quercetin and tricin
quercetin has been researched along with tricin* in 1 studies
Other Studies
1 other study(ies) available for quercetin and tricin
| Article | Year |
|---|---|
Increased bioavailability of tricin-amino acid derivatives via a prodrug approach.
Tricin (4',5,7-trihydroxy-3',5'-dimethoxyflavone) has demonstrated diverse biological activities. This compound has a high anti-human cytomegalovirus (HCMV) activity; however, its oral availability is low. To improve its bioavailability, we synthesized tricin-amino acid derivatives as prodrugs and investigated their cell permeability, stability in vitro, and oral availability in vivo. The results demonstrated that the tricin-alanine-glutamic acid conjugate exhibited enhanced permeability, stability in MDCK cells, and excellent bioavailability after oral administration in Crl:CD (SD) male rats. Tricin-alanine-glutamic acid conjugate is a potential new anti-HCMV drug. Topics: Administration, Oral; Alanine; Animals; Antiviral Agents; Biological Availability; Cell Line; Cell Membrane Permeability; Cytomegalovirus; Dogs; Drug Stability; Flavonoids; Glutamic Acid; Male; Prodrugs; Rats; Structure-Activity Relationship | 2011 |