Page last updated: 2024-12-10

gentisin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

gentisin: a hydroxyxanthone from methanol extract of Gentianae (Gentian?) radix and Calophyllum [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

gentisin : A member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 1 and 7 and a methoxy group at position 3. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

FloraRankFlora DefinitionFamilyFamily Definition
CalophyllumgenusA plant genus of the family CLUSIACEAE. Members contain costatolide, calanolides and 4-phenylfuranocoumarins (FUROCOUMARINS).[MeSH]Calophyllaceae[no description available]

Cross-References

ID SourceID
PubMed CID5281636
CHEMBL ID3093478
CHEBI ID5324
SCHEMBL ID996402
MeSH IDM0112405

Synonyms (36)

Synonym
1,7-dihydroxy-3-methoxy-xanthen-9-one
gentisin
437-50-3
1,7-dihydroxy-3-methoxyxanthone
brn 0384788
9h-xanthen-9-one, 1,7-dihydroxy-3-methoxy-
gentianin
einecs 207-114-1
gentisine
xanthen-9-one, 1,7-dihydroxy-3-methoxy-
1,7-dihydroxy-3-methoxyxanthen-9-one
gentianic acid
ccris 3151
k57mop2hm0 ,
unii-k57mop2hm0
gentisin [mi]
4,7-dihydroxy-2-methoxyxanthone
gentiin
1,7-dihydroxy-3-methoxy-9h-xanthen-9-one
chebi:5324 ,
CHEMBL3093478
AKOS024258078
SCHEMBL996402
A1-01883
DTXSID20195907 ,
gentianin?
FT-0757753
BCP17139
1,7-dihydroxy-3-methoxyxanthone; 1,7-dihydroxy-3-methoxyxanthen-9-one
mfcd00075947
Q27106720
CS-0032629
HY-N4279
MS-23634
1,7-dihydroxy-3-methoxyanthone
dtxcid20118398
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
plant metaboliteAny eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (3)

ClassDescription
xanthonesAny member of the class of xanthenes based on a xanthone skeleton.
polyphenolMembers of the class of phenols that contain 2 or more benzene rings each of which is substituted by at least one hydroxy group.
aromatic etherAny ether in which the oxygen is attached to at least one aryl substituent.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (4)

Assay IDTitleYearJournalArticle
AID1434698Cytotoxicity against Taxol-resistant human SMMC7721 cells measured after 48 hrs by MTT assay2017Bioorganic & medicinal chemistry letters, 02-01, Volume: 27, Issue:3
Structure-activity relationships of diverse xanthones against multidrug resistant human tumor cells.
AID1058589Cytotoxicity against human PANC1 cells assessed as cell viability after 24 hrs by WST8 assay2013Bioorganic & medicinal chemistry, Dec-15, Volume: 21, Issue:24
Heptaoxygenated xanthones as anti-austerity agents from Securidaca longepedunculata.
AID1434700Cytotoxicity against human MCF7/ADR cells measured after 48 hrs by MTT assay2017Bioorganic & medicinal chemistry letters, 02-01, Volume: 27, Issue:3
Structure-activity relationships of diverse xanthones against multidrug resistant human tumor cells.
AID1434699Cytotoxicity against Taxol-resistant human A549 cells measured after 48 hrs by MTT assay2017Bioorganic & medicinal chemistry letters, 02-01, Volume: 27, Issue:3
Structure-activity relationships of diverse xanthones against multidrug resistant human tumor cells.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (33.33)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's3 (50.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 48.91

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index48.91 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.80 (4.65)
Search Engine Demand Index72.10 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (48.91)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]