interleukin-8 receptor activity

Definition

Target type: molecularfunction

Combining with interleukin-8 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]

Interleukin-8 receptor activity is a molecular function that describes the ability of a protein to bind to interleukin-8 (IL-8), a chemokine that plays a crucial role in inflammation and immune responses. IL-8 receptors, specifically CXCR1 and CXCR2, are G protein-coupled receptors (GPCRs) expressed on the surface of various cells, including neutrophils, T cells, and endothelial cells. Upon binding to IL-8, these receptors initiate a signaling cascade that involves the activation of heterotrimeric G proteins, leading to the production of second messengers like inositol trisphosphate (IP3) and diacylglycerol (DAG). This signaling pathway ultimately results in the recruitment and activation of neutrophils, the primary effector cells in the innate immune response. The recruitment of neutrophils to the site of inflammation is crucial for the clearance of pathogens and damaged tissue. Furthermore, IL-8 receptor activation can also stimulate the release of other pro-inflammatory mediators, such as chemokines and cytokines, further amplifying the inflammatory response. The molecular function of IL-8 receptor activity is therefore essential for orchestrating the inflammatory response, a complex process that involves the coordinated action of various cells and signaling molecules.'
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Proteins (2)

Compounds (18)