trienomycin A: isolated from Streptomyces sp. No. 83-16; related to ansamycin antibiotics; active against hepatoma cells in vitro; MW 622; MF C36-H50-N2-O7 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 10908301 |
| CHEMBL ID | 2017441 |
| SCHEMBL ID | 24139969 |
| MeSH ID | M0133386 |
| Synonym |
|---|
| trienomycin a |
| CHEMBL2017441 |
| ncgc00380800-01_c36h50n2o7_(5r,13s,14r,15r)-15,22-dihydroxy-5-methoxy-14,16-dimethyl-3-oxo-2-azabicyclo[18.3.1]tetracosa-1(24),6,8,10,16,20,22-heptaen-13-yl n-(cyclohexylcarbonyl)-d-alaninate |
| cyclohexane-1-carbonyl-d-alanyl-3-o-methylprotoansatrienin |
| [(5r,6e,8e,10e,13s,14r,15r,16z)-15,22-dihydroxy-5-methoxy-14,16-dimethyl-3-oxo-2-azabicyclo[18.3.1]tetracosa-1(23),6,8,10,16,20(24),21-heptaen-13-yl] (2r)-2-(cyclohexanecarbonylamino)propanoate |
| SCHEMBL24139969 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1385976 | Cytotoxicity against human HepG2 cells after 72 hrs by sulforhodamine B assay | 2018 | Journal of natural products, 09-28, Volume: 81, Issue:9 | Ansamycins with Antiproliferative and Antineuroinflammatory Activity from Moss-Soil-Derived Streptomyces cacaoi subsp. asoensis H2S5. |
| AID1385998 | Cytotoxicity against LPS-induced mouse BV2 cells assessed as cell viability after 24 hrs by MTT assay | 2018 | Journal of natural products, 09-28, Volume: 81, Issue:9 | Ansamycins with Antiproliferative and Antineuroinflammatory Activity from Moss-Soil-Derived Streptomyces cacaoi subsp. asoensis H2S5. |
| AID1385975 | Cytotoxicity against human PC3 cells after 72 hrs by sulforhodamine B assay | 2018 | Journal of natural products, 09-28, Volume: 81, Issue:9 | Ansamycins with Antiproliferative and Antineuroinflammatory Activity from Moss-Soil-Derived Streptomyces cacaoi subsp. asoensis H2S5. |
| AID656627 | Cytotoxicity against human HeLa cells at 72 hrs by MTS assay | 2011 | ACS medicinal chemistry letters, Oct-13, Volume: 2, Issue:10 | Monoenomycin: A Simplified Trienomycin A Analogue that Manifests Anticancer Activity. |
| AID1385997 | Inhibition of LPS-induced nitric oxide production in mouse BV2 cells after 24 hrs by Griess assay | 2018 | Journal of natural products, 09-28, Volume: 81, Issue:9 | Ansamycins with Antiproliferative and Antineuroinflammatory Activity from Moss-Soil-Derived Streptomyces cacaoi subsp. asoensis H2S5. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 6 (42.86) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 4 (28.57) | 24.3611 |
| 2020's | 2 (14.29) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 14 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||