Compounds > 5'-(sulfonylbenzoyl)adenosine
Page last updated: 2024-09-25

5'-(sulfonylbenzoyl)adenosine

Description

5'-(sulfonylbenzoyl)adenosine: covalently binds to platelet membrane [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID133129
CHEMBL ID490985
SCHEMBL ID4629734
MeSH IDM0150859

Synonyms (13)

Synonym
[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl 4-fluorosulfonylbenzoate
[(3s,2r,4r,5r)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl 4-(fluorosulfonyl)benzoate
5'-[p-(fluorosulphonyl)benzoyl]adenosine
5'-(sulfonylbenzoyl)adenosine
57454-44-1
CHEMBL490985 ,
bdbm50292495
((2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl 4-(fluorosulfonyl)benzoate
adenosine, 5'-(4-(fluorosulfonyl)benzoate)
SCHEMBL4629734
DTXSID00972930
9-{5-o-[4-(fluorosulfonyl)benzoyl]pentofuranosyl}-9h-purin-6-amine
PD137812

Pathways (2)

5'-(sulfonylbenzoyl)adenosine is involved in 2 pathway(s), involving a total of 7 unique proteins and 22 unique compounds

PathwayProteinsCompounds
glycerol degradation I310
glycerol and glycerophosphodiester degradation412

Protein Targets (4)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Tyrosine-protein kinase transforming protein AblAbelson murine leukemia virusIC50 (µMol)175.00000.00600.47871.4000AID224437; AID358184
ATP-dependent translocase ABCB1Homo sapiens (human)IC50 (µMol)0.35330.00022.318510.0000AID1377537; AID1377569; AID1377603
Calmodulin-sensitive adenylate cyclaseBacillus anthracisKi18.40000.98000.98000.9800AID1368661
Heat shock-related 70 kDa protein 2Homo sapiens (human)Ki600.00000.19950.19980.2000AID1617546
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (30)

Processvia Protein(s)Taxonomy
G2/M transition of mitotic cell cycleATP-dependent translocase ABCB1Homo sapiens (human)
xenobiotic metabolic processATP-dependent translocase ABCB1Homo sapiens (human)
response to xenobiotic stimulusATP-dependent translocase ABCB1Homo sapiens (human)
phospholipid translocationATP-dependent translocase ABCB1Homo sapiens (human)
terpenoid transportATP-dependent translocase ABCB1Homo sapiens (human)
regulation of response to osmotic stressATP-dependent translocase ABCB1Homo sapiens (human)
transmembrane transportATP-dependent translocase ABCB1Homo sapiens (human)
transepithelial transportATP-dependent translocase ABCB1Homo sapiens (human)
stem cell proliferationATP-dependent translocase ABCB1Homo sapiens (human)
ceramide translocationATP-dependent translocase ABCB1Homo sapiens (human)
export across plasma membraneATP-dependent translocase ABCB1Homo sapiens (human)
transport across blood-brain barrierATP-dependent translocase ABCB1Homo sapiens (human)
positive regulation of anion channel activityATP-dependent translocase ABCB1Homo sapiens (human)
carboxylic acid transmembrane transportATP-dependent translocase ABCB1Homo sapiens (human)
xenobiotic detoxification by transmembrane export across the plasma membraneATP-dependent translocase ABCB1Homo sapiens (human)
xenobiotic transport across blood-brain barrierATP-dependent translocase ABCB1Homo sapiens (human)
regulation of chloride transportATP-dependent translocase ABCB1Homo sapiens (human)
positive regulation of protein phosphorylationHeat shock-related 70 kDa protein 2Homo sapiens (human)
response to unfolded proteinHeat shock-related 70 kDa protein 2Homo sapiens (human)
male meiotic nuclear divisionHeat shock-related 70 kDa protein 2Homo sapiens (human)
male meiosis IHeat shock-related 70 kDa protein 2Homo sapiens (human)
spermatogenesisHeat shock-related 70 kDa protein 2Homo sapiens (human)
spermatid developmentHeat shock-related 70 kDa protein 2Homo sapiens (human)
response to heatHeat shock-related 70 kDa protein 2Homo sapiens (human)
response to coldHeat shock-related 70 kDa protein 2Homo sapiens (human)
positive regulation of G2/M transition of mitotic cell cycleHeat shock-related 70 kDa protein 2Homo sapiens (human)
protein refoldingHeat shock-related 70 kDa protein 2Homo sapiens (human)
synaptonemal complex disassemblyHeat shock-related 70 kDa protein 2Homo sapiens (human)
negative regulation of inclusion body assemblyHeat shock-related 70 kDa protein 2Homo sapiens (human)
chaperone cofactor-dependent protein refoldingHeat shock-related 70 kDa protein 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (24)

