Compounds > 7,4'-dimethoxy-5-hydroxyisoflavone
Page last updated: 2024-11-11

7,4'-dimethoxy-5-hydroxyisoflavone

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Description

7,4'-dimethoxy-5-hydroxyisoflavone: isolated from Myristica malabarica; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID5386259
CHEMBL ID464433
SCHEMBL ID572108
MeSH IDM0358629

Synonyms (61)

Synonym
nsc-604926
nsc604926
smr000150588
MLS000570796 ,
SPECTRUM5_001866
5-hydroxy-4',7-dimethoxyisoflavone
5-hydroxy-7-methoxy-3-(4-methoxyphenyl)chromen-4-one
34086-51-6
4h-1-benzopyran-4-one, 5-hydroxy-7-methoxy-3-(4-methoxyphenyl)-
DIVK1C_006481
KBIO1_001425
NCI60_004625
SPECTRUM_001916
OPREA1_378910
KBIO2_007587
KBIO2_002451
KBIO2_005019
KBIOSS_002458
SPECPLUS_000385
CHEMBL464433
5-hydroxy4',7-dimethoxyisoflavone
AKOS003624283
NCGC00246143-01
unii-o617edc7ht
nsc 604926
genistein-7,4'-dimethyl ether
o617edc7ht ,
7,4'-dimethoxy-5-hydroxyisoflavone
A822068
5-hydroxy-7-methoxy-3-(4-methoxyphenyl)-1-benzopyran-4-one
7-methoxy-3-(4-methoxyphenyl)-5-oxidanyl-chromen-4-one
FT-0639155
SCHEMBL572108
AB00052939-11
genistein-4',7-dimethyl ether
cid_5386259
5-hydroxy-7-methoxy-3-(4-methoxyphenyl)chromone
bdbm49475
4',7-dimethoxy-5-hydroxyisoflavone
DQNLRFRBAWCJHQ-UHFFFAOYSA-N
7-o-methylbiochanin a
biochanin a 7-methyl ether
biochanin a, monomethyl ether
CCG-231517
DTXSID60187684
mfcd00075976
5-hydroxy-7-methoxy-3-(4-methoxyphenyl)-4h-chromen-4-one
BCP10000
E78703
4',7-di-o-methylgenistein
hydroxy-4',7-dimethoxyisoflavone, 5-
isoflavone, 5-hydroxy-4',7-dimethoxy-
5-hydroxy-7-methoxy-3-(4-methoxyphenyl)-4h-1-benzopyran-4-one
5-hydroxy-7,4'-dimethoxyisoflavone
dimethylgenistein
BS-49344
genistein 4',7-dimethyl ether
CS-0135002
HY-N7655
Z56823094
biochanin a, 7-methyl ether
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (13)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
LuciferasePhotinus pyralis (common eastern firefly)Potency1.51010.007215.758889.3584AID588342
BRCA1Homo sapiens (human)Potency2.51190.89137.722525.1189AID624202
ATAD5 protein, partialHomo sapiens (human)Potency4.78190.004110.890331.5287AID504466; AID504467
regulator of G-protein signaling 4Homo sapiens (human)Potency79.43280.531815.435837.6858AID504845
NPC intracellular cholesterol transporter 1 precursorHomo sapiens (human)Potency0.63100.01262.451825.0177AID485313
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency23.10930.00419.984825.9290AID504444
ras-related protein Rab-9AHomo sapiens (human)Potency1.00000.00022.621531.4954AID485297
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency89.12510.050127.073689.1251AID588590
survival motor neuron protein isoform dHomo sapiens (human)Potency12.58930.125912.234435.4813AID1458
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
nuclear factor NF-kappa-B p105 subunit isoform 1Homo sapiens (human)EC50 (µMol)1.72500.05905.559627.2100AID1241
transcription factor p65 isoform 1Homo sapiens (human)EC50 (µMol)1.72500.05905.559627.2100AID1241
Estrogen receptor betaMus musculus (house mouse)EC50 (µMol)1.72500.05905.559627.2100AID1241
Estrogen receptorMus musculus (house mouse)EC50 (µMol)1.72500.05905.559627.2100AID1241
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (75)

