Trial | Phase | Enrollment | Study Type | Start Date | Status |
Comparison of Anaesthetic Effectiveness of Different Volumes of Articaine for Inferior Alveolar Nerve Block in Molar Teeth With Symptomatic Irreversible Pulpitis [NCT05840913] | Phase 2 | 78 participants (Anticipated) | Interventional | 2023-04-30 | Recruiting |
Make up for the Epinephrine Autoinjector: Effect on Its Use by Untrained Users [NCT01217138] | Phase 4 | 164 participants (Actual) | Interventional | 2009-06-30 | Completed |
Bupivacaine in the Treatment of Postoperative Pain of Impacted Third Molar Extraction. A Randomized Clinical Trial. [NCT03950700] | Phase 4 | 40 participants (Actual) | Interventional | 2019-06-01 | Completed |
Effect of Papillary Epinephrine Spraying for the Prevention of Post-ERCP Pancreatitis in Patients Received Sublingual Nitroglycerin: A Multi-center, Single-blind, Randomized Controlled Trial [NCT03756116] | | 2,000 participants (Anticipated) | Interventional | 2018-10-01 | Recruiting |
Saline Injection - Assisted Anesthesia in Eyelid Surgery [NCT01239498] | Phase 4 | 60 participants (Anticipated) | Interventional | 2010-11-30 | Recruiting |
Double-blind Comparison of Intrapleural Bupivacaine and Saline for Ipsilateral Shoulder Pain After Thoracotomy in Patients Receiving Thoracic Epidural Analgesia [NCT03862404] | Phase 4 | 42 participants (Actual) | Interventional | 2017-07-01 | Completed |
Bupivacaine Versus Lidocaine Infiltration for Postoperative Pain in Thyroid Surgery: A Randomized Controlled Trial [NCT04427904] | Phase 2 | 210 participants (Anticipated) | Interventional | 2022-06-01 | Recruiting |
Endoscopic Injection of Autologous Blood Versus Diluted Epinephrine for Control of Actively Bleeding Gastroduodenal Ulcers [NCT01560702] | | 100 participants (Actual) | Interventional | 2012-03-31 | Completed |
Application of Iced Normal Saline Combined With Cocktail Perfusion in Total Knee Arthroplasty: Randomized Controlled Trial [NCT05204056] | | 60 participants (Actual) | Interventional | 2018-03-02 | Completed |
Post-cesarean Analgesia With Epidural Morphine Following Epidural 2-chloroprocaine [NCT04369950] | Phase 4 | 44 participants (Actual) | Interventional | 2020-05-11 | Completed |
Effect of a Vibration System on Pain Reduction During Injection of Local Dental Anaesthesia in Children: a Randomized Controlled Clinical Trial [NCT03953001] | | 51 participants (Actual) | Interventional | 2018-01-01 | Completed |
Ilioinguinal/Iliohypogastric vs. Quadratus Lumborum Nerve Blockade for Elective Open Inguinal Herniorrhaphy [NCT03007966] | Phase 2 | 60 participants (Actual) | Interventional | 2017-01-30 | Completed |
Local Effects of Epinephrine on Lactate, Glucose, Lipid and Protein Metabolism in Bilaterally Perfused Human Legs [NCT01116609] | | 10 participants (Actual) | Interventional | 2004-10-31 | Completed |
Comparison of Perfusion Index, T Wave Amplitude, Systolic Blood Pressure and Heart Rate as an Indicator for Detecting Intravascular Injection of Epinephrine Containing Test Dose During Operation in Anesthetized Adults [NCT01131741] | | 50 participants (Anticipated) | Interventional | 2010-05-31 | Recruiting |
Hemostatic and Hemodynamic Effects of Intranasal Injection Compared to Topical Administration of Epinephrin in Endoscopic Sinus Surgery [NCT01075581] | | 50 participants (Anticipated) | Interventional | 2010-04-30 | Not yet recruiting |
A Two-Period Crossover Study to Compare the Systemic Exposure to Trans-Capsaicin and Cis-Capsaicin From an Intra-Articular Injection of CNTX-4975-05 (Trans-capsaicin for Injection) and Topical 8% Capsaicin Patch (Qutenza®) in Subjects With Painful Knee Os [NCT03576508] | Phase 1 | 16 participants (Actual) | Interventional | 2018-06-25 | Completed |
ED50 and ED95 of Intrathecal Bupivacaine With or Without Epinephrine for Total Knee Replacement Arthroplasty [NCT01264575] | | 162 participants (Actual) | Interventional | 2009-12-31 | Completed |
Study of Intracameral Adrenaline for Pupil Dilation Without Topical Mydriatics in Refractive Cataract Surgery [NCT01264653] | | 60 participants (Actual) | Interventional | 2010-12-31 | Completed |
Combined Subconjunctival Atropine and Intracameral Epinephrine Injection for Pupil Dilation in Phacoemulsification Under Peribulbar Anesthesia. [NCT03638726] | Phase 4 | 40 participants (Anticipated) | Interventional | 2018-09-28 | Recruiting |
Pretreatment of Lacerations With Topical LET (Lidocaine-Epinephrine-Tetracaine) Reduces Pain During Tissue Adhesive Repair in Children: Double-blind, Randomized, Controlled Trial of Efficacy [NCT01202487] | Phase 2 | 222 participants (Actual) | Interventional | 2011-04-30 | Completed |
Antecubital Versus Femoral Approach for Adrenal Venous Sampling: A Randomised Controlled Trial [NCT06029803] | | 154 participants (Anticipated) | Interventional | 2022-04-01 | Recruiting |
Randomized Control Trial of Ultrasound-Guided Erector Spinae Block Versus Shoulder Periarticular Anesthetic Infiltration for Pain Control After Arthroscopic Shoulder Surgery [NCT03691922] | | 62 participants (Actual) | Interventional | 2019-07-06 | Completed |
Analgesic Efficacy of Liposomal Bupivacaine in Total Knee Arthroplasty [NCT02426164] | Phase 4 | 0 participants (Actual) | Interventional | 2015-06-30 | Withdrawn(stopped due to Could not receive facility approval) |
Randomized, Placebo-controlled Trial of Erector Spinae Plane Blocks (ESPB) for Perioperative Pain Management for Minimally Invasive (MIS) Lumbar Spine Surgery [NCT05029726] | Phase 4 | 125 participants (Anticipated) | Interventional | 2022-02-01 | Recruiting |
Hemodynamic Stability of Bupivacaine With and Without Adrenaline for Paracervical Block for Cervical Conization During General Anesthesia: A Randomized Controlled Double Blinded Study [NCT02368054] | Phase 4 | 34 participants (Actual) | Interventional | 2015-05-31 | Completed |
Pilot Study: Comparison of Buffered 1% vs. Unbuffered 2% Lidocaine in Pediatric Subjects; Clinical Outcomes [NCT03562481] | Phase 4 | 26 participants (Actual) | Interventional | 2018-07-24 | Completed |
Bioavailability Comparison of Epinephrine Following a Single Nasal Dose of Microspheres Powder With Epinephrine Intramuscular Injection in Adults With Seasonal Allergic Rhinitis With and Without Nasal Allergen Challenge [NCT04696822] | Phase 1 | 12 participants (Actual) | Interventional | 2020-11-01 | Completed |
Can Trajectory Nor-epinephrine Infiltration Reduce Blood Loss During Percutaneous Nephrolithotomy?: A Double-blind Randomized Placebo Controlled Study. [NCT05035303] | | 140 participants (Actual) | Interventional | 2020-03-10 | Completed |
Role of Low Dose Epinephrine Boluses For Acute Hypotension in The Pediatrics ICU [NCT03671070] | | 50 participants (Anticipated) | Interventional | 2019-01-01 | Not yet recruiting |
Randomized Trial Comparing Bupivacaine vs Lipossomic Extended Release Bupivacaine for Postoperative Pain Control After Minimally Invasive Thoracic Surgery [NCT03560362] | Phase 1/Phase 2 | 50 participants (Anticipated) | Interventional | 2015-07-09 | Recruiting |
Towards Cost-effective Management of Patients With Hypertension Due to Primary Aldosteronism: Adrenal Vein Sampling or Ct-scan? [NCT01096654] | Phase 3 | 200 participants (Actual) | Interventional | 2010-07-31 | Completed |
The Application of Recombinant Human Hyaluronidase is Effective for the Use of Local Blocks for Eyelid Surgery [NCT02059694] | | 0 participants (Actual) | Interventional | | Withdrawn |
Optimizing the Use of Vasopressor After Coronary Reperfusion in Cardiogenic Shock Secondary to Myocardial Infarction. Pathophysiological Study Comparing the Efficacy and Cardio-circulatory Tolerability of Epinephrine and Norepinephrine [NCT01367743] | Phase 4 | 58 participants (Actual) | Interventional | 2011-09-30 | Completed |
Effect of Dexamethasone and Epinephrine on the Duration of Sciatic Nerve Blocks With Ropivacaine in Ankle and Foot Surgery [NCT02104778] | | 90 participants (Anticipated) | Interventional | 2014-04-30 | Recruiting |
Randomized Clinical Trial to Verify the Effectiveness of Topical Aminocaproic Acid in the Prevention of Post-exodontic Bleeding in Patients on Anticoagulants [NCT02238288] | Phase 4 | 154 participants (Anticipated) | Interventional | 2013-12-31 | Enrolling by invitation |
Laparoscopically Guided Rectus Sheath Block in Pediatric Appendicitis - a Randomized Control Trial [NCT04717193] | Phase 2 | 100 participants (Anticipated) | Interventional | 2021-05-28 | Recruiting |
Ultrasound-Guided Erector Spinae Plane Block Versus Intercostal Nerve Block For Postoperative Pain Control in Video-Assisted Thoracoscopic Surgery: A Prospective, Double Blind Randomized Controlled Trial [NCT03902782] | | 100 participants (Anticipated) | Interventional | 2019-06-26 | Recruiting |
The Bupivacaine Dose Sparing Effect of Intrathecal Epinephrine for Spinal Anesthesia in Total Knee Replacement Arthroplasty [NCT01261078] | | 75 participants (Anticipated) | Interventional | 2010-12-31 | Completed |
A Randomised Clinical Trial Comparing Endovenous Laser Ablation and Mechanochemical Ablation (ClariVein®) in the Management of Superficial Venous Insufficiency [NCT02627846] | Phase 4 | 150 participants (Actual) | Interventional | 2015-06-01 | Completed |
Randomized Double-blind Clinical Trial Comparing the Cardiovascular Effects of Local Anesthesia Solutions Containing 1:100,000 and 1:200,000 of Epinephrine Concentrations [NCT02735018] | Phase 4 | 40 participants (Actual) | Interventional | 2014-12-31 | Completed |
The Effect of BMI on Median Effective Dose (ED50) of Intrathecal Hyperbaric Bupivacaine for Total Knee Replacement Arthroplasty [NCT01291186] | | 108 participants (Actual) | Interventional | 2010-01-31 | Completed |
"The Effect Of Subcutaneous Epinephrine Dosage On Blood Loss In Surgical Incision" [NCT05670808] | Phase 1 | 90 participants (Anticipated) | Interventional | 2023-02-01 | Not yet recruiting |
Comparison of the Analgesic Effect of Femoral Nerve Block, Intraarticular Infiltration or a Combination of Both in the Control of Pain in Total Knee Arthroplasty [NCT01304212] | Phase 4 | 137 participants (Actual) | Interventional | 2011-04-30 | Completed |
Study of Drug Exposure in Systemic Circulation of Primatene Mist (0.25mg) by Oral Inhalation, Versus Epinephrine Injection (0.30mg) by Intramuscular Injection and ProAir (0.18mg) by Oral Inhalation in Healthy Individuals: A Randomized, Safety Evaluator-bl [NCT04207840] | Phase 4 | 28 participants (Actual) | Interventional | 2019-12-09 | Completed |
Surgicel; a Probable Analgesic Reservoir for Post-laparoscopic Cholecystectomy Pain Management; Randomized Controlled Double-blind Trial [NCT03730714] | Phase 2/Phase 3 | 90 participants (Actual) | Interventional | 2018-11-15 | Completed |
Tumescent Antibiotic Delivery for Prevention of Surgical Site Infection: A Multicenter Open Label Randomized Clinical Trial [NCT02503904] | Phase 2/Phase 3 | 400 participants (Anticipated) | Interventional | 2015-10-31 | Not yet recruiting |
2%-Mepivacaine With Two Different Vasoconstrictors; 1:20.000 Levonordefrin or 1:100.000 Epinephrin for Local Anesthesia in Third Molar Surgery: A Comparative Randomized Clinical Trial [NCT02603198] | | 30 participants (Anticipated) | Interventional | 2014-08-31 | Active, not recruiting |
An Analysis of the Functional Benefit, Narcotic Use and Time to Discharge Readiness Following the Implementation of a Comprehensive Pain Management Protocol for Primary Total Knee Arthroplasty [NCT02474654] | Phase 4 | 220 participants (Actual) | Interventional | 2015-07-31 | Completed |
Multimodal Nonopioid Pain Protocol Following Shoulder Arthroplasty Surgery [NCT05488847] | Phase 4 | 80 participants (Anticipated) | Interventional | 2022-06-25 | Recruiting |
Role of Chemokine and Chemokine Receptor in Psoriasis [NCT03302390] | | 0 participants (Actual) | Observational | 2017-04-17 | Withdrawn(stopped due to PI failed to submit study for continuing review by IRB) |
A Pilot Clinical Trial to Reduce Side-effects of Autologous Skin Tissue Harvesting [NCT02234193] | Early Phase 1 | 8 participants (Actual) | Interventional | 2016-06-30 | Completed |
Comparing the Effect of 4% Articaine and 2% Mepivacaine Without Palatal Injection in Pain Assessment During Maxillary Teeth Extraction- A Randomized Clinical Trial [NCT03470532] | Phase 4 | 60 participants (Actual) | Interventional | 2017-02-25 | Completed |
Phase III Study of Epinephrine Inhalation Aerosol for Evaluation of Efficacy and Safety of E004 in Children With Asthma [NCT01460511] | Phase 3 | 70 participants (Actual) | Interventional | 2011-10-31 | Completed |
The Effect of Epinephrine, Norepinephrine and Phenylephrine on Intraoperative Hemodynamic Performance - a Prospective Double-blinded Randomized Clinical Trial [NCT05492968] | Phase 4 | 225 participants (Anticipated) | Interventional | 2022-09-01 | Recruiting |
The Effect of The Serratus Block on Analgesia After Breast Surgery A Randomized Controlled Double-Blinded Study [NCT02453516] | Phase 2/Phase 3 | 40 participants (Actual) | Interventional | 2014-10-29 | Completed |
Comparison of Zero- and Two-centimeter Distance From Sapheno-femoral Junction in Laser Ablation of Long Saphenous Vein Incompetence: Evaluating the Kissing Technique [NCT05707169] | | 800 participants (Anticipated) | Interventional | 2023-01-04 | Active, not recruiting |
The Effect of Intracameral Carbachol and Epinephrine Use on Choroidal Thickness After Uncomplicated Phacoemulsification [NCT05225597] | | 81 participants (Actual) | Interventional | 2021-01-01 | Completed |
Managing Post Spinal Hypotension During Elective Cesarean Section: Epinephrine Versus Ephedrine, a Randomized Double-blinded Controlled Trial [NCT03704909] | Phase 4 | 143 participants (Actual) | Interventional | 2018-09-01 | Completed |
The Randomized Controlled Trial of Inferior Vena Cava Ultrasound-guided Fluid Management in Septic Shock Resuscitation [NCT03020407] | | 211 participants (Actual) | Interventional | 2017-01-18 | Completed |
Management of Acute Pulmonary Hypertensive Crisis in Children With Known Pulmonary Arterial Hypertension [NCT05439460] | Phase 4 | 15 participants (Actual) | Interventional | 2012-01-31 | Completed |
A Phase 2B, Randomized, Controlled Study of HTX-011 Administered Via Pectoral Nerve Block in Subjects Undergoing Upper Extremity Surgery for Augmentation Mammoplasty [NCT03011333] | Phase 2 | 243 participants (Actual) | Interventional | 2017-01-14 | Completed |
Effect of Local Infiltration Anesthesia With Ropivacaine on Pain After Primary Total Hip Arthroplasty [NCT02359136] | | 116 participants (Actual) | Interventional | 2013-03-31 | Completed |
Adrenal Artery Ablation for Primary Aldosteronism:A Randomized, Parallel, Active-controlled Clinical Trial to Evaluate the Efficacy and Safety of Adrenal Artery Ablation(AAA)in the Treatment of Primary Aldosteronism [NCT03653845] | Phase 3 | 40 participants (Anticipated) | Interventional | 2018-07-01 | Recruiting |
"Clinical Study to Evaluate Efficacy and Safety of CEGP003(Wound Dressing Solution Containing EGF) for Achieving Hemostasis and Protecting Ulcer in Patients With Acute Peptic Ulcer Bleeding: A Prospective, Randomized Trial" [NCT03469167] | | 76 participants (Actual) | Interventional | 2014-10-15 | Completed |
Comparison of the Effects of Two Concentrations of Adrenaline (0.33 mg/l vs 1 mg/l) in the Irrigation Serum of Arthroscopic Shoulder Surgery. [NCT05439213] | | 170 participants (Anticipated) | Interventional | 2022-06-22 | Recruiting |
Ultrasound-Guided Versus Conventional Method for Caudal Block in Children [NCT03427437] | | 275 participants (Actual) | Interventional | 2017-02-01 | Completed |
