Compounds > mansonone c
Page last updated: 2024-12-06

mansonone c

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Mansonone C is a natural product isolated from the bark of the Mansoniodendron gazungule tree. It exhibits a range of biological activities, including anti-inflammatory, anti-tumor, and antioxidant properties. Research on Mansonone C is driven by its potential therapeutic applications. Its unique chemical structure, characterized by a benzophenone core and a prenylated pyran ring, contributes to its pharmacological activities. Studies have explored its synthesis, both through natural extraction and laboratory methods, to investigate its biological mechanisms and potential applications in drug development.'

mansonone C: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID21742
CHEMBL ID508283
CHEBI ID6689
SCHEMBL ID9863621
MeSH IDM0506627

Synonyms (17)

Synonym
5-isopropyl-3,8-dimethyl-naphthalene-1,2-dione
1,2-naphthalenedione, 3,8-dimethyl-5-(1-methylethyl)-
mansonone c
3,8-dimethyl-5-isopropyl-1,2-naphthalenedione
5574-34-5
3,8-dimethyl-5-propan-2-ylnaphthalene-1,2-dione
AC1L2IZM ,
SCHEMBL9863621
CHEMBL508283 ,
chebi:6689 ,
surecn9863621
1,2-naphthoquinone, 5-isopropyl-3,8-dimethyl-
mansonone o
5-isopropyl-3,8-dimethyl-1,2-naphthalenedione #
GREWJSSEUGRGIT-UHFFFAOYSA-N
DTXSID80204286
Q27107297
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

ClassDescription
sesquiterpenoidAny terpenoid derived from a sesquiterpene. The term includes compounds in which the C15 skeleton of the parent sesquiterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups).
1,2-naphthoquinonesAny napthoquinone in which the oxo groups of the quinone moiety are at the 1 and 2 positions of the naphthalene ring.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (22)

