bile acid binding

Definition

Target type: molecularfunction

Binding to a bile acid, a steroid carboxylic acids occurring in bile. [GOC:rph]

Bile acid binding is a crucial molecular function involving the interaction of proteins or other molecules with bile acids. Bile acids are synthesized in the liver from cholesterol and play vital roles in digestion and lipid metabolism. They act as detergents, emulsifying dietary fats in the small intestine, which promotes their digestion and absorption. The binding of bile acids to specific proteins, known as bile acid transporters, is essential for their transport across cell membranes. These transporters facilitate the uptake of bile acids from the intestinal lumen, their secretion into bile, and their reabsorption in the ileum. Bile acid binding can also influence signaling pathways, as some bile acids act as ligands for nuclear receptors, such as the farnesoid X receptor (FXR). Activation of FXR regulates gene expression involved in bile acid synthesis, transport, and metabolism. Moreover, bile acid binding proteins can contribute to the detoxification of potentially harmful bile acids by sequestering them away from sensitive tissues or organs. Overall, bile acid binding is a multifaceted process that is critical for maintaining lipid homeostasis, regulating cholesterol metabolism, and promoting intestinal health.'
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Proteins (9)

Compounds (318)