Comparison of the Effect of a Single Shot Saphenous Block With Plain Bupivacaine vs. Protracted Bupivacaine Mixture as a Supplement to Continuous Sciatic Catheter After Major Ankle and Foot Surgery [NCT02346110] | Phase 4 | 40 participants (Actual) | Interventional | 2015-04-30 | Completed |
Nebulized Hypertonic Saline (3%) Versus Nebulized Adrenaline for Treatment of Bronchiolitis: A Randomized Control Trial [NCT03614273] | | 60 participants (Actual) | Interventional | 2015-03-01 | Completed |
A Prospective, Randomized Comparison Between Single and Double Injection Ultrasound-Guided Axillary Brachial Plexus Block [NCT02334176] | | 320 participants (Anticipated) | Interventional | 2015-01-31 | Not yet recruiting |
An Exploratory Phase I Randomized, Single-site, Double-blind, Active-controlled, Parallel-group, Single-administration, Dose-escalation Trial to Investigate the Safety and Tolerability of Neosaxitoxin Alone and in Combination With Bupivacaine (With and Wi [NCT03399435] | Phase 1 | 242 participants (Actual) | Interventional | 2018-01-30 | Terminated(stopped due to The sponsor decided to stop further dosing of healthy volunteers after reviewing the obtained efficacy data. The decision is not related to any safety concern.) |
Pectoral Nerves Block to Relieve Post-sternotomy Pain After Cardiac Surgery [NCT04282239] | | 0 participants (Actual) | Interventional | 2021-03-01 | Withdrawn(stopped due to Did not have the staff to conduct the study) |
Pulpal Blood Flow With the Use of Intra-nasal Anesthetic: a Randomized Double-blind Crossover Study [NCT03368391] | Phase 4 | 25 participants (Anticipated) | Interventional | 2018-01-03 | Not yet recruiting |
WALANT Versus Axillary Brachial Plexus Block in Carpal Tunnel Release: a Non-inferiority Randomized Controlled Trial [NCT06040840] | | 130 participants (Anticipated) | Interventional | 2023-11-01 | Not yet recruiting |
The Effect of Protracted Saphenous Nerve and Obturator Nerve Block Versus Saphenous Nerve Block Versus Local Infiltration Analgesia on Opioid Consumption, Pain, Block Duration of Action and Mobilization After Total Knee Arthroplasty. [NCT02067078] | Phase 4 | 75 participants (Actual) | Interventional | 2014-02-28 | Completed |
Efficacy of Lidocaine Saline Irrigation in Patients Undergoing Shoulder Arthroscopy: Randomized Controlled Study [NCT05624957] | | 50 participants (Actual) | Interventional | 2022-11-25 | Completed |
A Volunteer Study to Determine the Anatomical Distribution of Injectate, the Extent of Sensory Block, and the Pharmacokinetics of Ropivacaine Following Erector Spinae Plane (ESP) Blocks. [NCT03476642] | Phase 4 | 24 participants (Anticipated) | Interventional | 2019-07-02 | Recruiting |
A Randomized, Double-blinded or Evaluator-blinded, Placebo and Active Controlled, Six-arm, Crossover, Single Dose, Dose-ranging Study, for Initial Evaluation of Safety and Efficacy in Asthma Patients [NCT01025648] | Phase 1/Phase 2 | 9 participants (Actual) | Interventional | 2009-12-31 | Terminated(stopped due to Optimization of protocol) |
Evaluation of Cardiac Arrhythmias in Patients Undergoing Kidney Cancer Surgery Depending on the Anaesthesia Method [NCT02988219] | Phase 4 | 50 participants (Actual) | Interventional | 2010-06-30 | Completed |
Prospective Randomized Clinical Trial to Evaluate the Use of Caudal Nerve Blocks in Adult Penile Prosthesis Surgery [NCT02740127] | Phase 3 | 52 participants (Actual) | Interventional | 2016-06-30 | Completed |
Influence of Synacthen Infusion on the Results of Adrenal Venous Sampling in Patient With Primary Aldosteronism [NCT02127840] | Phase 4 | 40 participants (Anticipated) | Interventional | 2011-03-31 | Recruiting |
Phase II Clinical Trial for a Stepwise Progression in the Treatment of Cardiogenic Shock [NCT02591771] | Phase 2 | 24 participants (Actual) | Interventional | 2015-10-31 | Completed |
Magnesium-sulfate as Adjuvant in Prehospital Femoral Nerve Block for Patient With Diaphysial Femoral Fracture: a Randomized Controlled Trial [NCT03597945] | | 48 participants (Actual) | Interventional | 2015-04-30 | Completed |
Bacteriostatic Saline as a Local Anesthetic in Minor Eyelid Procedures [NCT05294640] | Phase 4 | 95 participants (Actual) | Interventional | 2022-05-17 | Completed |
Pharmacokinetic Study of Epinephrine During Cardiac Arrest Determining T1/2 and Time to Peak Concentration [NCT03036202] | | 8 participants (Actual) | Observational | 2017-06-26 | Completed |
Is the Direct Inferior Alveolar Nerve Block Required for Third Lower Molar Extraction? [NCT03443726] | | 120 participants (Actual) | Interventional | 2017-06-10 | Completed |
Three-level Injection Paravertebral Block Using Paravertebral Catheter Compared to General Anesthesia in Mastectomy Surgery [NCT02065947] | Phase 1/Phase 2 | 60 participants (Actual) | Interventional | 2013-10-31 | Completed |
Anterior Ethmoidal Nerve Block in Prevention of Postoperative Agitation Following Nasal Surgeries With Nasal Packs Under General Anesthesia: A Double Blind Randomized Control Trial [NCT03427502] | | 100 participants (Actual) | Interventional | 2018-06-01 | Completed |
Randomized Clinical Trial Examining Use of Adjunct EXPAREL for Post-tonsillectomy Pain Management in Adults [NCT03420638] | Phase 4 | 38 participants (Anticipated) | Interventional | 2018-02-15 | Recruiting |
Effect of Local Infiltration Anesthesia in a Hip Arthroplasty Fast Track Program. [NCT03513276] | Phase 4 | 63 participants (Actual) | Interventional | 2016-02-29 | Completed |
Bacteraemia Secondary to Tooth Extraction: a Randomized Clinical Trial on Efficacy of Three Different Chlorhexidine Prophylaxis Protocols [NCT02150031] | Phase 4 | 208 participants (Actual) | Interventional | 2010-12-31 | Completed |
Epinephrine Inhalation Aerosol USP, an HFA-MDI: Clinical Study-C For Evaluation Of Efficacy And Safety In Asthma Patients [NCT01357642] | Phase 3 | 373 participants (Actual) | Interventional | 2011-07-31 | Completed |
A 3-month Safety Evaluation Extension to the 12-week E004-C Study in Asthma Patients (A Double Blinded, Placebo-controlled, Parallel, 3-month Safety Study in Adolescent and Adult Patients With Asthma) [NCT01476904] | Phase 3 | 208 participants (Actual) | Interventional | 2011-11-30 | Completed |
Usage of Tranexamic Acid During Colonic Endoscopic Resection Procedures for Reduction Intraprocedural and Postprocedural Bleeding [NCT05345613] | Phase 4 | 200 participants (Anticipated) | Interventional | 2022-05-01 | Recruiting |
Effect of Lidocaine/Dexamethasone on the Success of IANB in Patients With Irreversible Pulpitis [NCT03531970] | Phase 2/Phase 3 | 100 participants (Actual) | Interventional | 2016-08-01 | Completed |
Photobiomodulation for Controlling Pre-Local Anesthetic Injection Pain: A Double-Blind, Randomized Controlled Clinical Study [NCT06128590] | | 50 participants (Anticipated) | Interventional | 2023-11-15 | Not yet recruiting |
Protracted Mixture of Local Anesthetics for Major Foot and Ankle Surgery. A Randomized Double-blind, Controlled Study Comparing Bupivacaine-Epinephrine 0.5% Versus Bupivacaine-Epinephrine 0.5% With Dexamethasone [NCT02526199] | Phase 4 | 56 participants (Actual) | Interventional | 2015-08-31 | Completed |
An Open, Randomised, Parallel Group Controlled, Single Centre Safety Study to Assess the Safety and Efficacy of Tri-Solfen in Providing Anaesthesia Prior to Surgical Debridement of Leg Ulcers and Post-operative Pain Relief [NCT03865147] | Phase 2 | 90 participants (Anticipated) | Interventional | 2019-01-15 | Recruiting |
Does the Use of CBCT Pre-operative Measurements Improve the Success Rate of Inferior Alveolar Nerve Block? - A Randomized Controlled Clinical Trial [NCT05406895] | | 200 participants (Anticipated) | Interventional | 2022-05-25 | Recruiting |
Quadratus Lumborum Block Versus Control for Total Hip Arthroplasty [NCT03408483] | Phase 2/Phase 3 | 80 participants (Actual) | Interventional | 2018-04-01 | Completed |
Randomized, Double Blind Trial of Thoracolumbar Interfascial Plane Block and Erector Spinae Plane Block for Adult Spinal Surgery [NCT03931343] | | 60 participants (Anticipated) | Interventional | 2020-12-31 | Not yet recruiting |
Local Infiltration Analgesia During Total Knee Arthroplasty - Reduced Opiate Consumption and Faster Mobilisation Postoperatively - Randomized Controlled Trial [NCT01305733] | | 60 participants (Actual) | Interventional | 2011-03-31 | Active, not recruiting |
Low Dose EPInephrine to Improve Platelet Reactivity in TICagrelor-treated Subjects: A Proof of Concept Study in Healthy Volunteers (EPITIC) [NCT03441412] | Phase 1 | 10 participants (Actual) | Interventional | 2018-02-28 | Completed |
Adrenal Venous Sampling Via an Antecubital Approach: A Multicenter Study [NCT03778645] | | 1,500 participants (Anticipated) | Observational | 2018-07-01 | Recruiting |
Evaluation of Efficacy and Safety for Single Dose of E004 in Children With Asthma (A Randomized, Double-Blind, Placebo-Controlled, Crossover, Single Dose Study in 4 - 11 Year Old Children With Asthma) [NCT01737905] | Phase 3 | 28 participants (Actual) | Interventional | 2012-10-31 | Completed |
A Prospective, Randomized, Single-Blind, Active Control Trial to Compare Safety and Effectiveness Of Liposomal Bupivacaine (Exparel) to Standard Bupivacaine HCl (Marcaine) for Pain Management in Patients Undergoing Video-Assisted Thoracoscopic Lobectomy [NCT03682224] | Phase 3 | 57 participants (Actual) | Interventional | 2018-07-05 | Completed |
How Successful is Supplemental Intraseptal Anaesthesia in Patients With Mandibular Teeth Extraction or Irreversible Pulpitis [NCT03880409] | Phase 1 | 100 participants (Actual) | Interventional | 2019-02-09 | Completed |
Role of Platelet Rich Plasma in the Treatment of Actively Bleeding Peptic Ulcer [NCT03733171] | | 80 participants (Anticipated) | Interventional | 2018-09-20 | Recruiting |
Effect of Buffered Lidocaine With Epinephrine in Local Anesthesia During Subcutaneous Implantable Venous Access Devices Insertion: Double Blind Randomized Study. [NCT03628430] | | 120 participants (Actual) | Interventional | 2017-01-01 | Completed |
ENHANCED RECOVERY AFTER ORTHOGNATHIC SURGERY USING LIPOSOMAL BUPIVACAINE: A RANDOMIZED CONTROL TRIAL [NCT03844451] | Phase 4 | 75 participants (Anticipated) | Interventional | 2019-05-17 | Recruiting |
WALANT Technique (Wide Awake Local Anesthesia No Tourniquet) in Association With Analgesic Troncular Blocks at the Wirst for Carpal Tunnel Release. [NCT04494100] | | 60 participants (Actual) | Interventional | 2020-09-11 | Completed |
Formulations of Liposomal Local Anesthetics for Dental Anesthesia [NCT01307969] | Phase 1 | 40 participants (Actual) | Interventional | 2007-02-28 | Completed |
Comparison of Postoperative Pain With Two Different Types of Local Anesthesia in Surgery for a Drooping Eyelid [NCT01350024] | | 34 participants (Actual) | Interventional | 2011-05-01 | Completed |
[NCT02864095] | | 200 participants (Anticipated) | Interventional | 2015-05-31 | Recruiting |
A Prospective, Randomized, Controlled Trial of Combination Vasopressin and Epinephrine to Epinephrine Only for In-Intensive Care Unit Pediatric Cardiopulmonary Resuscitation [NCT00628550] | Phase 1 | 130 participants (Anticipated) | Interventional | 2008-04-30 | Completed |
A Randomized, Prospective Trial Comparing Peri-articular Injection Utilizing a Pain Cocktail With and Without Exparel [NCT02571283] | Phase 4 | 0 participants (Actual) | Interventional | 2015-10-31 | Withdrawn(stopped due to PI decided to focus on more current topics of interest.) |
Evaluation of Liposomal Bupivacaine Compared to Usual Care and Its Effects on Pain for Cardiac Surgery [NCT04065919] | Phase 4 | 300 participants (Anticipated) | Interventional | 2019-10-01 | Enrolling by invitation |
Hypoglycemia Associated Autonomic Failure in Type 1 DM, Question 5 [NCT00605774] | | 0 participants (Actual) | Interventional | | Withdrawn |
Hypoglycemia Associated Autonomic Failure in Type 1 DM, Question 4 [NCT00608816] | | 0 participants (Actual) | Interventional | | Withdrawn |
Analgesic Benefit of Locally Injected Bupivacaine on Perineal Pain Among Women With Epidural Anesthesia After a Vaginal Delivery: a Randomized, Single-masked, Controlled Trial [NCT03672500] | | 23 participants (Actual) | Interventional | 2018-09-14 | Terminated(stopped due to Recruitment issues) |
Intraoperative Use of Perineal Block for Hemorrhoidectomy [NCT04288349] | | 100 participants (Anticipated) | Interventional | 2020-02-20 | Recruiting |
Efficacy and Safety of Periarticular Multimodal Drug Injections in Total Knee Arthroplasty [NCT00901628] | Phase 4 | 101 participants (Actual) | Interventional | 2008-04-30 | Completed |
[NCT02839356] | Phase 4 | 670 participants (Anticipated) | Interventional | 2016-07-31 | Recruiting |
Multimodal Drug Infiltration in Total Knee Arthroplasty: Is Posterior Capsular Infiltration Worth the Risk? A Prospective, Double-Blind, Randomized Controlled Trial [NCT02860949] | Phase 2 | 90 participants (Actual) | Interventional | 2014-04-30 | Completed |
[NCT02807298] | Phase 3 | 25 participants (Actual) | Interventional | 2014-06-30 | Completed |
A Randomized, Single-Blinded, Placebo-Controlled Study Evaluating Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated Coagulation [NCT04814433] | Phase 4 | 5 participants (Actual) | Interventional | 2021-03-24 | Terminated(stopped due to Both lack of enrollment as well as study staff turnover) |
Effect of Sodium Bicarbonate Buffered Lidocaine on the Success of Inferior Alveolar Nerve Block for Teeth With Symptomatic Irreversible Pulpitis: A Prospective, Randomized Double-blind Study [NCT02226913] | Phase 3 | 80 participants (Actual) | Interventional | 2013-02-28 | Completed |
Occurrence of Heart Arrhythmia During Restorative Dental Procedure Under Local Anesthesia , in Heart Failure Pacients. A Double-blind Study [NCT02228083] | | 70 participants (Anticipated) | Interventional | 2014-09-30 | Recruiting |
Effectiveness of Bupivacaine With Epinephrine Injections Into the Uterosacral Ligaments for Post-operative Pain Control and the Use of Narcotic Pain Medication Following Robotic Assisted Total Hysterectomies [NCT02230735] | | 0 participants (Actual) | Interventional | 2014-08-31 | Withdrawn(stopped due to Study was never started.) |
Prophylactic Topical Epinephrine to Reduce Transbronchial Lung Biopsy-related Hemorrhage in Lung Transplant Recipients: a Prospective Double-blind Placebo-controlled Trial (PROPHylactic Epinephrine in Transbronchial Biopsy [PROPHET] Trial) [NCT03126968] | Phase 2/Phase 3 | 100 participants (Actual) | Interventional | 2017-07-01 | Completed |
A Comparison Between Tourniquet Application and Epinephrine Injection for Hemostasis During Hypospadias Surgery: the Effect on Bleeding and Post-operative Outcome [NCT02268019] | | 70 participants (Anticipated) | Interventional | 2013-01-31 | Recruiting |
Shamrock Versus Lumbar Ultrasound Trident - Ultrasound Guided Block of the Lumbar Plexus: A Randomized Controlled Trial [NCT02255591] | Phase 4 | 20 participants (Actual) | Interventional | 2015-02-28 | Completed |
Analgesic Benefit of PECS Blocks for Biceps Tenodesis Shoulder Surgery [NCT02741713] | Phase 3 | 40 participants (Actual) | Interventional | 2016-04-30 | Completed |
Double-Blinded Randomized Controlled Study Investigating the Efficacy of Exparel (Liposomal Bupivacaine) for Postoperative Pain Relief in Mandibular Third Molar Extractions [NCT05374499] | Phase 4 | 40 participants (Anticipated) | Interventional | 2022-09-01 | Active, not recruiting |
Fractional Carbon Dioxide Laser Assisted Delivery of Topical Anesthetics: a Randomized Controlled Pilot Study [NCT02246179] | Phase 4 | 10 participants (Actual) | Interventional | 2014-09-30 | Completed |