Assay IDTitleYearJournalArticle
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1347083qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347082qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1347086qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1400574Cytoprotective activity in human BEAS2B cells assessed as decrease in As(+3)-induced cell apoptosis at 6.25 uM preincubated for 8 hrs followed by As(+3) challenge and measured after 24 hrs by annexin V-FITC/propidium iodide staining-based flow cytometric 2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400591Activation of Nrf2 in human BEAS2B cells assessed as upregulation of Nrf2 protein expression at 6.25 uM pretreated for 1 hr followed by co-treatment with PKC inhibitor Go6983 for 18 hrs by immunoblot analysis2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400533Induction of Nrf2 translocation from cytoplasm to nucleus in human BEAS2B cells at 6.25 uM after 18 hrs by DAPI staining-based immunofluorescence analysis2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400600Activation of Nrf2 in human BEAS2B cells assessed as upregulation of GSH levels after 24 hrs2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400560Activation of Nrf2 in human BEAS2B cells assessed as upregulation of gamma-GCS protein expression at 6.25 uM after 48 hrs by immunoblot analysis2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400581Activation of Nrf2 in mouse Heap1c1c7 cells assessed as induction of NAD(P)H:quinone reductase activity at 6.25 uM pretreated for 1 hr followed by co-treatment with PKC inhibitor Ro-31-8220 for 24 hrs2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400577Induction of Nrf2 translocation from cytoplasm to nucleus in human BEAS2B cells at 6.25 uM after 18 hrs by immunoblot analysis2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400571Cytotoxicity against human BEAS2B cells assessed as decrease in cell viability up to 25 uM after 48 hrs by MTT assay2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400598Activation of Nrf2 in human BEAS2B cells assessed as upregulation of NQO1 protein expression at 6.25 uM pretreated for 1 hr followed by co-treatment with PERK inhibitor GSK2606414 for 18 hrs by immunoblot analysis2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400602Effect on reactive oxygen species production in human BEAS2B cells at 6.25 uM treated for 8 hrs2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400589Activation of Nrf2 in human BEAS2B cells assessed as upregulation of Nrf2 protein expression at 6.25 uM pretreated for 1 hr followed by co-treatment with MEK1/2 inhibitor PD98059 for 18 hrs by immunoblot analysis2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400550Activation of Nrf2 in human BEAS2B cells assessed as upregulation of Nrf2 protein expression at 50 to 100 uM after 18 hrs by immunoblot analysis2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400547Activation of Nrf2 in human BEAS2B cells assessed as upregulation of Nrf2 protein expression at 0.31 to 20 uM after 18 hrs by immunoblot analysis2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400583Activation of Nrf2 in mouse Heap1c1c7 cells assessed as induction of NAD(P)H:quinone reductase activity at 6.25 uM pretreated for 1 hr followed by co-treatment with MEK1/2 inhibitor PD98059 for 24 hrs2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400552Activation of Nrf2 in human BEAS2B cells assessed as upregulation of gamma-GCS protein expression at 50 to 100 uM after 18 hrs by immunoblot analysis2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400578Inhibition of Nrf2 (unknown origin) ubiquitylation transfected in human BEAS2B cells at 6.25 uM after 6 hrs by immunoblot analysis2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400596Activation of Nrf2 in human BEAS2B cells assessed as upregulation of NQO1 protein expression at 6.25 uM pretreated for 1 hr followed by co-treatment with PKC inhibitor Ro-31-8220 for 18 hrs by immunoblot analysis2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400580Activation of Nrf2 in mouse Heap1c1c7 cells assessed as induction of NAD(P)H:quinone reductase activity at 6.25 uM pretreated for 1 hr followed by co-treatment with PKC inhibitor Go6983 for 24 hrs2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400556Activation of Nrf2 in human BEAS2B cells assessed as upregulation of NQO1 protein expression at 6.25 uM after 8 to 24 hrs by immunoblot analysis2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400595Activation of Nrf2 in human BEAS2B cells assessed as upregulation of NQO1 protein expression at 6.25 uM pretreated for 1 hr followed by co-treatment with MEK1/2 inhibitor PD98059 for 18 hrs by immunoblot analysis2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400548Activation of Nrf2 in human BEAS2B cells assessed as upregulation of NQO1 protein expression at 0.31 to 20 uM after 18 hrs by immunoblot analysis2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400582Activation of Nrf2 in mouse Heap1c1c7 cells assessed as induction of NAD(P)H:quinone reductase activity at 6.25 uM pretreated for 1 hr followed by co-treatment with PI3K inhibitor LY294002 for 24 hrs2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400563Activation of Nrf2 in human BEAS2B cells assessed as upregulation of NQO1 protein expression at 3.12 to 25 uM after 12 hrs by immunoblot analysis2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400586Activation of Nrf2 in mouse Heap1c1c7 cells assessed as induction of NAD(P)H:quinone reductase activity at 6.25 uM pretreated for 1 hr followed by co-treatment with MEK1/2 inhibitor Uo126 for 24 hrs2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400594Activation of Nrf2 in human BEAS2B cells assessed as upregulation of NQO1 protein expression at 6.25 uM pretreated for 1 hr followed by co-treatment with p38 MAPK inhibitor SB203580 for 18 hrs by immunoblot analysis2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400599Activation of Nrf2 in human BEAS2B cells assessed as upregulation of GSH levels at 5 uM measured over 1 to 24 hrs2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400573Cytoprotective activity in human BEAS2B cells assessed as decrease in 5 to 20 uM As(+3)-induced cell death at 6.25 uM preincubated for 8 hrs followed by As(+3) challenge and measured after 24 hrs by MTT assay2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400587Activation of Nrf2 in human BEAS2B cells assessed as upregulation of Nrf2 protein expression at 6.25 uM pretreated for 1 hr followed by co-treatment with PI3K inhibitor LY294002 for 18 hrs by immunoblot analysis2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400554Downregulation of Keap1 protein levels in human BEAS2B cells at 50 to 100 uM after 18 hrs by immunoblot