Page last updated: 2024-12-05

phthivazide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Cross-References

ID SourceID
PubMed CID135412163
CHEMBL ID2105120
CHEBI ID135117
SCHEMBL ID436184
MeSH IDM0011773

Synonyms (47)

Synonym
MLS001331695
isonicotinic acid vanillylidenehydrazide
isonicotinic acid, vanillylidenehydrazide
vanizide
phthivazid
nsc-31725
phthivazide
vanicid
vanillaberon
ftivazide
149-17-7
nsc31725
ftivazid
n'-{(1e)-[4-hydroxy-3-(methyloxy)phenyl]methylidene}pyridine-4-carbohydrazide
phtivazide
4-pyridinecarboxylic acid, ((4-hydroxy-3-methoxyphenyl)methylene)hydrazide
nsc 31725
phtivazid
isonicotinic acid (4-hydroxy-3-methoxy-benzylidene)-hydrazide
n-[(e)-(4-hydroxy-3-methoxy-phenyl)methyleneamino]pyridine-4-carboxamide
MLS001211239
smr000516769
vancide
MLS001183794
MLS001240247
n'-[(e)-(4-hydroxy-3-methoxyphenyl)methylidene]pyridine-4-carbohydrazide
CHEBI:135117
AKOS000567419
n'-[(z)-(3-methoxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]pyridine-4-carbohydrazide
NCGC00245297-02
NCGC00245297-01
CHEMBL2105120
AKOS005380583
AB01209617-01
SCHEMBL436184
PSWOBQSIXLVPDV-CXUHLZMHSA-N
n'-[(4-hydroxy-3-methoxyphenyl)methylidene]isonicotinohydrazide #
AE-641/02422012
n'-(4-hydroxy-3-methoxybenzylidene)isonicotinohydrazide
n'-[(e)-(4-hydroxy-3-methoxyphenyl)methylidene]isonicotinohydrazide
(e)-n'-(4'-hydroxy-3-methoxybenzylidene)isonicotinohydrazide (3g)
bdbm223077
n'-[(e)-4-hydroxy-3-methoxybenzylidene]pyridine-4-carbohydrazide
n-[(e)-(4-hydroxy-3-methoxyphenyl)methylideneamino]pyridine-4-carboxamide
Z49547277
CS-0821883
HY-W716673
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (17)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
USP1 protein, partialHomo sapiens (human)Potency0.22390.031637.5844354.8130AID743255
IDH1Homo sapiens (human)Potency23.10930.005210.865235.4813AID686970
lysosomal alpha-glucosidase preproproteinHomo sapiens (human)Potency39.81070.036619.637650.1187AID2100
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency16.36010.00419.984825.9290AID504444
importin subunit beta-1 isoform 1Homo sapiens (human)Potency50.11875.804836.130665.1308AID540263
snurportin-1Homo sapiens (human)Potency50.11875.804836.130665.1308AID540263
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1Homo sapiens (human)Potency50.11870.425612.059128.1838AID504891
urokinase-type plasminogen activator precursorMus musculus (house mouse)Potency3.98110.15855.287912.5893AID540303
plasminogen precursorMus musculus (house mouse)Potency3.98110.15855.287912.5893AID540303
urokinase plasminogen activator surface receptor precursorMus musculus (house mouse)Potency3.98110.15855.287912.5893AID540303
gemininHomo sapiens (human)Potency1.25890.004611.374133.4983AID624297
muscleblind-like protein 1 isoform 1Homo sapiens (human)Potency11.22020.00419.962528.1838AID2675
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
MyeloperoxidaseHomo sapiens (human)IC50 (µMol)0.46000.02001.88117.6800AID1337095
Alkaline phosphatase, tissue-nonspecific isozyme Bos taurus (cattle)IC50 (µMol)1.13500.35002.57407.3400AID1802638
Intestinal-type alkaline phosphataseBos taurus (cattle)IC50 (µMol)1.13500.35002.88337.3400AID1802638
5'-nucleotidaseRattus norvegicus (Norway rat)IC50 (µMol)0.41000.14000.78671.9000AID1802637
5'-nucleotidaseHomo sapiens (human)IC50 (µMol)0.41000.05002.24118.2000AID1802637
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (41)

Processvia Protein(s)Taxonomy
hydrogen peroxide catabolic processMyeloperoxidaseHomo sapiens (human)
response to yeastMyeloperoxidaseHomo sapiens (human)
hypochlorous acid biosynthetic processMyeloperoxidaseHomo sapiens (human)
