Compounds > quercetin pentaacetate
Page last updated: 2024-11-05

quercetin pentaacetate

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Description

Quercetin pentaacetate is a synthetic derivative of the natural flavonoid quercetin. It is prepared by acetylation of quercetin with acetic anhydride. Quercetin pentaacetate has been studied for its potential therapeutic effects, including anti-inflammatory, antioxidant, and anticancer activities. The compound exhibits enhanced lipophilicity compared to quercetin, which may improve its bioavailability and cellular uptake. It is investigated for its potential to modulate signaling pathways involved in inflammation and cancer cell proliferation. The acetylation of quercetin may also alter its pharmacological properties, making it a promising candidate for drug development.'

quercetin pentaacetate: inhibits PGE2 production and COX-2 protein expression; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID14005
CHEMBL ID19074
SCHEMBL ID4064499
MeSH IDM0400343

Synonyms (36)

Synonym
unii-g0b9kj0vki
g0b9kj0vki ,
5-18-05-00510 (beilstein handbook reference)
nsc-718503
nsc718503
quercetin acetate
3,3',4',5,7-pentahydroxyflavone pentaacetate
pentaacetylquercetin
quercetin pentaacetate
flavone, 3,3',4',5,7-pentahydroxy-, pentaacetate
nsc 115919
brn 0380215
4h-1-benzopyran-4-one, 3,5,7-tris(acetyloxy)-2-(3,4-bis(acetyloxy)phenyl)-
3,3',4',5,7-pentaacetoxyflavone
nsc-115919
nsc115919
4h-1-benzopyran-4-one,5,7-tris(acetyloxy)-2-[3,4-bis(acetyloxy)phenyl]-
1064-06-8
AKOS000365733
[2-acetyloxy-4-(3,5,7-triacetyloxy-4-oxochromen-2-yl)phenyl] acetate
CHEMBL19074
3,7-diacetyloxy-2-(3,4-diacetyloxyphenyl)-4-oxochromen-5-yl acetate
bdbm50404746
SCHEMBL4064499
DTXSID30147593
3,5,7-tris(acetyloxy)-2-(3,4-bis(acetyloxy)phenyl)-4h-1-benzopyran-4-one
2-[3,4-bis(acetyloxy)phenyl]-4-oxo-4h-chromene-3,5,7-triyl triacetate
STL513054
HY-124512
Q63409134
quercetinpentaacetate
CS-0086730
3,5,7-triacetoxy-2-(3,4-diacetoxyphenyl)-4h-1-benzopyran-4-one
[5,7-diacetyloxy-2-(3,4-diacetyloxyphenyl)-4-oxochromen-3-yl] acetate
[5,7-diacetyloxy-2-(3,4-diacetyloxyphenyl)-4-oxochromen-3-yl]acetate
E87525
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Arginase Leishmania amazonensisIC50 (µMol)120.80001.60002.28004.0000AID1066694
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (42)

Assay IDTitleYearJournalArticle
AID404069In vivo antitumor activity against mouse L1210 cells
AID430320Ratio of compound IC50 to pentostam IC50 for BALB/c mouse J774.2 cells2009Journal of natural products, Jun, Volume: 72, Issue:6
Antileishmaniasis activity of flavonoids from Consolida oliveriana.
AID220006Relative inhibition of cAMP and cGMP hydrolysis by particulate phosphodiesterase1982Journal of medicinal chemistry, Oct, Volume: 25, Issue:10
Pentasubstituted quercetin analogues as selective inhibitors of particulate 3':5'-cyclic-AMP phosphodiesterase from rat brain.
AID195382Effect of compound on AFB1-induced micronuclei formation in rat bone marrow cells (Activity: Micronucleated cells/1000 cells)2002Bioorganic & medicinal chemistry letters, Sep-16, Volume: 12, Issue:18
Comparison of the prevention of aflatoxin b(1)-induced genotoxicity by quercetin and quercetin pentaacetate.
