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pro-angiogenic agent

Any compound that promotes the growth of new blood vessels from pre-existing vessels.

ChEBI ID: 72571

Members (8)

MemberDefinitionClass
12-hydroxy-5,8,10,14-eicosatetraenoic acidA HETE having a (12S)-hydroxy group and (5Z)-, (8Z)-, (10E)- and (14Z)-double bonds.12(S)-HETE
agnusideA benzoate ester resulting from the formal condensation of the carboxy group of 4-hydroxybenzoic acid with the primary hydroxy group of aucubin. It is an iridoid glycoside found in several Vitex plants including Vitex agnus-castus.agnuside
astragaloside IVA pentacyclic triterpenoid that is cycloastragenol having beta-D-xylopyranosyl and beta-D-glucopyranosyl residues attached at positions O-3 and O-6 respectively. It is isolated from Astragalus membranaceus var mongholicus.astragaloside IV
ginsenoside rg1A ginsenoside found in Panax ginseng and Panax japonicus var. major that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy groups at positions 6 and 20 have been converted to the corresponding beta-D-glucopyranosides, and in which a double bond has been introduced at the 24-25 position.ginsenoside Rg1
goralatideA tetrapeptide that is Ser-Asp-Lys-Pro in which the N-terminal amino group carries an acetyl group. It is selective inhibitor of primitive haematopoietic cell proliferation and exhibits anti-inflammatory, anti-fibrotic, and pro-angiogenic properties.Ac-Ser-Asp-Lys-Pro-OH; goralatide
jte 013A semicarbazide derivative that is semicarbazide in which the amino group at position 2 is replaced by a [1,3-dimethyl-4-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridin-6-yl]amino group and the amino group adjacent to the carbonyl is replaced by a (2,6-dichloropyridin-4-yl)amino group. It is a potent S1P2 antagonist (IC50 = 17.6 nM).JTE-013
n-arachidonoyl l-serineAn N-acyl-amino acid resulting from the formal condensation of the carboxy group of arachidonic acid with the amino group of L-serine. It is an endocannabinoid-like lipid isolated from bovine brains.N-arachidonoyl-L-serine
rosiglitazoneA coumarin substituted by a methyl group at position 4 and by acetyloxy groups at positions 7 and 8. It exhibits strong antioxidant and radical scavenging properties.7,8-diacetoxy-4-methylcoumarin

Research

Studies (1,185)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-199022 (1.86)18.7374
1990's137 (11.56)18.2507
2000's288 (24.30)29.6817
2010's556 (46.92)24.3611
2020's182 (15.36)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials17 (1.41%)5.53%
Reviews62 (5.14%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other1,127 (93.45%)84.16%

Protein Targets (14)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency11.750412
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency15.848911
phosphopantetheinyl transferaseBacillus subtilisPotency89.125111
RAR-related orphan receptor gammaMus musculus (house mouse)Potency26.603211
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency22.387211

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Cannabinoid receptor 1Homo sapiens (human)Ki10.000011
Cannabinoid receptor 2 Homo sapiens (human)Ki10.000011
Oxoeicosanoid receptor 1Homo sapiens (human)IC500.500011
Sphingosine 1-phosphate receptor 1Homo sapiens (human)IC501.000022
Sphingosine 1-phosphate receptor 2Homo sapiens (human)IC500.040166
Sphingosine 1-phosphate receptor 2Rattus norvegicus (Norway rat)IC500.020011
Sphingosine 1-phosphate receptor 3Homo sapiens (human)IC501.000022
Sphingosine 1-phosphate receptor 4Homo sapiens (human)IC501.000011
Sphingosine 1-phosphate receptor 5Homo sapiens (human)IC501.000011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Sphingosine 1-phosphate receptor 2Homo sapiens (human)Kd1.960011

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Sphingosine 1-phosphate receptor 2Homo sapiens (human)Activity1.750011