Hemorrhagic A highly contagious disease characterized by subconjunctival hemorrhage, sudden swelling of the eyelids and congestion, redness, and pain in the eye. Epidemic conjunctivitis caused by Enterovirus 70 (EV-70) was first described in Africa in 1969. It is caused also by Coxsackievirus A24 variant (CA24v). Epidemics by this organism have appeared most frequently in Asia.	1.96	1	0
Enterovirus Infections Diseases caused by ENTEROVIRUS.	2.88	1	0
Infections, Picornaviridae [description not available]	2.88	1	0
Echo Virus Infections [description not available]	2.88	1	0
Recrudescence [description not available]	3.35	1	1
Genital Herpes [description not available]	8.35	1	1
Herpes Genitalis Infection of the genitals (GENITALIA) with HERPES SIMPLEX VIRUS in either the males or the females.	3.35	1	1

arildone

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Synonyms (33)

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Drug Classes (1)

Bioassays (26)

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Studies (25)

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Research Demand Index: 25.27

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arildone

Cross-References

Synonyms (33)

Research Excerpts

Overview

Actions

Drug Classes (1)

Bioassays (26)

Research

Studies (25)

Market Indicators

Research Demand Index: 25.27

Study Types

Related Drugs (37)

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