AID430323Antileishmanial activity against intracellular Leishmania braziliensis amastigotes after 72 hrs by Giemsa staining2009Journal of natural products, Jun, Volume: 72, Issue:6
Antileishmaniasis activity of flavonoids from Consolida oliveriana.
AID430322Antileishmanial activity against intracellular Leishmania peruviana amastigotes after 72 hrs by Giemsa staining2009Journal of natural products, Jun, Volume: 72, Issue:6
Antileishmaniasis activity of flavonoids from Consolida oliveriana.
AID430312Antileishmanial activity against Leishmania peruviana infected in BALB/c mouse J774.2 cells assessed as decrease in parasite infection rate measured on day 10 relative to control2009Journal of natural products, Jun, Volume: 72, Issue:6
Antileishmaniasis activity of flavonoids from Consolida oliveriana.
AID220001Inhibition of rat brain cytosolic cAMP phosphodiesterase1982Journal of medicinal chemistry, Oct, Volume: 25, Issue:10
Pentasubstituted quercetin analogues as selective inhibitors of particulate 3':5'-cyclic-AMP phosphodiesterase from rat brain.
AID430317Inhibition of succinate catabolite excretion in Leishmania peruviana promastigotes at IC25 after 96 hrs by NMR spectroscopy2009Journal of natural products, Jun, Volume: 72, Issue:6
Antileishmaniasis activity of flavonoids from Consolida oliveriana.
AID339129Inhibition of collagen-induced platelet aggregation in rabbit platelet-rich plasma at 100 ug/mL after 3 mins by turbidimetric method1993Journal of natural products, Jun, Volume: 56, Issue:6
Antiplatelet effects and vasorelaxing action of some constituents of Formosan plants.
AID195229Influence (5 uM) on transacetylase catalyzed time dependent activation of NADPH cytochrome C reductase at pre-incubation time being 10 mins2002Bioorganic & medicinal chemistry letters, Sep-16, Volume: 12, Issue:18
Comparison of the prevention of aflatoxin b(1)-induced genotoxicity by quercetin and quercetin pentaacetate.
AID339130Inhibition of platelet activity factor-induced platelet aggregation in rabbit platelet-rich plasma at 100 ug/mL after 3 mins by turbidimetric method1993Journal of natural products, Jun, Volume: 56, Issue:6
Antiplatelet effects and vasorelaxing action of some constituents of Formosan plants.
AID220160Inhibition of rat brain cytosolic cGMP phosphodiesterase (Inactive)1982Journal of medicinal chemistry, Oct, Volume: 25, Issue:10
Pentasubstituted quercetin analogues as selective inhibitors of particulate 3':5'-cyclic-AMP phosphodiesterase from rat brain.
AID430311Cytotoxicity against BALB/c mouse J774.2 cells after 72 hrs by trypan blue assay2009Journal of natural products, Jun, Volume: 72, Issue:6
Antileishmaniasis activity of flavonoids from Consolida oliveriana.
AID1066694Inhibition of Leishmania amazonensis recombinant arginase expressed in Escherichia coli Rosetta (DE3) pLysS using L-arginine as substrate incubated for 10 mins prior to substrate addition measured after 10 mins by colorimetry2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Isolation of arginase inhibitors from the bioactivity-guided fractionation of Byrsonima coccolobifolia leaves and stems.
AID195231Influence (5 uM) on transacetylase catalyzed time dependent activation of NADPH cytochrome C reductase at pre-incubation time being 30 mins2002Bioorganic & medicinal chemistry letters, Sep-16, Volume: 12, Issue:18
Comparison of the prevention of aflatoxin b(1)-induced genotoxicity by quercetin and quercetin pentaacetate.
AID430217Antileishmanial activity against extracellular Leishmania peruviana promastigotes after 72 hrs2009Journal of natural products, Jun, Volume: 72, Issue:6
Antileishmaniasis activity of flavonoids from Consolida oliveriana.
