Compounds > betulin-3-caffeate
Page last updated: 2024-11-12

betulin-3-caffeate

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Description

betulin-3-caffeate: has antineoplastic activity; isolated from Hibiscus syriacus; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10153267
CHEMBL ID502663
SCHEMBL ID3960460
SCHEMBL ID5448728
MeSH IDM000604726

Synonyms (16)

Synonym
89130-86-9
betulin caffeate
CHEMBL502663 ,
betulin-3beta-caffeate
betulin-3-caffeate
SCHEMBL3960460
SCHEMBL5448728
[(1r,3as,5ar,5br,7ar,9s,11ar,11br,13ar,13br)-3a-(hydroxymethyl)-1-isopropenyl-5a,5b,8,8,11a-pentamethyl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysen-9-yl] (e)-3-(3,4-dihydroxyphenyl)prop-2-enoate
FS-9135
[(1r,3as,5ar,5br,7ar,9s,11ar,11br,13ar,13br)-3a-(hydroxymethyl)-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysen-9-yl] (e)-3-(3,4-dihydroxyphenyl)prop-2-enoate
lup-20(29)en-28-ol-3-yl caffeate
betulin-3-caffeate; betulin-3-yl caffeate; caffeic acid betulin ester; lup-20(29)en-28-ol 3-caffeate
AKOS040761412
bdbm50601888
HY-N2934
CS-0023553
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Sodium/bile acid cotransporterHomo sapiens (human)IC50 (µMol)6.00001.00005.92679.6000AID1896150
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (11)

Processvia Protein(s)Taxonomy
sodium ion transportSodium/bile acid cotransporterHomo sapiens (human)
response to organic cyclic compoundSodium/bile acid cotransporterHomo sapiens (human)
bile acid and bile salt transportSodium/bile acid cotransporterHomo sapiens (human)
response to nutrient levelsSodium/bile acid cotransporterHomo sapiens (human)
bile acid signaling pathwaySodium/bile acid cotransporterHomo sapiens (human)
response to estrogenSodium/bile acid cotransporterHomo sapiens (human)
response to ethanolSodium/bile acid cotransporterHomo sapiens (human)
symbiont entry into host cellSodium/bile acid cotransporterHomo sapiens (human)
transmembrane transportSodium/bile acid cotransporterHomo sapiens (human)
cellular response to xenobiotic stimulusSodium/bile acid cotransporterHomo sapiens (human)
regulation of bile acid secretionSodium/bile acid cotransporterHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (3)

Processvia Protein(s)Taxonomy
virus receptor activitySodium/bile acid cotransporterHomo sapiens (human)
protein bindingSodium/bile acid cotransporterHomo sapiens (human)
bile acid:sodium symporter activitySodium/bile acid cotransporterHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (2)

Processvia Protein(s)Taxonomy
plasma membraneSodium/bile acid cotransporterHomo sapiens (human)
basolateral plasma membraneSodium/bile acid cotransporterHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (27)

