SH3 domain binding

Definition

Target type: molecularfunction

Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins. [GOC:go_curators, Pfam:PF00018]

SH3 domains are protein modules that recognize and bind to proline-rich motifs in other proteins. These interactions play critical roles in a wide range of cellular processes, including signal transduction, cytoskeletal organization, and protein trafficking. SH3 domains typically bind to short sequences containing a core proline residue, often flanked by basic and hydrophobic residues. This binding is mediated by a combination of hydrophobic interactions, hydrogen bonds, and electrostatic interactions. The specific sequence requirements for SH3 domain binding can vary depending on the individual domain. However, the core proline residue is generally essential for binding. SH3 domain binding can be regulated by phosphorylation or other post-translational modifications. For example, phosphorylation of a proline-rich motif can disrupt its binding to an SH3 domain. SH3 domains can also bind to other protein modules, such as SH2 domains and WW domains. These interactions can create complex protein networks that regulate cellular function. The binding of SH3 domains to proline-rich motifs is crucial for the proper function of many signaling pathways. For example, SH3 domains are involved in the activation of the MAPK pathway, a key signaling cascade that regulates cell growth and differentiation. SH3 domains also play important roles in the regulation of the immune system. For example, SH3 domains are involved in the activation of T cell receptors, which are essential for the recognition and destruction of pathogens. The study of SH3 domains has provided valuable insights into the molecular mechanisms underlying protein-protein interactions. Understanding the specificity of SH3 domain binding has also led to the development of new therapeutic strategies for diseases such as cancer and inflammatory disorders.'
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Proteins (25)

Compounds (1,091)