AID430324Increase in L-alanine catabolite excretion in Leishmania peruviana promastigotes at IC25 after 96 hrs by NMR spectroscopy2009Journal of natural products, Jun, Volume: 72, Issue:6
Antileishmaniasis activity of flavonoids from Consolida oliveriana.
AID430314Antileishmanial activity against Leishmania peruviana in BALB/c mouse J774.2 cells assessed as reduction of morphological conversion to parasite amastigote number per cell measured on day 10 by Giemsa staining relative to control2009Journal of natural products, Jun, Volume: 72, Issue:6
Antileishmaniasis activity of flavonoids from Consolida oliveriana.
AID219998Inhibition of rat brain cytosolic cAMP phosphodiesterase1982Journal of medicinal chemistry, Oct, Volume: 25, Issue:10
Pentasubstituted quercetin analogues as selective inhibitors of particulate 3':5'-cyclic-AMP phosphodiesterase from rat brain.
AID338974Inhibition of cow milk xanthine oxidase at 50 ug/mL
AID430316Inhibition of acetate catabolite excretion in Leishmania peruviana promastigotes at IC25 after 96 hrs by NMR spectroscopy2009Journal of natural products, Jun, Volume: 72, Issue:6
Antileishmaniasis activity of flavonoids from Consolida oliveriana.
AID195230Influence (5 uM) on transacetylase catalyzed time dependent activation of NADPH cytochrome C reductase at pre-incubation time being 20 mins2002Bioorganic & medicinal chemistry letters, Sep-16, Volume: 12, Issue:18
Comparison of the prevention of aflatoxin b(1)-induced genotoxicity by quercetin and quercetin pentaacetate.
AID456183Inhibition of reduced carboxymethylated kappa-casein fibril formation at 50 ug/mL measured every 5 mins after 1000 mins by thioflavin T staining-based binding assay2010Bioorganic & medicinal chemistry, Jan-01, Volume: 18, Issue:1
Carboxymethylated-kappa-casein: a convenient tool for the identification of polyphenolic inhibitors of amyloid fibril formation.
AID220162Inhibition of rat brain particulate cGMP phosphodiesterase1982Journal of medicinal chemistry, Oct, Volume: 25, Issue:10
Pentasubstituted quercetin analogues as selective inhibitors of particulate 3':5'-cyclic-AMP phosphodiesterase from rat brain.
AID430334Antileishmanial activity against Leishmania peruviana assessed as abundance of morphologically altered glycosomes at IC25 after 96 hrs by transmission electron microscopy2009Journal of natural products, Jun, Volume: 72, Issue:6
Antileishmaniasis activity of flavonoids from Consolida oliveriana.
AID195232Influence (5 uM) on transacetylase catalyzed time dependent activation of NADPH cytochrome C reductase at pre-incubation time being 5 mins2002Bioorganic & medicinal chemistry letters, Sep-16, Volume: 12, Issue:18
Comparison of the prevention of aflatoxin b(1)-induced genotoxicity by quercetin and quercetin pentaacetate.
AID456187Inhibition of reduced carboxymethylated kappa-casein fibril formation measured every 5 mins after 1000 mins by thioflavin T staining-based binding assay2010Bioorganic & medicinal chemistry, Jan-01, Volume: 18, Issue:1
Carboxymethylated-kappa-casein: a convenient tool for the identification of polyphenolic inhibitors of amyloid fibril formation.
AID310887Permeability from apical to basolateral side of dog MDCK2 cell monolayer assessed as intact drug level in basolateral compartment after 6 hrs2007Journal of medicinal chemistry, Jan-25, Volume: 50, Issue:2
Ester-based precursors to increase the bioavailability of quercetin.