respiratory burst involved in defense responseMyeloperoxidaseHomo sapiens (human)
defense responseMyeloperoxidaseHomo sapiens (human)
response to oxidative stressMyeloperoxidaseHomo sapiens (human)
response to mechanical stimulusMyeloperoxidaseHomo sapiens (human)
removal of superoxide radicalsMyeloperoxidaseHomo sapiens (human)
response to foodMyeloperoxidaseHomo sapiens (human)
response to lipopolysaccharideMyeloperoxidaseHomo sapiens (human)
low-density lipoprotein particle remodelingMyeloperoxidaseHomo sapiens (human)
hydrogen peroxide catabolic processMyeloperoxidaseHomo sapiens (human)
negative regulation of apoptotic processMyeloperoxidaseHomo sapiens (human)
defense response to fungusMyeloperoxidaseHomo sapiens (human)
response to gold nanoparticleMyeloperoxidaseHomo sapiens (human)
defense response to bacteriumMyeloperoxidaseHomo sapiens (human)
endochondral ossificationAlkaline phosphatase, tissue-nonspecific isozyme Bos taurus (cattle)
developmental process involved in reproductionAlkaline phosphatase, tissue-nonspecific isozyme Bos taurus (cattle)
cellular homeostasisAlkaline phosphatase, tissue-nonspecific isozyme Bos taurus (cattle)
bone mineralizationAlkaline phosphatase, tissue-nonspecific isozyme Bos taurus (cattle)
biomineral tissue developmentAlkaline phosphatase, tissue-nonspecific isozyme Bos taurus (cattle)
response to vitamin DAlkaline phosphatase, tissue-nonspecific isozyme Bos taurus (cattle)
response to vitamin B6Alkaline phosphatase, tissue-nonspecific isozyme Bos taurus (cattle)
pyridoxal phosphate metabolic processAlkaline phosphatase, tissue-nonspecific isozyme Bos taurus (cattle)
response to antibioticAlkaline phosphatase, tissue-nonspecific isozyme Bos taurus (cattle)
phosphate ion homeostasisAlkaline phosphatase, tissue-nonspecific isozyme Bos taurus (cattle)
calcium ion homeostasisAlkaline phosphatase, tissue-nonspecific isozyme Bos taurus (cattle)
cellular response to organic cyclic compoundAlkaline phosphatase, tissue-nonspecific isozyme Bos taurus (cattle)
positive regulation of cold-induced thermogenesisAlkaline phosphatase, tissue-nonspecific isozyme Bos taurus (cattle)
futile creatine cycleAlkaline phosphatase, tissue-nonspecific isozyme Bos taurus (cattle)
inhibition of non-skeletal tissue mineralizationAlkaline phosphatase, tissue-nonspecific isozyme Bos taurus (cattle)
response to sodium phosphateAlkaline phosphatase, tissue-nonspecific isozyme Bos taurus (cattle)
dephosphorylationIntestinal-type alkaline phosphataseBos taurus (cattle)
DNA metabolic process5'-nucleotidaseHomo sapiens (human)
leukocyte cell-cell adhesion5'-nucleotidaseHomo sapiens (human)
response to inorganic substance5'-nucleotidaseHomo sapiens (human)
response to ATP5'-nucleotidaseHomo sapiens (human)
ADP catabolic process5'-nucleotidaseHomo sapiens (human)
ATP metabolic process5'-nucleotidaseHomo sapiens (human)
adenosine biosynthetic process5'-nucleotidaseHomo sapiens (human)
negative regulation of inflammatory response5'-nucleotidaseHomo sapiens (human)
calcium ion homeostasis5'-nucleotidaseHomo sapiens (human)
inhibition of non-skeletal tissue mineralization5'-nucleotidaseHomo sapiens (human)
AMP catabolic process5'-nucleotidaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (25)

Processvia Protein(s)Taxonomy
chromatin bindingMyeloperoxidaseHomo sapiens (human)
peroxidase activityMyeloperoxidaseHomo sapiens (human)
protein bindingMyeloperoxidaseHomo sapiens (human)
heparin bindingMyeloperoxidaseHomo sapiens (human)
heme bindingMyeloperoxidaseHomo sapiens (human)
metal ion bindingMyeloperoxidaseHomo sapiens (human)
alkaline phosphatase activityAlkaline phosphatase, tissue-nonspecific isozyme Bos taurus (cattle)