Assay IDTitleYearJournalArticle
AID402648Antibacterial activity against Bacillus cereus CECT 496 up to 40 ug/mL by broth microdilution method2005Journal of natural products, Jul, Volume: 68, Issue:7
Lupane triterpenoids from Maytenus species.
AID402646Antibacterial activity against Enterococcus faecalis CECT 795 up to 40 ug/mL by broth microdilution method2005Journal of natural products, Jul, Volume: 68, Issue:7
Lupane triterpenoids from Maytenus species.
AID1364708Cytotoxicity against human SK-MEL-2 cells assessed as inhibition of cell growth by SRB assay2017Journal of natural products, 04-28, Volume: 80, Issue:4
Bioactive Triterpenoids from the Twigs of Chaenomeles sinensis.
AID1364707Cytotoxicity against human SKOV3 cells assessed as inhibition of cell growth by SRB assay2017Journal of natural products, 04-28, Volume: 80, Issue:4
Bioactive Triterpenoids from the Twigs of Chaenomeles sinensis.
AID402655Antibacterial activity against Pseudomonas aeruginosa AK 958 up to 40 ug/mL by broth microdilution method2005Journal of natural products, Jul, Volume: 68, Issue:7
Lupane triterpenoids from Maytenus species.
AID402652Antibacterial activity against Escherichia coli CECT 99 up to 40 ug/mL by broth microdilution method2005Journal of natural products, Jul, Volume: 68, Issue:7
Lupane triterpenoids from Maytenus species.
AID400568Cytotoxicity against vincristine-sensitive human KB cells after 72 hrs by alamar blue assay2004Journal of natural products, Mar, Volume: 67, Issue:3
Four new triterpenoids from Maytenus ilicifolia.
AID402661Cytotoxicity against human Hep2 cells after 48 hrs by MTT assay2005Journal of natural products, Jul, Volume: 68, Issue:7
Lupane triterpenoids from Maytenus species.
AID402662Cytotoxicity against african green monkey Vero cells after 48 hrs by MTT assay2005Journal of natural products, Jul, Volume: 68, Issue:7
Lupane triterpenoids from Maytenus species.
AID402644Antibacterial activity against Staphylococcus epidermidis CECT 232 up to 40 ug/mL by broth microdilution method2005Journal of natural products, Jul, Volume: 68, Issue:7
Lupane triterpenoids from Maytenus species.
AID402656Antifungal activity against Candida albicans UBC1 up to 40 ug/mL by broth microdilution method2005Journal of natural products, Jul, Volume: 68, Issue:7
Lupane triterpenoids from Maytenus species.
AID1364709Cytotoxicity against human HCT15 cells assessed as inhibition of cell growth by SRB assay2017Journal of natural products, 04-28, Volume: 80, Issue:4
Bioactive Triterpenoids from the Twigs of Chaenomeles sinensis.
AID402649Antibacterial activity against Bacillus pumilus CECT 29 up to 40 ug/mL by broth microdilution method2005Journal of natural products, Jul, Volume: 68, Issue:7
Lupane triterpenoids from Maytenus species.
AID1364706Cytotoxicity against human A549 cells assessed as inhibition of cell growth by SRB assay2017Journal of natural products, 04-28, Volume: 80, Issue:4
Bioactive Triterpenoids from the Twigs of Chaenomeles sinensis.
AID402660Cytotoxicity against human HeLa cells after 48 hrs by MTT assay2005Journal of natural products, Jul, Volume: 68, Issue:7
Lupane triterpenoids from Maytenus species.
AID402645Antibacterial activity against Staphylococcus saprophyticus CECT 235 up to 40 ug/mL by broth microdilution method2005Journal of natural products, Jul, Volume: 68, Issue:7
Lupane triterpenoids from Maytenus species.
AID402643Antibacterial activity against Staphylococcus aureus ATCC 6538 up to 40 ug/mL by broth microdilution method2005Journal of natural products, Jul, Volume: 68, Issue:7
Lupane triterpenoids from Maytenus species.
AID402651Antibacterial activity against Mycobacterium smegmatis CECT 3032 up to 40 ug/mL by broth microdilution method2005Journal of natural products, Jul, Volume: 68, Issue:7
Lupane triterpenoids from Maytenus species.
AID402654Antibacterial activity against Salmonella sp. CECT 456 up to 40 ug/mL by broth microdilution method2005Journal of natural products, Jul, Volume: 68, Issue:7
Lupane triterpenoids from Maytenus species.
AID1228702Antiviral activity against HIV1 NL4.3-Ren infected in human MT2 cells assessed as inhibition of viral growth at 10 uM measured 48 hrs post infection by luminometry2015Journal of natural products, May-22, Volume: 78, Issue:5
Isolation, Structural Modification, and HIV Inhibition of Pentacyclic Lupane-Type Triterpenoids from Cassine xylocarpa and Maytenus cuzcoina.
