Sphinganine, its homologs and stereoisomers, and the hydroxy and unsaturated derivatives of these compounds.
ChEBI ID: 35785
| Member | Definition | Role |
|---|---|---|
| es-285 | A bioactive sphingoid, sphinganine, in which the terminal hydroxy group has been replaced by a hydrogen. | 1-deoxysphinganine |
| n,n-dimethylsphingenine | A sphingoid that is sphingosine in which the two amino hydrogens are replaced by methyl groups. | N,N-dimethylsphingosine |
| phytosphingosine | phytosphingosine | |
| safingol | An aminodiol that is octadecane bearing two hydroxy substituents at positions 1 and 3 as well as an amino substituent at position 2. | 2-aminooctadecane-1,3-diol |
| thermozymocidin | An amino acid-based antibiotic derived from certain thermophilic fungi; acts as a potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis. Myriocin also possesses immunosuppressant activity. | myriocin |
| xestoaminol c | A sphingoid that is tetradecasphinganine in which the terminal hydroxy group has been replaced by a hydrogen. | 1-deoxytetradecasphinganine |
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 18 (2.54) | 18.7374 |
| 1990's | 71 (10.03) | 18.2507 |
| 2000's | 264 (37.29) | 29.6817 |
| 2010's | 283 (39.97) | 24.3611 |
| 2020's | 72 (10.17) | 2.80 |
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 9 (1.23%) | 5.53% |
| Reviews | 22 (3.00%) | 6.00% |
| Case Studies | 2 (0.27%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 701 (95.50%) | 84.16% |