C-C chemokine receptor activity

Definition

Target type: molecularfunction

Combining with a C-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif. [GOC:signaling, PMID:8662823]

C-C chemokine receptor activity is a molecular function associated with transmembrane receptors that specifically bind and respond to chemokines belonging to the C-C chemokine family. These chemokines are characterized by the presence of two adjacent cysteine residues near their N-terminus. Upon binding of a C-C chemokine, the receptor undergoes conformational changes that activate downstream signaling pathways. These pathways typically involve heterotrimeric G proteins, particularly those coupled to Gαi or Gα12/13 subunits. This activation leads to a cascade of intracellular events, including changes in intracellular calcium levels, activation of kinases and phosphatases, and cytoskeletal rearrangements. The ultimate outcome of this signaling cascade is the recruitment and migration of cells, primarily immune cells, towards the chemokine source. This directed cell migration is crucial for various immune responses, including inflammation, wound healing, and immune surveillance. C-C chemokine receptor activity plays a vital role in regulating the trafficking and activation of immune cells, contributing to both beneficial and detrimental immune responses. In some cases, dysregulation of C-C chemokine receptor signaling can contribute to the development of inflammatory and autoimmune diseases.'
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Proteins (13)

Compounds (75)