inorganic diphosphate phosphatase activityAlkaline phosphatase, tissue-nonspecific isozyme Bos taurus (cattle)
calcium ion bindingAlkaline phosphatase, tissue-nonspecific isozyme Bos taurus (cattle)
pyrophosphatase activityAlkaline phosphatase, tissue-nonspecific isozyme Bos taurus (cattle)
ATP hydrolysis activityAlkaline phosphatase, tissue-nonspecific isozyme Bos taurus (cattle)
pyridoxal phosphatase activityAlkaline phosphatase, tissue-nonspecific isozyme Bos taurus (cattle)
ADP phosphatase activityAlkaline phosphatase, tissue-nonspecific isozyme Bos taurus (cattle)
phosphoamidase activityAlkaline phosphatase, tissue-nonspecific isozyme Bos taurus (cattle)
phosphoethanolamine phosphatase activityAlkaline phosphatase, tissue-nonspecific isozyme Bos taurus (cattle)
magnesium ion bindingIntestinal-type alkaline phosphataseBos taurus (cattle)
alkaline phosphatase activityIntestinal-type alkaline phosphataseBos taurus (cattle)
zinc ion bindingIntestinal-type alkaline phosphataseBos taurus (cattle)
nucleotide binding5'-nucleotidaseHomo sapiens (human)
5'-deoxynucleotidase activity5'-nucleotidaseHomo sapiens (human)
protein binding5'-nucleotidaseHomo sapiens (human)
5'-nucleotidase activity5'-nucleotidaseHomo sapiens (human)
zinc ion binding5'-nucleotidaseHomo sapiens (human)
identical protein binding5'-nucleotidaseHomo sapiens (human)
thymidylate 5'-phosphatase activity5'-nucleotidaseHomo sapiens (human)
IMP 5'-nucleotidase activity5'-nucleotidaseHomo sapiens (human)
GMP 5'-nucleotidase activity5'-nucleotidaseHomo sapiens (human)
XMP 5'-nucleosidase activity5'-nucleotidaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (21)

Processvia Protein(s)Taxonomy
extracellular regionMyeloperoxidaseHomo sapiens (human)
extracellular spaceMyeloperoxidaseHomo sapiens (human)
nucleusMyeloperoxidaseHomo sapiens (human)
nucleoplasmMyeloperoxidaseHomo sapiens (human)
lysosomeMyeloperoxidaseHomo sapiens (human)
secretory granuleMyeloperoxidaseHomo sapiens (human)
azurophil granule lumenMyeloperoxidaseHomo sapiens (human)
azurophil granuleMyeloperoxidaseHomo sapiens (human)
intracellular membrane-bounded organelleMyeloperoxidaseHomo sapiens (human)
extracellular exosomeMyeloperoxidaseHomo sapiens (human)
phagocytic vesicle lumenMyeloperoxidaseHomo sapiens (human)
extracellular spaceMyeloperoxidaseHomo sapiens (human)
mitochondrial intermembrane spaceAlkaline phosphatase, tissue-nonspecific isozyme Bos taurus (cattle)
mitochondrial membraneAlkaline phosphatase, tissue-nonspecific isozyme Bos taurus (cattle)
extracellular matrixAlkaline phosphatase, tissue-nonspecific isozyme Bos taurus (cattle)
extracellular membrane-bounded organelleAlkaline phosphatase, tissue-nonspecific isozyme Bos taurus (cattle)
side of membraneAlkaline phosphatase, tissue-nonspecific isozyme Bos taurus (cattle)
side of membraneIntestinal-type alkaline phosphataseBos taurus (cattle)
plasma membrane5'-nucleotidaseHomo sapiens (human)
nucleoplasm5'-nucleotidaseHomo sapiens (human)
cytosol5'-nucleotidaseHomo sapiens (human)
plasma membrane5'-nucleotidaseHomo sapiens (human)
external side of plasma membrane5'-nucleotidaseHomo sapiens (human)
cell surface5'-nucleotidaseHomo sapiens (human)
membrane5'-nucleotidaseHomo sapiens (human)
extracellular exosome5'-nucleotidaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (50)

Assay IDTitleYearJournalArticle
AID1802637Ecto-5'-Nucleotidase Inhibition Assay from Article 10.1111/cbdd.12861: \\Isonicotinohydrazones as inhibitors of alkaline phosphatase and ecto-5'-nucleotidase.\\2017Chemical biology & drug design, 03, Volume: 89, Issue:3
Isonicotinohydrazones as inhibitors of alkaline phosphatase and ecto-5'-nucleotidase.