Assay IDTitleYearJournalArticle
AID386974Antitrypanosomal activity against Leptomonas seymouri2008European journal of medicinal chemistry, Oct, Volume: 43, Issue:10
Studies of trypanocidal (inhibitory) power of naphthoquinones: evaluation of quantum chemical molecular descriptors for structure-activity relationships.
AID751080Cytotoxicity against human Bel7402 cells by MTT assay2013Journal of natural products, Jun-28, Volume: 76, Issue:6
Sesquiterpenes and alkaloids from the roots of Alangium chinense.
AID1197345Toxicity in Artemia salina Linn.2015European journal of medicinal chemistry, Mar-06, Volume: 92Medicinal uses, phytochemistry and pharmacology of family Sterculiaceae: a review.
AID751078Cytotoxicity against human HCT8 cells by MTT assay2013Journal of natural products, Jun-28, Volume: 76, Issue:6
Sesquiterpenes and alkaloids from the roots of Alangium chinense.
AID1322212Antibacterial activity against Propionibacterium acnes KCCM 41747 at 1000 uM after 24 hrs by agar well-diffusion method2016Bioorganic & medicinal chemistry letters, 11-01, Volume: 26, Issue:21
Allyl and prenyl ethers of mansonone G, new potential semisynthetic antibacterial agents.
AID751079Cytotoxicity against human A2780 cells by MTT assay2013Journal of natural products, Jun-28, Volume: 76, Issue:6
Sesquiterpenes and alkaloids from the roots of Alangium chinense.
AID1322208Antibacterial activity against Streptococcus mutans ATCC 25175 at 1000 uM after 24 hrs by agar well-diffusion method2016Bioorganic & medicinal chemistry letters, 11-01, Volume: 26, Issue:21
Allyl and prenyl ethers of mansonone G, new potential semisynthetic antibacterial agents.
AID386975Antitrypanosomal activity against Crithidia fasciculata2008European journal of medicinal chemistry, Oct, Volume: 43, Issue:10
Studies of trypanocidal (inhibitory) power of naphthoquinones: evaluation of quantum chemical molecular descriptors for structure-activity relationships.
AID1322218Antibacterial activity against Streptococcus sobrinus KCCM 11898 by resazurin based broth microdilution method2016Bioorganic & medicinal chemistry letters, 11-01, Volume: 26, Issue:21
Allyl and prenyl ethers of mansonone G, new potential semisynthetic antibacterial agents.
AID1322214Antibacterial activity against Salmonella typhi ATCC 422 at 1000 uM after 24 hrs by agar well-diffusion method2016Bioorganic & medicinal chemistry letters, 11-01, Volume: 26, Issue:21
Allyl and prenyl ethers of mansonone G, new potential semisynthetic antibacterial agents.
AID1322219Antibacterial activity against Propionibacterium acnes KCCM 41747 by resazurin based broth microdilution method2016Bioorganic & medicinal chemistry letters, 11-01, Volume: 26, Issue:21
Allyl and prenyl ethers of mansonone G, new potential semisynthetic antibacterial agents.
AID751081Cytotoxicity against human BGC823 cells by MTT assay2013Journal of natural products, Jun-28, Volume: 76, Issue:6
Sesquiterpenes and alkaloids from the roots of Alangium chinense.
AID1322217Antibacterial activity against Streptococcus mutans ATCC 25175 by resazurin based broth microdilution method2016Bioorganic & medicinal chemistry letters, 11-01, Volume: 26, Issue:21
Allyl and prenyl ethers of mansonone G, new potential semisynthetic antibacterial agents.
AID1322216Antibacterial activity against Staphylococcus aureus ATCC 25923 by resazurin based broth microdilution method2016Bioorganic & medicinal chemistry letters, 11-01, Volume: 26, Issue:21
Allyl and prenyl ethers of mansonone G, new potential semisynthetic antibacterial agents.
AID1322206Antibacterial activity against Staphylococcus aureus ATCC 25923 at 1000 uM after 24 hrs by agar well-diffusion method2016Bioorganic & medicinal chemistry letters, 11-01, Volume: 26, Issue:21
Allyl and prenyl ethers of mansonone G, new potential semisynthetic antibacterial agents.
AID386973Oxidation of dihydrolipoamide assessed as oxygen consumption at 50 uM2008European journal of medicinal chemistry, Oct, Volume: 43, Issue:10
Studies of trypanocidal (inhibitory) power of naphthoquinones: evaluation of quantum chemical molecular descriptors for structure-activity relationships.
AID1322210Antibacterial activity against Streptococcus sobrinus KCCM 11898 at 1000 uM after 24 hrs by agar well-diffusion method2016Bioorganic & medicinal chemistry letters, 11-01, Volume: 26, Issue:21
Allyl and prenyl ethers of mansonone G, new potential semisynthetic antibacterial agents.
AID751082Cytotoxicity against human A549 cells by MTT assay2013Journal of natural products, Jun-28, Volume: 76, Issue:6
Sesquiterpenes and alkaloids from the roots of Alangium chinense.
AID1424433Cytotoxicity in human K562 cells by SRB assay2017European journal of medicinal chemistry, Dec-15, Volume: 142Recent discoveries of anticancer flavonoids.
AID1322220Antibacterial activity against Salmonella typhi ATCC 422 by resazurin based broth microdilution method2016Bioorganic & medicinal chemistry letters, 11-01, Volume: 26, Issue:21
Allyl and prenyl ethers of mansonone G, new potential semisynthetic antibacterial agents.
AID751085Antiviral activity against Coxsackievirus B3 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect2013Journal of natural products, Jun-28, Volume: 76, Issue:6
Sesquiterpenes and alkaloids from the roots of Alangium chinense.
AID751084Antioxidant activity in rat liver microsome assessed as inhibition of Fe2+-cysteine-induced lipid peroxidation after 15 mins2013Journal of natural products, Jun-28, Volume: 76, Issue:6
Sesquiterpenes and alkaloids from the roots of Alangium chinense.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (28.57)29.6817
2010's5 (71.43)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.75

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.75 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.83 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.75)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (28.57%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (71.43%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
tocopheroxy radical
tocopheroxy radical: RN given refers to radical ion (1+), (2R-(2R*(4R*,8R*)))-isomer; RN for cpd without isomeric designation not available 12/90		3.2110tocopherol
fluorouracil
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.		3.2510nucleobase analogue;
organofluorine compound		antimetabolite;
antineoplastic agent;
environmental contaminant;
immunosuppressive agent;
radiosensitizing agent;
xenobiotic
beta-lapachone
beta-lapachone: antineoplastic inhibitor of reverse transcriptase, DNA topoisomerase, and DNA polymerase. beta-lapachone : A benzochromenone that is 3,4-dihydro-2H-benzo[h]chromene-5,6-dione substituted by geminal methyl groups at position 2. Isolated from Tabebuia avellanedae, it exhibits antineoplastic and anti-inflammatory activities.		2.0410benzochromenone;
orthoquinones		anti-inflammatory agent;
antineoplastic agent;
plant metabolite
chloramphenicol
Amphenicol: Chloramphenicol and its derivatives.		3.6220C-nitro compound;
carboxamide;
diol;
organochlorine compound		antibacterial drug;
antimicrobial agent;
Escherichia coli metabolite;
geroprotector;
Mycoplasma genitalium metabolite;
protein synthesis inhibitor
flavone
flavone: RN given refers to unlabeled cpd; structure given in first source. flavone : The simplest member of the class of flavones that consists of 4H-chromen-4-one bearing a phenyl substituent at position 2.		3.2510flavonesmetabolite;
nematicide
3-hydroxyflavone
3-hydroxyflavone: structure given in first source. flavonol : A monohydroxyflavone that is the 3-hydroxy derivative of flavone.		3.2510flavonols;
monohydroxyflavone
d-alpha tocopherol
Vitamin E: A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.. tocopherol : A collective name for a group of closely related lipids that contain a chroman-6-ol nucleus substituted at position 2 by a methyl group and by a saturated hydrocarbon chain consisting of three isoprenoid units. They are designated as alpha-, beta-, gamma-, and delta-tocopherol depending on the number and position of additional methyl substituents on the aromatic ring. Tocopherols occur in vegetable oils and vegetable oil products, almost exclusively with R,R,R configuration. Tocotrienols differ from tocopherols only in having three double bonds in the hydrocarbon chain.. vitamin E : Any member of a group of fat-soluble chromanols that exhibit biological activity against vitamin E deficiency. The vitamers in this class consists of a chroman-6-ol core which is substituted at position 2 by a methyl group and (also at position 2) either a saturated or a triply-unsaturated hydrocarbon chain consisting of three isoprenoid units. The major function of vitamin E is to act as a natural antioxidant by scavenging free radicals and molecular oxygen.. (R,R,R)-alpha-tocopherol : An alpha-tocopherol that has R,R,R configuration. The naturally occurring stereoisomer of alpha-tocopherol, it is found particularly in sunflower and olive oils.		2.0810alpha-tocopherolalgal metabolite;
antiatherogenic agent;
anticoagulant;
antioxidant;
antiviral agent;
EC 2.7.11.13 (protein kinase C) inhibitor;
immunomodulator;
micronutrient;
nutraceutical;
plant metabolite
ribavirin
Rebetron: Rebetron is tradename		2.08101-ribosyltriazole;
aromatic amide;
monocarboxylic acid amide;
primary carboxamide		anticoronaviral agent;
antiinfective agent;
antimetabolite;
antiviral agent;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
epicatechin
(-)-epicatechin : A catechin with (2R,3R)-configuration.		3.2110catechin;
polyphenol		antioxidant
hesperetin
[no description available]		3.25103'-hydroxyflavanones;
4'-methoxyflavanones;
monomethoxyflavanone;
trihydroxyflavanone		antineoplastic agent;
antioxidant;
plant metabolite
alpha-lapachone
alpha-lapachone: structure in first source		2.0410organic heterotricyclic compound;
organooxygen compound
mansonone e
mansonone E: a potent anti-bacterial sesquiterpenoid isolated from the dried root bark of Ulmus pumila; structure in first source		2.9940
mansonone f
mansonone F: a potent anti-bacterial sesquiterpenoid; structure in first source		2.0410
procyanidin b2
procyanidin B2 : A proanthocyanidin consisting of two molecules of (-)-epicatechin joined by a bond between positions 4 and 8' in a beta-configuration. Procyanidin B2 can be found in Cinchona pubescens (Chinchona, in the rind, bark and cortex), in Cinnamomum verum (Ceylon cinnamon, in the rind, bark and cortex), in Crataegus monogyna (Common hawthorn, in the flower and blossom), in Uncaria guianensis (Cat's claw, in the root), in Vitis vinifera (Common grape vine, in the leaf), in Litchi chinensis (litchi, in the pericarp), in the apple, in Ecdysanthera utilis and in red wine.		3.2110biflavonoid;
hydroxyflavan;
polyphenol;
proanthocyanidin		antioxidant;
metabolite
procyanidin b5
procyanidin B5 : A proanthocyanidin consisting of two molecules of (-)-epicatechin joined by a bond between positions 4 and 6' in beta-configuration. It can be found in grape seeds, in Hibiscus cannabinus (kenaf) root and bark, in apple and in cacao.		3.2110biflavonoid;
hydroxyflavan;
polyphenol;
proanthocyanidin		metabolite
procyanidin C1
procyanidin trimer C1: a flavonoid found in multiple plant sources including grape, apple, and cacao, which has antioxidant and anti-inflammatory properties. procyanidin C1 : A proanthocyanidin consisting of three (-)-epicatechin units joined by two successive (4beta->8)-linkages.		3.2110hydroxyflavan;
polyphenol;
proanthocyanidin		anti-inflammatory agent;
antioxidant;
EC 1.17.3.2 (xanthine oxidase) inhibitor;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
lipoxygenase inhibitor;
metabolite
7-hydroxycadalin
7-hydroxycadalin: isolated from Heterotheca inuloides; structure in first source		2.0810sesquiterpenoid
mansonone g
[no description available]		3.6220
Methyl nigakinone
4,5-dimethoxycanthin-6-one: an active metabolite of Picrasma quassiodes; structure in first source		2.0810beta-carbolines
cardamonin
cardamonin: found in Zingiberaceae; structure in first source		3.2510chalcones
sesquiterpenes
[no description available]		2.0710
naphthoquinones
Naphthoquinones: Naphthalene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.		2.4520
quercetin
[no description available]		3.25107-hydroxyflavonol;
pentahydroxyflavone		antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
kaempferol
[no description available]		3.25107-hydroxyflavonol;
flavonols;
tetrahydroxyflavone		antibacterial agent;
geroprotector;
human blood serum metabolite;
human urinary metabolite;
human xenobiotic metabolite;
plant metabolite
cucurbitacin d
cucurbitacin D: toxic constituent in edible gourd; see also records for cucurbitacins & specific cucurbitacins. cucurbitacin D : A cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 5 and 23.		3.2110cucurbitacin;
secondary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone
chrysin
chrysin : A dihydroxyflavone in which the two hydroxy groups are located at positions 5 and 7.		3.25107-hydroxyflavonol;
dihydroxyflavone		anti-inflammatory agent;
antineoplastic agent;
antioxidant;
EC 2.7.11.18 (myosin-light-chain kinase) inhibitor;
hepatoprotective agent;
plant metabolite
fustin
fustin : A dihydroflavonol that is the 2,3-dihydro derivative of fisetin.. tetrahydroxyflavanone : A hydroxyflavanone with atleast four hydroxy substituents.		3.2510
pyracrenic acid
pyracrenic acid: a lupane from bark of Pyracantha crenulata; structure given in first source		3.2110triterpenoidmetabolite
cinnamtannin a2
cinnamtannin A2: a tetrameric proanthcyanidin; isolated from cacao products; structure in first source. cinnamtannin A2 : A proanthocyanidin isolated from Cinnamomum cassia.		3.2110proanthocyanidinplant metabolite
warfarin
Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group.		2.0710benzenes;
hydroxycoumarin;
methyl ketone
ConditionIndicatedRelationship StrengthStudiesTrials
Benign Neoplasms
[description not available]		03.0610
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		03.0610