quercetin and Gas-Gangrene

quercetin has been researched along with Gas-Gangrene* in 1 studies

Other Studies

1 other study(ies) available for quercetin and Gas-Gangrene

Article	Year
Potent inhibition of bacterial neuraminidase activity by pterocarpans isolated from the roots of Lespedeza bicolor. Bioorganic & medicinal chemistry letters, 2011, Oct-15, Volume: 21, Issue:20 Bacterial neuraminidase has been highlighted as a key enzyme for pathogenic infection and sepsis. Six pterocarpans displaying significant levels of neuraminidase inhibitory activity were isolated from the root bark of Lespedeza bicolor. The isolated compounds were identified as three new pterocarpans (1-3) together with known compounds erythrabyssin II (4), lespebuergine G4 (5), and 1-methoxyerythrabyssin II (6). The new compounds were characterized as bicolosin A (1), bicolosin B (2), and bicolosin C (3). All compounds inhibited bacterial neuraminidase in a dose-dependent manner with significant inhibition (IC(50)=0.09-3.25 μM). All neuraminidase inhibitors screened were found to exhibit noncompetitive kinetics. The three most potent neuraminidase inhibitors (1, 3 and 6) feature a methoxy substitution on C-1. Topics: Anti-Bacterial Agents; Clostridium perfringens; Enzyme Inhibitors; Gas Gangrene; Humans; Lespedeza; Neuraminidase; Plant Roots; Pterocarpans	2011

Article

Year

Potent inhibition of bacterial neuraminidase activity by pterocarpans isolated from the roots of Lespedeza bicolor.

Bioorganic & medicinal chemistry letters, 2011, Oct-15, Volume: 21, Issue:20

Bacterial neuraminidase has been highlighted as a key enzyme for pathogenic infection and sepsis. Six pterocarpans displaying significant levels of neuraminidase inhibitory activity were isolated from the root bark of Lespedeza bicolor. The isolated compounds were identified as three new pterocarpans (1-3) together with known compounds erythrabyssin II (4), lespebuergine G4 (5), and 1-methoxyerythrabyssin II (6). The new compounds were characterized as bicolosin A (1), bicolosin B (2), and bicolosin C (3). All compounds inhibited bacterial neuraminidase in a dose-dependent manner with significant inhibition (IC(50)=0.09-3.25 μM). All neuraminidase inhibitors screened were found to exhibit noncompetitive kinetics. The three most potent neuraminidase inhibitors (1, 3 and 6) feature a methoxy substitution on C-1.

Topics: Anti-Bacterial Agents; Clostridium perfringens; Enzyme Inhibitors; Gas Gangrene; Humans; Lespedeza; Neuraminidase; Plant Roots; Pterocarpans

2011