AID402647Antibacterial activity against Bacillus subtilis CECT 39 up to 40 ug/mL by broth microdilution method2005Journal of natural products, Jul, Volume: 68, Issue:7
Lupane triterpenoids from Maytenus species.
AID1896150Inhibition of HBV subgenotype D3 [3H]-myr-preS1 (2 to 48 residues) peptide binding to human NTCP in HEK293 cells preincubated for 5 mins followed by substrate addition and measured after 10 mins using by microplate scintillation counter analysis2022Journal of medicinal chemistry, 10-13, Volume: 65, Issue:19
Inhibiting Sodium Taurocholate Cotransporting Polypeptide in HBV-Related Diseases: From Biological Function to Therapeutic Potential.
AID402653Antibacterial activity against Proteus mirabilis CECT170 up to 40 ug/mL by broth microdilution method2005Journal of natural products, Jul, Volume: 68, Issue:7
Lupane triterpenoids from Maytenus species.
AID402650Antibacterial activity against Bacillus megaterium CECT 44 up to 40 ug/mL by broth microdilution method2005Journal of natural products, Jul, Volume: 68, Issue:7
Lupane triterpenoids from Maytenus species.
AID400571Induction of human HL60 cell differentiation assessed as morphological change at 0.05 to 25 ug/ml by phase-contrast microscopy2004Journal of natural products, Mar, Volume: 67, Issue:3
Four new triterpenoids from Maytenus ilicifolia.
AID1896151Selectivity index, ratio of IC50 for inhibition of human NTCP mediated TCA uptake in HEK293 cells overexpressing NTCP to IC50 for inhibition of HBV subgenotype D3 [3H]-myr-preS1 (2 to 48 residues) peptide binding to human NTCP in HEK293 cells overexpressi2022Journal of medicinal chemistry, 10-13, Volume: 65, Issue:19
Inhibiting Sodium Taurocholate Cotransporting Polypeptide in HBV-Related Diseases: From Biological Function to Therapeutic Potential.
AID400572Reversal of vincristine resistance in human KB/VJ300 cells2004Journal of natural products, Mar, Volume: 67, Issue:3
Four new triterpenoids from Maytenus ilicifolia.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (33.33)29.6817
2010's3 (50.00)24.3611
2020's1 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (16.67%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (83.33%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
azelastine
azelastine: azeptin is azelastine hydrochloride; structure; eye drop formulation effective in relieving symptoms of allergic conjunctivitis; do not confuse with 5-loxin which is an extract of Boswellia. azelastine : A phthalazine compound having an oxo substituent at the 1-position, a 1-methylazepan-4-yl group at the 2-position and a 4-chlorobenzyl substituent at the 4-position.		3.5110monochlorobenzenes;
phthalazines;
tertiary amino compound		anti-allergic agent;
anti-asthmatic drug;
bronchodilator agent;
EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor;
H1-receptor antagonist;
platelet aggregation inhibitor
ciglitazone
ciglitazone: structure given in second source; PPAR agonist used for type II diabetes. ciglitazone : An aromatic ether that consists of 1,3-thiazolidine-2,4-dione with position 5 substituted by a 4-[(1-methylcyclohexyl)methoxy]benzyl group. A selective PPARgamma agonist.		3.5110aromatic ether;
thiazolidinone		antineoplastic agent;
insulin-sensitizing drug
avapro
Irbesartan: A spiro compound, biphenyl and tetrazole derivative that acts as an angiotensin II type 1 receptor antagonist. It is used in the management of HYPERTENSION, and in the treatment of kidney disease.. irbesartan : A biphenylyltetrazole that is an angiotensin II receptor antagonist used mainly for the treatment of hypertension.		3.5110azaspiro compound;
biphenylyltetrazole		angiotensin receptor antagonist;
antihypertensive agent;
environmental contaminant;
xenobiotic
sulfasalazine
Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907). sulfasalazine : An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.		3.5110
troglitazone
Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.		3.5110chromanes;
thiazolidinone		anticoagulant;
anticonvulsant;
antineoplastic agent;
antioxidant;
EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor;
ferroptosis inhibitor;
hypoglycemic agent;
platelet aggregation inhibitor;
vasodilator agent
ici 204,219
zafirlukast: a leukotriene D4 receptor antagonist		3.5110carbamate ester;
indoles;
N-sulfonylcarboxamide		anti-asthmatic agent;
leukotriene antagonist
3,3',5-triiodothyroacetic acid
tiratricol : A monocarboxylic acid that is (4-hydroxy-3,5-diiodophenyl)acetic acid in which the phenolic hydroxy group has been replaced by a 4-hydroxy-3-iodophenoxy group. It is a thyroid hormone analogue that has been used in the treatment of thyroid hormone resistance syndrome.		3.5110
taurocholic acid
Taurocholic Acid: The product of conjugation of cholic acid with taurine. Its sodium salt is the chief ingredient of the bile of carnivorous animals. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as a cholagogue and cholerectic.. taurocholate : An organosulfonate oxoanion that is the conjugate base of taurocholic acid.. taurocholic acid : A bile acid taurine conjugate of cholic acid that usually occurs as the sodium salt of bile in mammals.		3.5110amino sulfonic acid;
bile acid taurine conjugate		human metabolite
c.i. direct blue 1
[no description available]		3.5110
betulinic acid
[no description available]		2.1510hydroxy monocarboxylic acid;
pentacyclic triterpenoid		anti-HIV agent;
anti-inflammatory agent;
antimalarial;
antineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
plant metabolite
epigallocatechin gallate
epigallocatechin gallate: a steroid 5alpha-reductase inhibitor and antimutagen in green tea (Camellia sinensis). (-)-epigallocatechin 3-gallate : A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.		3.5110flavans;
gallate ester;
polyphenol		antineoplastic agent;
antioxidant;
apoptosis inducer;
geroprotector;
Hsp90 inhibitor;
neuroprotective agent;
plant metabolite
betulin
betulin: isolated from various white birch bark (BETULA). betulin : A pentacyclic triterpenoid that is lupane having a double bond at position 20(29) as well as 3beta-hydroxy and 28-hydroxymethyl substituents.		4.0840diol;
pentacyclic triterpenoid		analgesic;
anti-inflammatory agent;
antineoplastic agent;
antiviral agent;
metabolite
Tormentic acid
tormentic acid: aglycone of Rosamultin		2.1510triterpenoidmetabolite
maslinic acid
(2Alpha,3beta)-2,3-dihydroxyolean-12-en-28-oic acid: from Luehea divaricata and Agrimonia eupatoria		2.1510dihydroxy monocarboxylic acid;
pentacyclic triterpenoid		anti-inflammatory agent;
antineoplastic agent;
antioxidant;
plant metabolite
rosiglitazone
[no description available]		3.5110aminopyridine;
thiazolidinediones		EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor;
ferroptosis inhibitor;
insulin-sensitizing drug
lupenone
lupenone: structure in first source		2.4620triterpenoidmetabolite
erythrodiol
[no description available]		2.0210diol;
pentacyclic triterpenoid;
primary alcohol;
secondary alcohol		plant metabolite
omega-n-methylarginine
omega-N-Methylarginine: A competitive inhibitor of nitric oxide synthetase.. N(omega)-methyl-L-arginine : A L-arginine derivative with a N(omega)-methyl substituent.		2.1510amino acid zwitterion;
arginine derivative;
guanidines;
L-arginine derivative;
non-proteinogenic L-alpha-amino acid
ezetimibe
Ezetimibe: An azetidine derivative and ANTICHOLESTEREMIC AGENT that inhibits intestinal STEROL absorption. It is used to reduce total CHOLESTEROL; LDL CHOLESTEROL, and APOLIPOPROTEINS B in the treatment of HYPERLIPIDEMIAS.. ezetimibe : A beta-lactam that is azetidin-2-one which is substituted at 1, 3, and 4 by p-fluorophenyl, 3-(p-fluorophenyl)-3-hydroxypropyl, and 4-hydroxyphenyl groups, respectively (the 3R,3'S,4S enantiomer).		3.5110azetidines;
beta-lactam;
organofluorine compound		anticholesteremic drug;
antilipemic drug;
antimetabolite
lupeol
[no description available]		2.4620pentacyclic triterpenoid;
secondary alcohol		anti-inflammatory drug;
plant metabolite
ochraceolide a
ochraceolide A: structure given in first source; isolated from Kokoona ochracea stem bark		2.1110
ritonavir
Ritonavir: An HIV protease inhibitor that works by interfering with the reproductive cycle of HIV. It also inhibits CYTOCHROME P-450 CYP3A.. ritonavir : An L-valine derivative that is L-valinamide in which alpha-amino group has been acylated by a [(2-isopropyl-1,3-thiazol-4-yl)methyl]methylcarbamoyl group and in which a hydrogen of the carboxamide amino group has been replaced by a (2R,4S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl group. A CYP3A inhibitor and antiretroviral drug from the protease inhibitor class used to treat HIV infection and AIDS, it is often used as a fixed-dose combination with another protease inhibitor, lopinavir. Also used in combination with dasabuvir sodium hydrate, ombitasvir and paritaprevir (under the trade name Viekira Pak) for treatment of chronic hepatitis C virus genotype 1 infection as well as cirrhosis of the liver.		3.51101,3-thiazoles;