Processvia Protein(s)Taxonomy
protein bindingATP-dependent translocase ABCB1Homo sapiens (human)
ATP bindingATP-dependent translocase ABCB1Homo sapiens (human)
ABC-type xenobiotic transporter activityATP-dependent translocase ABCB1Homo sapiens (human)
efflux transmembrane transporter activityATP-dependent translocase ABCB1Homo sapiens (human)
ATP hydrolysis activityATP-dependent translocase ABCB1Homo sapiens (human)
transmembrane transporter activityATP-dependent translocase ABCB1Homo sapiens (human)
ubiquitin protein ligase bindingATP-dependent translocase ABCB1Homo sapiens (human)
ATPase-coupled transmembrane transporter activityATP-dependent translocase ABCB1Homo sapiens (human)
xenobiotic transmembrane transporter activityATP-dependent translocase ABCB1Homo sapiens (human)
carboxylic acid transmembrane transporter activityATP-dependent translocase ABCB1Homo sapiens (human)
phosphatidylcholine floppase activityATP-dependent translocase ABCB1Homo sapiens (human)
phosphatidylethanolamine flippase activityATP-dependent translocase ABCB1Homo sapiens (human)
ceramide floppase activityATP-dependent translocase ABCB1Homo sapiens (human)
floppase activityATP-dependent translocase ABCB1Homo sapiens (human)
adenylate cyclase activityCalmodulin-sensitive adenylate cyclaseBacillus anthracis
protein bindingHeat shock-related 70 kDa protein 2Homo sapiens (human)
ATP bindingHeat shock-related 70 kDa protein 2Homo sapiens (human)
enzyme bindingHeat shock-related 70 kDa protein 2Homo sapiens (human)
tau protein bindingHeat shock-related 70 kDa protein 2Homo sapiens (human)
unfolded protein bindingHeat shock-related 70 kDa protein 2Homo sapiens (human)
protein-folding chaperone bindingHeat shock-related 70 kDa protein 2Homo sapiens (human)
glycolipid bindingHeat shock-related 70 kDa protein 2Homo sapiens (human)
disordered domain specific bindingHeat shock-related 70 kDa protein 2Homo sapiens (human)
ATP-dependent protein folding chaperoneHeat shock-related 70 kDa protein 2Homo sapiens (human)
ATP hydrolysis activityHeat shock-related 70 kDa protein 2Homo sapiens (human)
heat shock protein bindingHeat shock-related 70 kDa protein 2Homo sapiens (human)
protein folding chaperoneHeat shock-related 70 kDa protein 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (14)

Processvia Protein(s)Taxonomy
cytoplasmATP-dependent translocase ABCB1Homo sapiens (human)
plasma membraneATP-dependent translocase ABCB1Homo sapiens (human)
cell surfaceATP-dependent translocase ABCB1Homo sapiens (human)
membraneATP-dependent translocase ABCB1Homo sapiens (human)
apical plasma membraneATP-dependent translocase ABCB1Homo sapiens (human)
extracellular exosomeATP-dependent translocase ABCB1Homo sapiens (human)
external side of apical plasma membraneATP-dependent translocase ABCB1Homo sapiens (human)
plasma membraneATP-dependent translocase ABCB1Homo sapiens (human)
synaptonemal complexHeat shock-related 70 kDa protein 2Homo sapiens (human)
male germ cell nucleusHeat shock-related 70 kDa protein 2Homo sapiens (human)
nucleusHeat shock-related 70 kDa protein 2Homo sapiens (human)
cytosolHeat shock-related 70 kDa protein 2Homo sapiens (human)
cell surfaceHeat shock-related 70 kDa protein 2Homo sapiens (human)
membraneHeat shock-related 70 kDa protein 2Homo sapiens (human)
extracellular exosomeHeat shock-related 70 kDa protein 2Homo sapiens (human)
blood microparticleHeat shock-related 70 kDa protein 2Homo sapiens (human)
meiotic spindleHeat shock-related 70 kDa protein 2Homo sapiens (human)
CatSper complexHeat shock-related 70 kDa protein 2Homo sapiens (human)
cytosolHeat shock-related 70 kDa protein 2Homo sapiens (human)
nucleusHeat shock-related 70 kDa protein 2Homo sapiens (human)
plasma membraneHeat shock-related 70 kDa protein 2Homo sapiens (human)
cytoplasmHeat shock-related 70 kDa protein 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (17)