A Randomized Comparison Between 1 Plane - 1 Injection (Cluster Approach) and 2 Plane - 2 Injection Ultrasound-guided Supraclavicular Brachial Plexus Block (US-SCBPB) in Upper Extremity Surgery [NCT02505633] | | 36 participants (Actual) | Interventional | 2015-07-31 | Completed |
High Volume, Multilevel Local Anesthetic-Epinephrine Infiltration in Kyphoscoliosis Surgery: Blood Conservation and Analgesia [NCT03319563] | | 52 participants (Actual) | Interventional | 2017-04-11 | Completed |
The Effect of Adding Nebulized Epinephrine in Asthma Exacerbation Management in Pediatric Age Group Compared to Standard of Care: Superiority Trial [NCT05667727] | Phase 4 | 30 participants (Anticipated) | Interventional | 2023-10-15 | Recruiting |
Periarticular Bupivacaine + Meloxicam ER Solution Versus Standard Practice During Total Knee Arthroplasty: A Single Institution, Single-blinded, Randomized Clinical Trial [NCT05188053] | Phase 4 | 98 participants (Anticipated) | Interventional | 2022-02-07 | Enrolling by invitation |
A Two-Treatment, Sequential, Crossover Study of the Pharmacokinetics of Adrenaline After Administration of ARS -1 in Subjects With Upper Respiratory Tract Infection (Infectious Rhinitis) [NCT04930900] | Phase 1 | 15 participants (Actual) | Interventional | 2021-08-09 | Completed |
Efficacy of Peri-Incisional Multimodal Drug Injection Following Operative Management of Femur Fractures: A Randomized Controlled Trial [NCT02793947] | Phase 4 | 102 participants (Actual) | Interventional | 2015-05-31 | Completed |
A Randomized Controlled Trial of Bupivacaine for Local Pain Control Following Perineal Laceration Repair in Patients With Pre-existing Epidural Analgesia [NCT05972681] | | 60 participants (Anticipated) | Interventional | 2023-12-31 | Not yet recruiting |
Efficacy of Multimodal Periarticular Injections in Operatively Treated Ankle Fractures: A Randomized Controlled Trial [NCT02967172] | Phase 4 | 100 participants (Actual) | Interventional | 2016-10-31 | Completed |
[NCT02135627] | | 20 participants (Actual) | Interventional | 2014-04-30 | Completed |
Efficacy of Adrenaline in Periarticular Analgesic Injection on Postoperative Pain Control After Total Knee Arthroplasty: A Randomized Controlled Trial [NCT03549221] | Phase 2 | 82 participants (Anticipated) | Interventional | 2018-01-26 | Recruiting |
Epinephrine Self-injection and Self-management of Food Allergies [NCT02417493] | | 60 participants (Actual) | Interventional | 2015-03-31 | Completed |
Bilateral Paravertebral Blockade for Improvement of Quality of Recovery Following Cardiac Surgery (P-QOR): a Randomized Controlled Trial [NCT06008821] | | 224 participants (Anticipated) | Interventional | 2023-09-30 | Not yet recruiting |
Postoperative Pain Management Following Total Hip Arthroplasty. A Comparison Between Local Infiltration Analgesia and Ultrasound Guided 3-in-1 Block [NCT02568995] | Phase 3 | 55 participants (Actual) | Interventional | 2014-05-31 | Completed |
Assessment of Airway Obstruction in Infants With Lower Respiratory Infections [NCT00435994] | | 59 participants (Actual) | Interventional | 2003-12-31 | Completed |
Tumescent Lidocaine Bioavailability and Absorption Kinetics:Maximum Safe mg/kg Lidocaine Dosage [NCT00977028] | Phase 1/Phase 2 | 14 participants (Actual) | Interventional | 2005-01-31 | Enrolling by invitation |
Awake Caudal Catheter Infusion Versus General Anesthesia and Single-dose Caudal Injection for Preterm NICU Patients Undergoing Inguinal Herniorraphy. [NCT05919732] | Phase 4 | 40 participants (Actual) | Interventional | 2016-03-08 | Completed |
Can Epinephrine Coated Syringe for Subcutaneous Immunotherapy (SCIT) Reduce Large Local Reaction? [NCT03963115] | Phase 1/Phase 2 | 17 participants (Actual) | Interventional | 2018-10-24 | Completed |
A Phase 2 Multicenter, Randomized, Double-blind, Parallel-group, Active-control, Dose-ranging Study to Evaluate the Safety, Efficacy, and Comparative Systemic Bioavailability of a Single Administration of SKY0402 Via Local Infiltration for Prolonged Posto [NCT00485693] | Phase 2 | 138 participants (Actual) | Interventional | 2007-06-30 | Completed |
A Single Center, Prospective, Observational Study to Explore and Evaluate the Differences of Cognitive Function and Brain Function Between Non-functioning Adrenal Adenomas and Autonomous Cortisol Secretion Patients, and the Different Treatments Methods on [NCT05357456] | | 62 participants (Anticipated) | Observational | 2021-10-01 | Recruiting |
Local Infiltration Analgesia With Ropivacaine, Ketorolac and Epinephrine Intra- and Postoperatively in Total Knee Arthroplasty [NCT00799175] | | 48 participants (Actual) | Interventional | 2007-04-30 | Completed |
Local Infiltration Analgesia or Intrathecal Morphine in Total Knee Arthroplasty [NCT00992082] | | 50 participants (Anticipated) | Interventional | 2009-08-31 | Recruiting |
Effectiveness of Caudal Epidural Block on Intraoperative Blood Loss During Hypospadias Repair; A Randomized Clinical Trial [NCT02752308] | Phase 2/Phase 3 | 60 participants (Actual) | Interventional | 2014-09-30 | Completed |
Platform Adaptive Embedded Trial for Acute Respiratory Distress Syndrome [NCT05658692] | Phase 4 | 1,000 participants (Anticipated) | Interventional | 2022-10-01 | Recruiting |
Comparison of Perioperative Opioid Consumption Following Pectoral Nerve Block Under General Anesthesia for Breast Cancer Surgery: A Randomized Clinical Trial [NCT02741232] | | 50 participants (Actual) | Interventional | 2016-03-31 | Completed |
The Use of Tranexamic Acid in Irrigation Fluid to Improve Arthroscopic Visualization in Shoulder Surgery: A Randomized Controlled Trial [NCT04594408] | Phase 4 | 128 participants (Actual) | Interventional | 2020-09-01 | Active, not recruiting |
The Prevention of Hypotension After Epidural Analgesia After Major Surgery by Adding Epinephrine to Infusions to Counteract Sympathectomy: a Double- Blind, Controlled, Randomized, Prospective Dose-finding Study [NCT02722746] | | 66 participants (Actual) | Interventional | 2016-11-15 | Completed |
Efficacy of Multimodal Peri- and Intraarticular Drug Injections in Total Knee Arthroplasty [NCT00562627] | Phase 4 | 102 participants (Actual) | Interventional | 2007-11-30 | Completed |
Interest of the Alkalinization of the Adrenaline Lidocaine Solution for Conversion of Epidural Analgesia Into Epidural Anesthesia During an Emergency Caesarean [NCT04255121] | Phase 3 | 400 participants (Actual) | Interventional | 2020-06-22 | Completed |
Randomized Controlled Trial of Dopamine, Adrenaline, and Blood Transfusion for Treatment of Fluid Refractory Shock in Children With Severe Acute Malnutrition or Severe Underweight and Cholera or Other Dehydrating Diarrheas [NCT04750070] | Phase 3 | 135 participants (Anticipated) | Interventional | 2021-08-17 | Recruiting |
Effect of Intrapartum Epidural Fentanyl Upon Breastfeeding in the Immediate Postpartum Period: a Randomized, Controlled, Double-blinded Study [NCT01497509] | | 0 participants (Actual) | Interventional | 2012-05-31 | Withdrawn(stopped due to Study never started) |
Efficacy of Post-FESS Implantation of Composite Removable Sinus Stent System to Prevent Post-Operative Complications and Revision Surgery [NCT02812199] | | 30 participants (Anticipated) | Interventional | 2016-08-31 | Recruiting |
A Multi-center, Randomized, Double-blind, Crossover, phase4 Trial to Evaluate the Efficacy on Local Anesthesia and Safety of 2% Lidocaine HCl With Different Epinephrine Concentration in Patients Undergoing Surgical Extraction of Impacted Lower Third Molar [NCT02696369] | Phase 4 | 65 participants (Actual) | Interventional | 2014-12-31 | Completed |
The Influence of Local Infiltration Analgesia by Catheter in Postoperative Control Pain After Total Hip Replacement [NCT02630160] | Phase 4 | 100 participants (Actual) | Interventional | 2013-03-31 | Completed |
A Novel Method for Chronic Anal Fissure Treatment: Adipose Derived Regenerative Cells - A Pilot Study [NCT02628522] | | 6 participants (Actual) | Interventional | 2014-12-31 | Completed |
A Phase 1, 2-Part Study in Healthy Male and Female Participants; Part 1 - A Randomised, Double-Blind, Placebo-Controlled, Single Ascending Dose-Escalation Study of Inhaled DMC-IH1; Part 2 - An Open-Label, 3-Arm Study Assessing the Carryover Effects of Inh [NCT06013150] | Phase 1 | 63 participants (Anticipated) | Interventional | 2023-10-23 | Not yet recruiting |
Does the Addition of Epinephrine to Bilateral Ultrasound Guided Pterygopalatine Ganglion Block Reduce Bleeding During Functional Endoscopic Sinus Surgery (FESS)? A Pilot Study [NCT03970655] | Phase 1/Phase 2 | 80 participants (Anticipated) | Interventional | 2019-09-25 | Recruiting |
The Efficacy of Liposomal Bupivacaine in the Management of Post-operative Pain Following Septorhinoplasty: A Double-blinded, Prospective Clinical Trial [NCT05964868] | Phase 3 | 72 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting |
Postmortem Evaluation of Adrenal and Other Endocrine Tumors in Patients With Sudden Death Without Definitive Causative Diagnosis (PEA-SuddenDeath) [NCT05446779] | | 400 participants (Anticipated) | Observational | 2022-06-03 | Recruiting |
The Effects of Hydrocortisone in Endotoxemia in Normal Volunteers [NCT01064986] | Phase 1 | 12 participants (Actual) | Interventional | 2010-02-28 | Completed |
Analgesic Efficacy of Intravenous Lidocaine for Postoperative Pain Following Adult Spine Surgery: A Randomized Controlled Trial [NCT01043211] | | 0 participants (Actual) | Interventional | 2012-01-31 | Withdrawn(stopped due to Did not have the research staff necessary to follow through with this study.) |
Diesel Exhaust Inhalation, Systemic Nitric Oxide Inhibition and Cardiac Output [NCT01060930] | | 14 participants (Actual) | Interventional | 2010-03-31 | Completed |
Endoscopic Application of a Hemostatic Powder TC-325 Versus Standard Treatment in the Control of Acute Upper Gastrointestinal Bleeding From Nonvariceal Causes; A Non-inferiority Randomized Trial [NCT02534571] | Phase 3 | 224 participants (Actual) | Interventional | 2015-09-07 | Completed |
A Randomized Comparison Between 1 Plane-2 Injection and 2 Plane-2 Injection Ultrasound-guided Supraclavicular Brachial Plexus Block (US-SCBPB) in Upper Extremity Surgery [NCT02533557] | | 70 participants (Actual) | Interventional | 2015-08-31 | Completed |
Double Blinded Controled Study:Treatment With Adrenaline Inhalation Versus Nasal Decongestant Drops for Bronchiolitis [NCT00622817] | | 65 participants (Actual) | Interventional | 2004-10-31 | Completed |
Comparison of the Analgesic Duration of 0.5% Bupivacaine With 1:200,000 Epinephrine Versus 0.5% Ropivicaine Versus 1 % Ropivicaine for Low Volume Ultrasound-guided Interscalene Brachial Plexus Block [NCT02643563] | | 60 participants (Actual) | Interventional | 2016-01-31 | Completed |
A Phase 1 Comparative Bioavailability Study of Inhaled Epinephrine and Intramuscular Epinephrine Administered to Healthy Adults [NCT05152901] | Phase 1 | 23 participants (Actual) | Interventional | 2022-01-06 | Completed |
Intraoperative Injection of Exparel Effect on Postoperative Opioid Use in Thyroid and Parathyroid Surgery [NCT04085913] | Early Phase 1 | 100 participants (Anticipated) | Interventional | 2019-09-30 | Enrolling by invitation |
Comparing General Anesthesia With Single Injection Peribulbar Block With Articaine 4% vs Lidocaine 2% vs Mepivacaine 3 % for Prevention of Oculocardiac Reflex in Children Undergoing Strabismus Surgery : A Randomized Control Study [NCT05728151] | | 55 participants (Anticipated) | Interventional | 2023-02-12 | Recruiting |
Effects of Pre-emptive Scalp Infiltration With Ketorolac and Ropivacaine for Postoperative Pain Relief After Elective Supratentorial Craniotomy (PAINLESS) [NCT04141319] | Phase 4 | 100 participants (Anticipated) | Interventional | 2021-12-31 | Not yet recruiting |
''To Compare the Response Rate of Noradrenaline vs. Terlipressin in Hepatorenal Syndrome in Patients With Acute on Chronic Liver Failure' [NCT02573727] | | 120 participants (Actual) | Interventional | 2015-10-31 | Completed |
Dynamics and State Transitions During Resuscitation in In-hospital Cardiac Arrest [NCT00920244] | | 285 participants (Actual) | Observational | 2009-08-31 | Completed |
A Prospective, Randomized, Double-Blind Controlled Clinical Trial to Evaluate the Post-Operative Blood Loss and Transfusion Rate Following Total Joint Arthroplasty With Intra-articular Injection of Bupivacaine and Epinephrine [NCT00737139] | | 33 participants (Actual) | Interventional | 2008-09-30 | Terminated(stopped due to Prohibitively expensive and efficacy of tranexamic acid rendered topic clinically less relevant.) |
[NCT02593370] | Phase 1 | 26 participants (Actual) | Interventional | 2015-10-31 | Completed |
Articaine Efficacy and Safety in Young Children Below Age of Four Years: An Equivalent Parallel Randomized Control Trial [NCT04061265] | Phase 1/Phase 2 | 184 participants (Actual) | Interventional | 2019-08-25 | Completed |
Prospective, Randomized Trial of Hemospray Plus Epinephrine Injection Versus Endoscopic Hemoclip Plus Epinephrine Injection in Nonvariceal Upper Gastrointestinal Bleeding [NCT02537353] | Phase 4 | 40 participants (Anticipated) | Interventional | 2015-09-30 | Not yet recruiting |
Study of Tramadol Addiction Impact on Dental Anesthesia Succes. [NCT05908305] | Phase 4 | 300 participants (Anticipated) | Interventional | 2023-06-10 | Not yet recruiting |
Electromechanical Profiling of Arrhythmogenic Substrates and Triggers in the Long-QT Syndrome [NCT04074122] | | 150 participants (Anticipated) | Observational | 2020-01-01 | Not yet recruiting |
Vasopressin, Epinephrine, and Corticosteroids for Inhospital Cardiac Arrest: A Multicenter Randomized Controlled Trial [NCT00729794] | Phase 3 | 300 participants (Actual) | Interventional | 2008-09-30 | Completed |
A Multicenter Double-Blind Randomized Placebo Controlled Two-Arm Study Evaluating the Safety and Efficacy of the Iontophoretic Administration of Lidocaine and Epinephrine Using Lidocaine Iontophoretic Drug Delivery System (IDDS) to Provide Local Anesthesi [NCT00889642] | Phase 2 | 90 participants (Anticipated) | Interventional | 2009-05-31 | Completed |
Mechanisms of Hypoglycemia Associated Autonomic Failure [NCT00678145] | Phase 2 | 116 participants (Anticipated) | Interventional | 2008-03-31 | Active, not recruiting |
Fractional CO2 Laser Assisted Topical Articaine Anesthesia vs. Topical EMLA Administration: a Randomized Controlled Study [NCT02548533] | Phase 4 | 3 participants (Actual) | Interventional | 2015-06-30 | Terminated(stopped due to Not enough patients eligible for recruitment.) |
Evidence of Spreading Vasoconstriction in Human Gingiva [NCT04131283] | | 29 participants (Actual) | Interventional | 2019-05-01 | Completed |
Shamrock - Ultrasound/MR Image Fusion Guided Lumbar Plexus Block [NCT02718976] | Phase 2 | 22 participants (Actual) | Interventional | 2016-03-31 | Completed |
Efficacy and Safety of Percutaneous Superselective Adrenal Arterial Embolization in the Treatment of Primary Aldosteronism With Bilateral Idiopathic Hyperaldosteronism: A Prospective Cohort Study [NCT05186675] | | 50 participants (Anticipated) | Interventional | 2022-01-01 | Enrolling by invitation |
Comparison of the Efficacy of Irrigation With Epinephrine or Tranexamic Acid on Visual Clarity During Arthroscopic Rotator Cuff Repair: A Randomized Double-Blind Study [NCT04628676] | | 100 participants (Actual) | Interventional | 2017-02-01 | Completed |
The Effects of Epinephrine in Endotoxemia in Normal Volunteers [NCT00753402] | Phase 1 | 37 participants (Actual) | Interventional | 2012-02-29 | Completed |
