1-methoxyerythrabyssin ii

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

1-methoxyerythrabyssin II: from the bark of Erythrina subumbrans; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Flora	Rank	Flora Definition	Family	Family Definition
Erythrina	genus	A genus of leguminous shrubs or trees, mainly tropical, yielding useful compounds such as ALKALOIDS and PLANT LECTINS.[MeSH]	Fabaceae	The large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of beans belong to this family.[MeSH]

Cross-References

ID Source	ID
PubMed CID	24761044
CHEMBL ID	401566
MeSH ID	M0519801

Synonyms (4)

Synonym
1-methoxyerythrabyssin ii
CHEMBL401566 ,
bdbm50355214
(6ar,11ar)-1-methoxy-2,10-bis(3-methylbut-2-enyl)-6a,11a-dihydro-6h-[1]benzofuro[3,2-c]chromene-3,9-diol

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Sialidase	Clostridium perfringens	IC50 (µMol)	0.0900	0.0010	2.4572	9.8000	AID622873
Sialidase	Clostridium perfringens	Ki	0.1100	0.1030	1.9784	7.4100	AID622872
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (12)

Assay ID	Title	Year	Journal	Article
AID1072992	Bactericidal activity against Porphyromonas gingivalis ATCC 33277 after 3 days	2014	Journal of natural products, Mar-28, Volume: 77, Issue:3	Pyrano-isoflavans from Glycyrrhiza uralensis with antibacterial activity against Streptococcus mutans and Porphyromonas gingivalis.
AID622873	Inhibition of Clostridium perfringens neuraminidase using 4-methylumbelliferyl-alpha-D-N-acetylneuraminic acid as substrate by fluorimetry	2011	Bioorganic & medicinal chemistry letters, Oct-15, Volume: 21, Issue:20	Potent inhibition of bacterial neuraminidase activity by pterocarpans isolated from the roots of Lespedeza bicolor.
AID327478	Cytotoxicity against human BC cells	2008	Journal of natural products, Jan, Volume: 71, Issue:1	Erythrina alkaloids and a pterocarpan from the bark of Erythrina subumbrans.
AID1072991	Antibacterial activity against Streptococcus mutans ATCC 35668 after 24 hrs by microbroth dilution assay	2014	Journal of natural products, Mar-28, Volume: 77, Issue:3	Pyrano-isoflavans from Glycyrrhiza uralensis with antibacterial activity against Streptococcus mutans and Porphyromonas gingivalis.
AID327479	Cytotoxicity against human NCI-H187 cells	2008	Journal of natural products, Jan, Volume: 71, Issue:1	Erythrina alkaloids and a pterocarpan from the bark of Erythrina subumbrans.
AID1072993	Antibacterial activity against Porphyromonas gingivalis ATCC 33277 after 24 hrs by microbroth dilution assay	2014	Journal of natural products, Mar-28, Volume: 77, Issue:3	Pyrano-isoflavans from Glycyrrhiza uralensis with antibacterial activity against Streptococcus mutans and Porphyromonas gingivalis.
AID1072990	Bactericidal activity against Streptococcus mutans ATCC 35668 after 3 days	2014	Journal of natural products, Mar-28, Volume: 77, Issue:3	Pyrano-isoflavans from Glycyrrhiza uralensis with antibacterial activity against Streptococcus mutans and Porphyromonas gingivalis.
AID327476	Antimycobacterial activity against Mycobacterium tuberculosis H37Ra by Alamar blue assay	2008	Journal of natural products, Jan, Volume: 71, Issue:1	Erythrina alkaloids and a pterocarpan from the bark of Erythrina subumbrans.
AID327477	Cytotoxicity against human KB cells	2008	Journal of natural products, Jan, Volume: 71, Issue:1	Erythrina alkaloids and a pterocarpan from the bark of Erythrina subumbrans.
AID1617238	Antiproliferative activity against human Jurkat cells at 5 to 100 uM incubated for 48 hrs by MTS assay	2019	Journal of natural products, 11-22, Volume: 82, Issue:11	Antiproliferative Pterocarpans and Coumestans from
AID622871	Ratio of quercetin IC50 to compound IC50 for Clostridium perfringens neuraminidase using 4-methylumbelliferyl-alpha-D-N-acetylneuraminic acid as substrate by fluorimetry	2011	Bioorganic & medicinal chemistry letters, Oct-15, Volume: 21, Issue:20	Potent inhibition of bacterial neuraminidase activity by pterocarpans isolated from the roots of Lespedeza bicolor.
AID622872	Non-competitive inhibition of Clostridium perfringens neuraminidase using 4-methylumbelliferyl-alpha-D-N-acetylneuraminic acid as substrate by Lineweaver-Burk plot analysis	2011	Bioorganic & medicinal chemistry letters, Oct-15, Volume: 21, Issue:20	Potent inhibition of bacterial neuraminidase activity by pterocarpans isolated from the roots of Lespedeza bicolor.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (20.00)	29.6817
2010's	3 (60.00)	24.3611
2020's	1 (20.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.20

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	13.20 (24.57)
Research Supply Index	1.79 (2.92)
Research Growth Index	4.99 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (13.20)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
penicillin g Penicillin G: A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.. benzylpenicillin : A penicillin in which the substituent at position 6 of the penam ring is a phenylacetamido group.	2.1	1	penicillin allergen; penicillin	antibacterial drug; drug allergen; epitope
palladium Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.	2.1	1	metal allergen; nickel group element atom; platinum group metal atom
palladium chloride palladium chloride: RN given refers to parent cpd; structure. palladium(II) chloride : A palladium coordination entity consisting of palladium(II) bound to two chlorine atoms.	2.1	1	palladium coordination entity	catalyst
abyssinone v abyssinone V: isolated from Erythrina sigboidea; RN from Chemical Abstracts Index Guide; structure given in first source. abyssinone V : A trihydroxyflavanone that is flavanone substituted by hydroxy groups at positions 5, 7 and 4' and prenyl groups at positions 3' and 5' respectively.	2.04	1	4'-hydroxyflavanones; phenols; trihydroxyflavanone	metabolite
6,8-diprenylgenistein 6,8-diprenylgenistein: a lysoPAF acetyltransferase inhibitor isolated from licorice root; structure in first source. 5,7,4'-trihydroxy-6,8-diprenylisoflavone : A member of the class of 7-hydroxyisoflavones that is genistein substituted by prenyl groups at positions 6 and 8. It has been isolated from Derris scandens and Glycyrrhiza uralensis.	2.1	1	7-hydroxyisoflavones	antibacterial agent; plant metabolite
licoricidin licoricidin: a lysoPAF acetyltransferase inhibitor isolated from licorice root; structure in first source. licoricidin : A member of the class of hydroxyisoflavans that is R-isoflavan with hydroxy groups at positions 7, 2' and 4', a methoxy group at position 5 and prenyl groups at positions 6 and 3'. Isolated from Glycyrrhiza uralensis, it exhibits antibacterial activity.	2.1	1	aromatic ether; hydroxyisoflavans; methoxyisoflavan	antibacterial agent; plant metabolite
Euchrestaflavanone A [no description available]	2.04	1	flavanones
quercetin [no description available]	2.06	1	7-hydroxyflavonol; pentahydroxyflavone	antibacterial agent; antineoplastic agent; antioxidant; Aurora kinase inhibitor; chelator; EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor; geroprotector; phytoestrogen; plant metabolite; protein kinase inhibitor; radical scavenger
genistein [no description available]	2.1	1	7-hydroxyisoflavones	antineoplastic agent; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; geroprotector; human urinary metabolite; phytoestrogen; plant metabolite; tyrosine kinase inhibitor
tetracycline Tetracycline: A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.. tetracycline : A broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria.	2.1	1

Condition	Relationship Strength	Studies
Gas Gangrene A severe condition resulting from bacteria invading healthy muscle from adjacent traumatized muscle or soft tissue. The infection originates in a wound contaminated with bacteria of the genus CLOSTRIDIUM. C. perfringens accounts for the majority of cases (over eighty percent), while C. noyvi, C. septicum, and C. histolyticum cause most of the other cases.	2.06	1
Hematologic Malignancies [description not available]	2.21	1
Hematologic Neoplasms Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.	2.21	1
Fatty Liver, Nonalcoholic [description not available]	2.6	1
Innate Inflammatory Response [description not available]	2.6	1
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	7.6	1
Non-alcoholic Fatty Liver Disease Fatty liver finding without excessive ALCOHOL CONSUMPTION.	2.6	1

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