Assay IDTitleYearJournalArticle
AID1368661Inactivation of Bacillus anthracis edema factor in presence of CaM incubated for 10 to 240 mins by EnzChek pyrophosphate assay2018Bioorganic & medicinal chemistry letters, 01-15, Volume: 28, Issue:2
Small molecule inhibitors of anthrax edema factor.
AID1617545Covalent inhibition of HSP72-NBD (unknown origin) assessed as half life (infinity) nucleotide-derived FP probe displacement based by fluorescence polarization assay2019Journal of medicinal chemistry, 12-26, Volume: 62, Issue:24
Kinetic Optimization of Lysine-Targeting Covalent Inhibitors of HSP72.
AID1368665Irreversible inactivation of Bacillus anthracis edema factor pre-incubated for 90 mins followed by drug filtration by EnzChek pyrophosphate assay2018Bioorganic & medicinal chemistry letters, 01-15, Volume: 28, Issue:2
Small molecule inhibitors of anthrax edema factor.
AID1617542Covalent inhibition of HSP72-NBD (unknown origin) assessed as Kinact/Ki ratio nucleotide-derived FP probe displacement based by fluorescence polarization assay2019Journal of medicinal chemistry, 12-26, Volume: 62, Issue:24
Kinetic Optimization of Lysine-Targeting Covalent Inhibitors of HSP72.
AID1377603Displacement of 8-azido[alpha-32P]ATP from human MDR1 expressed in baculovirus infected insect cell membranes by phosphorimaging method2017European journal of medicinal chemistry, Sep-29, Volume: 138Natural alkaloids as P-gp inhibitors for multidrug resistance reversal in cancer.
AID1368660Inactivation of Bacillus anthracis edema factor assessed as inactivation rate constant in presence of CaM incubated for 10 to 240 mins by EnzChek pyrophosphate assay2018Bioorganic & medicinal chemistry letters, 01-15, Volume: 28, Issue:2
Small molecule inhibitors of anthrax edema factor.
AID1617544Covalent inhibition of HSP72-NBD (unknown origin) assessed as inactivation constant nucleotide-derived FP probe displacement based by fluorescence polarization assay2019Journal of medicinal chemistry, 12-26, Volume: 62, Issue:24
Kinetic Optimization of Lysine-Targeting Covalent Inhibitors of HSP72.
AID1377537Inhibition of [125I]IAAP labeling to human MDR1 expressed in baculovirus infected insect cell membranes by electrophoresis method2017European journal of medicinal chemistry, Sep-29, Volume: 138Natural alkaloids as P-gp inhibitors for multidrug resistance reversal in cancer.
AID1368693Cytotoxicity against mouse RAW264.7 cells assessed a reduction in cell viability incubated for 24 hrs in absence of 10% FBS by MTT assay2018Bioorganic & medicinal chemistry letters, 01-15, Volume: 28, Issue:2
Small molecule inhibitors of anthrax edema factor.
AID1368662Inactivation of Bacillus anthracis edema factor assessed as Kinact/Ki ratio in presence of CaM incubated for 10 to 240 mins by EnzChek pyrophosphate assay2018Bioorganic & medicinal chemistry letters, 01-15, Volume: 28, Issue:2
Small molecule inhibitors of anthrax edema factor.
AID224437Inhibition of p60-vabl tyrosine kinase isolated from Abelson murine leukemia virus (A-MuLV)1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Synthesis and evaluation of multisubstrate inhibitors of an oncogene-encoded tyrosine-specific protein kinase. 1.
AID1368664Cytotoxicity against mouse RAW264.7 cells assessed a reduction in cell viability incubated for 24 hrs in presence of 10% FBS by MTT assay2018Bioorganic & medicinal chemistry letters, 01-15, Volume: 28, Issue:2
Small molecule inhibitors of anthrax edema factor.
AID358184Inhibition of Abelson murine leukemia virus p60 v-abl1992Journal of natural products, Nov, Volume: 55, Issue:11
Protein-tyrosine kinase inhibition: mechanism-based discovery of antitumor agents.
AID1377569Inhibition of human MDR1 ATPase activity expressed in baculovirus infected insect cells preincubated for 30 mins followed by ATP addition measured after 20 mins by colorimetric method2017European journal of medicinal chemistry, Sep-29, Volume: 138Natural alkaloids as P-gp inhibitors for multidrug resistance reversal in cancer.