Anesthetic Efficacy of %4Alexadricaine Versus %2 Mepicaine-L for Infiltration Anesthesia in Extraction of Maxillary First Primary Molars in Children [NCT04477317] | Phase 3 | 10 participants (Actual) | Interventional | 2021-08-01 | Completed |
Adrenal Venous Sampling in Patients With Overt or Subclinical Cushings Syndrome, and Bilateral Adrenal Tumors [NCT02543697] | | 30 participants (Anticipated) | Interventional | 2015-02-28 | Recruiting |
Periarticular Injection and Hamstring Block Versus Placebo for Pain Control in Anterior Cruciate Ligament Reconstruction: A Randomized Controlled Trial [NCT05248724] | | 44 participants (Actual) | Interventional | 2017-08-01 | Completed |
The Use of Epinephrine Infusion for Prophylaxis Against Maternal Hypotension During Cesarean Delivery: a Randomized Controlled Dose-finding Trial [NCT05051150] | Phase 4 | 18 participants (Actual) | Interventional | 2021-09-15 | Terminated(stopped due to tachycardia and arrhythmia in the high doses groups 0.05 and 0.07 necessitate stopping the infusion) |
An Open-label, 8-Week Study to Compare the Comfort and Ease of Use of Five Different Treatment Regimens for CNTX-4975-05 Intra-articular Injection in Subjects With Chronic, Moderate-to-Severe Osteoarthritis Knee Pain [NCT03661996] | Phase 3 | 854 participants (Actual) | Interventional | 2018-09-18 | Completed |
Prospective Evaluation of Topical Analgesia Using a Lidocaine/Prilocaine Cream for Laceration Repair in the Emergency Department [NCT03071601] | Phase 4 | 132 participants (Actual) | Interventional | 2017-12-01 | Completed |
Surgery of Subclinical Cortisol Secreting Adrenal Incidentalomas [NCT02364089] | | 78 participants (Actual) | Interventional | 2015-04-09 | Completed |
Effect of Chronic Catecholamine Overproduction on Brown Adipose Tissue [NCT01949714] | | 10 participants (Actual) | Observational | 2013-08-31 | Completed |
Buffered vs. Unbuffered Local Anesthesia in Mandibular Molars Diagnosed With Symptomatic Irreversible Pulpitis: A Controlled, Randomized Double-blind Study [NCT05227300] | Phase 4 | 40 participants (Anticipated) | Interventional | 2022-02-14 | Recruiting |
The Hemostatic and Hemodynamic Effects of Adrenaline During Endoscopic Sinus Surgery: Randomized Clinical Trial [NCT00852410] | Phase 3 | 140 participants (Anticipated) | Interventional | 2009-03-31 | Not yet recruiting |
Epinephrine, Dexamethasone, and Hypertonic Saline in Children With Bronchiolitis in the Hospital General Naval de Alta Especialidad. A Randomized Controlled Trial [NCT02585531] | Phase 2 | 100 participants (Anticipated) | Interventional | 2015-11-30 | Not yet recruiting |
Pharmacokinetic Interaction Effects of Combined Fentanyl and Adrenalin in Epidural Analgesia During Child Birth [NCT00685672] | Phase 4 | 40 participants (Actual) | Interventional | 2008-08-31 | Completed |
Duration of Blockade of Peripheral Nerves With Low Concentrated Bupivacaine Solution Depending of the Adjuvants [NCT04498923] | | 68 participants (Actual) | Observational | 2018-01-01 | Completed |
A Randomized, Phase 4 Study of the Efficacy, Safety, and Pharmacokinetics of Bupivacaine Administered as Liposomal Bupivacaine or Continuous Infusion Via Elastomeric Pump Following Unilateral Open Inguinal Herniorrhaphy [NCT04102267] | Phase 4 | 32 participants (Actual) | Interventional | 2018-07-02 | Completed |
"Clinical Trial Protocol of Primary Study on Efficacy and Safety of Telesurgery for Patients With Tumors of the Urinary System Using Chinese Independently Developed MicroHand Surgical Robot System" [NCT04570176] | | 1 participants (Actual) | Interventional | 2020-08-27 | Completed |
Intraoperative Angiotensin 2 for the Prevention of Kidney Injury After Liver Transplant [NCT04592744] | Phase 4 | 30 participants (Anticipated) | Interventional | 2022-04-08 | Enrolling by invitation |
A Randomized Double Blind Trial of Vasoactive Drugs for the Management of Shock in the ICU [NCT02118467] | Phase 4 | 836 participants (Anticipated) | Interventional | 2014-05-31 | Recruiting |
Prospective, Multicenter, Randomized, Double-Blind Study Comparing Safety and Efficacy of Norepinephrine Plus Dobutamine Versus Epinephrine Alone in Septic Shock. [NCT00148278] | Phase 2/Phase 3 | 330 participants (Actual) | Interventional | 1999-10-31 | Completed |
Nebulized Adrenalin and Oral Betamethasone in Children With Bronchiolitis Attending Pediatric Emergencies : a Multicentre Randomized Controlled Trial [NCT02586961] | Phase 2/Phase 3 | 195 participants (Actual) | Interventional | 2015-10-31 | Terminated(stopped due to Removal of Adrénaline lots for safety reasons.) |
7% Hypertonic Saline for Acute Bronchiolitis: A Randomized Controlled Trial [NCT01871857] | Phase 4 | 101 participants (Actual) | Interventional | 2010-11-30 | Completed |
Comparative Evaluation of Handling Characteristics of Two Adrenaline Autoinjectors,EpiPen in Comparison With Jext; the HEJ-study [NCT01887405] | Phase 4 | 91 participants (Actual) | Interventional | 2012-01-31 | Completed |
Assessment of the Operative Course in Connection With Removal of Lower Third Molars With Particular Consideration to the Occurence of Pain and Swelling [NCT00805298] | | 154 participants (Actual) | Interventional | 2008-08-31 | Completed |
Bronchiolitis All-study, SE-Norway What is the Optimal Inhalation Treatment for Children 0-12 Months With Acute Bronchiolitis? [NCT00817466] | Phase 4 | 500 participants (Anticipated) | Interventional | 2010-01-31 | Active, not recruiting |
The Effects of Epinephrine and Cortisol on Emotion in Depression [NCT04148261] | Early Phase 1 | 0 participants (Actual) | Interventional | 2020-12-31 | Withdrawn(stopped due to Principal Investigator left lab before study start) |
Nebulized 5% Hypertonic Saline for Infirmary Treatment of Acute Infant Bronchiolitis: A Randomized Trial [NCT01016249] | Phase 4 | 187 participants (Actual) | Interventional | 2007-04-30 | Completed |
High Flow Therapy vs Hypertonic Saline in Bronchiolitis Treatment. Randomized Controlled Trial [NCT01873144] | Phase 3 | 75 participants (Actual) | Interventional | 2010-10-31 | Completed |
The Efficacy of Analgesic Buffering With Sodium Bicarbonate for the Pediatric Dental Patient [NCT01883232] | | 0 participants (Actual) | Interventional | 2013-08-31 | Withdrawn |
Phase 2, Single-Center, Placebo-Controlled Study of the Effects of Combined Administration of Vasopressin, Methylprednisolone, and Epinephrine During Cardiopulmonary Resuscitation on Survival After Cardiac Arrest [NCT00411879] | Phase 2 | 100 participants (Actual) | Interventional | 2006-06-30 | Completed |
An Ultrasound Guided Fascia Iliaca Block Placed at the Level of the Inguinal Ligament for Analgesia After Hip Arthroplasty [NCT01911949] | | 24 participants (Actual) | Interventional | 2017-01-31 | Completed |
Anesthetic Efficacy of 4% Articaine (Mandibular Infiltration) and 2% Lidocaine (Alveolar Nerve Block), Associated With 1:100.000 Epinephrine, in Lower Molars With Irreversible Pulpits [NCT01912755] | Phase 4 | 50 participants (Actual) | Interventional | 2010-02-28 | Completed |
Effect of Preventive Medicine on the Postreperfusion Syndrome [NCT01080625] | | 96 participants (Actual) | Interventional | 2010-04-30 | Completed |
Efficiency of Multi-Modal Anesthesia (MMA) Protocol in Pain Control and Analgesia in Patients Undergoing Posterior Lumbar Spinal Fusion Surgery [NCT05413902] | Phase 4 | 100 participants (Actual) | Interventional | 2021-04-05 | Completed |
Compare Articaine 1:100.000, 4% Epinephrine, Subperiosteal With Loco-regional Anesthesia for Placing Dental Implants in Posterior Mandible - Double-Blinded Randomized Clinical Trial [NCT01963754] | Phase 4 | 88 participants (Anticipated) | Interventional | 2017-04-01 | Active, not recruiting |
Phase 4 Study of Comparison of Preincisional Infiltrated Dexmedetomidine and Lidocaine Plus Adrenaline for Surgical Conditions and Postoperative Analgesic Consumption in Nasal Sephoplasty Surgery. [NCT01964586] | Phase 4 | 60 participants (Actual) | Interventional | 2013-03-31 | Completed |
The Effect of Topical Administration of Tranexamic Acid, Adrenaline and Bupivacain on Postoperative Bleeding and Pain in Patients Undergoing Breast Surgery. A Four-armed Placebo-controlled Double Blinded Randomized Study [NCT01964781] | Phase 4 | 30 participants (Actual) | Interventional | 2013-08-31 | Completed |
An Evaluation of Post Caesarean-Section Pain Control Regimens: Non-Opioid Oral Regimen With and Without Transversus Abdominis Plane Block [NCT01982929] | | 180 participants (Actual) | Interventional | 2013-11-30 | Completed |
Can we Gain an Advantage by Combining Distal Median, Radial and Ulnar Nerve Blocks With Supraclavicular Block? A Randomized Controlled Study [NCT01989312] | Phase 4 | 75 participants (Actual) | Interventional | 2012-02-29 | Completed |
Does Saphenous Nerve Block Improve Analgesia After Total Knee Replacement When Used in Combination With Local Infiltration Analgesia? A Prospective Randomised Double Blinded Trial. [NCT01991288] | Phase 4 | 20 participants (Actual) | Interventional | 2012-11-30 | Completed |
Regional Anesthesia Block of the Transversus Abdominis Plane in Children Undergoing Gastric Tube Insertion [NCT00564655] | Phase 3 | 3 participants (Actual) | Interventional | 2007-10-31 | Terminated |
Efficacy of Hemostasis by Soft Coagulation Using Endoscopic Hemostatic Forceps in Comparison With Argon Plasma Coagulation for Acute Peptic Ulcer Bleeding [NCT02020603] | | 151 participants (Actual) | Interventional | 2012-01-31 | Completed |
Effects of Adrenaline Infiltration on Surgical Field of View in Endoscopic Sinus Surgery [NCT05867342] | Phase 4 | 40 participants (Actual) | Interventional | 2017-05-12 | Completed |
The Effect of Oral Midodrine Versus Oral Desmopressin Acetate Use for Liberation From IV Noradrenaline in Intensive Care Unit Patients Recovering From Spinal Shock . [NCT04586790] | Phase 2 | 90 participants (Anticipated) | Interventional | 2020-10-15 | Recruiting |
Comparison Between Effect of Adrenaline and Without Adrenaline in Tumescent Solutions on Bleeding Control of Skin Graft Donor Site. [NCT04590638] | | 56 participants (Actual) | Interventional | 2020-10-17 | Completed |
Comparison of Ropivacaine Plasma Concentration With or Without Epinephrine for Posterior Quadratus Lumborum Block in Cesarean Section [NCT04562103] | | 52 participants (Actual) | Interventional | 2020-07-03 | Completed |
A Randomised, Open Label Study to Compare the Efficacy of Nor Adrenaline and Terlipressin vs Step up Terlipressin Therapy in Hepatorenal Syndrome [NCT01649037] | | 0 participants (Actual) | Interventional | 2012-08-31 | Withdrawn(stopped due to lack of funds) |
Topical Adrenaline Versus Warm Saline Solution for Minimizing Intraperitoneal Bleeding During Caesarian Delivery for Placenta Previa / Accreta Spectrum ( PAS): A Randomized Controlled Study [NCT06030479] | | 84 participants (Anticipated) | Interventional | 2023-02-01 | Recruiting |
Randomized, Double-Blind, Placebo-Controlled Study of Effects of Combined Spinal Epidural Analgesia on Intrapartum Fever. [NCT00802646] | | 0 participants (Actual) | Interventional | 2009-06-30 | Withdrawn(stopped due to study moved to alternate site) |
Ultrasound Guided Motor Sparing Knee Blocks With or Without Dexmedetomidine for Postoperative Analgesia Following Knee Arthroplasty: a Randomized Double Blinded Study [NCT02540070] | Phase 3 | 135 participants (Anticipated) | Interventional | 2014-08-31 | Recruiting |
Prophylactic Racemic Epinephrine for the Prevention of Dysphagia in Patients Undergoing Anterior Cervical Discectomy and Fusion: A Randomized Control Trial [NCT02724761] | | 90 participants (Anticipated) | Interventional | 2016-09-30 | Not yet recruiting |
A Prospective Randomized Case Series Comparison on the Clinical Efficacy of Exparel Local Anesthetic in Total Knee Arthroplasty Patients [NCT02765815] | Phase 4 | 0 participants (Actual) | Interventional | 2016-02-29 | Withdrawn(stopped due to competing protocol) |
An Parallel Control Clinical Trail on Effects of Adrenal Artery Ablation and Adrenalectomy in Patients With Primary Aldosteronism [NCT04269928] | | 60 participants (Anticipated) | Interventional | 2016-01-19 | Recruiting |
The Effect of Subsartorial Saphenous Block on Postoperative Pain Following Major Ankle and Hind Foot Surgery [NCT02697955] | Phase 4 | 18 participants (Actual) | Interventional | 2016-06-21 | Completed |
[NCT02860221] | | 210 participants (Anticipated) | Interventional | 2015-05-31 | Recruiting |
Ophthalmic Artery Resistance Index After Peribulbar Block in the Presence of Epinephrine [NCT04153123] | | 26 participants (Actual) | Interventional | 2013-12-01 | Completed |
Topical Use of Tranexamic Acid Versus Epinephrine to Optimize Surgical Field During Exploratory Tympanotomy [NCT04188184] | | 60 participants (Actual) | Interventional | 2019-12-04 | Completed |
Comparison of the Analgesic Effect of the Local Anesthetics Ropicacaine, Levobupivacaine, and Levobupivacaine + Epinephrin Via Interscalene Nerve Block in Patients Undergoing Shoulder Arthroscopy Under General Anesthesia [NCT02691442] | Phase 4 | 30 participants (Actual) | Interventional | 2010-12-31 | Completed |
Comparison of the Efficacy and Safety of Two Homologous Active Principles for Local Dental Anesthesia: Non-inferiority Trial [NCT04166890] | Phase 4 | 179 participants (Actual) | Interventional | 2018-09-04 | Completed |
Local Infiltration Analgesia (LIA) With Ropivacaine, Ketorolac and Epinephrine Intra- and Postoperatively in Unicompartmental Knee Arthroplasty [NCT00653926] | | 40 participants (Actual) | Interventional | 2005-09-30 | Completed |
Protective Analgesia Using Bupivacaine and Conventional Release Ibuprofen Versus Bupivacaine and Sustained Release Ibuprofen for Postoperative Pain Relief in Patients Undergoing Third Molar Surgery: a Randomised Controlled Trial [NCT00895843] | | 122 participants (Actual) | Interventional | 2006-11-30 | Completed |
An Assessment of the Effects of Pressors on Graft Blood Flow After Free Tissue Transfer Surgery: A Randomised Study [NCT01418118] | Phase 4 | 25 participants (Actual) | Interventional | 2008-10-31 | Completed |
Comparison of Absorption of Epinephrine Into the Circulation After Epinephrine Intranasal Spray Administration and After Intramuscular Injection [NCT01432522] | | 12 participants (Anticipated) | Interventional | 2010-07-31 | Completed |
Pectoral Nerve (PECS) Block for Cardiac Implantable Electronic Devices (CIED) Implantation Surgery [NCT04577690] | Phase 4 | 48 participants (Anticipated) | Interventional | 2019-12-01 | Recruiting |
Prophylactic Tranexamic Acid Versus Adrenaline for Bleeding Prevention During Flexible Bronchoscopy: a Double Blind, Randomized Controlled Trial [NCT06145191] | | 840 participants (Anticipated) | Interventional | 2023-12-18 | Recruiting |
Assessment and Evaluation of Pharmacokinetic Profile of E004 in Healthy Adults (A Randomized, Evaluator-Blind, Single-Dose, Two Arm, Crossover, PK Study in Healthy Volunteers) [NCT01737892] | Phase 1/Phase 2 | 21 participants (Actual) | Interventional | 2012-11-30 | Terminated(stopped due to unable to validate analytical method) |
"The Efficacy of Exparel Versus a Multidrug Cocktail in Soft Tissue Tumors" [NCT05355597] | Phase 2 | 140 participants (Anticipated) | Interventional | 2021-01-27 | Recruiting |
Effect of Local Infiltration Anesthesia With Ropivacaine on Postoperative Pain After Hip Hemiarthroplasty [NCT02585011] | | 123 participants (Actual) | Interventional | 2015-12-31 | Completed |
