Page last updated: 2024-10-15

azure c

Description

Azure C: RN given refers to chloride [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

azure C : An organic chloride salt having 3-amino-7-(methylamino)phenothiazin-5-ium as the counterion. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID135421845
CHEMBL ID261368
CHEBI ID87641
SCHEMBL ID333986
SCHEMBL ID1813064
SCHEMBL ID1813066
MeSH IDM0131943

Synonyms (44)

Synonym
azur c
531-57-7
methylene azure c
nsc16165
nsc-16165
monomethylthionine
azure c
monomethylthionine chloride
nsc 16165
phenothiazin-5-ium, 3-amino-7-methylamino-, chloride
einecs 208-512-8
3-amino-7-methylaminophenothiazin-5-ium chloride
3-imino-7-(methylamino)-3h-phenothiazine hydrochloride
monomethyldiaminodiphenazothionium chloride
azure c (van)
azure c, dye content 40 %
3-amino-7-(methylamino)phenothiazin-5-ium chloride
chebi:87641 ,
CHEMBL261368
ccris 9313
unii-jgc8ohd9z9
jgc8ohd9z9 ,
FT-0622540
AKOS015916295
azure c [mi]
c.i. 52002
methylthioninium chloride hydrate impurity c [ep impurity]
methylene blue impurity c
3-amino-7-methylaminophenazathonium chloride
3-amino-7-(methylamino)phenothiazin-5-ium chloride (1:1)
SCHEMBL333986
SCHEMBL1813064
SCHEMBL1813066
DTXSID2040159
mfcd00067677
(3e)-7-amino-3-(methylimino)-3h-phenothiazin-10-ium chloride
azurec
Q27159794
CS-0205244
7-methyliminophenothiazin-10-ium-3-amine;chloride
azzurro c
HY-W143216
F71912
ci 52002
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (8)

Assay IDTitleYearJournalArticle
AID475505Binding affinity to amyloid beta (1 to 42) oligomers by change in fluorescence at 100 uM after 10 mins2009Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17
A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta.
AID1871221Inhibition of human HSP70 ATPase activity at incubated for 3 hrs by malachite green reagent based HTS analysis2021European journal of medicinal chemistry, Jan-01, Volume: 209Small molecule therapeutics for tauopathy in Alzheimer's disease: Walking on the path of most resistance.
AID475504Binding affinity to amyloid beta (1 to 42) fibrils by change in fluorescence at 100 uM after 10 mins2009Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17
A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta.
AID322956Inhibition of synthetic amyloid beta42 oligomer formation by Western blot2007The Journal of biological chemistry, Apr-06, Volume: 282, Issue:14
Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct.
AID322958Inhibition of synthetic amyloid beta-42 fibrillation by light scattering analysis relative to control2007The Journal of biological chemistry, Apr-06, Volume: 282, Issue:14
Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct.
AID322955Inhibition of synthetic amyloid beta-42 oligomerization by ELISA2007The Journal of biological chemistry, Apr-06, Volume: 282, Issue:14
Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct.
AID1871220Inhibition of human HSP70 ATPase activity at 10 uM incubated for 3 hrs by malachite green reagent based HTS analysis relative to control2021European journal of medicinal chemistry, Jan-01, Volume: 209Small molecule therapeutics for tauopathy in Alzheimer's disease: Walking on the path of most resistance.
AID322957Inhibition of synthetic amyloid beta-42 fibrillation by ThT fluorescence analysis relative to control2007The Journal of biological chemistry, Apr-06, Volume: 282, Issue:14
Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (13)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (15.38)18.7374
1990's1 (7.69)18.2507
2000's4 (30.77)29.6817
2010's4 (30.77)24.3611
2020's2 (15.38)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (7.69%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (92.31%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]