AID1617546Covalent inhibition of HSP72-NBD (unknown origin) assessed as initial inhibition constant nucleotide-derived FP probe displacement based by fluorescence polarization assay2019Journal of medicinal chemistry, 12-26, Volume: 62, Issue:24
Kinetic Optimization of Lysine-Targeting Covalent Inhibitors of HSP72.
AID159260Inhibition of Phosphorylase (serine) Kinase activity1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Synthesis and evaluation of multisubstrate inhibitors of an oncogene-encoded tyrosine-specific protein kinase. 1.
AID1368666Permeability of the compound at 200 uM incubated for 1 hr by PAMPA assay2018Bioorganic & medicinal chemistry letters, 01-15, Volume: 28, Issue:2
Small molecule inhibitors of anthrax edema factor.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (33.33)18.7374
1990's1 (16.67)18.2507
2000's0 (0.00)29.6817
2010's3 (50.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (33.33%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (66.67%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
4-hydroxybenzoic acid[no description available]medium10monohydroxybenzoic acidalgal metabolite;
plant metabolite
7,8-dihydroxyflavone[no description available]medium10dihydroxyflavoneantidepressant;
antineoplastic agent;
antioxidant;
plant metabolite;
tropomyosin-related kinase B receptor agonist
emodin[no description available]medium10trihydroxyanthraquinoneantineoplastic agent;
laxative;
plant metabolite;
tyrosine kinase inhibitor
lavendustin a[no description available]medium10aromatic amine
lavendustin b[no description available]medium10
adenosine monophosphate[no description available]medium10adenosine 5'-phosphate;
purine ribonucleoside 5'-monophosphate		adenosine A1 receptor agonist;
cofactor;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
EC 3.1.3.11 (fructose-bisphosphatase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical
1-hydroxyanthraquinone[no description available]medium10monohydroxyanthraquinone
physcione[no description available]medium10dihydroxyanthraquinoneanti-inflammatory agent;
antibacterial agent;
antifungal agent;
antineoplastic agent;
apoptosis inducer;
hepatoprotective agent;
metabolite
flavone[no description available]medium10flavonesmetabolite;
nematicide
adenosine 5'-tetraphosphate[no description available]medium10adenosine 5'-phosphate;
purine ribonucleoside 5'-tetraphosphate
diadenosine tetraphosphate[no description available]medium10diadenosyl tetraphosphateEscherichia coli metabolite;
mouse metabolite
staurosporine[no description available]medium30indolocarbazole alkaloid;
organic heterooctacyclic compound		apoptosis inducer;
bacterial metabolite;
EC 2.7.11.13 (protein kinase C) inhibitor;
geroprotector
pinocembrin[no description available]medium10(2S)-flavan-4-one;
dihydroxyflavanone		antineoplastic agent;
antioxidant;
metabolite;
neuroprotective agent;
vasodilator agent
4'-amino-6-hydroxyflavone[no description available]medium10flavones
(hydroxy-2-naphthalenylmethyl)phosphonic acid[no description available]medium10
4',6-dihydroxyflavone[no description available]medium10dihydroxyflavone
4'-hydroxyflavone[no description available]medium10
3',4',5'-trimethoxyflavone[no description available]medium10ether;
flavonoids
naringenin[no description available]medium10(2S)-flavan-4-one;
naringenin		expectorant;
plant metabolite
taxifolin[no description available]medium10taxifolinmetabolite
ferulic acid[no description available]medium10ferulic acidsanti-inflammatory agent;
antioxidant;
apoptosis inhibitor;
cardioprotective agent;
MALDI matrix material;
plant metabolite
trans-4-coumaric acid[no description available]medium104-coumaric acidfood component;
mouse metabolite;
plant metabolite
ag-213[no description available]medium10
3,3',4,5'-tetrahydroxystilbene[no description available]medium10catechols;
polyphenol;
resorcinols;
stilbenol		antineoplastic agent;
apoptosis inducer;
geroprotector;
hypoglycemic agent;
plant metabolite;
protein kinase inhibitor;
tyrosine kinase inhibitor
7,8,3'-trihydroxyflavone[no description available]medium10
(2S)-7-hydroxyflavanone[no description available]medium107-hydroxyflavanone