Myocardial Deformation Before and After Birth, and Under Altered Preload, Afterload and Heart Rate in New-borns [NCT04060381] | | 300 participants (Anticipated) | Observational | 2017-04-04 | Active, not recruiting |
Comparing the Hemodynamic Effects of Epinephrine Versus Dexmedetomidine as an Adjuvant to Bupivacaine in Caudal Anaesthesia Assessed by Cardiometry: a Randomized, Double-blind, Controlled Study [NCT05860010] | | 39 participants (Anticipated) | Interventional | 2023-06-05 | Not yet recruiting |
Subacromial Injection of Epinephrine Improves Visualization in Shoulder Arthroscopy [NCT05244525] | Phase 4 | 60 participants (Actual) | Interventional | 2022-03-14 | Completed |
Use of Vasopressin Versus Epinephrine to Reduce Hemorrhage During Myomectomy: a Randomized Controlled Trial [NCT01861015] | Phase 3 | 60 participants (Actual) | Interventional | 2013-05-31 | Completed |
Fluid Management in Patients Undergoing Cardiac Surgery - Effects of an Acetate Versus Lactate Buffered Balanced Infusion Solution on Hemodynamic Stability, a Randomized Controlled Double-blind Trial [NCT02895659] | Phase 4 | 150 participants (Actual) | Interventional | 2016-12-01 | Completed |
Evaluation of Two Approaches in Enhancing the Efficacy of Inferior Alveolar Nerve Block During Treatment of Mandibular First Permanent Molars With Symptomatic Irreversible Pulpitis: A Randomized Parallel Controlled Trial [NCT05427903] | | 180 participants (Anticipated) | Interventional | 2022-03-04 | Recruiting |
Pharmacokinetics and Pharmacodynamics for Levobupivacaine With and Without Epinephrine After Ultrasound Guided Erector Spinae Plane Block [NCT04799184] | Phase 4 | 38 participants (Anticipated) | Interventional | 2019-04-03 | Recruiting |
Postoperative Pain Control Using Local Wound Infiltration in Adolescent Idiopathic Surgery: A Randomized Control Trial [NCT04730531] | | 100 participants (Anticipated) | Interventional | 2022-06-02 | Recruiting |
Low-dose Epinephrine Infusion Tests in Adolescent and Pediatric Patients [NCT00548886] | | 7 participants (Actual) | Interventional | 2008-02-29 | Terminated(stopped due to Lack of enrollment) |
Over-the-scope Clips and Standard Treatments in Endoscopic Control of of Acute Bleeding From Non-variceal Upper GI Causes(OTSC Study) [NCT03216395] | | 191 participants (Actual) | Interventional | 2018-01-02 | Completed |
Use of Percutaneously-Placed Continuous Flow Bupivacaine Pain Pumps to Decrease Post-operative Pain Following Mastectomy With Immediate Reconstruction: A Prospective, Randomized, Double-Blind Clinical Trial [NCT01494259] | Phase 4 | 0 participants (Actual) | Interventional | 2016-01-31 | Withdrawn |
Efficacy of Intracoronary Adrenaline and Its Comparison With Intracoronary Adenosine in the Treatment of No-Reflow in Normotensive Patients With Acute Coronary Syndrome [NCT04699110] | Phase 4 | 201 participants (Actual) | Interventional | 2021-01-01 | Completed |
Adrenal Scans With Radioiodine-Labeled Norcholesterol (NP-59) [NCT00591643] | Phase 1 | 93 participants (Actual) | Interventional | 1977-07-31 | Completed |
Comparison the Effect of Lidocaine (With Epinephrine) With and Without Sufentanil on the Rate of Anesthesia of Intra-ligamentary Injection in Teeth With Irreversible Pulpitis [NCT01572116] | Phase 2 | 60 participants (Actual) | Interventional | 2010-01-31 | Completed |
Maternal-Fetal Monitoring of Patients With Rheumatic Heart Disease During Dental Procedure Under Local Anesthesia [NCT00482573] | Phase 1 | 31 participants (Actual) | Interventional | 2004-04-30 | Completed |
Evaluating the Effectiveness of Local Multimodal Injection in Controlling Pain, Limiting Complications, and Reducing Cost as Compared to Regional Anesthesia for Treating Rotational Ankle Fractures. [NCT05019638] | Early Phase 1 | 200 participants (Anticipated) | Interventional | 2021-05-15 | Enrolling by invitation |
Comparative Effect of Palatal Injection on Pain Perception in Pediatric Patient [NCT06025825] | | 96 participants (Anticipated) | Observational [Patient Registry] | 2023-05-02 | Recruiting |
Epinephrine Versus Phenylephrine Infusion for Prophylaxis Against Maternal Hypotension After Spinal Anesthesia for Cesarean Delivery: a Randomized Controlled Trial. [NCT05881915] | | 196 participants (Anticipated) | Interventional | 2023-06-01 | Recruiting |
Intercostal Cryoneurolysis Following Traumatic Rib Fractures [NCT04198662] | Phase 4 | 20 participants (Actual) | Interventional | 2020-04-03 | Active, not recruiting |
Parameters in Fractional Laser Assisted Delivery of Topical Anesthetics: Role of Laser Type and Laser Settings [NCT02938286] | Phase 4 | 15 participants (Actual) | Interventional | 2016-03-31 | Completed |
A Prospective, Multicenter, Single-blind, Controlled Clinical Trial to Confirm the Efficacy and Safety of 'UI-EWD', a Wound Dressing Used for Wound Protection and Hemostasis After Ulcer Bleeding Due to Peptic Ulcer, EMR and ESD [NCT02978391] | | 76 participants (Actual) | Interventional | 2016-05-23 | Completed |
Cardiovascular Effects of Racemic Epinephrine Pellets Used in Pediatric Restorative Dentistry Under General Anesthesia [NCT04688346] | Phase 2/Phase 3 | 13 participants (Actual) | Interventional | 2019-06-10 | Completed |
Efficacy of Perioperative US-Guided Serratus Anterior Plane Block Versus Thoracic Epidural in Adult Patient Undergoing Thoracotomy: A Randomized Comparative Double-Blinded Trial [NCT05672394] | | 74 participants (Actual) | Interventional | 2021-06-01 | Completed |
The Use of Lidocaine Ophtesic Gel Versus Subconjunctival Xylocaine Injection in Pterygium Excision [NCT05978687] | Phase 4 | 50 participants (Anticipated) | Interventional | 2023-09-01 | Recruiting |
A Randomized Controlled Trial Comparing Epinephrine and Dexamethasone to Placebo in the Treatment of Infants With Bronchiolitis [NCT03567473] | Phase 3 | 864 participants (Anticipated) | Interventional | 2018-12-13 | Recruiting |
Hemodynamics and Extravascular Lung Water in Acute Lung Injury: A Prospective Randomized Controlled Multicentered Trial of Goal Directed Treatment of EVLW Versus Standard Management for the Treatment of Acute Lung Injury [NCT00624650] | Phase 2 | 33 participants (Actual) | Interventional | 2008-02-29 | Completed |
A Phase 3, Multicenter, Randomized, Double-blind Parallel-group, Active-control Study to Evaluate the Safety and Efficacy of Local Administration of SKY0402 for Prolonged Postoperative Analgesia in Subjects Undergoing Bilateral, Cosmetic Sub-muscular Brea [NCT00813111] | Phase 3 | 136 participants (Actual) | Interventional | 2008-11-30 | Terminated(stopped due to Sponsor decision, unrelated to safety) |
Multicenter Randomized Controlled Trial of Gastric Endoscopic Submucosal Dissection With or Without Epineprhine Added Solution [NCT04032119] | Phase 3 | 800 participants (Actual) | Interventional | 2020-01-10 | Completed |
Acoustic Assessment of Nebulized Epinephrine Versus Albuterol for RSV Bronchiolitis- a Double Blind Study [NCT00361452] | Phase 4 | 30 participants | Interventional | 2000-12-31 | Terminated |
Effect of Dexmedetomidine as Adjuvant to Ropivacaine for Brachial Plexus Block [NCT05767827] | | 40 participants (Anticipated) | Interventional | 2023-02-01 | Recruiting |
Effects of Epinephrine and I.V. Needle on CPR Outcome [NCT00121524] | Phase 2 | 904 participants (Actual) | Interventional | 2003-01-31 | Completed |
Can the Risk of RD and Hypoglycemia in Children Born at Elective CS be Reduced by Injection of Adrenaline [NCT00322660] | | 270 participants (Actual) | Interventional | 2006-06-30 | Completed |
A Phase 2B, Randomized, Double Blind, Active Comparator, Multicenter, Safety, and Efficacy Trial of ATX-101 in Subjects Undergoing Total Knee Arthroplasty [NCT05260008] | Phase 2 | 305 participants (Anticipated) | Interventional | 2022-06-07 | Recruiting |
Parameters in Fractional Laser Assisted Delivery of Topical Anesthetics: Role of Anesthetic and Application Time [NCT03279757] | Phase 4 | 15 participants (Actual) | Interventional | 2016-10-01 | Completed |
Phase 3 Study of Adrenaline and Milrinone in Patients With Myocardial Dysfunction [NCT00446017] | Phase 3 | 60 participants | Interventional | 2003-06-30 | Completed |
Randomized Controlled Trial Examining the Effect of Subcutaneous Xylocaine 2% on the Incidence of Vasovagal Reactions and Pain Intensity During Femoral Artery Sheath Removal. [NCT00465439] | | 78 participants (Actual) | Interventional | 2007-05-31 | Completed |
Comparison of Epinephrine Associated With Vasopressin vs Epinephrine Alone in the Treatment of Out-of-Hospital Cardiac Arrests [NCT00127907] | Phase 4 | 2,416 participants | Interventional | 2004-05-31 | Completed |
Effect of Adrenaline Concentration in Tumescence Solution on Intraoperative Hemodynamics of Liposuction Patients: A Randomized Controlled Trial [NCT05822765] | Phase 3 | 40 participants (Actual) | Interventional | 2023-05-01 | Completed |
Neosaxitoxin (NeoSTX) Alone and in Combination With Bupivacaine as Prolonged Duration Local Anesthetics: A Phase I Investigator-initiated Dose Escalation Study [NCT01786655] | Phase 1 | 105 participants (Actual) | Interventional | 2013-05-31 | Completed |
Selective Trunk Block Versus Hybrid Interscalene-Supraclavicular Brachial Plexus Block for Anaesthesia of the Entire Upper Extremity: A Randomized Double-Blind Controlled Trial [NCT04908371] | | 0 participants (Actual) | Interventional | 2022-12-31 | Withdrawn(stopped due to Published data indicated Selective Trunk Block is a better choice) |
Intracoronary Administration of Epinephrine and Verapamil in the Refractory No-reflow Phenomenon in Patients With Acute Myocardial Infarction: The EPIVER Randomized Controlled Trial [NCT04573751] | | 104 participants (Actual) | Interventional | 2020-12-30 | Active, not recruiting |
Randomized Trial of Transversus Abdominal Plane (TAP) Block at Total Laparoscopic Hysterectomy: Effect of Regional Analgesia on Quality of Recovery [NCT01479270] | | 56 participants (Actual) | Interventional | 2011-05-31 | Completed |
Phase I/II Study Epinephrine Inhalation Aerosol USP, an HFA-MDI Clinical Study-B for Assessment of Pharmacokinetics [NCT01143051] | Phase 1/Phase 2 | 24 participants (Actual) | Interventional | 2010-01-31 | Completed |
Determining the Role of Periarticular Multimodal Analgesia in Decreasing Perioperative Pain in Tibial Plateau Fractures [NCT05037812] | Early Phase 1 | 150 participants (Anticipated) | Interventional | 2019-03-25 | Active, not recruiting |
Post-Caesarean Section Incisional Infiltration With Lidocaine Versus Lidocaine and Epinephrine;Randomized Controlled Trial. [NCT02274974] | Phase 4 | 160 participants (Actual) | Interventional | 2014-08-31 | Completed |
A Comparative Study for Evaluation of the Analgesic Profile of Ultrasound-Guided Modified Pectoral Nerves Block Versus Serratus Plane Block in Major Breast Cancer Surgery [NCT02946294] | Phase 2 | 90 participants (Actual) | Interventional | 2016-10-31 | Completed |
Liposomal Bupivacaine Versus Bupivacaine for Postoperative Analgesia Following Video-assisted Thoracoscopic Surgery. [NCT03036085] | Phase 2/Phase 3 | 200 participants (Anticipated) | Interventional | 2017-02-28 | Not yet recruiting |
Endoscopic Ultrasound-guided Radiofrequency Ablation as a Novel Treatment Option Compared With Adrenalectomy in Left-sided Primary Aldosteronism [NCT05368090] | | 40 participants (Anticipated) | Interventional | 2022-06-03 | Recruiting |
A Prospective Randomized Comparison of the Effects of Lidocaine and Levobupivacaine on Block Dynamics After a Subparaneural Popliteal Sciatic Nerve Block [NCT04397484] | Phase 4 | 40 participants (Anticipated) | Interventional | 2023-09-20 | Recruiting |
Effect of Epinephrine on Systemic Absorption of Mepivacaine Administered for Brachial Plexus Block in Patients With Chronic Renal Insufficiency [NCT01533545] | | 16 participants (Actual) | Interventional | 2012-09-30 | Terminated(stopped due to Slow recruitment) |
Articaine Efficacy and Safety for 3 Years Old Children: A Clinical Randomized Control Trial [NCT05839548] | Phase 3 | 200 participants (Anticipated) | Interventional | 2023-06-01 | Not yet recruiting |
Randomized Controlled Trial of Epinephrine and Albuterol in Bronchiolitis [NCT00114478] | | 600 participants | Interventional | 2003-11-30 | Active, not recruiting |
Comparison of Infraclavicular and Supraclavicular Block Approaches in Ultrasound Guided Brachial Plexus Block [NCT04784104] | Phase 4 | 70 participants (Anticipated) | Interventional | 2021-03-05 | Not yet recruiting |
Prospective Comparison of Epinephrine and Phenylephrine/Ketorolac (Omidria®) Additives With Regards to Intraoperative Pupil Size [NCT02895035] | Phase 4 | 59 participants (Actual) | Interventional | 2016-09-01 | Terminated(stopped due to Data analysis was never performed by sub-investigator) |
Subcutaneous Injection of Large Volumes of Tumescent Lidocaine and Epinephrine (TLE) by Laypersons: a Double-blind, Non-inferiority, Randomized Clinical Trial [NCT04733781] | Phase 2/Phase 3 | 36 participants (Anticipated) | Interventional | 2021-02-22 | Not yet recruiting |
Trigger Finger Corticosteroid Injection With and Without Local Anesthetic; a Randomized, Double Blind Controlled Trial [NCT04023695] | Phase 4 | 110 participants (Actual) | Interventional | 2017-10-01 | Completed |
Propofol-dexmedetomidine Versus Propofol-remifentanil Conscious Sedation for Awake Craniotomy During Epilepsy Surgery [NCT02988050] | | 60 participants (Actual) | Interventional | 2013-08-31 | Completed |
Effect of Epinephrine on Immediate Post-polypectomy Pain in Colorectal Lesions Larger Than 20 mm [NCT04065451] | Phase 4 | 22 participants (Actual) | Interventional | 2020-01-06 | Completed |
Prospective, Randomized Study on Two Parallel Groups Comparing Dopexamine and Norepinephrine in Combination to Epinephrine Alone on Systemic and Pulmonary Hemodynamics, Gastric Mucosal Perfusion, and Oxidative Stress in Septic Shock [NCT00134212] | Phase 2 | 20 participants | Interventional | 2002-03-31 | Completed |
[NCT00225043] | | 60 participants (Actual) | Interventional | 2005-06-30 | Completed |
A Randomised, Double-blinded Multi-centre Trial Comparing Vasopressin and Adrenaline in Patients With Cardiac Arrest at the Emergency Department. (Preadmission Intravenous Vasopressin, Adrenaline Outcome Trial: PIVOT vII) [NCT00358579] | Phase 3 | 727 participants (Actual) | Interventional | 2006-03-31 | Completed |
Analgesic Efficacy of a Combination of Fentanyl and Lidocaine for Maxillary Infiltration in Teeth With Irreversible Pulpitis [NCT01794533] | Phase 2 | 64 participants (Actual) | Interventional | 2012-10-31 | Completed |
A Randomized Comparison Between Single- and Double-injection Ultrasound-Guided Costoclavicular Block [NCT03595514] | | 90 participants (Anticipated) | Interventional | 2018-07-30 | Recruiting |
Peri-articular Injections Containing a Corticosteroid During Total Knee Arthroplasty [NCT00492973] | | 101 participants (Actual) | Interventional | 2006-03-31 | Completed |
Surgical Treatment of Carpal Tunnel Syndrome: Local Anesthesia With Epinephrine x Intravenous Regional Anesthesia. Randomized Clinical Trial. [NCT02986347] | | 78 participants (Actual) | Interventional | 2017-05-27 | Completed |
Vasopressin vs. Epinephrine During Neonatal Cardiopulmonary Resuscitation - a Cluster Randomized Controlled Phase I Trial [NCT05738148] | Phase 1 | 20 participants (Anticipated) | Interventional | 2023-11-27 | Recruiting |
Effect of Lidocaine and Adrenaline Soaked Gauze Versus Normal Saline Soaked at Skin Graft Donor Site of Thigh: A Randomized Control Trial [NCT04344483] | | 60 participants (Actual) | Interventional | 2019-12-10 | Completed |