AID430333Antileishmanial activity against Leishmania peruviana assessed as disruption of parasite cytoplasm at IC25 after 96 hrs by transmission electron microscopy2009Journal of natural products, Jun, Volume: 72, Issue:6
Antileishmaniasis activity of flavonoids from Consolida oliveriana.
AID195383Effect of compound on AFB1-induced micronuclei formation in rat bone marrow cells in the presence of AFB1 (Activity: Micronucleated cells/1000 cells)2002Bioorganic & medicinal chemistry letters, Sep-16, Volume: 12, Issue:18
Comparison of the prevention of aflatoxin b(1)-induced genotoxicity by quercetin and quercetin pentaacetate.
AID430326Effect on glycerol catabolite excretion in Leishmania peruviana promastigotes at IC25 after 96 hrs by NMR spectroscopy2009Journal of natural products, Jun, Volume: 72, Issue:6
Antileishmaniasis activity of flavonoids from Consolida oliveriana.
AID33222The compound was evaluated for in Vitro binding of AFB1 to DNA in rat liver microsomes; Pre-incubation time being 20 mins2002Bioorganic & medicinal chemistry letters, Sep-16, Volume: 12, Issue:18
Comparison of the prevention of aflatoxin b(1)-induced genotoxicity by quercetin and quercetin pentaacetate.
AID456191Inhibition of reduced carboxymethylated kappa-casein fibril formation assessed as formation of shorter and stunted fibrils at 1 uM by transmission electron microscopy2010Bioorganic & medicinal chemistry, Jan-01, Volume: 18, Issue:1
Carboxymethylated-kappa-casein: a convenient tool for the identification of polyphenolic inhibitors of amyloid fibril formation.
AID33221The compound was evaluated for in Vitro binding of AFB1 to DNA in rat liver microsomes; Pre-incubation time being 10 mins2002Bioorganic & medicinal chemistry letters, Sep-16, Volume: 12, Issue:18
Comparison of the prevention of aflatoxin b(1)-induced genotoxicity by quercetin and quercetin pentaacetate.
AID430218Antileishmanial activity against extracellular Leishmania braziliensis promastigotes after 72 hrs2009Journal of natural products, Jun, Volume: 72, Issue:6
Antileishmaniasis activity of flavonoids from Consolida oliveriana.
AID430318Antileishmanial activity against Leishmania peruviana assessed as induction of death of parasite with distortion of parasite body at IC25 after 96 hrs by transmission electron microscopy2009Journal of natural products, Jun, Volume: 72, Issue:6
Antileishmaniasis activity of flavonoids from Consolida oliveriana.
AID339128Inhibition of arachidonic acid-induced platelet aggregation in rabbit platelet-rich plasma at 100 ug/mL after 3 mins by turbidimetric method1993Journal of natural products, Jun, Volume: 56, Issue:6
Antiplatelet effects and vasorelaxing action of some constituents of Formosan plants.
AID33223The compound was evaluated for in Vitro binding of AFB1 to DNA in rat liver microsomes; Pre-incubation time being 30 mins2002Bioorganic & medicinal chemistry letters, Sep-16, Volume: 12, Issue:18
Comparison of the prevention of aflatoxin b(1)-induced genotoxicity by quercetin and quercetin pentaacetate.
AID430325Effect on pyruvate catabolite excretion in Leishmania peruviana promastigotes at IC25 after 96 hrs by NMR spectroscopy2009Journal of natural products, Jun, Volume: 72, Issue:6
Antileishmaniasis activity of flavonoids from Consolida oliveriana.
AID310884Solubility in Hanks balanced salt solution at 1 mg after 24 hrs2007Journal of medicinal chemistry, Jan-25, Volume: 50, Issue:2
Ester-based precursors to increase the bioavailability of quercetin.