AID1802638Alkaline Phosphatase Inhibition Assay from Article 10.1111/cbdd.12861: \\Isonicotinohydrazones as inhibitors of alkaline phosphatase and ecto-5'-nucleotidase.\\2017Chemical biology & drug design, 03, Volume: 89, Issue:3
Isonicotinohydrazones as inhibitors of alkaline phosphatase and ecto-5'-nucleotidase.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1416257Antimycobacterial activity against rifampicin-resistant Mycobacterium tuberculosis H37Rv by resazurin dye based fluorimetric method2017MedChemComm, Jun-01, Volume: 8, Issue:6
Benzylsulfanyl benzo-heterocycle amides and hydrazones as new agents against drug-susceptible and resistant
AID1668218Antioxidant activity assessed as DPPH radical scavenging activity at 100 uM after 30 mins (Rvb = 1.9 +/- 1.2%)2020Bioorganic & medicinal chemistry, 05-15, Volume: 28, Issue:10
Acylhydrazones as isoniazid derivatives with multi-target profiles for the treatment of Alzheimer's disease: Radical scavenging, myeloperoxidase/acetylcholinesterase inhibition and biometal chelation.
AID1416256Antimycobacterial activity against streptomycin-resistant Mycobacterium tuberculosis ATCC 35820 by resazurin dye based fluorimetric method2017MedChemComm, Jun-01, Volume: 8, Issue:6
Benzylsulfanyl benzo-heterocycle amides and hydrazones as new agents against drug-susceptible and resistant
AID1416264Cytotoxicity against African green monkey Vero cells assessed as cell viability at 0.625 ug/ml after 72 hrs by CCK8 assay (Rvb = 100%)2017MedChemComm, Jun-01, Volume: 8, Issue:6
Benzylsulfanyl benzo-heterocycle amides and hydrazones as new agents against drug-susceptible and resistant
AID1416265Cytotoxicity against African green monkey Vero cells assessed as cell viability at 1.25 ug/ml after 72 hrs by CCK8 assay (Rvb = 100%)2017MedChemComm, Jun-01, Volume: 8, Issue:6
Benzylsulfanyl benzo-heterocycle amides and hydrazones as new agents against drug-susceptible and resistant
AID1416268Cytotoxicity against African green monkey Vero cells assessed as cell viability at 10 ug/ml after 72 hrs by CCK8 assay (Rvb = 100%)2017MedChemComm, Jun-01, Volume: 8, Issue:6
Benzylsulfanyl benzo-heterocycle amides and hydrazones as new agents against drug-susceptible and resistant
AID1179731Cytoprotection in mouse CRL2181 cells assessed as reduction in UV-oxidized LDL-induced cytotoxicity by measuring cell viability at 1 uM after 24 hrs by MTT assay relative to untreated control2014Bioorganic & medicinal chemistry, Aug-01, Volume: 22, Issue:15
Synthesis, antioxidant and cytoprotective evaluation of potential antiatherogenic phenolic hydrazones. A structure-activity relationship insight.
AID1416254Antimycobacterial activity against kanamycin-resistant Mycobacterium tuberculosis ATCC 35827 by resazurin dye based fluorimetric method2017MedChemComm, Jun-01, Volume: 8, Issue:6
Benzylsulfanyl benzo-heterocycle amides and hydrazones as new agents against drug-susceptible and resistant
AID1416263Cytotoxicity against African green monkey Vero cells assessed as cell viability at 0.312 ug/ml after 72 hrs by CCK8 assay (Rvb = 100%)2017MedChemComm, Jun-01, Volume: 8, Issue:6
Benzylsulfanyl benzo-heterocycle amides and hydrazones as new agents against drug-susceptible and resistant
AID1179730Cytoprotection in mouse CRL2181 cells assessed as reduction in UV-oxidized LDL-induced cytotoxicity by measuring cell viability at 10 uM after 24 hrs by MTT assay relative to untreated control2014Bioorganic & medicinal chemistry, Aug-01, Volume: 22, Issue:15
Synthesis, antioxidant and cytoprotective evaluation of potential antiatherogenic phenolic hydrazones. A structure-activity relationship insight.