Goal-Directed Intraoperative Fluid Management Using FloTrac© Monitoring in High-Risk Neurosurgical Patients [NCT02701582] | | 66 participants (Actual) | Interventional | 2014-03-31 | Completed |
Decision Support for Intraoperative Low Blood Pressure [NCT02726620] | | 22,435 participants (Actual) | Interventional | 2017-01-05 | Completed |
Does the Choice of Perioperative Inotropes Has Influence on the Morbidity and Mortality of Infants Operated for Complex Heart Defects? [NCT04380181] | | 250 participants (Actual) | Observational | 2020-05-11 | Completed |
Efficacy of Multimodal Perioperative Analgesia Protocol With Periarticular Drug Injection in Total Knee Arthroplasty: A Randomized, Double Blind Study [NCT01042093] | | 160 participants (Actual) | Interventional | 2010-01-31 | Completed |
Comparison of Topical Vasoconstriction in Endoscopic Sinus Surgery: Cocaine Versus Adrenaline [NCT01706952] | Phase 4 | 45 participants (Actual) | Interventional | 2012-12-31 | Completed |
Does Single Injection Adductor Canal Block Improve Postoperative Analgesia in Patients Receiving Periarticular Local Anesthesia Injections for Total Knee Arthroplasty? [NCT02276495] | | 55 participants (Actual) | Interventional | 2014-09-26 | Active, not recruiting |
The Effect of Intranasal Vasoconstrictor Medications on Hemodynamic Parameters: A Randomized Double-blind, Placebo-controlled Trial. [NCT02285634] | | 68 participants (Actual) | Interventional | 2014-11-30 | Completed |
Perineural Steroids for Saphenous Peripheral Nerve Blocks: An Equivalency Dosing Study. [NCT02462148] | Phase 4 | 85 participants (Actual) | Interventional | 2015-07-31 | Completed |
The Effects of Systemic Steroids on the Duration of a Psoas Compartment Block. [NCT02464176] | Phase 4 | 115 participants (Actual) | Interventional | 2015-06-30 | Completed |
Does Selective Intraoperative Administration of Local Anesthesia in Breast Reconstruction Reduce Postoperative Pain and Opioid Requirement?: A Prospective Double-Blinded Randomized Controlled Trial [NCT02525718] | Phase 2 | 47 participants (Actual) | Interventional | 2015-08-31 | Completed |
Ultrasound-guided Fascia Iliaca Compartment Block Versus Periarticular Infiltration for Pain Management After Total Hip Arthroplasty: A Randomized Controlled Trial [NCT02658240] | | 60 participants (Actual) | Interventional | 2016-04-05 | Completed |
Efficacy of Liposomal Bupivacaine Versus Standard Analgesia in Pain Management of Total Joint Arthroplasty [NCT02197273] | | 211 participants (Actual) | Interventional | 2014-07-31 | Completed |
Prospective Randomized Study Comparing Suprainguinal Fascia Iliaca Block vs. Pericapsular Nerve Group Block vs. Local Anesthetic Infiltration vs. Spinal Anesthetic Without Adjuncts for Pain Control Following Total Hip Arthroplasty [NCT05062356] | Phase 1 | 240 participants (Anticipated) | Interventional | 2021-11-04 | Recruiting |
Perioperative Analgesia for Total Hip Arthroplasty: Lumbar Plexus Block Using Shamrock Technique Versus Fascia Iliaca Block [NCT04670497] | | 70 participants (Actual) | Interventional | 2018-07-01 | Completed |
The Effect of Intranasal Irrigation With Adrenaline Solution on Intraoperative Visualization and Bleeding During Functional Endoscopic Sinus Surgery [NCT04551703] | Phase 1 | 60 participants (Actual) | Interventional | 2016-07-01 | Completed |
Comparison of 2 Application Techniques for LET (Lidocaine 4%; Epinephrine 0.1%; Tetracaine 0.5%) Gel Used Prior to Simple Laceration Repair [NCT04536493] | Phase 4 | 48 participants (Actual) | Interventional | 2019-06-19 | Completed |
Postoperative Analgesia After Total Hip Arthroplasty. A Comparison of Continuous Epidural Infusion and Wound Infiltration With Intraarticular Bolus Injection. [NCT00289419] | Phase 4 | 80 participants (Actual) | Interventional | 2005-02-28 | Completed |
Low Dose Adrenaline, Promethazine, & Hydrocortisone (Alone and in Combination) to Prevent Acute Adverse Reactions to Antivenom in People Bitten by Snakes: Randomised, Double Blind, Placebo-Controlled Trial [NCT00270777] | Phase 4 | 1,000 participants (Anticipated) | Interventional | 2005-03-31 | Completed |
Safety and Efficacy of Cocktail Periarticular Injection for Pain Management in Simultaneous Bilateral Total Knee Arthroplasty- A Prospective, Randomized Trial [NCT02270437] | Phase 4 | 55 participants (Actual) | Interventional | 2014-06-30 | Completed |
[NCT00298571] | Phase 2/Phase 3 | 100 participants (Anticipated) | Interventional | 2006-02-28 | Completed |
Buffered vs Unbuffered Local Anesthesia Using Lidocaine, Carbocaine, and Articaine in Mandibular Molars Diagnosed With Symptomatic Irreversible Pulpitis [NCT06047366] | Phase 4 | 60 participants (Anticipated) | Interventional | 2023-12-05 | Recruiting |
The Effect and Safety of Low Dose Nebulized Epinephrine in the Treatment of Croup [NCT01664507] | Phase 4 | 84 participants (Anticipated) | Interventional | 2016-01-31 | Recruiting |
Efficacy of Intraoperative Injections on Postoperative Pain Control During Total Hip Arthroplasty: A Prospective, Blinded, Randomized Controlled Study [NCT03119038] | Phase 4 | 0 participants (Actual) | Interventional | 2016-04-30 | Withdrawn(stopped due to Investigator no longer actively pursuing this study.) |
Microneedle Pretreatment as a Strategy to Improve the Effectiveness of Topical Anesthetics Formulations [NCT05267938] | Phase 1 | 30 participants (Actual) | Interventional | 2019-08-01 | Completed |
Bupivacaine Digital Blocks: How Long is the Pain Relief and Temperature Elevation? [NCT01698593] | | 44 participants (Actual) | Interventional | 2009-07-31 | Completed |
The Effect of Intraoperative Low Dose Adrenaline on Bleeding in Total Hip Arthroplasty - a Randomized Placebo-controlled Trial [NCT01708642] | Phase 3 | 106 participants (Actual) | Interventional | 2012-11-30 | Completed |
"Hemodynamic and Electrocardiographic Effects of Hyaluronidase Associated With Local Anaesthetics: a Double-blind Split-mouth Controlled Trial." [NCT01719978] | Phase 4 | 20 participants (Actual) | Interventional | 2007-10-31 | Completed |
A Prospective, Double-blinded, Randomized Comparison of Ultrasound-guided Femoral Nerve Block With Lateral Femoral Cutaneous Nerve Block Versus Standard Anesthetic Management for Traumatic Femur Fracture Repair in the Pediatric Population [NCT01759407] | Phase 2 | 19 participants (Actual) | Interventional | 2013-05-31 | Terminated(stopped due to Interim analysis showed no significant difference between study arms.) |
Comparison Between Epinephrine and Exercise Test in QT Long Syndrome Patients With KCNQ1 or KCNH2 Mutation Without Long QT Interval in Rest ECG [NCT01745666] | | 130 participants (Anticipated) | Interventional | 2012-05-31 | Recruiting |
A Randomized Single-blinded Trial of Combined Spinal-Epidural Versus Continuous Epidural Analgesia [NCT01750099] | | 202 participants (Anticipated) | Interventional | 2013-02-28 | Completed |
MCP Study, A Double-Blinded, Randomized Controlled Trial To Compare Multifidus Cervicis Plane Block (MCP) Vs. Sham Block, In Reducing Postoperative Pain And Opioid Consumption In Patients Undergoing Elective Primary Posterior Cervical Spine Fusion Surgery [NCT05996133] | Phase 4 | 38 participants (Anticipated) | Interventional | 2023-12-12 | Recruiting |
Sciatic Nerve Block for Ankle/Foot Surgeries. A Comparison Between a Premixed Solution of Lidocaine Plus Bupivacaine and Consecutive Infiltration of Lidocaine and Bupivacaine. A Double Blinded Randomised Controlled Prospective Study [NCT01756443] | Phase 4 | 40 participants (Actual) | Interventional | 2011-08-31 | Completed |
Incident and Extent of Pulse Alteration During Administration of Various Modes of Local Anesthesia in Children During Routine Dental Treatment [NCT02328729] | | 300 participants (Anticipated) | Observational | 2015-01-31 | Not yet recruiting |
Local Infiltration Analgesia After Abdominal Hysterectomy [NCT01782781] | Phase 3 | 60 participants (Actual) | Interventional | 2012-11-30 | Completed |
Autologous Fat Grafting for Pedal Fat Pad Atrophy [NCT01796808] | | 31 participants (Actual) | Interventional | 2013-03-31 | Completed |
Pilot Study: Epinephrine, Dexamethasone, and Hypertonic Saline in Children With Bronchiolitis, Randomised Clinical Trial of Efficacy and Safety [NCT01834820] | Phase 4 | 120 participants (Actual) | Interventional | 2013-01-31 | Completed |
Efficacy of Prophylactic Epinephrine Solution Injection in Prevention of Delayed Post-sphincterotomy Bleeding in Patients With Transient Bleeding During ERCP [NCT04964869] | | 400 participants (Anticipated) | Interventional | 2021-07-15 | Recruiting |
Onset and Duration of Effect of Lidocaine, Bupivacaine, and Lidocaine/Bupivacaine Mixture With Epinephrine. [NCT01243112] | Phase 4 | 25 participants (Actual) | Interventional | 2010-05-31 | Completed |
Control of Tourniquet Pain With an Axillary Ring of Subcutaneous Local Anesthetic [NCT01829399] | Phase 4 | 24 participants (Actual) | Interventional | 2013-04-30 | Completed |
A Prospective, Multicenter Study to Evaluate Effectiveness and Safety of Tymbion Iontophoresis and Tympanostomy Tube Placement Using the Tula Iontophoresis and Tube Delivery Systems for Adults in an Office Setting [NCT03119181] | Phase 2 | 40 participants (Actual) | Interventional | 2017-04-27 | Completed |
Intramuscular Epinephrine as an Adjunctive Treatment for Severe Pediatric Asthma Exacerbation [NCT01705964] | Phase 4 | 49 participants (Actual) | Interventional | 2013-06-30 | Completed |
A Comparison of Tumescence in Breast Reduction Surgery [NCT01602692] | Phase 4 | 40 participants (Actual) | Interventional | 2012-08-31 | Completed |
Reduction of Hip Arthroscopy Post-operative Pain Using Ultrasound-guided Fascia-iliaca Block [NCT02365961] | Phase 4 | 84 participants (Actual) | Interventional | 2015-04-30 | Completed |
Comparison of 2 Application Techniques for LET (Lidocaine 4%; Epinephrine 0.1%; Tetracaine 0.5%) Gel Used Prior to Simple Laceration Repair in Children [NCT04203225] | Phase 4 | 48 participants (Actual) | Interventional | 2017-05-22 | Completed |
A Prospective Randomized Trial of Transversus Abdominis Plane (TAP) INtraoperative Block With Bupivacaine/Dexamethasone aGainst Liposomal Bupivacaine (Exparel®): the TINGLE Trial [NCT03723447] | Phase 4 | 102 participants (Actual) | Interventional | 2018-10-23 | Completed |
Vapocoolant Spray as a Novel Local Anesthetic for Cutaneous Abscess Incision and Drainage [NCT01673061] | Phase 4 | 21 participants (Actual) | Interventional | 2012-08-31 | Terminated(stopped due to Vapocoolant not effective controlling pain compared with Lidocaine.) |
Comparing the Effectiveness of Misoprostol, Oxytocin, Carbetocin, Vasopressin, Bupivacaine and Epinephrine, Combined IV TXA Acid and Ethamsylate and Peri Cervical Tourniquet for the Reduction of Blood Loss During of Abdominal Myomectomy. [NCT05806307] | Phase 4 | 105 participants (Anticipated) | Interventional | 2023-03-15 | Recruiting |
The Effect of Buccal Infiltration Administration of Clonidine on the Success Rate of Inferior Alveolar Nerve Block on Mandibular Molars With Symptomatic Irreversible Pulpitis: a Randomized Double-blind Clinical Trial [NCT04186299] | Phase 4 | 0 participants (Actual) | Interventional | 2021-08-31 | Withdrawn(stopped due to Study activities never commenced.) |
Pre-emptive Epinephrine Nebulization Prior to Nasotracheal Intubation for Mandibular Fracture Fixation Surgeries:Dose it Really Differs? a Randomized Controlled Study [NCT05738564] | Phase 3 | 126 participants (Actual) | Interventional | 2021-09-01 | Completed |
Postoperative Analgesia After Total Knee Arthroplasty. A Comparison of Continuous Epidural Infusion and Wound Infiltration With Continuous Intraarticular Infusion [NCT00421967] | Phase 4 | 80 participants (Actual) | Interventional | 2007-01-31 | Terminated(stopped due to Interim analysis) |
A Single Center, Double-blind, Parallel-group, Two Factor Patient-Experience Management Study of ATX-101 (Deoxycholic Acid Injection) for the Reduction of Localized Subcutaneous Fat in the Submental Area [NCT02007434] | Phase 3 | 84 participants (Actual) | Interventional | 2013-12-31 | Completed |
Effect of Silver Diamine Fluoride on Local Anesthesia Efficacy in Molar Incisor Hypomineralization-affected Molars in Children: A Randomized Clinical Trial [NCT05964387] | | 50 participants (Anticipated) | Interventional | 2023-06-12 | Recruiting |
LIBERATE - LIposomal Bupivacaine vERsus Adjuncts in Total shouldErs: A Randomized Controlled Trial of Injection at the Brachial Plexus [NCT03887650] | Phase 4 | 90 participants (Actual) | Interventional | 2019-03-11 | Completed |
Loss of Resistance With Nerve Stimulation Versus Loss of Resistance Alone; Effect on Success of Thoracic Epidural Placement. [NCT03087604] | Phase 4 | 100 participants (Actual) | Interventional | 2017-03-17 | Completed |
Tranexamic Acid Versus Adrenaline for Controlling Iatrogenic Endobronchial Bleeding: a Double Blind, Randomized Controlled Trial [NCT04771923] | | 130 participants (Actual) | Interventional | 2021-02-22 | Completed |
The Role of Adrenaline in the Reduction of Subcutaneous Ecchymoses and Hematomas and in the Improvement of the Quality of Life of Patients After Classic Great Saphenous Vein Stripping [NCT04758728] | | 40 participants (Actual) | Interventional | 2015-09-10 | Completed |
Epinephrine Inhalation Aerosol USP, an HFA-MDI CLINICAL STUDY-B2 FOR ASSESSMENT OF PHARMACOKINETICS (A Randomized, Evaluator-Blind, Single-Dose, Two Arm, Crossover, PK Study in Healthy Volunteers) [NCT01188577] | Phase 1/Phase 2 | 23 participants (Actual) | Interventional | 2010-08-31 | Completed |
Infiltration Between the Popliteal Artery and the Capsule of the Knee (iPACK) With Local Infiltration of Analgesia (LIA) and Adductor Canal Block (ACB) Improves Postoperative Pain in Total Knee Arthroplasty: A Randomized Controlled Trial [NCT04635176] | Phase 4 | 120 participants (Anticipated) | Interventional | 2022-10-30 | Recruiting |
Efficacy of Ultrasound-guided Transversalis Fascia Plane Blocks for Post-cesarean Section Analgesia: a Randomized Double Blinded Control Study [NCT03236324] | Phase 2 | 106 participants (Actual) | Interventional | 2017-09-22 | Completed |
LIA in Hip Arthroscopy Patients: An Extra-Capsular Approach [NCT03070054] | Early Phase 1 | 74 participants (Actual) | Interventional | 2016-06-30 | Completed |
Arterial Pressure and Stress-Dose Steroids in In-hospital Cardiac Arrest: a Mediation Analysis of Prior Randomized Clinical Trial Data. [NCT02785224] | | 191 participants (Anticipated) | Observational | 2023-12-31 | Not yet recruiting |
Efficacy of Nebulised Hypertonic Saline (3%) Among Children With Mild to Moderately Severe Bronchiolitis - A Double Blind Randomized Controlled Trial. [NCT01276821] | Phase 4 | 100 participants (Actual) | Interventional | 2011-01-31 | Completed |
A Randomized Controlled Trial of a Full and a Fractional Ablative Carbon Dioxide Laser as Pretreatment for Photodynamic Therapy in the Management of Superficial Non Melanoma Skin Cancer [NCT03012009] | | 16 participants (Actual) | Interventional | 2014-09-30 | Completed |
A Randomized Trial of Rectal Indomethacin and Papillary Spray of Epinephrine Versus Rectal Indomethacin to Prevent Post-ERCP Pancreatitis in High Risk Patients [NCT02116309] | | 948 participants (Actual) | Interventional | 2014-08-31 | Completed |
Perioperative Pain Management for Total Shoulder Arthroplasty: A Pilot Non-Inferiority Trial [NCT05908851] | | 80 participants (Anticipated) | Interventional | 2023-11-01 | Not yet recruiting |
Optimal Timing of Intercostal Nerve Blocks During Video-Assisted Thoracic Surgeries [NCT02980835] | Phase 4 | 36 participants (Actual) | Interventional | 2016-09-28 | Completed |
