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D-xylulose reductase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: NAD+ + xylitol = D-xylulose + H+ + NADH. [EC:1.1.1.9, RHEA:20433]

D-xylulose reductase activity catalyzes the NADPH-dependent reduction of D-xylulose to xylitol. This enzymatic reaction is crucial in the pentose phosphate pathway, which is a key metabolic route for the production of NADPH and the synthesis of pentose sugars, such as ribose-5-phosphate. D-xylulose reductase plays a significant role in the metabolism of sugars and is involved in various biological processes, including the detoxification of reactive oxygen species, the biosynthesis of vitamins, and the regulation of cellular redox balance. The enzyme's catalytic mechanism involves the transfer of a hydride ion from NADPH to the carbonyl group of D-xylulose, resulting in the formation of xylitol. This reaction is highly specific for D-xylulose and NADPH as substrates, and the enzyme exhibits a strong preference for the reduced form of NADP. Mutations in the gene encoding D-xylulose reductase can lead to genetic disorders, such as xylulose reductase deficiency, which is characterized by the accumulation of D-xylulose in the urine and blood.'
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Proteins (1)

ProteinDefinitionTaxonomy
Sorbitol dehydrogenaseA sorbitol dehydrogenase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q00796]Homo sapiens (human)

Compounds (14)

CompoundDefinitionClassesRoles
coumarin2H-chromen-2-one: coumarin derivativecoumarinsfluorescent dye;
human metabolite;
plant metabolite
herniarinherniarin : A member of the class of coumarins that is coumarin substituted by a methoxy group at position 7.

herniarin: methoxy analog of umbelliferone; structure
coumarinsfluorochrome
3-hydroxy-1-benzopyran-2-one3-hydroxycoumarin: Photoprotective from sea urchin gametes and embryonic cells; structure in first source

hydroxycoumarin : Any coumarin carrying at least one hydroxy substituent.
hydroxycoumarin
isoscopoletinisoscopoletin : A hydroxycoumarin that is esculetin in which the hydroxy group at position 7 is replaced by a methoxy group. It is the major primary metabolite of scoparone.aromatic ether;
hydroxycoumarin
plant metabolite
cp-166,572
epalrestatepalrestat : A monocarboxylic acid that is 1,3-thiazolidine which is substituted on the nitrogen by a carboxymethyl group, at positions 2 and 4 by thioxo and oxo groups, respectively, and at position 5 by a 2-methyl-3-phenylprop-2-en-1-ylidene group. It is an inhibitor of aldose reductase (which catalyses the conversion of glucose to sorbitol) and is used for the treatment of some diabetic complications, including neuropathy.monocarboxylic acid;
thiazolidines
EC 1.1.1.21 (aldehyde reductase) inhibitor
quercetin7-hydroxyflavonol;
pentahydroxyflavone
antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
scopoletinhydroxycoumarinplant growth regulator;
plant metabolite
hymecromoneHymecromone: A coumarin derivative possessing properties as a spasmolytic, choleretic and light-protective agent. It is also used in ANALYTICAL CHEMISTRY TECHNIQUES for the determination of NITRIC ACID.hydroxycoumarinantineoplastic agent;
hyaluronic acid synthesis inhibitor
esculetinesculetin : A hydroxycoumarin that is umbelliferone in which the hydrogen at position 6 is substituted by a hydroxy group. It is used in filters for absorption of ultraviolet light.

esculetin: used in filters for absorption of ultraviolet light; structure
hydroxycoumarinantioxidant;
plant metabolite;
ultraviolet filter
7-hydroxycoumarin7-oxycoumarin: derivatives have anti-oxidant properties

umbelliferone : A hydroxycoumarin that is coumarin substituted by a hydroxy group ay position 7.
hydroxycoumarinfluorescent probe;
food component;
plant metabolite
4-methylesculetin4-methylesculetin: has antiinflammatory activity

6,7-dihydroxy-4-methylcoumarin : A hydroxycoumarin that is 4-methylcuomarin which is substituted by hydroxy groups at positions 3 and 4. A hyaluronan synthesis inhibitor. It has also been used as a fluorescent sensor to monitor the consumption of a boronic acid in Suzuki coupling reactions; fluorescence is readily detectable by the naked eye using a standard 365 nm UV lamp.
hydroxycoumarinanti-inflammatory agent;
antioxidant;
hyaluronan synthesis inhibitor
7-hydroxycoumarin-4-acetic acid7-hydroxycoumarin-4-acetic acid: pH-indicator dye; structure in first source
4-hydroxycoumarin2-hydroxychromone: structurehydroxycoumarin