AID1416252Antimycobacterial activity against ethambutol-resistant Mycobacterium tuberculosis ATCC 35837 by resazurin dye based fluorimetric method2017MedChemComm, Jun-01, Volume: 8, Issue:6
Benzylsulfanyl benzo-heterocycle amides and hydrazones as new agents against drug-susceptible and resistant
AID1668220Inhibition of rat bone marrow myeloperoxidase using H2O2 as substrate at 10 uM after 20 mins by TMB based method (Rvb = - 1.4 +/- 12.7%)2020Bioorganic & medicinal chemistry, 05-15, Volume: 28, Issue:10
Acylhydrazones as isoniazid derivatives with multi-target profiles for the treatment of Alzheimer's disease: Radical scavenging, myeloperoxidase/acetylcholinesterase inhibition and biometal chelation.
AID1416247Antimycobacterial activity against drug-susceptible Mycobacterium tuberculosis clinical isolate2017MedChemComm, Jun-01, Volume: 8, Issue:6
Benzylsulfanyl benzo-heterocycle amides and hydrazones as new agents against drug-susceptible and resistant
AID1416255Antimycobacterial activity against p-aminosalicyclic acid-resistant Mycobacterium tuberculosis ATCC 35821 by resazurin dye based fluorimetric method2017MedChemComm, Jun-01, Volume: 8, Issue:6
Benzylsulfanyl benzo-heterocycle amides and hydrazones as new agents against drug-susceptible and resistant
AID1416262Cytotoxicity against African green monkey Vero cells assessed as cell viability at 0.156 ug/ml after 72 hrs by CCK8 assay (Rvb = 100%)2017MedChemComm, Jun-01, Volume: 8, Issue:6
Benzylsulfanyl benzo-heterocycle amides and hydrazones as new agents against drug-susceptible and resistant
AID1416269Cytotoxicity against African green monkey Vero cells assessed as cell viability at 20 ug/ml after 72 hrs by CCK8 assay (Rvb = 100%)2017MedChemComm, Jun-01, Volume: 8, Issue:6
Benzylsulfanyl benzo-heterocycle amides and hydrazones as new agents against drug-susceptible and resistant
AID1179729Antioxidant activity assessed as reduction in mouse CRL2181 cells-mediated human LDL oxidation by measuring TBARS level at 1 uM after 18 hrs2014Bioorganic & medicinal chemistry, Aug-01, Volume: 22, Issue:15
Synthesis, antioxidant and cytoprotective evaluation of potential antiatherogenic phenolic hydrazones. A structure-activity relationship insight.
AID1668219Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins2020Bioorganic & medicinal chemistry, 05-15, Volume: 28, Issue:10
Acylhydrazones as isoniazid derivatives with multi-target profiles for the treatment of Alzheimer's disease: Radical scavenging, myeloperoxidase/acetylcholinesterase inhibition and biometal chelation.
AID1416248Antimycobacterial activity against multidrug-resistant Mycobacterium tuberculosis clinical isolate2017MedChemComm, Jun-01, Volume: 8, Issue:6
Benzylsulfanyl benzo-heterocycle amides and hydrazones as new agents against drug-susceptible and resistant
AID1337098Inhibition of human MPO assessed as residual activity in absence of H2O2017ACS medicinal chemistry letters, Feb-09, Volume: 8, Issue:2
From Dynamic Combinatorial Chemistry to
AID1337095Inhibition of human MPO2017ACS medicinal chemistry letters, Feb-09, Volume: 8, Issue:2
From Dynamic Combinatorial Chemistry to
AID1416253Antimycobacterial activity against ethionamide-resistant Mycobacterium tuberculosis ATCC 35830 by resazurin dye based fluorimetric method2017MedChemComm, Jun-01, Volume: 8, Issue:6
Benzylsulfanyl benzo-heterocycle amides and hydrazones as new agents against drug-susceptible and resistant
AID1179728Antioxidant activity assessed as reduction in mouse CRL2181 cells-mediated human LDL oxidation by measuring TBARS level at 10 uM after 18 hrs2014Bioorganic & medicinal chemistry, Aug-01, Volume: 22, Issue:15
Synthesis, antioxidant and cytoprotective evaluation of potential antiatherogenic phenolic hydrazones. A structure-activity relationship insight.