Assessment of Knee Pain in Patients Receiving Continuous Femoral Nerve Block Combined With Either Ultrasound Guided Posterior Capsular Injection or Selective Tibial Nerve Block Following Total Knee Arthroplasty [NCT02701296] | | 80 participants (Actual) | Interventional | 2011-11-07 | Completed |
Bilateral Mid-Abdominal Transverse Abdominis Plane and Rectus Sheath Blocks Comparing The Use of Liposomal Bupivacaine/Bupivacaine vs. Regular Bupivacaine in Laparoscopic Colectomy Procedures. [NCT05224089] | Phase 4 | 114 participants (Anticipated) | Interventional | 2022-04-27 | Recruiting |
Postoperative Analgesia After Elective Hip Surgery - Effect of Obturator [NCT03064165] | Phase 4 | 62 participants (Actual) | Interventional | 2017-08-15 | Completed |
Effect of Papillary Epinephrine Spraying on Post-ERCP Pancreatitis in Patients Received Rectal Indomethacin: A Multi-center, Double-blind, Randomized Controlled Trial [NCT03057769] | | 3,300 participants (Actual) | Interventional | 2017-02-01 | Terminated(stopped due to This study was terminated because of an interim analysis suggesting futility of papillary epinephrine spraying in PEP prevention.) |
Pediatric Out-of-Hospital Cardiac Arrest Resuscitation: Evaluation of IM Epinephrine (The PRIME Trial) [NCT05166343] | Phase 2/Phase 3 | 76 participants (Anticipated) | Interventional | 2023-01-31 | Not yet recruiting |
Prospective Evaluation of Topical Anesthesia in Children [NCT04378283] | | 99 participants (Actual) | Interventional | 2016-05-31 | Completed |
Second-look Endoscopy in High Risk Patients After Endoscopic Hemostasis to Their Bleeding Peptic Ulcers Improves Their Outcomes [NCT02352155] | | 157 participants (Actual) | Interventional | 2015-02-04 | Terminated |
Optimal Method for Mydriasis in Cataract Surgery [NCT02909140] | | 3 participants (Actual) | Interventional | 2016-09-30 | Terminated(stopped due to insufficient patient recruitment) |
Comparison of Adductor Canal Block Combined With IPACK Block and Adductor Canal Block Combined With PCI for Postoperative Analgesia and Function Recovery Following Total Knee Arthroplasty:A Prospective, Double-Blind, Randomized Controlled Study [NCT05943080] | | 159 participants (Anticipated) | Interventional | 2023-06-01 | Active, not recruiting |
A Randomized Double-Blinded, Placebo-Controlled Study of Omalizumab for Idiopathic Anaphylaxis [NCT00890162] | Phase 2 | 16 participants (Actual) | Interventional | 2009-04-27 | Completed |
Metabolic Adaptation to High-frequent Hypoglycaemia in Type 1 Diabetes - the HypoADAPT Study [NCT05095259] | | 60 participants (Anticipated) | Interventional | 2019-12-16 | Active, not recruiting |
A Clinical Comparison of Microsurgical Versus Conventional Surgical Approaches for the Semilunar Coronally Advanced Flap [NCT02433899] | Phase 4 | 14 participants (Actual) | Interventional | 2010-10-31 | Completed |
Comparison of Plasma Concentrations of Levobupivacaine With and Without Epinephrine for Transversus Abdominis Plane Block Under Ultrasound. [NCT01596998] | Phase 4 | 11 participants (Actual) | Interventional | 2011-12-31 | Completed |
Efficacy of Alkalinised 2% Mepivacaine for Local Infiltration Anesthesia, in Ambulatory Phlebectomy [NCT01611324] | Phase 4 | 100 participants (Actual) | Interventional | 2012-05-31 | Completed |
Assessment and Hemodynamic Response in CABG After Cardiopulmonary Bypass Using Intraoperative Transesophegeal Echocardiography [NCT01616069] | Phase 4 | 81 participants (Actual) | Interventional | 2012-02-29 | Completed |
Effect of Target Intraoperative Blood Pressure on the Incidence of Post-operative Cognitive Dysfunction in Patients Aged 75 and Older Undergoing General Anesthesia for Non-cardiac Surgery: an International Multicenter Randomized Controlled Trial [NCT02428062] | Phase 2/Phase 3 | 1,812 participants (Anticipated) | Interventional | 2014-10-31 | Suspended(stopped due to Pending Pilot study results evaluation) |
Bupivacaine Liposome Suspension Versus a Concentrated Multi Drug Periarticular Injection in 70 Patients Undergoing Total Knee Arthroplasty Without Femoral Nerve Block: a Double-blinded, Randomized Clinical Trial [NCT02299349] | | 70 participants (Actual) | Interventional | 2013-08-31 | Completed |
Cardiac Index Changes With Ephedrine, Phenylephrine, Ondansetron and Norepinephrine During Spinal Anesthesia for Cesarian Section [NCT03421860] | Phase 4 | 120 participants (Actual) | Interventional | 2017-02-23 | Completed |
Impact of Intracoronary Versus Central and Peripheral Intravenous Epinephrine Administration During Cardiac Arrest in The Cardiac Catheterization Laboratory for Acute Myocardial Infarction Patients. [NCT05253937] | | 160 participants (Actual) | Observational | 2018-04-01 | Completed |
A Prospective, Randomized, Single-Blind Study to Evaluate the Efficacy of Transversus Abdominis Plane Versus Paravertebral Regional Blockade in Patients Undergoing Laparoscopic Colectomy [NCT02164929] | | 17 participants (Actual) | Interventional | 2013-12-31 | Terminated(stopped due to Poor recruitment) |
The Effects of Injection Site Cooling and Solution Buffering on Perceived Pain During Local Anesthesia Administration [NCT04991597] | | 0 participants (Actual) | Interventional | 2022-01-01 | Withdrawn(stopped due to Shift in research focus) |
Efficacy of Injected Local Anesthetic vs Topical Anesthetic in Cosmetic Injectable Fillers [NCT02379221] | | 49 participants (Actual) | Interventional | 2014-09-30 | Completed |
Fertility and Pregnancy in Patients With Classic Congenital Adrenal Hyperplasia [NCT06153043] | | 55 participants (Anticipated) | Observational | 2023-12-31 | Not yet recruiting |
Optimal Vasopressor Titration Pilot Randomized Controlled Trial [NCT01800877] | | 120 participants (Actual) | Interventional | 2013-04-30 | Completed |
Comparing Pre-emptive Injection of Peri-Articular-Multimodal Drug With Oral Celecoxib for Postoperative Pain Management in Total Knee Arthroplasty: A Randomized Clinical Trial [NCT05324995] | Phase 2 | 146 participants (Actual) | Interventional | 2021-01-01 | Completed |
Anesthetic Efficacy of 4% Buffered Lidocaine in Emergency Patients With Facial Swelling. [NCT01981772] | | 88 participants (Actual) | Interventional | 2013-03-31 | Completed |
Comparision Between Hemodynamic Response of Dexmedetomidine and Remifentanil for Epinephrine Local Injection in Patient With Endoscopic Sinus Surgery Under General Anesthesia [NCT02464722] | Phase 4 | 50 participants (Anticipated) | Interventional | 2015-08-31 | Enrolling by invitation |
Epinephrine Sprayed on the Papilla and Rectal Indomethacin Versus Sterile Water Sprayed on the Papilla and Rectal Indomethacin for Preventing Pancreatitis After Endoscopic Retrograde Cholangiopancreatography: A Prospective, Randomized, Controlled Trial [NCT02959112] | | 548 participants (Actual) | Interventional | 2016-05-31 | Terminated(stopped due to Because previous studies had found no difference, and one recent study even reported a higher incidence of PEP in treatment arm) |
Transversus Abdominis Plane (TAP) Infiltration vs. Surgical Infiltration of Local Anesthetic in Laparoscopic and Robotic Assisted Hysterectomy [NCT02519023] | Phase 4 | 87 participants (Actual) | Interventional | 2016-07-31 | Completed |
A Comparison of Ultrasound Guided Transversus Abdominis Plane Nerve Block Technique Versus Laparoscopic Transversus Abdominis Plane Nerve Block Technique Versus No Block on Postoperative Opioid Consumption After Major Colorectal Surgery [NCT02538679] | | 127 participants (Actual) | Interventional | 2015-08-07 | Completed |
Liposomal Bupivacaine in Implant Based Breast Reconstruction [NCT02659501] | | 24 participants (Actual) | Interventional | 2015-07-31 | Terminated |
Post-surgical Pain Care Pathways During Enhanced Recovery Surgery Using Exparel (Bupivacaine Liposome Injectable Suspension) Plus Bupivacaine With Epinephrine Versus Bupivacaine. [NCT03001453] | Phase 2 | 107 participants (Actual) | Interventional | 2014-04-30 | Completed |
Comparing Blood Loss and Visualization After the Preoperative Use of Topical 0.05% Oxymetazoline Versus 1:1000 Epinephrine Prior to Endoscopic Sinus Surgery [NCT03228914] | Phase 4 | 20 participants (Actual) | Interventional | 2018-06-14 | Completed |
Efficacy of Subcutaneous Infiltration With Local Anesthetic During Elective Cesarean Delivery for Postoperative Pain Control: a Randomized Controlled Trial [NCT03383588] | Phase 2 | 26 participants (Actual) | Interventional | 2018-07-19 | Terminated(stopped due to study was published during initial recruitment that showed no difference) |
Comparison of the Effect of Epinephrine, Norepinephrine and Phenylephrine on Spinal Anesthesia Induced Hypotension [NCT03163914] | Phase 4 | 160 participants (Actual) | Interventional | 2017-07-19 | Completed |
Postoperative Prolonged Vasoactive-inotropic Support and Levosimendan Use After Lung Transplantation: a Retrospective Analysis of Risk Factors and Impact on Outcomes [NCT05702333] | | 150 participants (Actual) | Observational | 2017-02-01 | Completed |
An Open-label, Cohort Study on Effects and Long-term Prognosis of Adrenal Artery Ablation and Spironolactone in Patients With Primary Aldosteronism [NCT04409431] | | 60 participants (Anticipated) | Interventional | 2019-12-01 | Recruiting |
A Phase 2 Multicenter, Randomized, Double-blind, Parallel-group, Active-control, Dose-ranging Study to Evaluate the Safety and Efficacy of a Single Administration of SKY0402 for Prolonged Postoperative Analgesia in Subjects Undergoing Primary Unilateral I [NCT00485433] | Phase 2 | 98 participants (Actual) | Interventional | 2007-06-30 | Completed |
Inhaled Beta-2 Agonist Versus Epinephrine For Treatment of Transient Tachypnea of Newborn [NCT05006235] | Phase 1 | 135 participants (Actual) | Interventional | 2014-02-01 | Completed |
The Effect of Popliteal Plexus Block on Postoperative Pain After Total Knee Arthroplasty [NCT03198403] | Phase 4 | 17 participants (Actual) | Interventional | 2017-08-01 | Completed |
Efficacy of External Nasal Nerve Block on Postoperative Agitation Following Nasal Surgeries Under General Anesthesia. Randomized, Controlled Trial [NCT03069027] | | 100 participants (Actual) | Interventional | 2016-08-15 | Completed |
To Compare the Pulpal Oxygen Saturation Level After Administering Mepivacaine With and Without Vasoconstrictor: A Randomized Clinical Trial [NCT04947267] | Phase 2 | 60 participants (Actual) | Interventional | 2018-05-30 | Completed |
Addition of Clonidine to Ropivacaine in Adductor Canal Block for Postoperative Pain Relief in Total Knee Arthroplasty: A Prospective Randomized Double Blind Placebo Controlled Trial [NCT03057015] | Phase 4 | 80 participants (Anticipated) | Interventional | 2017-05-22 | Recruiting |
The Pectoral Block for Breast Augmentation Surgery: a Volunteers' and Patients' Study. [NCT03040167] | Phase 4 | 20 participants (Actual) | Interventional | 2017-10-01 | Completed |
Early Ultrasound-guided Nerve Block for Painful Hand Injuries in the Emergency Department [NCT03195413] | | 15 participants (Actual) | Interventional | 2017-07-01 | Completed |
Ultrasound-guided Median Nerve Block With Dextrose 5% Hydrodissection: Determination of the Minimal Effective Volume of Local Anesthetic [NCT02438657] | Phase 2/Phase 3 | 52 participants (Actual) | Interventional | 2015-05-21 | Completed |
Comparative Evaluation of the Anesthetic Efficacy of 1,8mL and 3,6mL of 4% Articaine With 1: 100,000 Epinephrine in Blocking the Inferior Alveolar Nerve in Patients With Irreversible Pulpitis of Mandibular Molars [NCT02422823] | | 90 participants (Actual) | Interventional | 2015-04-30 | Completed |
Two-arm, Double-blind Randomized Study Comparing Exparel and Exparel Plus an Adductor Canal Block in Total Knee Arthroplasty [NCT02365727] | Phase 4 | 0 participants (Actual) | Interventional | 2015-04-30 | Withdrawn(stopped due to Protocol not feasible as written) |
Adductor Canal Block and Functional Recovery After Total Knee Arthroplasty. A Double-Blind, Randomized Controlled Trial [NCT02411149] | Phase 4 | 200 participants (Actual) | Interventional | 2014-04-30 | Completed |
Psoas Compartment Block Versus Periarticular Local Anesthetic Infiltration for Pain Management for Total Hip Arthroplasty: A Prospective, Randomized Study [NCT02658149] | Phase 4 | 100 participants (Actual) | Interventional | 2016-05-31 | Completed |
Title of Project: Liposomal Bupivacaine (Exparel) Versus Bupivacaine And Dexamethasone Intercostal Nerve Blocks For Robotic Thoracic Surgery: A Prospective Randomized Single-Blinded Clinical Trial [NCT03906617] | Phase 4 | 34 participants (Anticipated) | Interventional | 2019-04-10 | Recruiting |
Comparison of Two Different Concentrations of Local Anesthetic in Patient Reported Pain in Oculoplastic Surgery [NCT06121141] | Phase 4 | 30 participants (Anticipated) | Interventional | 2023-08-07 | Enrolling by invitation |
Clinical Effectiveness of Erector Spinae Plane Block in Peri-operative Analgesia for Laparoscopic Kidney Procedures [NCT03874091] | | 62 participants (Actual) | Interventional | 2019-01-15 | Completed |
A Phase 2, Two-Part, Multicenter Study of HTX-011 in Spinal Surgery [NCT04911062] | Phase 2 | 32 participants (Actual) | Interventional | 2022-04-07 | Completed |
Comparison of Interscalene vs. Superficial Cervical Block vs. Combination of Both Blocks for Analgesia After Operative Repair of Midshaft and Lateral Clavicle Fractures [NCT03094481] | | 120 participants (Anticipated) | Interventional | 2016-10-21 | Recruiting |
Effect of Topical and Systemic Tranexemic Acid on Bleeding and Quality of Surgical Field During Ear Exploration Surgery. A Double Blind Randomized Clinical Trial [NCT03112135] | Phase 2 | 90 participants (Anticipated) | Interventional | 2017-04-30 | Recruiting |
Role of Adrenaline in the Inflammatory Response in People With Diabetes Mellitus Type 1, and Healthy Individuals [NCT05990933] | | 30 participants (Anticipated) | Interventional | 2023-09-30 | Not yet recruiting |
Effects of Nasal Desmopressin Spray Versus Topical Epinephrine on Surgical Field Clarity and Hemodynamics in Endonasal Dacryocystorhinostomy: A Randomized Clinical Study. [NCT05507476] | | 52 participants (Actual) | Interventional | 2022-09-01 | Completed |
Local Injection of Tranexamic Acid May Reduce Bleeding, Injection Pain, and Other Post-op Complications During Mohs Micrographic Surgery [NCT04630886] | Early Phase 1 | 200 participants (Anticipated) | Interventional | 2021-06-16 | Enrolling by invitation |
Adjuvants to Ultrasonic Guided Interscalene Block In Arthroscopic Rotator Cuff Repair; Morphine and/or Nalbuphine [NCT03034382] | Phase 2 | 80 participants (Anticipated) | Interventional | 2016-01-31 | Recruiting |
CanROC Epinephrine Dose: Optimal Versus Standard Evaluation Trial (CanROC EpiDOSE Trial) [NCT03826524] | Phase 4 | 3,790 participants (Anticipated) | Interventional | 2023-05-24 | Recruiting |
Evaluation of Cardiac Arrhythmias in Hand Surgery Using Local Anesthesia With Adrenaline [NCT04029610] | | 110 participants (Actual) | Interventional | 2018-08-14 | Completed |
Gonyautoxins Local Periarticular Injection for Pain Management After Total Knee Arthroplasty: A Double Blind Randomized Study [NCT03025594] | Phase 3 | 64 participants (Anticipated) | Interventional | 2017-01-31 | Recruiting |
Nebulized Epinephrine Versus Nebulized Salbutamol in Bronchiolitis Among Children Aged 1month-24months [NCT03814954] | | 90 participants (Actual) | Interventional | 2019-01-01 | Completed |
Ultrasound-guided Peripheral Nerve Block for Non-intubated Uniportal Video-assisted Thoracoscopic Surgery [NCT03083080] | | 30 participants (Anticipated) | Interventional | 2017-03-27 | Not yet recruiting |
