An antagonist at the odorant receptor.
ChEBI ID: 76531
| Member | Definition | Class |
|---|---|---|
| 5-(n,n-hexamethylene)amiloride | A member of the class of pyrazines that is amiloride in which the two amino hydrogens at position N-5 are replaced by a hexamethylene moiety, resulting in the formation of an azepane ring. | 5-(N,N-hexamethylene)amiloride |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 5 (3.50) | 18.7374 |
| 1990's | 64 (44.76) | 18.2507 |
| 2000's | 33 (23.08) | 29.6817 |
| 2010's | 26 (18.18) | 24.3611 |
| 2020's | 15 (10.49) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 2 (1.38%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 143 (98.62%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 67.9K protein | Vaccinia virus | Potency | 28.1838 | 1 | 1 |
| acid sphingomyelinase | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| arylsulfatase A | Homo sapiens (human) | Potency | 0.0054 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 9.4327 | 2 | 2 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 37.9330 | 1 | 1 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 12.5893 | 2 | 2 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 112.2020 | 1 | 1 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 25.1189 | 1 | 1 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 0.0251 | 1 | 1 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 5.0119 | 1 | 1 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| endonuclease IV | Escherichia coli | Potency | 11.2202 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 11.2370 | 2 | 2 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 31.8509 | 1 | 3 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 70.7946 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 20.5962 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 15.8489 | 1 | 2 |
| IDH1 | Homo sapiens (human) | Potency | 21.6092 | 1 | 2 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 4.4668 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 4.2562 | 1 | 1 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 17.7828 | 1 | 1 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 2.8184 | 1 | 1 |
| Parkin | Homo sapiens (human) | Potency | 14.5810 | 1 | 1 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 95.2834 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| pyruvate kinase | Leishmania mexicana mexicana | Potency | 19.9526 | 2 | 2 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 4.4668 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 1.4989 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 12.4391 | 2 | 6 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 59.7279 | 2 | 2 |
| Thrombopoietin | Homo sapiens (human) | Potency | 25.1189 | 2 | 2 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 15.8489 | 2 | 2 |
| transient receptor potential cation channel subfamily V member 1 | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 0.1259 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Adenosine receptor A2a | Homo sapiens (human) | IC50 | 2.6850 | 2 | 2 |
| Adenosine receptor A2b | Homo sapiens (human) | IC50 | 0.2700 | 1 | 1 |
| Coagulation factor X | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Coagulation factor XI | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Plasma kallikrein | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Plasminogen | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 3.3000 | 1 | 1 |
| Prothrombin | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Sodium channel protein type 5 subunit alpha | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| Sodium/hydrogen exchanger 1 | Rattus norvegicus (Norway rat) | Ki | 0.0130 | 2 | 2 |
| Sodium/hydrogen exchanger 3 | Rattus norvegicus (Norway rat) | Ki | 2.4000 | 2 | 2 |
| Sodium/hydrogen exchanger 5 | Homo sapiens (human) | Ki | 0.3700 | 2 | 2 |
| Tissue-type plasminogen activator | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Trypsin-1 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Trypsin-2 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Trypsin-3 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Urokinase-type plasminogen activator | Homo sapiens (human) | IC50 | 2.4000 | 1 | 1 |
| Urokinase-type plasminogen activator | Homo sapiens (human) | Ki | 1.3560 | 1 | 1 |
| Urokinase-type plasminogen activator | Mus musculus (house mouse) | Ki | 9.3080 | 1 | 1 |
| Vitamin K-dependent protein C | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |