regulation of cell-cell adhesion mediated by integrin

Definition

Target type: biologicalprocess

Any process that modulates the frequency, rate, or extent of cell-cell adhesion mediated by integrin. [GOC:add]

The regulation of cell-cell adhesion mediated by integrins is a complex and tightly controlled process that plays a crucial role in development, tissue homeostasis, and immune responses. Integrins are transmembrane receptors that bind to extracellular matrix (ECM) proteins and mediate cell adhesion, migration, and signaling. The regulation of integrin-mediated cell-cell adhesion involves a variety of mechanisms, including:

1. **Ligand Binding:** Integrins bind to specific ECM proteins, such as fibronectin, collagen, and laminin. The binding of integrins to their ligands is regulated by factors such as the availability of the ligand, the conformation of the integrin molecule, and the presence of co-receptors.
2. **Integrin Clustering:** The clustering of integrins at the cell surface is essential for the formation of stable cell-cell adhesions. Integrin clustering can be induced by ligand binding, by interactions with other cell surface receptors, or by cytoskeletal reorganization.
3. **Cytoskeletal Organization:** The cytoskeleton provides structural support for the cell and plays a critical role in the regulation of integrin-mediated adhesion. The cytoskeleton can interact with integrins directly or indirectly through adaptor proteins.
4. **Signal Transduction:** Integrin engagement triggers a cascade of intracellular signaling events that regulate cell behavior. These signaling pathways involve a variety of signaling molecules, including protein kinases, phosphatases, and small GTPases.
5. **Regulation by Intracellular Signaling Pathways:** The activity of integrins can be regulated by intracellular signaling pathways, such as the Rho GTPase signaling pathway, the PI3K/AKT signaling pathway, and the MAPK signaling pathway. These pathways can regulate integrin expression, integrin clustering, and integrin activation.

The regulation of integrin-mediated cell-cell adhesion is highly dynamic and is influenced by a variety of factors, including the cell type, the surrounding environment, and the developmental stage. This complex regulation ensures that cell-cell adhesion is properly controlled to maintain tissue integrity, promote cell migration, and facilitate immune responses.'
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Proteins (2)

Compounds (81)