Pharmacokinetics of Intramuscular Adrenaline in Food--Allergic Teenagers: Does Dose Matter? [NCT03366298] | Phase 4 | 12 participants (Actual) | Interventional | 2017-11-24 | Completed |
Characterizing and Comparing the Duration of Local Anesthetic in Dermatologic Surgery [NCT05767749] | Phase 4 | 75 participants (Actual) | Interventional | 2023-03-14 | Completed |
Does the Addition of Epinephrine Increase the Duration of Intrathecal Hyperbaric Bupivacaine for Repeat Cesarean Section? [NCT02369510] | Phase 4 | 68 participants (Actual) | Interventional | 2015-02-28 | Completed |
Comparison of Rectal Infiltration of Exparel vs. 0.25% Bupivacaine With Epinephrine vs. Placebo for Analgesic Benefit Following Hemorrhoidectomy [NCT02104414] | Phase 4 | 11 participants (Actual) | Interventional | 2014-04-30 | Terminated(stopped due to low enrollment) |
Preemptive Local Anesthesia in Vaginal Surgery, A Prospective, Randomised Trial [NCT00318292] | Phase 4 | 90 participants (Actual) | Interventional | 2006-04-30 | Completed |
Phase 3 Study of Ropivacaine (With Epinephrine) in BABA Endoscopic and Robotic Thyroidectomy [NCT02112370] | Phase 3 | 148 participants (Actual) | Interventional | 2014-05-31 | Completed |
A Phase 2 Multicenter, Randomized, Double-blind, Parallel-group, Active-control, Dose-ranging Study to Evaluate the Safety and Efficacy of a Single Administration of SKY0402 for Prolonged Postoperative Analgesia in Subject Undergoing Hemorrhoidectomy [NCT00529126] | Phase 2 | 100 participants (Actual) | Interventional | 2007-09-30 | Completed |
Methemoglobin Levels in Generally Anesthetized Pediatric Dental Patients Receiving Prilocaine Versus Lidocaine [NCT01402869] | | 91 participants (Actual) | Interventional | 2011-08-31 | Completed |
Subcutaneous Tranexamic Acid in Nasal Mohs Local Flap Reconstruction: Perioperative Bleeding, Edema, and Ecchymosis [NCT06057675] | Phase 2 | 100 participants (Anticipated) | Interventional | 2023-12-31 | Not yet recruiting |
The Effectiveness of Automated Soft Tissue Vibration in Reducing Pain and Accelerating Action of Intraoral Local Anesthesia Injections in Adult Dental Patients. A Randomized Crossover Clinical Trial. [NCT03839134] | | 166 participants (Actual) | Interventional | 2019-03-20 | Completed |
Effects of Pre-emptive Scalp Infiltration With Low-dose Ketorolac and Ropivacaine for Postoperative Pain Relief After Elective Supratentorial Craniotomy (PAINLESS): a Randomized Controlled Pilot Trial [NCT04380298] | Phase 4 | 40 participants (Anticipated) | Interventional | 2020-12-01 | Not yet recruiting |
A One-year Placebo-Controlled Study Evaluating the Efficacy and Safety of the House Dust Mite Sublingual Allergen Immunotherapy Tablet (SCH 900237/MK 8237) in Children and Adult Subjects With House Dust Mite-Induced Allergic Rhinitis/Rhinoconjunctivitis W [NCT01700192] | Phase 3 | 1,482 participants (Actual) | Interventional | 2013-01-31 | Completed |
Administration of Local Anesthetic in Trigger Thumb Surgery: A Randomized Clinical Trial [NCT03873480] | | 31 participants (Actual) | Interventional | 2018-10-02 | Completed |
The Role of Hypertonic Dextrose Spray as Endoscopic Topical Hemostatic Agent for Acute Non-Variceal Upper Gastrointestinal Bleeding: A Randomized Controlled Trial [NCT04979273] | | 66 participants (Anticipated) | Interventional | 2021-03-01 | Recruiting |
Fast-track Rehabilitation Protocol for Total Knee Arthroplasty: A Randomized Controlled Trial Comparing Local Infiltration Analgesia With Femoral Nerve Block [NCT01966263] | Phase 4 | 80 participants (Actual) | Interventional | 2013-11-30 | Completed |
Analgesia After Total Knee Arthroplasty: Adductor Canal Block With Periarticular Injection and IPACK (ACB/PAI/IPACK) Versus Periarticular Injection (PAI). A Double-Blinded Randomized Controlled Trial [NCT03094663] | | 86 participants (Anticipated) | Interventional | 2017-02-28 | Recruiting |
Alkalinization of Adrenalized Lidocaine in Extending Epidural Analgesia for Extremely Urgent Cesarean Section During Labor: a Randomized Controlled Trial. [NCT05313256] | Phase 2/Phase 3 | 66 participants (Anticipated) | Interventional | 2022-07-14 | Recruiting |
The Use of Epinephrine Infusion for Prophylaxis Against Maternal Hypotension During Cesarean Delivery: a Randomized Controlled Dose-finding Trial [NCT05279703] | Phase 4 | 276 participants (Anticipated) | Interventional | 2022-03-21 | Recruiting |
Voiding Function After Mid-Urethral Slings With and Without Local Anesthetic: Randomized Controlled Trial [NCT01583166] | | 90 participants (Actual) | Interventional | 2012-03-31 | Completed |
Comparison of Different Approaches for Supraclavicular Block and Their Effects on Diaphragm Muscle Function Evaluated With Diaphragm Thickening Fraction [NCT04756050] | Phase 4 | 90 participants (Actual) | Interventional | 2021-02-16 | Completed |
Efficacy of a Peri-Operative Surgical-Site, Multimodal Drug Injection in Pediatric Patients With Cerebral Palsy Undergoing Hip Surgery: A Randomized Controlled Trial [NCT04074265] | Phase 4 | 34 participants (Actual) | Interventional | 2019-12-01 | Completed |
Treatment of Ventricular Tachyarrhythmias Refractory To Shock With Beta Blockers: The SHOCK and BLOCK Trial [NCT00401882] | Phase 2 | 7 participants (Actual) | Interventional | 2007-01-31 | Terminated(stopped due to Difficult accrual) |
TAP-catheter With Intermittent Bolus Injections of Bupivacain, an Alternative to Epidural Catheter Infusion After Colon Surgery? [NCT01395043] | | 15 participants (Actual) | Interventional | 2010-09-30 | Completed |
Phase 3, Multicenter, Randomized, Double-Blind, Parallel-group, Active-control Study to Evaluate the Safety and Efficacy of a Single Administration of SKY0402 for Prolonged Postoperative Analgesia in Subjects Undergoing Hemorrhoidectomy [NCT00744848] | Phase 3 | 204 participants (Actual) | Interventional | 2008-08-31 | Completed |
Risk Factors and Postoperative Complications of Reperfusion Syndrome and Vasoplegic Syndrome in Patients With Vasoactive Support During Liver Transplant Surgery [NCT05658120] | | 246 participants (Actual) | Observational | 2022-12-13 | Completed |
Multicenter, Randomized, Split-mouth Study to Evaluate the Acceptance and Preference of Lidocaine Gel Compared to Injection Anesthesia After Non Surgical Periodontal Treatment [NCT03354312] | Phase 4 | 94 participants (Actual) | Interventional | 2017-12-05 | Completed |
Comparison of Pain of Conventional to Buffered Local Anesthesia During Injection in Pediatric Dental Patients. A Prospective, Double-blind, Randomized, Crossover Study [NCT01622296] | Phase 4 | 20 participants (Actual) | Interventional | 2012-04-30 | Completed |
A Prospective Randomized, Double-blind Study of the Anesthetic Efficacy of Buffered Articaine as a Primary Buccal Infiltration of the Mandibular First Molar. [NCT01862614] | Phase 4 | 80 participants (Actual) | Interventional | 2013-04-30 | Completed |
Epinephrine in the Pediatric Intensive Care Unit: A Dose-Effect Trial (EPI Dose) [NCT05327556] | Phase 2 | 86 participants (Anticipated) | Interventional | 2023-02-08 | Enrolling by invitation |
The Effect of Final Irrigation Using Antimicrobial-corticosteroid Mixture Versus Cryotherapy on Post-instrumentation Pain and Microbial Reduction in Patients Having Single Canal - Teeth With Necrotic Pulps: A Randomized Clinical Trial [NCT05739682] | Phase 3 | 28 participants (Anticipated) | Interventional | 2023-06-01 | Not yet recruiting |
Efficacy of Buprenorphine on Postoperative Endodontic Analgesia [NCT03268278] | Phase 1 | 10 participants (Actual) | Interventional | 2017-04-01 | Terminated(stopped due to Loss of interest) |
The Efficiency of Periarticular Multimodal Drug Injection in Pain Management Following Primary Unilateral Total Knee Arthroplasty: a Randomized Controlled Trial [NCT06112548] | | 80 participants (Anticipated) | Interventional | 2023-11-01 | Not yet recruiting |
Bipolar Hemostatic Forceps Versus Standard Therapy by Hemoclip and or Epinephrin Injection as Initial Endoscopic Treatment in Acute Non-variceal Upper GI Bleeding: a Prospective, Randomized Multicenter Study [NCT05353062] | | 80 participants (Anticipated) | Interventional | 2023-01-01 | Recruiting |
Evaluation of New Methods for Prediction of Fetal Lung Maturity in Diabetic Mothers [NCT03159234] | | 54 participants (Actual) | Interventional | 2016-04-30 | Completed |
CLINICAL STUDY-B3 FOR ASSESSMENT OF PHARMACOKINETICS, A Randomized, Evaluator-Blind, Single-Dose, Three Arm, Crossover,PK Study in Healthy Volunteers [NCT01255709] | Phase 2 | 24 participants (Actual) | Interventional | 2010-12-31 | Completed |
Comparison Between Epinephrine Versus Tranexamic Acid Usage During Upper Gastrointestinal Tract Endoscopic Resection Procedures for the Reduction of Intraprocedural and Postprocedural Bleeding [NCT05688020] | Phase 4 | 200 participants (Anticipated) | Interventional | 2023-02-01 | Recruiting |
Articaine Success in Pulpectomy of Primary Molars With Irreversible Pulpitis in Children Under Four Years: a Randomized Controlled Trial [NCT05944341] | | 164 participants (Anticipated) | Interventional | 2023-06-01 | Recruiting |
A Phase III, Randomized, Placebo-Controlled Clinical Trial to Study the Efficacy and Safety of MK-3641, a Ragweed (Ambrosia Artemisiifolia) Sublingual Immunotherapy Tablet, in Children With a History of Ragweed-Induced Rhinoconjunctivitis With or Without [NCT02478398] | Phase 3 | 1,025 participants (Actual) | Interventional | 2015-07-20 | Completed |
Hypoglycemia Associated Autonomic Dysfunction Dose Response of Epinephrine [NCT02692313] | Early Phase 1 | 32 participants (Anticipated) | Interventional | 2016-06-30 | Recruiting |
Articaine 4% Efficacy and Safety in Extraction and Pulpotomy of Primary Molars of Children Below the Age of Four Years. [NCT05101785] | | 292 participants (Anticipated) | Interventional | 2021-11-01 | Not yet recruiting |
Lidocaine With Epinephrine vs. Bupivacaine With Epinephrine as Local Anesthetic Agents in Wide-awake Hand Surgery: an Outcome Study of Patients' Pain Perception. [NCT02315573] | | 61 participants (Actual) | Interventional | 2014-10-31 | Completed |
Complication in Laparoscopic Renal and Adrenal Surgery (CLARAS): an International Multicenter Study [NCT05322265] | | 350 participants (Anticipated) | Observational | 2017-04-01 | Recruiting |
The Effect of the Popliteal Plexus Block on Postoperative Pain After Total Knee Arthroplasty - a Randomized, Controlled, Double-blinded Study [NCT03439787] | Phase 4 | 15 participants (Actual) | Interventional | 2018-05-15 | Terminated(stopped due to Methodological problems/problems in the study design (competing pain and a placebo effect). No serious adverse events or other safety issues) |
An Open-label, Prospective, Controlled Clinical Trial on Effects and Safety of Adrenal Artery Ablation (Triple A) for Primary Aldosteronism [NCT03398785] | Phase 3 | 66 participants (Actual) | Interventional | 2017-10-01 | Completed |
Nor-epinephrine Versus Midodrine/Octreotide in Patients With Hepatorenal Acute Kidney Injury [NCT04522297] | | 91 participants (Actual) | Interventional | 2018-04-15 | Completed |
Minimum Effective Local Anaesthetic Volume of a 1:1 Mixture of 2% Lidocaine With 5ug/ml of Epinephrine and 0.5% Levobupivacaine Required for Ultrasound Guided Selective Trunk Block: A Dose Finding Study [NCT04773405] | | 25 participants (Actual) | Interventional | 2021-03-10 | Completed |
Intravenous Epinephrine Bolus for Prevention of Postintubation Collapse in Intensive Care Septic Patients Predicted by Shock Index. [NCT06115473] | | 44 participants (Anticipated) | Interventional | 2023-08-01 | Recruiting |
Impact of Adding iPACK Block With Dexamethasone to Existing APS Multimodal Analgesia Protocol for Patients Undergoing Total Knee Arthroplasty [NCT04917055] | Phase 4 | 14 participants (Actual) | Interventional | 2021-06-07 | Terminated(stopped due to staffing) |
An Investigator-Initiated, Double-Blind, Patient-Controlled, Randomized Control Trial Comparing the Effectiveness of Liposomal Bupivacaine to a Solution of Bupivacaine, Epinephrine Clonidine and Dexamethasone in Bilateral, Single Shot, Erector Spinae Plan [NCT04603911] | Phase 2 | 75 participants (Actual) | Interventional | 2020-12-04 | Active, not recruiting |
Analgesic Effect of Adding Popliteal Plexus Block to Standard Saphenous Nerve Block in Patients Scheduled for Elective Arthroscopic Anterior Cruciate Ligament Reconstruction : Randomized Observer Blind Clinical Trial [NCT04020133] | | 58 participants (Anticipated) | Interventional | 2019-09-05 | Recruiting |
Levosimendan Versus Adrenaline in Patients With Low Left Ventricular Function Undergoing Elective On-Pump Coronary Artery Bypass Graft Surgery. A Randomized Controlled Study [NCT05222256] | | 52 participants (Anticipated) | Interventional | 2022-03-31 | Not yet recruiting |
Do Intraoperative Periarticular Injections Improve Postoperative Pain Control in Patients Receiving Duramorph (Preservative Free) During Total Knee Arthroplasty? A Prospective, Double-Blind, Randomized Controlled Trial [NCT02570503] | Phase 4 | 64 participants (Actual) | Interventional | 2015-10-31 | Terminated(stopped due to Study's primary aims are no longer clinically impactful, as intrathecal morphine has fallen out of favor and replaced with different agents so that outpatient/23 hr surgery is more predictably achievable.) |
Efficacy of Peri-Incisional Multimodal Drug Injection in Reducing Post-Operative Pain Following Lumbar Spine Surgery [NCT03513445] | Phase 3 | 0 participants (Actual) | Interventional | 2018-06-01 | Withdrawn(stopped due to No participants enrolled) |
Comparison of the Effect of Vasopressin, Steroid, and Epinephrine Treatment in Patients With Out-of-hospital Cardiac Arrest: Multi-center, Double Blind, Randomized, Placebo-controlled Study [NCT03317197] | Phase 4 | 834 participants (Anticipated) | Interventional | 2018-01-01 | Recruiting |
A Randomized Clinical Trial to Compare the Addition of Epinephrine (no Epinephrine, 100mcg, and 200mcg) to the Standard Dose of Hyperbaric Bupivacaine 12mg, Fentanyl 20mcg and Morphine 150mcg in Scheduled C-sections. [NCT03335293] | Phase 4 | 0 participants (Actual) | Interventional | 2019-10-31 | Withdrawn(stopped due to Due to FDA constraints on the off label use of the medications we will not be able to conduct this evaluation.) |
The Impact of Retropubic Lidocaine vs Saline on Postoperative Urinary Retention Following Midurethral Sling: A Randomized Placebo Controlled Trial [NCT03913845] | Phase 4 | 150 participants (Anticipated) | Interventional | 2019-11-25 | Recruiting |
Adrenal Artery Ablation Treats Primary Aldosteronism With Resistant Hypertension (AAA-RHT) [NCT04345198] | | 36 participants (Actual) | Interventional | 2017-10-01 | Completed |
Impact of intRacoronary adrEnaline on Myocardial reperfuSion in STEMI paTients With Persistent Impaired cORonary Flow After pErcutaneous Coronary Intervention: the RESTORE-SIRIO Randomized Controlled Trial [NCT02405130] | | 0 participants (Actual) | Interventional | 2015-04-30 | Withdrawn |
A Prospective, Randomized Clinical Trial of Two Periarticular Multimodal Drug Injections in Total Hip and Knee Arthroplasty [NCT02543801] | Phase 4 | 239 participants (Actual) | Interventional | 2016-01-25 | Completed |
Prospective, Randomized Controlled Trial Comparing Continuous Posterior Lumbar Plexus Nerve Block vs Periarticular Injection With Ropivacaine or Liposomal Bupivacaine (Exparel®) on Patients Undergoing Total Hip Arthroplasty [NCT02242201] | Phase 4 | 165 participants (Actual) | Interventional | 2014-09-30 | Completed |
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |