Compounds > 1-methoxyerythrabyssin ii
Page last updated: 2024-11-13

1-methoxyerythrabyssin ii

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

1-methoxyerythrabyssin II: from the bark of Erythrina subumbrans; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
ErythrinagenusA genus of leguminous shrubs or trees, mainly tropical, yielding useful compounds such as ALKALOIDS and PLANT LECTINS.[MeSH]FabaceaeThe large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of beans belong to this family.[MeSH]

Cross-References

ID SourceID
PubMed CID24761044
CHEMBL ID401566
MeSH IDM0519801

Synonyms (4)

Synonym
1-methoxyerythrabyssin ii
CHEMBL401566 ,
bdbm50355214
(6ar,11ar)-1-methoxy-2,10-bis(3-methylbut-2-enyl)-6a,11a-dihydro-6h-[1]benzofuro[3,2-c]chromene-3,9-diol
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
SialidaseClostridium perfringensIC50 (µMol)0.09000.00102.45729.8000AID622873
SialidaseClostridium perfringensKi0.11000.10301.97847.4100AID622872
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (12)

Assay IDTitleYearJournalArticle
AID1072992Bactericidal activity against Porphyromonas gingivalis ATCC 33277 after 3 days2014Journal of natural products, Mar-28, Volume: 77, Issue:3
Pyrano-isoflavans from Glycyrrhiza uralensis with antibacterial activity against Streptococcus mutans and Porphyromonas gingivalis.
AID622873Inhibition of Clostridium perfringens neuraminidase using 4-methylumbelliferyl-alpha-D-N-acetylneuraminic acid as substrate by fluorimetry2011Bioorganic & medicinal chemistry letters, Oct-15, Volume: 21, Issue:20
Potent inhibition of bacterial neuraminidase activity by pterocarpans isolated from the roots of Lespedeza bicolor.
AID327478Cytotoxicity against human BC cells2008Journal of natural products, Jan, Volume: 71, Issue:1
Erythrina alkaloids and a pterocarpan from the bark of Erythrina subumbrans.
AID1072991Antibacterial activity against Streptococcus mutans ATCC 35668 after 24 hrs by microbroth dilution assay2014Journal of natural products, Mar-28, Volume: 77, Issue:3
Pyrano-isoflavans from Glycyrrhiza uralensis with antibacterial activity against Streptococcus mutans and Porphyromonas gingivalis.
AID327479Cytotoxicity against human NCI-H187 cells2008Journal of natural products, Jan, Volume: 71, Issue:1
Erythrina alkaloids and a pterocarpan from the bark of Erythrina subumbrans.
AID1072993Antibacterial activity against Porphyromonas gingivalis ATCC 33277 after 24 hrs by microbroth dilution assay2014Journal of natural products, Mar-28, Volume: 77, Issue:3
Pyrano-isoflavans from Glycyrrhiza uralensis with antibacterial activity against Streptococcus mutans and Porphyromonas gingivalis.
AID1072990Bactericidal activity against Streptococcus mutans ATCC 35668 after 3 days2014Journal of natural products, Mar-28, Volume: 77, Issue:3
Pyrano-isoflavans from Glycyrrhiza uralensis with antibacterial activity against Streptococcus mutans and Porphyromonas gingivalis.
AID327476Antimycobacterial activity against Mycobacterium tuberculosis H37Ra by Alamar blue assay2008Journal of natural products, Jan, Volume: 71, Issue:1
Erythrina alkaloids and a pterocarpan from the bark of Erythrina subumbrans.
AID327477Cytotoxicity against human KB cells2008Journal of natural products, Jan, Volume: 71, Issue:1
Erythrina alkaloids and a pterocarpan from the bark of Erythrina subumbrans.
AID1617238Antiproliferative activity against human Jurkat cells at 5 to 100 uM incubated for 48 hrs by MTS assay2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antiproliferative Pterocarpans and Coumestans from
AID622871Ratio of quercetin IC50 to compound IC50 for Clostridium perfringens neuraminidase using 4-methylumbelliferyl-alpha-D-N-acetylneuraminic acid as substrate by fluorimetry2011Bioorganic & medicinal chemistry letters, Oct-15, Volume: 21, Issue:20
Potent inhibition of bacterial neuraminidase activity by pterocarpans isolated from the roots of Lespedeza bicolor.
AID622872Non-competitive inhibition of Clostridium perfringens neuraminidase using 4-methylumbelliferyl-alpha-D-N-acetylneuraminic acid as substrate by Lineweaver-Burk plot analysis2011Bioorganic & medicinal chemistry letters, Oct-15, Volume: 21, Issue:20
Potent inhibition of bacterial neuraminidase activity by pterocarpans isolated from the roots of Lespedeza bicolor.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's3 (60.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.20

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.20 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.99 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.20)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
penicillin g
Penicillin G: A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.. benzylpenicillin : A penicillin in which the substituent at position 6 of the penam ring is a phenylacetamido group.		2.110penicillin allergen;
penicillin		antibacterial drug;
drug allergen;
epitope
palladium
Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.		2.110metal allergen;
nickel group element atom;
platinum group metal atom
palladium chloride
palladium chloride: RN given refers to parent cpd; structure. palladium(II) chloride : A palladium coordination entity consisting of palladium(II) bound to two chlorine atoms.		2.110palladium coordination entitycatalyst
abyssinone v
abyssinone V: isolated from Erythrina sigboidea; RN from Chemical Abstracts Index Guide; structure given in first source. abyssinone V : A trihydroxyflavanone that is flavanone substituted by hydroxy groups at positions 5, 7 and 4' and prenyl groups at positions 3' and 5' respectively.		2.04104'-hydroxyflavanones;
phenols;
trihydroxyflavanone		metabolite
6,8-diprenylgenistein
6,8-diprenylgenistein: a lysoPAF acetyltransferase inhibitor isolated from licorice root; structure in first source. 5,7,4'-trihydroxy-6,8-diprenylisoflavone : A member of the class of 7-hydroxyisoflavones that is genistein substituted by prenyl groups at positions 6 and 8. It has been isolated from Derris scandens and Glycyrrhiza uralensis.		2.1107-hydroxyisoflavonesantibacterial agent;
plant metabolite
licoricidin
licoricidin: a lysoPAF acetyltransferase inhibitor isolated from licorice root; structure in first source. licoricidin : A member of the class of hydroxyisoflavans that is R-isoflavan with hydroxy groups at positions 7, 2' and 4', a methoxy group at position 5 and prenyl groups at positions 6 and 3'. Isolated from Glycyrrhiza uralensis, it exhibits antibacterial activity.		2.110aromatic ether;
hydroxyisoflavans;
methoxyisoflavan		antibacterial agent;
plant metabolite
Euchrestaflavanone A
[no description available]		2.0410flavanones
quercetin
[no description available]		2.06107-hydroxyflavonol;
pentahydroxyflavone		antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
genistein
[no description available]		2.1107-hydroxyisoflavonesantineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
human urinary metabolite;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor
tetracycline
Tetracycline: A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.. tetracycline : A broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria.		2.110
ConditionIndicatedRelationship StrengthStudiesTrials
Gas Gangrene
A severe condition resulting from bacteria invading healthy muscle from adjacent traumatized muscle or soft tissue. The infection originates in a wound contaminated with bacteria of the genus CLOSTRIDIUM. C. perfringens accounts for the majority of cases (over eighty percent), while C. noyvi, C. septicum, and C. histolyticum cause most of the other cases.		02.0610
Hematologic Malignancies
[description not available]		02.2110
Hematologic Neoplasms
Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.		02.2110
Fatty Liver, Nonalcoholic
[description not available]		02.610
Innate Inflammatory Response
[description not available]		02.610
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		07.610
Non-alcoholic Fatty Liver Disease
Fatty liver finding without excessive ALCOHOL CONSUMPTION.		02.610