homeostasis of number of cells

Definition

Target type: biologicalprocess

Any biological process involved in the maintenance of the steady-state number of cells within a population of cells. [GOC:isa_complete]

Homeostasis of cell number, also known as cellular homeostasis, is a fundamental biological process that ensures the maintenance of a stable and appropriate number of cells within an organism. This process involves a delicate balance between cell proliferation (growth and division) and cell death (apoptosis).

**Cellular Proliferation:**

* Cells divide to produce new cells, replacing damaged or old ones.
* This process is tightly regulated by signaling pathways that respond to cues from the environment, such as growth factors and nutrients.
* The cell cycle, a series of events that lead to cell division, is carefully controlled by checkpoints that ensure the integrity of the genetic material.

**Cell Death:**

* Apoptosis is a programmed cell death process that eliminates unwanted or damaged cells.
* It involves a series of biochemical events that lead to the dismantling of the cell's components in a controlled manner.
* Apoptosis is crucial for maintaining tissue homeostasis and eliminating cells that are no longer needed or have become potentially harmful.

**Regulation of Homeostasis:**

* Homeostasis of cell number is a dynamic process that constantly adapts to changing environmental conditions.
* Numerous factors, including hormones, growth factors, and signaling molecules, play a role in regulating cell proliferation and death.
* Feedback loops ensure that the number of cells remains within a stable range, preventing overgrowth or depletion.

**Disruptions in Homeostasis:**

* Disruptions in cellular homeostasis can lead to various diseases, such as cancer, where uncontrolled cell proliferation occurs.
* Conversely, excessive apoptosis can contribute to degenerative diseases, such as Alzheimer's disease.

**In summary, homeostasis of cell number is a vital process that ensures the proper function and development of organisms. It involves a precise balance between cell proliferation and death, which is tightly regulated by a complex network of signaling pathways and feedback loops.**'
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Proteins (6)

Compounds (306)