Roles > pro-angiogenic agent
Page last updated: 2024-08-05 15:37:17
pro-angiogenic agent
Any compound that promotes the growth of new blood vessels from pre-existing vessels.
ChEBI ID: 72571
Members (8)
| Member | Definition | Class |
|---|
| 12-hydroxy-5,8,10,14-eicosatetraenoic acid | A HETE having a (12S)-hydroxy group and (5Z)-, (8Z)-, (10E)- and (14Z)-double bonds. | 12(S)-HETE |
| agnuside | A benzoate ester resulting from the formal condensation of the carboxy group of 4-hydroxybenzoic acid with the primary hydroxy group of aucubin. It is an iridoid glycoside found in several Vitex plants including Vitex agnus-castus. | agnuside |
| astragaloside IV | A pentacyclic triterpenoid that is cycloastragenol having beta-D-xylopyranosyl and beta-D-glucopyranosyl residues attached at positions O-3 and O-6 respectively. It is isolated from Astragalus membranaceus var mongholicus. | astragaloside IV |
| ginsenoside rg1 | A ginsenoside found in Panax ginseng and Panax japonicus var. major that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy groups at positions 6 and 20 have been converted to the corresponding beta-D-glucopyranosides, and in which a double bond has been introduced at the 24-25 position. | ginsenoside Rg1 |
| goralatide | A tetrapeptide that is Ser-Asp-Lys-Pro in which the N-terminal amino group carries an acetyl group. It is selective inhibitor of primitive haematopoietic cell proliferation and exhibits anti-inflammatory, anti-fibrotic, and pro-angiogenic properties. | Ac-Ser-Asp-Lys-Pro-OH; goralatide |
| jte 013 | A semicarbazide derivative that is semicarbazide in which the amino group at position 2 is replaced by a [1,3-dimethyl-4-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridin-6-yl]amino group and the amino group adjacent to the carbonyl is replaced by a (2,6-dichloropyridin-4-yl)amino group. It is a potent S1P2 antagonist (IC50 = 17.6 nM). | JTE-013 |
| n-arachidonoyl l-serine | An N-acyl-amino acid resulting from the formal condensation of the carboxy group of arachidonic acid with the amino group of L-serine. It is an endocannabinoid-like lipid isolated from bovine brains. | N-arachidonoyl-L-serine |
| rosiglitazone | A coumarin substituted by a methyl group at position 4 and by acetyloxy groups at positions 7 and 8. It exhibits strong antioxidant and radical scavenging properties. | 7,8-diacetoxy-4-methylcoumarin |
Research
Studies (1,185)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|
| pre-1990 | 22 (1.86) | 18.7374 |
| 1990's | 137 (11.56) | 18.2507 |
| 2000's | 288 (24.30) | 29.6817 |
| 2010's | 556 (46.92) | 24.3611 |
| 2020's | 182 (15.36) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|
| Trials | 17 (1.41%) | 5.53% |
| Reviews | 62 (5.14%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 1,127 (93.45%) | 84.16% |
Protein Targets (14)
Potency Measurements
Inhibition Measurements
Activation Measurements
Other Measurements