AID430321Ratio of compound IC50 to glucatim IC50 for BALB/c mouse J774.2 cells2009Journal of natural products, Jun, Volume: 72, Issue:6
Antileishmaniasis activity of flavonoids from Consolida oliveriana.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (11.11)18.7374
1990's1 (11.11)18.2507
2000's4 (44.44)29.6817
2010's2 (22.22)24.3611
2020's1 (11.11)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 17.63

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index17.63 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index4.93 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (17.63)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
emodin
Emodin: Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as a laxative, but is now used mainly as a tool in toxicity studies.. emodin : A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.		1.9810trihydroxyanthraquinoneantineoplastic agent;
laxative;
plant metabolite;
tyrosine kinase inhibitor
indomethacin
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.		1.9810aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole		analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic metabolite;
xenobiotic
4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone
4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone: Inhibitor of phosphodiesterases.		1.9610methoxybenzenes
catechin
Catechin: An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.. catechin : Members of the class of hydroxyflavan that have a flavan-3-ol skeleton and its substituted derivatives.. rac-catechin : A racemate comprising equimolar amounts of (+)- and (-)-catechin. (+)-catechin : The (+)-enantiomer of catechin and a polyphenolic antioxidant plant metabolite.		2.4820catechinantioxidant;
plant metabolite
chrysophanic acid
chrysophanic acid: RN given refers to parent cpd; structure in Merck, 9th ed, #2260. chrysophanol : A trihydroxyanthraquinone that is chrysazin with a methyl substituent at C-3. It has been isolated from Aloe vera and exhibits antiviral and anti-inflammatory activity.		1.9810dihydroxyanthraquinoneanti-inflammatory agent;
antiviral agent;
plant metabolite
physcione
physcione: structure. physcion : A dihydroxyanthraquinone that is 9,10-anthraquinone bearing hydroxy substituents at positions 1 and 8, a methoxy group at position 3, and a methyl group at position 6. It has been widely isolated and characterised from both terrestrial and marine sources.		1.9810dihydroxyanthraquinoneanti-inflammatory agent;
antibacterial agent;
antifungal agent;
antineoplastic agent;
apoptosis inducer;
hepatoprotective agent;
metabolite
ng-nitroarginine methyl ester
NG-Nitroarginine Methyl Ester: A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.		210alpha-amino acid ester;
L-arginine derivative;
methyl ester;
N-nitro compound		EC 1.14.13.39 (nitric oxide synthase) inhibitor
epigallocatechin gallate
epigallocatechin gallate: a steroid 5alpha-reductase inhibitor and antimutagen in green tea (Camellia sinensis). (-)-epigallocatechin 3-gallate : A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.		2.0510flavans;
gallate ester;
polyphenol		antineoplastic agent;
antioxidant;
apoptosis inducer;
geroprotector;
Hsp90 inhibitor;
neuroprotective agent;
plant metabolite
epicatechin
(-)-epicatechin : A catechin with (2R,3R)-configuration.		2.4820catechin;
polyphenol		antioxidant
3,5,7,3',4'-pentamethoxyflavone
3,5,7,3',4'-pentamethoxyflavone: causes relaxation of cavernosum; structure in first source		1.9610
penta-o-ethylquercetin
penta-O-ethylquercetin: structure given in first source		1.9610
aflatoxin b1
Aflatoxin B1: A potent hepatotoxic and hepatocarcinogenic mycotoxin produced by the Aspergillus flavus group of fungi. It is also mutagenic, teratogenic, and causes immunosuppression in animals. It is found as a contaminant in peanuts, cottonseed meal, corn, and other grains. The mycotoxin requires epoxidation to aflatoxin B1 2,3-oxide for activation. Microsomal monooxygenases biotransform the toxin to the less toxic metabolites aflatoxin M1 and Q1.. aflatoxin B1 : An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.		2.0110aflatoxin;
aromatic ether;
aromatic ketone		carcinogenic agent;
human metabolite
rosiglitazone
7,8-diacetoxy-4-methylcoumarin: possess strong antioxidant and radical scavenging activities; structure in first source. 7,8-diacetoxy-4-methylcoumarin : A coumarin substituted by a methyl group at position 4 and by acetyloxy groups at positions 7 and 8. It exhibits strong antioxidant and radical scavenging properties.		2.0110acetate ester;
coumarins;
diester		pro-angiogenic agent;
radical scavenger
taxifolin
(+)-taxifolin : A taxifolin that has (2R,3R)-configuration.		2.0510taxifolinmetabolite
nitroarginine
Nitroarginine: An inhibitor of nitric oxide synthetase which has been shown to prevent glutamate toxicity. Nitroarginine has been experimentally tested for its ability to prevent ammonia toxicity and ammonia-induced alterations in brain energy and ammonia metabolites. (Neurochem Res 1995:200(4):451-6). N(gamma)-nitro-L-arginine : An L-arginine derivative that is L-arginine in which the terminal nitrogen of the guanidyl group is replaced by a nitro group.		210guanidines;
L-arginine derivative;
N-nitro compound;
non-proteinogenic L-alpha-amino acid
syringaresinol
(+)-syringaresinol : The (7alpha,7'alpha,8alpha,8'alpha)-stereoisomer of syringaresinol.		2.110syringaresinolantineoplastic agent
epiafzelechin
epiafzelechin: antioxidant; 3'-deoxy form of epicatechin; structure in first source. (-)-epiafzelechin : A catechin derivative having (2R,3R)-configuration.		2.0510catechinplant metabolite
quercetin
[no description available]		3.63907-hydroxyflavonol;
pentahydroxyflavone		antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
dinoprostone
prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.		210prostaglandins Ehuman metabolite;
mouse metabolite;
oxytocic
biochanin a
[no description available]		2.05104'-methoxyisoflavones;
7-hydroxyisoflavones		antineoplastic agent;
EC 3.5.1.99 (fatty acid amide hydrolase) inhibitor;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor
7,3'-dihydroxy-4'-methoxyisoflavone
7,3'-dihydroxy-4'-methoxyisoflavone: isolated from Astragali radix; structure in first source. calycosin : A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone which is substituted by an additional hydroxy group at the 3' position and a methoxy group at the 4' position.		2.05104'-methoxyisoflavones;
7-hydroxyisoflavones		antioxidant;
metabolite
quercitrin
[no description available]		2.110alpha-L-rhamnoside;
monosaccharide derivative;
quercetin O-glycoside;
tetrahydroxyflavone		antileishmanial agent;
antioxidant;
EC 1.1.1.184 [carbonyl reductase (NADPH)] inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.14.18.1 (tyrosinase) inhibitor;
plant metabolite
quercetin 3-o-glucopyranoside
quercetin 3-O-glucopyranoside: structure in first source. quercetin 3-O-beta-D-glucopyranoside : A quercetin O-glucoside that is quercetin with a beta-D-glucosyl residue attached at position 3. Isolated from Lepisorus contortus, it exhibits antineoplastic activityand has been found to decrease the rate of polymerization and sickling of red blood cells		2.110beta-D-glucoside;
monosaccharide derivative;
quercetin O-glucoside;
tetrahydroxyflavone		antineoplastic agent;
antioxidant;
antipruritic drug;
bone density conservation agent;
geroprotector;
histamine antagonist;
osteogenesis regulator;
plant metabolite
rutin
Hydroxyethylrutoside: Monohydroxyethyl derivative of rutin. Peripheral circulation stimulant used in treatment of venous disorders.		7.420disaccharide derivative;
quercetin O-glucoside;
rutinoside;
tetrahydroxyflavone		antioxidant;
metabolite
kaempferol
[no description available]		2.76307-hydroxyflavonol;
flavonols;
tetrahydroxyflavone		antibacterial agent;
geroprotector;
human blood serum metabolite;
human urinary metabolite;
human xenobiotic metabolite;
plant metabolite
genistein
[no description available]		2.05107-hydroxyisoflavonesantineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
human urinary metabolite;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor
3,7,4'-trihydroxyflavone
3,7,4'-trihydroxyflavone: structure in first source		2.0510hydroxyflavan
galangin
5,7-dihydroxyflavonol: antimicrobial from the twigs of Populus nigra x Populus deltoides; structure in first source. galangin : A 7-hydroxyflavonol with additional hydroxy groups at positions 3 and 5 respectively; a growth inhibitor of breast tumor cells.		2.05107-hydroxyflavonol;
trihydroxyflavone		antimicrobial agent;
EC 3.1.1.3 (triacylglycerol lipase) inhibitor;
plant metabolite
hyperoside
quercetin 3-O-beta-D-galactopyranoside : A quercetin O-glycoside that is quercetin with a beta-D-galactosyl residue attached at position 3. Isolated from Artemisia capillaris, it exhibits hepatoprotective activity.		1.9810beta-D-galactoside;
monosaccharide derivative;
quercetin O-glycoside;
tetrahydroxyflavone		hepatoprotective agent;
plant metabolite
morin
morin: a light yellowish pigment found in the wood of old fustic (Chlorophora tinctoria). morin : A pentahydroxyflavone that is 7-hydroxyflavonol bearing three additional hydroxy substituents at positions 2' 4' and 5.		2.05107-hydroxyflavonol;
pentahydroxyflavone		angiogenesis modulating agent;
anti-inflammatory agent;
antibacterial agent;
antihypertensive agent;
antineoplastic agent;
antioxidant;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
hepatoprotective agent;
metabolite;
neuroprotective agent
myricetin
[no description available]		2.48207-hydroxyflavonol;
hexahydroxyflavone		antineoplastic agent;
antioxidant;
cyclooxygenase 1 inhibitor;
food component;
geroprotector;
hypoglycemic agent;
plant metabolite
robinetin
robinetin: structure given in first source. robinetin : A pentahydroxyflavone that is flavone substituted by hydroxy groups at positions 3, 7, 3, 4' and 5'.		2.05107-hydroxyflavonol;
pentahydroxyflavone		plant metabolite
daidzein
[no description available]		2.05107-hydroxyisoflavonesantineoplastic agent;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
phytoestrogen;
plant metabolite
kaempferol-3-o-galactoside
kaempferol-3-O-galactoside: isolated from Ardisia pusilla; RN given refers to (3-(beta-D-galactopyranosyloxy))-isomer. kaempferol 3-O-beta-D-galactoside : A beta-D-galactoside compound with a 4',5,7-trihydroxychromen-3-yl group at the anomeric position.		2.0510beta-D-galactoside;
glycosyloxyflavone;
monosaccharide derivative;
trihydroxyflavone		antifungal agent;
plant metabolite
7,8-dihydroxy-4-methylcoumarin
7,8-dihydroxy-4-methylcoumarin: possess strong antioxidant and radical scavenging activities; structure in first source		2.0110hydroxycoumarin
zaprinast
zaprinast: anaphylaxis inhibitor; structure		1.9610triazolopyrimidines
ConditionIndicatedRelationship StrengthStudiesTrials
Muscle Contraction
A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.		01.9810
Leishmania Infection
[description not available]		02.0510
Leishmaniasis
A disease caused by any of a number of species of protozoa in the genus LEISHMANIA. There are four major clinical types of this infection: cutaneous (Old and New World) (LEISHMANIASIS, CUTANEOUS), diffuse cutaneous (LEISHMANIASIS, DIFFUSE CUTANEOUS), mucocutaneous (LEISHMANIASIS, MUCOCUTANEOUS), and visceral (LEISHMANIASIS, VISCERAL).		02.0510
Acute Confusional Senile Dementia
[description not available]		02.0510
Alzheimer Disease
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)		02.0510