carbamate ester;
carboxamide;
L-valine derivative;
ureas		antiviral drug;
environmental contaminant;
HIV protease inhibitor;
xenobiotic
bevirimat
bevirimat: an HIV inhibitor; disrupts late step in processing HIV Major Core Protein p24, preventing the capsid precursor p25 from being converted to mature capsid p24. bevirimat : A pentacyclic triterpenoid obtained by the formal condensation of 2,2-dimethylsuccinic acid with the 3-hydroxy group of betulinic acid. It is isolated from the Chinese herb Syzygium claviflorum. The first in the class of HIV-1 maturation inhibitors to be studied in humans, bevirimat was identified as a potent HIV drug candidate and several clinical trials were conducted, but development into a new drug was plagued by numerous resistance-related problems.		2.1110dicarboxylic acid monoester;
monocarboxylic acid;
pentacyclic triterpenoid		HIV-1 maturation inhibitor;
metabolite
betulonal
betulonal: originally isolated from white birch bark (Betula pendula); structure in first source		2.1110
3-epi-betulinic acid
[no description available]		2.0210
curcumin
Curcumin: A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.. curcumin : A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.		3.5110aromatic ether;
beta-diketone;
diarylheptanoid;
enone;
polyphenol		anti-inflammatory agent;
antifungal agent;
antineoplastic agent;
biological pigment;
contraceptive drug;
dye;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor;
EC 1.8.1.9 (thioredoxin reductase) inhibitor;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
flavouring agent;
food colouring;
geroprotector;
hepatoprotective agent;
immunomodulator;
iron chelator;
ligand;
lipoxygenase inhibitor;
metabolite;
neuroprotective agent;
nutraceutical;
radical scavenger
quercetin
[no description available]		3.51107-hydroxyflavonol;
pentahydroxyflavone		antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
shogaol
shogaol: from ginger, ZINGIBER OFFICINALE; less mutagenic than GINGEROL; structure given in first source		2.1510enone;
monomethoxybenzene;
phenols
ergosterol-5,8-peroxide
ergosterol-5,8-peroxide: also inhibits sulfatase; isolated from fungus Cercospora kikuchii; structure given in first source. ergosterol peroxide : An ergostanoid that is ergosta-6,22-dien-3-ol with a peroxy group between positions 5 and 8 (the 3beta,5alpha,8alpha,22E stereoisomer). Isolated from Ganoderma lucidum and Cordyceps sinensis, it exhibits antimycobacterial, trypanocidal and antineoplastic activities.		3.51103beta-sterol;
ergostanoid;
organic peroxide;
phytosterols		antimycobacterial drug;
antineoplastic agent;
metabolite;
trypanocidal drug
pyracrenic acid
pyracrenic acid: a lupane from bark of Pyracantha crenulata; structure given in first source		2.1510triterpenoidmetabolite
corosolic acid
[no description available]		2.1510triterpenoidmetabolite
betulone
[no description available]		2.4620triterpenoidmetabolite
2alpha,3beta-dihydroxy-20(29)-lupen-28-oic acid
alphitolic acid: from the aerial parts of Gouania longipetala; structure in first source. 2alpha,3beta-dihydroxy-20(29)-lupen-28-oic acid : A pentacyclic triterpenoid that is betulinic acid carrying an additional alpha-hydroxy group at position 2. It has been isolated from Breynia fruticosa.		2.1510dihydroxy monocarboxylic acid;
pentacyclic triterpenoid		plant metabolite
tak-875
[no description available]		3.5110biphenyls
epi-maslinic acid
epi-maslinic acid : A pentacyclic triterpenoid that is 3alpha-hydroxy epimer of maslinic acid. Isolated from Prunella vulgaris and Isodon japonicus, it exhibits anti-inflammatory activity.		2.1510dihydroxy monocarboxylic acid;
pentacyclic triterpenoid		anti-inflammatory agent;
metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Hepatitis B Virus Infection
[description not available]		03.3310
Hepatocellular Carcinoma
[description not available]		03.3310
Cancer of Liver
[description not available]		03.3310
Hepatitis B
INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.		03.3310
Carcinoma, Hepatocellular
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.		03.3310
Liver Neoplasms
Tumors or cancer of the LIVER.		03.3310