AID1668222Inhibition of Electrophorus electricus AChE at 100 uM using acetylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition and measured after 10 mins by Ellman's method (Rvb = 7 +/- 7.1%)2020Bioorganic & medicinal chemistry, 05-15, Volume: 28, Issue:10
Acylhydrazones as isoniazid derivatives with multi-target profiles for the treatment of Alzheimer's disease: Radical scavenging, myeloperoxidase/acetylcholinesterase inhibition and biometal chelation.
AID1668221Inhibition of rat bone marrow myeloperoxidase using H2O2 as substrate after 20 mins by TMB based method2020Bioorganic & medicinal chemistry, 05-15, Volume: 28, Issue:10
Acylhydrazones as isoniazid derivatives with multi-target profiles for the treatment of Alzheimer's disease: Radical scavenging, myeloperoxidase/acetylcholinesterase inhibition and biometal chelation.
AID1416267Cytotoxicity against African green monkey Vero cells assessed as cell viability at 5 ug/ml after 72 hrs by CCK8 assay (Rvb = 100%)2017MedChemComm, Jun-01, Volume: 8, Issue:6
Benzylsulfanyl benzo-heterocycle amides and hydrazones as new agents against drug-susceptible and resistant
AID1416260Cytotoxicity against African green monkey Vero cells assessed as cell viability at 0.039 ug/ml after 72 hrs by CCK8 assay (Rvb = 100%)2017MedChemComm, Jun-01, Volume: 8, Issue:6
Benzylsulfanyl benzo-heterocycle amides and hydrazones as new agents against drug-susceptible and resistant
AID1416259Cytotoxicity against African green monkey Vero cells assessed as cell viability at 0.02 ug/ml after 72 hrs by CCK8 assay (Rvb = 100%)2017MedChemComm, Jun-01, Volume: 8, Issue:6
Benzylsulfanyl benzo-heterocycle amides and hydrazones as new agents against drug-susceptible and resistant
AID1416261Cytotoxicity against African green monkey Vero cells assessed as cell viability at 0.078 ug/ml after 72 hrs by CCK8 assay (Rvb = 100%)2017MedChemComm, Jun-01, Volume: 8, Issue:6
Benzylsulfanyl benzo-heterocycle amides and hydrazones as new agents against drug-susceptible and resistant
AID1416258Cytotoxicity against African green monkey Vero cells assessed as cell viability at 0.01 ug/ml after 72 hrs by CCK8 assay (Rvb = 100%)2017MedChemComm, Jun-01, Volume: 8, Issue:6
Benzylsulfanyl benzo-heterocycle amides and hydrazones as new agents against drug-susceptible and resistant
AID1416249Antimycobacterial activity against extensively drug-resistant Mycobacterium tuberculosis clinical isolate2017MedChemComm, Jun-01, Volume: 8, Issue:6
Benzylsulfanyl benzo-heterocycle amides and hydrazones as new agents against drug-susceptible and resistant
AID1422878Binding affinity to recombinant Trypanosoma cruzi His/haemaglutinin-tagged BDF3 expressed in Escherichia coli BL21 assessed as compound amplification factor at 75 uM by LC-MS based dynamic combinatorial chemistry analysis2018ACS medicinal chemistry letters, Oct-11, Volume: 9, Issue:10
Discovery of a Biologically Active Bromodomain Inhibitor by Target-Directed Dynamic Combinatorial Chemistry.
AID1337097Inhibition of human MPO assessed as residual activity in presence of H2O22017ACS medicinal chemistry letters, Feb-09, Volume: 8, Issue:2
From Dynamic Combinatorial Chemistry to
AID1416266Cytotoxicity against African green monkey Vero cells assessed as cell viability at 2.5 ug/ml after 72 hrs by CCK8 assay (Rvb = 100%)2017MedChemComm, Jun-01, Volume: 8, Issue:6
Benzylsulfanyl benzo-heterocycle amides and hydrazones as new agents against drug-susceptible and resistant
AID1179727Antioxidant activity assessed as DPPH radical scavenging activity by UV-Visible spectrophotometry2014Bioorganic & medicinal chemistry, Aug-01, Volume: 22, Issue:15
Synthesis, antioxidant and cytoprotective evaluation of potential antiatherogenic phenolic hydrazones. A structure-activity relationship insight.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (9.09)29.6817
2010's8 (72.73)24.3611
2020's2 (18.18)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]