protein tyrosine kinase binding

Definition

Target type: molecularfunction

Binding to protein tyrosine kinase. [PMID:25499537]

Protein tyrosine kinase binding is a molecular function that describes the interaction of proteins with tyrosine kinases. Tyrosine kinases are a family of enzymes that catalyze the transfer of a phosphate group from ATP to a tyrosine residue on a protein. This phosphorylation event can regulate the activity of the target protein, often by altering its conformation or interactions with other proteins. Protein tyrosine kinases play critical roles in various cellular processes, including cell growth, differentiation, proliferation, survival, and signal transduction pathways.

The interaction between a protein and a tyrosine kinase can be direct, where the protein binds directly to the tyrosine kinase, or indirect, where the protein interacts with a protein that binds to the tyrosine kinase. The binding of a protein to a tyrosine kinase can either activate or inhibit the kinase activity.

Examples of proteins that participate in protein tyrosine kinase binding include:

* **Adaptor proteins:** These proteins lack enzymatic activity but act as intermediaries to link tyrosine kinases to downstream signaling pathways. Examples include Grb2, Shc, and Gab1.
* **Scaffold proteins:** These proteins serve as platforms to bring together multiple signaling proteins, including tyrosine kinases, and facilitate the formation of signaling complexes. An example is the protein scaffold protein Gab2.
* **Transcription factors:** These proteins can bind to tyrosine kinases and regulate gene expression. An example is the STAT family of transcription factors.
* **Substrates:** These proteins are phosphorylated by tyrosine kinases, leading to changes in their activity or function. Examples include the insulin receptor substrate (IRS) proteins and the epidermal growth factor receptor (EGFR).

The specificity of protein tyrosine kinase binding is determined by the amino acid sequence of the protein and the kinase. The binding site on the tyrosine kinase can vary depending on the kinase, but often involves the catalytic domain or the regulatory domain.

In conclusion, protein tyrosine kinase binding is a fundamental molecular function that underpins numerous cellular processes and pathways. It is a complex process involving diverse protein interactions and regulatory mechanisms.'
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Proteins (15)

Compounds (444)