caffeic acid[no description available]medium10caffeic acidgeroprotector;
mouse metabolite
quercetin[no description available]medium107-hydroxyflavonol;
pentahydroxyflavone		antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
biochanin a[no description available]medium104'-methoxyisoflavones;
7-hydroxyisoflavones		antineoplastic agent;
EC 3.5.1.99 (fatty acid amide hydrolase) inhibitor;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor
acacetin[no description available]medium10dihydroxyflavone;
monomethoxyflavone		anticonvulsant;
plant metabolite
apigenin[no description available]medium10trihydroxyflavoneantineoplastic agent;
metabolite
luteolin[no description available]medium103'-hydroxyflavonoid;
tetrahydroxyflavone		angiogenesis inhibitor;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
c-Jun N-terminal kinase inhibitor;
EC 2.3.1.85 (fatty acid synthase) inhibitor;
immunomodulator;
nephroprotective agent;
plant metabolite;
radical scavenger;
vascular endothelial growth factor receptor antagonist
kaempferol[no description available]medium107-hydroxyflavonol;
flavonols;
tetrahydroxyflavone		antibacterial agent;
geroprotector;
human blood serum metabolite;
human urinary metabolite;
human xenobiotic metabolite;
plant metabolite
genistein[no description available]medium107-hydroxyisoflavonesantineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
human urinary metabolite;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor
genistin[no description available]medium107-hydroxyisoflavones 7-O-beta-D-glucoside
chrysin[no description available]medium107-hydroxyflavonol;
dihydroxyflavone		anti-inflammatory agent;
antineoplastic agent;
antioxidant;
EC 2.7.11.18 (myosin-light-chain kinase) inhibitor;
hepatoprotective agent;
plant metabolite
fisetin[no description available]medium103'-hydroxyflavonoid;
7-hydroxyflavonol;
tetrahydroxyflavone		anti-inflammatory agent;
antioxidant;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
metabolite;
plant metabolite
galangin[no description available]medium107-hydroxyflavonol;
trihydroxyflavone		antimicrobial agent;
EC 3.1.1.3 (triacylglycerol lipase) inhibitor;
plant metabolite
genkwanin[no description available]medium10dihydroxyflavone;
monomethoxyflavone		metabolite
myricetin[no description available]medium107-hydroxyflavonol;
hexahydroxyflavone		antineoplastic agent;
antioxidant;
cyclooxygenase 1 inhibitor;
food component;
geroprotector;
hypoglycemic agent;
plant metabolite
daidzein[no description available]medium107-hydroxyisoflavonesantineoplastic agent;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
phytoestrogen;
plant metabolite
orobol[no description available]medium107-hydroxyisoflavonesanti-inflammatory agent;
fungal metabolite;
plant metabolite;
radical scavenger
prunetin[no description available]medium107-methoxyisoflavones;
hydroxyisoflavone		anti-inflammatory agent;
EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor;
EC 1.3.1.22 [3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+))] inhibitor;
metabolite
7-hydroxyflavone[no description available]medium10hydroxyflavonoid
syringetin[no description available]medium103',5'-dimethoxyflavone;
3'-methoxyflavones;
7-hydroxyflavonol;
dimethoxyflavone;
tetrahydroxyflavone		metabolite;
platelet aggregation inhibitor
4',7-dihydroxyflavone[no description available]medium10dihydroxyflavonemetabolite
fustin[no description available]medium10
erbstatin[no description available]medium10
ag 538[no description available]medium10
ag 99[no description available]medium10
tyrphostin ag 555[no description available]medium10
tyrphostin ag-494[no description available]medium10
ag-490[no description available]medium10catechols;
enamide;
monocarboxylic acid amide;
nitrile;
secondary carboxamide		anti-inflammatory agent;
antioxidant;
apoptosis inducer;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor;
geroprotector;
STAT3 inhibitor
alpha-cyano-4-hydroxycinnamic acid[no description available]medium10monohydroxycinnamic acid;
nitrile;
phenols		MALDI matrix material