analysis2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400561Effect on Keap1 protein levels in human BEAS2B cells at 6.25 uM after 4 to 48 hrs by immunoblot analysis2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400585Activation of Nrf2 in mouse Heap1c1c7 cells assessed as induction of NAD(P)H:quinone reductase activity at 6.25 uM pretreated for 1 hr followed by co-treatment with PI3K inhibitor wortmannin for 24 hrs2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400551Activation of Nrf2 in human BEAS2B cells assessed as upregulation of NQO1 protein expression at 50 to 100 uM after 18 hrs by immunoblot analysis2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400553Effect on Keap1 protein levels in human BEAS2B cells at <= 20 uM after 18 hrs by immunoblot analysis2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400540Cytotoxicity against human MDA-MB-231 cells assessed as decrease in cell viability at 3.12 to 100 uM after 24 hrs by MTT assay2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400543Activation of Nrf2 in human MDA-MB-231 cells assessed as upregulation of gamma-GCS protein expression after 16 hrs by immunoblot analysis2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400542Activation of Nrf2 in human MDA-MB-231 cells assessed as upregulation of NQO1 protein expression after 16 hrs by immunoblot analysis2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400575Cytotoxicity against human BEAS2B cells assessed as decrease in cell viability at 6.25 after 24 hrs by MTT assay2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400532Activation of Nrf2 in mouse Heap1c1c7 cells assessed as induction of NAD(P)H:quinone reductase activity at 6.25 uM pretreated for 1 hr followed by co-treatment with p38 MAPK inhibitor SB203580 for 24 hrs2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400549Activation of Nrf2 in human BEAS2B cells assessed as upregulation of gamma-GCS protein expression at 0.31 to 20 uM after 18 hrs by immunoblot analysis2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400572Cytoprotective activity in human BEAS2B cells assessed as decrease in As(+3)-induced cell death at 3.12 to 25 uM preincubated for 8 hrs followed by As(+3) challenge and measured after 24 hrs by MTT assay2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400579Stabilization of Nrf2 in human BEAS2B cells assessed as protein half life at 6.25 uM preincubated for 8 hrs followed by CHX addition and measured over 10 to 40 mins by immunoblot analysis (Rvb = 14.7 min)2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400564Activation of Nrf2 in human BEAS2B cells assessed as upregulation of gamma-GCS protein expression at 3.12 to 25 uM after 12 hrs by immunoblot analysis2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400601Activation of Nrf2 in human BEAS2B cells assessed as suppression of As(+3)-induced overproduction of reactive oxygen species at 6.25 uM pretreated for 8 hrs followed by As(+3) challenge and measured after 10 hrs2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400590Activation of Nrf2 in human BEAS2B cells assessed as upregulation of Nrf2 protein expression at 6.25 uM pretreated for 1 hr followed by co-treatment with PKC inhibitor Ro-31-8220 for 18 hrs by immunoblot analysis2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400562Activation of Nrf2 in human BEAS2B cells assessed as upregulation of Nrf2 protein expression at 3.12 to 25 uM after 12 hrs by immunoblot analysis2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400584Activation of Nrf2 in mouse Heap1c1c7 cells assessed as induction of NAD(P)H:quinone reductase activity at 6.25 uM pretreated for 1 hr followed by co-treatment with PERK inhibitor GSK2606414 for 24 hrs2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400558Activation of Nrf2 in human BEAS2B cells assessed as upregulation of Nrf2 protein expression at 6.25 uM after 48 hrs by immunoblot analysis2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400541Activation of Nrf2 in human MDA-MB-231 cells assessed as upregulation of Nrf2 protein expression after 16 hrs by immunoblot analysis2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400592Activation of Nrf2 in human BEAS2B cells assessed as upregulation of Nrf2 protein expression at 6.25 uM pretreated for 1 hr followed by co-treatment with PERK inhibitor GSK2606414 for 18 hrs by immunoblot analysis2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400588Activation of Nrf2 in human BEAS2B cells assessed as upregulation of Nrf2 protein expression at 6.25 uM pretreated for 1 hr followed by co-treatment with p38 MAPK inhibitor SB203580 for 18 hrs by immunoblot analysis2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID335258Chemopreventive activity in Chinese hamster embryonic cells assessed as inhibition of benzo[a]pyrene metabolism to water soluble derivatives
AID1400535Activation of Nrf2 in mouse Heap1c1c7 cells assessed as induction of NAD(P)H:quinone reductase activity at 25 uM relative to control2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400555Activation of Nrf2 in human BEAS2B cells assessed as upregulation of Nrf2 protein expression at 6.25 uM after 8 to 24 hrs by immunoblot analysis2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400557Activation of Nrf2 in human BEAS2B cells assessed as upregulation of gamma-GCS protein expression at 6.25 uM after 8 to 24 hrs by immunoblot analysis2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400559Activation of Nrf2 in human BEAS2B cells assessed as upregulation of NQO1 protein expression at 6.25 uM after 48 hrs by immunoblot analysis2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400593Activation of Nrf2 in human BEAS2B cells assessed as upregulation of NQO1 protein expression at 6.25 uM pretreated for 1 hr followed by co-treatment with PI3K inhibitor LY294002 for 18 hrs by immunoblot analysis2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400576Cytoprotective activity in human BEAS2B cells transfected with Nrf2-SiRNA assessed as decrease in As(+3)-induced cell death at 6.25 uM preincubated for 8 hrs followed by As(+3) challenge and measured after 24 hrs by MTT assay2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1400597Activation of Nrf2 in human BEAS2B cells assessed as upregulation of NQO1 protein expression at 6.25 uM pretreated for 1 hr followed by co-treatment with PKC inhibitor Go6983 for 18 hrs by immunoblot analysis2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID1159607Screen for inhibitors of RMI FANCM (MM2) intereaction2016Journal of biomolecular screening, Jul, Volume: 21, Issue:6
A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (22.22)29.6817
2010's5 (55.56)24.3611
2020's2 (22.22)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.48

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.48 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.88 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.48)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (10.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (90.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
sulforaphane
sulforaphane: from Cardaria draba L.. sulforaphane : An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.		2.1710isothiocyanate;
sulfoxide		antineoplastic agent;
antioxidant;
EC 3.5.1.98 (histone deacetylase) inhibitor;
plant metabolite
2-tert-butylhydroquinone
2-tert-butylhydroquinone: an anticarcinogenic and chemopreventive agent. 2-tert-butylhydroquinone : A member of the class of hydroquinones in which one of the ring hydrogens of hydroquinone is replaced by a tert-butyl group.		2.1710hydroquinonesfood antioxidant
homoeriodictyol
homoeriodictyol: structure in first source. homoeriodictyol : A trihydroxyflavanone that consists of 3'-methoxyflavanone in which the three hydroxy substituents are located at positions 4', 5, and 7.		2.17103'-methoxyflavanones;
4'-hydroxyflavanones;
monomethoxyflavanone;
trihydroxyflavanone		flavouring agent;
metabolite
eriodictyol
eriodictyol: structure. eriodictyol : A tetrahydroxyflavanone that is flavanone substituted by hydroxy groups at positions 5, 7, 3' and 4' respectively.		2.17103'-hydroxyflavanones;
tetrahydroxyflavanone
quercetin
[no description available]		2.17107-hydroxyflavonol;
pentahydroxyflavone		antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
kaempferol
[no description available]		2.17107-hydroxyflavonol;
flavonols;
tetrahydroxyflavone		antibacterial agent;
geroprotector;
human blood serum metabolite;
human urinary metabolite;
human xenobiotic metabolite;
plant metabolite
isobavachalcone
isobavachalcone: RN given for (E)-isomer; structure in first source. isobavachalcone : A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 4, 2' and 4' and a prenyl group at position 3'.		2.1710chalcones;
polyphenol		antibacterial agent;
metabolite;
platelet aggregation inhibitor
amentoflavone
[no description available]		2.1710biflavonoid;
hydroxyflavone;
ring assembly		angiogenesis inhibitor;
antiviral agent;
cathepsin B inhibitor;
P450 inhibitor;
plant metabolite
morachalcone a
morachalcone A: tyrosinase inhibitor from the wood of Artocarpus heterophyllus; structure in first source		2.1710chalcones
ConditionIndicatedRelationship StrengthStudiesTrials
Innate Inflammatory Response
[description not available]		02.0510
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		02.0510
Anemia, Fanconi
[description not available]		02.1310
Fanconi Anemia
Congenital disorder affecting all bone marrow elements, resulting in ANEMIA; LEUKOPENIA; and THROMBOPENIA, and associated with cardiac, renal, and limb malformations as well as dermal pigmentary changes. Spontaneous CHROMOSOME BREAKAGE is a feature of this disease along with predisposition to LEUKEMIA. There are at least 7 complementation groups in Fanconi anemia: FANCA, FANCB, FANCC, FANCD1, FANCD2, FANCE, FANCF, FANCG, and FANCL. (from Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227650, August 20, 2004)		02.1310