ag 30[no description available]medium10
ag 112[no description available]medium10
ag 183[no description available]medium10
methyl 2,5-dihydroxycinnamate[no description available]medium10cinnamate ester;
hydroquinones;
methyl ester		EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor;
geroprotector;
human urinary metabolite;
plant metabolite
psi-tectorigenin[no description available]medium10
st 638[no description available]medium10
herbimycin[no description available]medium10
st 271[no description available]medium10
1,2-dihydroxy-4-(nitroethenyl)benzene[no description available]medium10
diguanosine tetraphosphate[no description available]medium10guanosine 5'-phosphate;
purine ribonucleoside 5'-tetraphosphate		Escherichia coli metabolite;
mouse metabolite
verapamil[no description available]medium10aromatic ether;
nitrile;
polyether;
tertiary amino compound
sanguinarine[no description available]medium10alkaloid antibiotic;
benzophenanthridine alkaloid;
botanical anti-fungal agent
reserpine[no description available]medium10alkaloid ester;
methyl ester;
yohimban alkaloid		adrenergic uptake inhibitor;
antihypertensive agent;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
environmental contaminant;
first generation antipsychotic;
plant metabolite;
xenobiotic
glaucine[no description available]medium10aporphine alkaloid;
organic heterotetracyclic compound;
polyether;
tertiary amino compound		antibacterial agent;
antineoplastic agent;
antitussive;
muscle relaxant;
NF-kappaB inhibitor;
plant metabolite;
platelet aggregation inhibitor;
rat metabolite
tryptanthrine[no description available]medium10alkaloid antibiotic;
organic heterotetracyclic compound;
organonitrogen heterocyclic compound
matrine[no description available]medium10alkaloid
ecteinascidin 743[no description available]medium10acetate ester;
azaspiro compound;
bridged compound;
hemiaminal;
isoquinoline alkaloid;
lactone;
organic heteropolycyclic compound;
organic sulfide;
oxaspiro compound;
polyphenol;
tertiary amino compound		alkylating agent;
angiogenesis modulating agent;
anti-inflammatory agent;
antineoplastic agent;
marine metabolite
quinidine[no description available]medium10cinchona alkaloidalpha-adrenergic antagonist;
anti-arrhythmia drug;
antimalarial;
drug allergen;
EC 1.14.13.181 (13-deoxydaunorubicin hydroxylase) inhibitor;
EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor;
muscarinic antagonist;
P450 inhibitor;
potassium channel blocker;
sodium channel blocker
piperine[no description available]medium10benzodioxoles;
N-acylpiperidine;
piperidine alkaloid;
tertiary carboxamide		food component;
human blood serum metabolite;
NF-kappaB inhibitor;
plant metabolite
antofine[no description available]medium10alkaloid antibiotic;
alkaloid;
aromatic ether;
organic heteropentacyclic compound		angiogenesis inhibitor;
anti-inflammatory agent;
antimicrobial agent;
antineoplastic agent;
antiviral agent;
phytotoxin;
plant metabolite
discodermolide[no description available]medium10diterpenoid
tiamulin[no description available]medium10carbotricyclic compound;
carboxylic ester;
cyclic ketone;
organic sulfide;
secondary alcohol;
semisynthetic derivative;
tertiary amino compound;
tetracyclic diterpenoid		antibacterial drug
stemofoline[no description available]medium10
vinpocetine[no description available]medium10alkaloidgeroprotector
ver 155008[no description available]medium10purine nucleoside
5'-(4-fluorosulfonylbenzoyl)adenosine[no description available]medium10
adenosine diphosphate[no description available]medium10adenosine 5'-phosphate;
purine ribonucleoside 5'-diphosphate		fundamental metabolite;
human metabolite
adenosine[no description available]medium10adenosines;
purines D-ribonucleoside		analgesic;
anti-arrhythmia drug;
fundamental metabolite;
human metabolite;
vasodilator agent
ConditionIndicatedRelationship StrengthStudiesTrials
Anthrax0low10
Bacillus anthracis Infection0low10
Benign Neoplasms0low10
Cancer0low10
Malignancy0low10
Malignant Neoplasms0low10
Neoplasia0low10
Neoplasm0low10
Neoplasms0low10
Neoplasms, Benign0low10
Tumors0low10